Amino acid dipepetide frequency for Mesorhizobium sp. 8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.627AlaAla: 18.627 ± 0.161	1.021AlaCys: 1.021 ± 0.028	7.498AlaAsp: 7.498 ± 0.083	7.994AlaGlu: 7.994 ± 0.099	4.932AlaPhe: 4.932 ± 0.067	12.151AlaGly: 12.151 ± 0.132	2.157AlaHis: 2.157 ± 0.04	6.502AlaIle: 6.502 ± 0.069	4.463AlaLys: 4.463 ± 0.074	13.422AlaLeu: 13.422 ± 0.132	3.721AlaMet: 3.721 ± 0.062	3.067AlaAsn: 3.067 ± 0.06	5.323AlaPro: 5.323 ± 0.076	3.347AlaGln: 3.347 ± 0.052	8.654AlaArg: 8.654 ± 0.103	6.481AlaSer: 6.481 ± 0.091	6.213AlaThr: 6.213 ± 0.087	9.492AlaVal: 9.492 ± 0.101	1.482AlaTrp: 1.482 ± 0.038	2.746AlaTyr: 2.746 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.845CysAla: 0.845 ± 0.028	0.103CysCys: 0.103 ± 0.008	0.464CysAsp: 0.464 ± 0.02	0.386CysGlu: 0.386 ± 0.02	0.335CysPhe: 0.335 ± 0.015	0.911CysGly: 0.911 ± 0.027	0.21CysHis: 0.21 ± 0.013	0.325CysIle: 0.325 ± 0.015	0.166CysLys: 0.166 ± 0.01	0.743CysLeu: 0.743 ± 0.025	0.144CysMet: 0.144 ± 0.011	0.194CysAsn: 0.194 ± 0.012	0.391CysPro: 0.391 ± 0.018	0.199CysGln: 0.199 ± 0.011	0.608CysArg: 0.608 ± 0.023	0.442CysSer: 0.442 ± 0.021	0.407CysThr: 0.407 ± 0.019	0.608CysVal: 0.608 ± 0.02	0.116CysTrp: 0.116 ± 0.011	0.201CysTyr: 0.201 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.063AspAla: 7.063 ± 0.079	0.461AspCys: 0.461 ± 0.018	3.141AspAsp: 3.141 ± 0.06	3.428AspGlu: 3.428 ± 0.051	2.373AspPhe: 2.373 ± 0.043	5.478AspGly: 5.478 ± 0.084	1.237AspHis: 1.237 ± 0.033	3.156AspIle: 3.156 ± 0.051	1.941AspLys: 1.941 ± 0.053	5.821AspLeu: 5.821 ± 0.072	1.445AspMet: 1.445 ± 0.029	1.378AspAsn: 1.378 ± 0.042	3.381AspPro: 3.381 ± 0.061	1.496AspGln: 1.496 ± 0.033	4.32AspArg: 4.32 ± 0.064	2.174AspSer: 2.174 ± 0.039	2.635AspThr: 2.635 ± 0.051	4.126AspVal: 4.126 ± 0.069	1.003AspTrp: 1.003 ± 0.027	1.466AspTyr: 1.466 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.028GluAla: 8.028 ± 0.095	0.321GluCys: 0.321 ± 0.019	2.694GluAsp: 2.694 ± 0.046	3.111GluGlu: 3.111 ± 0.059	1.724GluPhe: 1.724 ± 0.035	4.239GluGly: 4.239 ± 0.063	1.14GluHis: 1.14 ± 0.031	3.473GluIle: 3.473 ± 0.053	2.782GluLys: 2.782 ± 0.051	4.811GluLeu: 4.811 ± 0.071	1.472GluMet: 1.472 ± 0.04	1.654GluAsn: 1.654 ± 0.032	2.868GluPro: 2.868 ± 0.051	2.031GluGln: 2.031 ± 0.047	4.938GluArg: 4.938 ± 0.085	2.211GluSer: 2.211 ± 0.046	3.518GluThr: 3.518 ± 0.053	3.752GluVal: 3.752 ± 0.058	0.714GluTrp: 0.714 ± 0.022	0.951GluTyr: 0.951 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.741PheAla: 4.741 ± 0.062	0.374PheCys: 0.374 ± 0.015	2.781PheAsp: 2.781 ± 0.05	2.104PheGlu: 2.104 ± 0.04	1.507PhePhe: 1.507 ± 0.032	3.956PheGly: 3.956 ± 0.058	0.794PheHis: 0.794 ± 0.024	1.751PheIle: 1.751 ± 0.038	1.033PheLys: 1.033 ± 0.029	3.573PheLeu: 3.573 ± 0.052	0.848PheMet: 0.848 ± 0.029	1.031PheAsn: 1.031 ± 0.031	1.616PhePro: 1.616 ± 0.031	1.03PheGln: 1.03 ± 0.028	2.396PheArg: 2.396 ± 0.046	2.423PheSer: 2.423 ± 0.042	1.953PheThr: 1.953 ± 0.045	3.104PheVal: 3.104 ± 0.053	0.553PheTrp: 0.553 ± 0.022	0.951PheTyr: 0.951 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.666GlyAla: 9.666 ± 0.129	0.819GlyCys: 0.819 ± 0.024	4.598GlyAsp: 4.598 ± 0.087	5.062GlyGlu: 5.062 ± 0.069	3.814GlyPhe: 3.814 ± 0.059	7.773GlyGly: 7.773 ± 0.195	2.002GlyHis: 2.002 ± 0.04	4.954GlyIle: 4.954 ± 0.062	3.906GlyLys: 3.906 ± 0.062	8.986GlyLeu: 8.986 ± 0.088	2.506GlyMet: 2.506 ± 0.046	2.269GlyAsn: 2.269 ± 0.062	3.459GlyPro: 3.459 ± 0.05	2.793GlyGln: 2.793 ± 0.046	6.294GlyArg: 6.294 ± 0.087	4.774GlySer: 4.774 ± 0.093	4.989GlyThr: 4.989 ± 0.129	6.234GlyVal: 6.234 ± 0.07	1.387GlyTrp: 1.387 ± 0.033	2.408GlyTyr: 2.408 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.361HisAla: 2.361 ± 0.049	0.206HisCys: 0.206 ± 0.013	1.256HisAsp: 1.256 ± 0.026	1.038HisGlu: 1.038 ± 0.027	0.867HisPhe: 0.867 ± 0.024	1.989HisGly: 1.989 ± 0.048	0.498HisHis: 0.498 ± 0.02	0.935HisIle: 0.935 ± 0.027	0.532HisLys: 0.532 ± 0.022	1.868HisLeu: 1.868 ± 0.043	0.5HisMet: 0.5 ± 0.021	0.439HisAsn: 0.439 ± 0.016	1.247HisPro: 1.247 ± 0.033	0.506HisGln: 0.506 ± 0.02	1.376HisArg: 1.376 ± 0.033	0.863HisSer: 0.863 ± 0.027	0.796HisThr: 0.796 ± 0.024	1.505HisVal: 1.505 ± 0.031	0.321HisTrp: 0.321 ± 0.015	0.515HisTyr: 0.515 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.351IleAla: 7.351 ± 0.07	0.481IleCys: 0.481 ± 0.018	3.591IleAsp: 3.591 ± 0.056	3.493IleGlu: 3.493 ± 0.05	1.722IlePhe: 1.722 ± 0.038	5.177IleGly: 5.177 ± 0.069	0.914IleHis: 0.914 ± 0.026	1.987IleIle: 1.987 ± 0.045	1.397IleLys: 1.397 ± 0.037	4.349IleLeu: 4.349 ± 0.074	0.988IleMet: 0.988 ± 0.028	1.306IleAsn: 1.306 ± 0.039	2.274IlePro: 2.274 ± 0.048	1.115IleGln: 1.115 ± 0.03	3.285IleArg: 3.285 ± 0.047	2.792IleSer: 2.792 ± 0.055	2.41IleThr: 2.41 ± 0.055	4.72IleVal: 4.72 ± 0.058	0.553IleTrp: 0.553 ± 0.022	1.127IleTyr: 1.127 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	5.148LysAla: 5.148 ± 0.083	0.146LysCys: 0.146 ± 0.011	2.048LysAsp: 2.048 ± 0.044	1.81LysGlu: 1.81 ± 0.046	0.948LysPhe: 0.948 ± 0.03	2.987LysGly: 2.987 ± 0.053	0.556LysHis: 0.556 ± 0.02	1.743LysIle: 1.743 ± 0.043	1.644LysLys: 1.644 ± 0.05	3.492LysLeu: 3.492 ± 0.059	0.87LysMet: 0.87 ± 0.026	0.956LysAsn: 0.956 ± 0.03	2.344LysPro: 2.344 ± 0.048	1.078LysGln: 1.078 ± 0.03	2.488LysArg: 2.488 ± 0.051	1.816LysSer: 1.816 ± 0.04	2.106LysThr: 2.106 ± 0.041	2.825LysVal: 2.825 ± 0.055	0.384LysTrp: 0.384 ± 0.018	0.681LysTyr: 0.681 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	13.97LeuAla: 13.97 ± 0.154	0.804LeuCys: 0.804 ± 0.028	6.074LeuAsp: 6.074 ± 0.073	4.995LeuGlu: 4.995 ± 0.07	3.772LeuPhe: 3.772 ± 0.059	8.238LeuGly: 8.238 ± 0.073	1.708LeuHis: 1.708 ± 0.04	4.741LeuIle: 4.741 ± 0.072	4.026LeuLys: 4.026 ± 0.061	8.992LeuLeu: 8.992 ± 0.125	2.248LeuMet: 2.248 ± 0.041	2.387LeuAsn: 2.387 ± 0.044	5.326LeuPro: 5.326 ± 0.066	2.372LeuGln: 2.372 ± 0.043	6.058LeuArg: 6.058 ± 0.077	6.411LeuSer: 6.411 ± 0.072	5.357LeuThr: 5.357 ± 0.078	7.77LeuVal: 7.77 ± 0.089	1.111LeuTrp: 1.111 ± 0.031	2.116LeuTyr: 2.116 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.408MetAla: 3.408 ± 0.051	0.146MetCys: 0.146 ± 0.011	1.167MetAsp: 1.167 ± 0.029	1.169MetGlu: 1.169 ± 0.031	0.717MetPhe: 0.717 ± 0.026	1.751MetGly: 1.751 ± 0.04	0.41MetHis: 0.41 ± 0.017	1.296MetIle: 1.296 ± 0.03	1.064MetLys: 1.064 ± 0.029	2.573MetLeu: 2.573 ± 0.048	0.658MetMet: 0.658 ± 0.022	0.819MetAsn: 0.819 ± 0.027	1.562MetPro: 1.562 ± 0.034	0.855MetGln: 0.855 ± 0.024	1.834MetArg: 1.834 ± 0.038	1.522MetSer: 1.522 ± 0.034	1.838MetThr: 1.838 ± 0.037	1.826MetVal: 1.826 ± 0.038	0.218MetTrp: 0.218 ± 0.012	0.304MetTyr: 0.304 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.201AsnAla: 3.201 ± 0.066	0.219AsnCys: 0.219 ± 0.014	1.378AsnAsp: 1.378 ± 0.048	1.253AsnGlu: 1.253 ± 0.032	0.983AsnPhe: 0.983 ± 0.03	2.567AsnGly: 2.567 ± 0.065	0.522AsnHis: 0.522 ± 0.021	1.301AsnIle: 1.301 ± 0.036	0.712AsnLys: 0.712 ± 0.025	2.466AsnLeu: 2.466 ± 0.048	0.622AsnMet: 0.622 ± 0.021	0.651AsnAsn: 0.651 ± 0.026	1.806AsnPro: 1.806 ± 0.039	0.732AsnGln: 0.732 ± 0.026	1.739AsnArg: 1.739 ± 0.039	1.208AsnSer: 1.208 ± 0.046	1.237AsnThr: 1.237 ± 0.037	1.962AsnVal: 1.962 ± 0.057	0.417AsnTrp: 0.417 ± 0.018	0.674AsnTyr: 0.674 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.615ProAla: 6.615 ± 0.101	0.313ProCys: 0.313 ± 0.016	3.607ProAsp: 3.607 ± 0.063	3.403ProGlu: 3.403 ± 0.061	1.981ProPhe: 1.981 ± 0.037	4.416ProGly: 4.416 ± 0.056	1.043ProHis: 1.043 ± 0.025	2.125ProIle: 2.125 ± 0.041	1.882ProLys: 1.882 ± 0.042	4.73ProLeu: 4.73 ± 0.062	1.155ProMet: 1.155 ± 0.03	1.318ProAsn: 1.318 ± 0.03	2.364ProPro: 2.364 ± 0.05	1.62ProGln: 1.62 ± 0.036	2.74ProArg: 2.74 ± 0.057	2.615ProSer: 2.615 ± 0.043	2.292ProThr: 2.292 ± 0.042	4.302ProVal: 4.302 ± 0.059	0.685ProTrp: 0.685 ± 0.025	1.258ProTyr: 1.258 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.975GlnAla: 3.975 ± 0.06	0.169GlnCys: 0.169 ± 0.011	1.412GlnAsp: 1.412 ± 0.03	1.365GlnGlu: 1.365 ± 0.034	1.0GlnPhe: 1.0 ± 0.028	2.261GlnGly: 2.261 ± 0.044	0.544GlnHis: 0.544 ± 0.02	1.653GlnIle: 1.653 ± 0.038	1.136GlnLys: 1.136 ± 0.034	2.501GlnLeu: 2.501 ± 0.044	0.843GlnMet: 0.843 ± 0.025	0.78GlnAsn: 0.78 ± 0.023	1.716GlnPro: 1.716 ± 0.04	1.066GlnGln: 1.066 ± 0.033	2.164GlnArg: 2.164 ± 0.048	1.575GlnSer: 1.575 ± 0.034	1.539GlnThr: 1.539 ± 0.041	2.12GlnVal: 2.12 ± 0.039	0.374GlnTrp: 0.374 ± 0.016	0.58GlnTyr: 0.58 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.763ArgAla: 7.763 ± 0.096	0.472ArgCys: 0.472 ± 0.019	3.918ArgAsp: 3.918 ± 0.063	3.987ArgGlu: 3.987 ± 0.064	2.974ArgPhe: 2.974 ± 0.056	4.64ArgGly: 4.64 ± 0.068	1.799ArgHis: 1.799 ± 0.043	4.019ArgIle: 4.019 ± 0.065	2.493ArgLys: 2.493 ± 0.05	7.748ArgLeu: 7.748 ± 0.102	1.827ArgMet: 1.827 ± 0.04	1.85ArgAsn: 1.85 ± 0.037	3.469ArgPro: 3.469 ± 0.069	2.548ArgGln: 2.548 ± 0.056	5.646ArgArg: 5.646 ± 0.098	3.431ArgSer: 3.431 ± 0.054	3.429ArgThr: 3.429 ± 0.053	4.349ArgVal: 4.349 ± 0.061	0.892ArgTrp: 0.892 ± 0.027	1.674ArgTyr: 1.674 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.278SerAla: 6.278 ± 0.083	0.359SerCys: 0.359 ± 0.016	2.84SerAsp: 2.84 ± 0.051	2.622SerGlu: 2.622 ± 0.047	2.298SerPhe: 2.298 ± 0.041	5.842SerGly: 5.842 ± 0.11	1.015SerHis: 1.015 ± 0.026	2.741SerIle: 2.741 ± 0.055	1.621SerLys: 1.621 ± 0.037	5.289SerLeu: 5.289 ± 0.068	1.328SerMet: 1.328 ± 0.031	1.291SerAsn: 1.291 ± 0.045	2.628SerPro: 2.628 ± 0.043	1.517SerGln: 1.517 ± 0.032	3.484SerArg: 3.484 ± 0.057	2.777SerSer: 2.777 ± 0.064	2.643SerThr: 2.643 ± 0.055	4.061SerVal: 4.061 ± 0.077	0.707SerTrp: 0.707 ± 0.024	1.267SerTyr: 1.267 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.49ThrAla: 6.49 ± 0.098	0.397ThrCys: 0.397 ± 0.017	2.712ThrAsp: 2.712 ± 0.054	2.601ThrGlu: 2.601 ± 0.042	2.059ThrPhe: 2.059 ± 0.038	5.336ThrGly: 5.336 ± 0.085	0.941ThrHis: 0.941 ± 0.023	2.92ThrIle: 2.92 ± 0.055	1.51ThrLys: 1.51 ± 0.038	5.677ThrLeu: 5.677 ± 0.092	1.269ThrMet: 1.269 ± 0.032	1.22ThrAsn: 1.22 ± 0.039	2.994ThrPro: 2.994 ± 0.051	1.25ThrGln: 1.25 ± 0.031	3.091ThrArg: 3.091 ± 0.048	2.635ThrSer: 2.635 ± 0.065	2.876ThrThr: 2.876 ± 0.07	4.902ThrVal: 4.902 ± 0.097	0.658ThrTrp: 0.658 ± 0.023	1.223ThrTyr: 1.223 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.942ValAla: 9.942 ± 0.102	0.605ValCys: 0.605 ± 0.02	4.204ValAsp: 4.204 ± 0.066	4.838ValGlu: 4.838 ± 0.059	3.009ValPhe: 3.009 ± 0.057	5.966ValGly: 5.966 ± 0.074	1.347ValHis: 1.347 ± 0.033	3.831ValIle: 3.831 ± 0.059	2.556ValLys: 2.556 ± 0.044	7.604ValLeu: 7.604 ± 0.092	1.875ValMet: 1.875 ± 0.041	1.979ValAsn: 1.979 ± 0.048	3.919ValPro: 3.919 ± 0.057	1.949ValGln: 1.949 ± 0.041	4.945ValArg: 4.945 ± 0.059	4.521ValSer: 4.521 ± 0.069	4.605ValThr: 4.605 ± 0.084	6.475ValVal: 6.475 ± 0.088	0.899ValTrp: 0.899 ± 0.029	1.545ValTyr: 1.545 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.252TrpAla: 1.252 ± 0.03	0.131TrpCys: 0.131 ± 0.011	0.61TrpAsp: 0.61 ± 0.023	0.511TrpGlu: 0.511 ± 0.022	0.551TrpPhe: 0.551 ± 0.02	0.829TrpGly: 0.829 ± 0.03	0.312TrpHis: 0.312 ± 0.015	0.663TrpIle: 0.663 ± 0.024	0.517TrpLys: 0.517 ± 0.019	1.647TrpLeu: 1.647 ± 0.041	0.349TrpMet: 0.349 ± 0.016	0.477TrpAsn: 0.477 ± 0.016	0.681TrpPro: 0.681 ± 0.022	0.56TrpGln: 0.56 ± 0.021	1.107TrpArg: 1.107 ± 0.033	0.763TrpSer: 0.763 ± 0.025	0.779TrpThr: 0.779 ± 0.027	0.78TrpVal: 0.78 ± 0.026	0.216TrpTrp: 0.216 ± 0.012	0.304TrpTyr: 0.304 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.573TyrAla: 2.573 ± 0.046	0.249TyrCys: 0.249 ± 0.013	1.532TyrAsp: 1.532 ± 0.032	1.262TyrGlu: 1.262 ± 0.031	0.952TyrPhe: 0.952 ± 0.027	2.185TyrGly: 2.185 ± 0.04	0.469TyrHis: 0.469 ± 0.018	0.916TyrIle: 0.916 ± 0.027	0.692TyrLys: 0.692 ± 0.024	2.184TyrLeu: 2.184 ± 0.044	0.469TyrMet: 0.469 ± 0.019	0.583TyrAsn: 0.583 ± 0.021	1.098TyrPro: 1.098 ± 0.03	0.704TyrGln: 0.704 ± 0.023	1.759TyrArg: 1.759 ± 0.038	1.173TyrSer: 1.173 ± 0.029	1.141TyrThr: 1.141 ± 0.034	1.701TyrVal: 1.701 ± 0.038	0.348TyrTrp: 0.348 ± 0.018	0.597TyrTyr: 0.597 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4486 proteins (1410974 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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