Amino acid dipepetide frequency for Kotonkan virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.832AlaAla: 0.832 ± 0.409
0.624AlaCys: 0.624 ± 0.356
0.832AlaAsp: 0.832 ± 0.439
1.871AlaGlu: 1.871 ± 0.476
0.832AlaPhe: 0.832 ± 0.711
2.287AlaGly: 2.287 ± 0.963
0.416AlaHis: 0.416 ± 0.303
2.703AlaIle: 2.703 ± 0.563
2.495AlaLys: 2.495 ± 0.503
2.495AlaLeu: 2.495 ± 0.665
0.832AlaMet: 0.832 ± 0.483
2.079AlaAsn: 2.079 ± 0.591
1.04AlaPro: 1.04 ± 0.478
0.624AlaGln: 0.624 ± 0.295
1.248AlaArg: 1.248 ± 0.449
1.871AlaSer: 1.871 ± 0.723
0.624AlaThr: 0.624 ± 0.32
1.664AlaVal: 1.664 ± 0.539
0.624AlaTrp: 0.624 ± 0.304
1.871AlaTyr: 1.871 ± 1.083
0.0AlaXaa: 0.0 ± 0.0
Cys
0.416CysAla: 0.416 ± 0.186
0.0CysCys: 0.0 ± 0.0
1.04CysAsp: 1.04 ± 0.483
2.079CysGlu: 2.079 ± 0.844
0.832CysPhe: 0.832 ± 0.327
0.832CysGly: 0.832 ± 0.454
0.416CysHis: 0.416 ± 0.246
1.04CysIle: 1.04 ± 0.492
2.911CysLys: 2.911 ± 0.682
2.287CysLeu: 2.287 ± 1.105
0.0CysMet: 0.0 ± 0.0
1.248CysAsn: 1.248 ± 0.387
1.04CysPro: 1.04 ± 0.624
0.416CysGln: 0.416 ± 0.216
0.624CysArg: 0.624 ± 0.367
1.664CysSer: 1.664 ± 0.301
1.04CysThr: 1.04 ± 0.486
0.624CysVal: 0.624 ± 0.359
0.832CysTrp: 0.832 ± 0.308
0.624CysTyr: 0.624 ± 0.566
0.0CysXaa: 0.0 ± 0.0
Asp
1.871AspAla: 1.871 ± 0.334
1.248AspCys: 1.248 ± 0.844
5.199AspAsp: 5.199 ± 1.926
4.991AspGlu: 4.991 ± 1.17
1.456AspPhe: 1.456 ± 0.562
3.743AspGly: 3.743 ± 0.836
1.248AspHis: 1.248 ± 0.606
4.991AspIle: 4.991 ± 1.484
4.575AspLys: 4.575 ± 0.895
5.199AspLeu: 5.199 ± 1.358
1.871AspMet: 1.871 ± 0.613
4.991AspAsn: 4.991 ± 0.705
1.871AspPro: 1.871 ± 0.356
1.664AspGln: 1.664 ± 0.415
1.456AspArg: 1.456 ± 0.425
2.495AspSer: 2.495 ± 0.691
1.871AspThr: 1.871 ± 0.639
4.367AspVal: 4.367 ± 0.944
1.456AspTrp: 1.456 ± 0.876
2.495AspTyr: 2.495 ± 0.47
0.0AspXaa: 0.0 ± 0.0
Glu
1.664GluAla: 1.664 ± 0.573
0.832GluCys: 0.832 ± 0.359
3.743GluAsp: 3.743 ± 0.653
7.07GluGlu: 7.07 ± 1.852
2.495GluPhe: 2.495 ± 0.904
4.783GluGly: 4.783 ± 0.797
2.287GluHis: 2.287 ± 0.655
4.575GluIle: 4.575 ± 2.176
5.407GluLys: 5.407 ± 0.985
7.486GluLeu: 7.486 ± 1.699
1.871GluMet: 1.871 ± 0.545
4.783GluAsn: 4.783 ± 1.379
1.456GluPro: 1.456 ± 0.977
1.248GluGln: 1.248 ± 0.428
3.119GluArg: 3.119 ± 0.844
4.783GluSer: 4.783 ± 1.439
3.951GluThr: 3.951 ± 0.814
6.238GluVal: 6.238 ± 0.951
1.04GluTrp: 1.04 ± 0.46
2.911GluTyr: 2.911 ± 0.635
0.0GluXaa: 0.0 ± 0.0
Phe
1.248PheAla: 1.248 ± 0.591
1.664PheCys: 1.664 ± 0.564
2.495PheAsp: 2.495 ± 0.481
2.495PheGlu: 2.495 ± 1.104
1.456PhePhe: 1.456 ± 0.35
2.911PheGly: 2.911 ± 0.846
1.248PheHis: 1.248 ± 0.511
2.703PheIle: 2.703 ± 0.408
2.703PheLys: 2.703 ± 0.532
3.535PheLeu: 3.535 ± 0.473
0.208PheMet: 0.208 ± 0.137
2.703PheAsn: 2.703 ± 0.692
2.287PhePro: 2.287 ± 0.64
1.456PheGln: 1.456 ± 0.383
1.248PheArg: 1.248 ± 0.537
2.495PheSer: 2.495 ± 0.624
1.871PheThr: 1.871 ± 0.475
1.871PheVal: 1.871 ± 0.572
0.208PheTrp: 0.208 ± 0.137
1.871PheTyr: 1.871 ± 0.779
0.0PheXaa: 0.0 ± 0.0
Gly
1.456GlyAla: 1.456 ± 0.684
0.624GlyCys: 0.624 ± 0.334
3.119GlyAsp: 3.119 ± 0.84
3.951GlyGlu: 3.951 ± 0.535
2.079GlyPhe: 2.079 ± 0.967
2.703GlyGly: 2.703 ± 0.484
0.832GlyHis: 0.832 ± 0.409
6.862GlyIle: 6.862 ± 0.998
6.03GlyLys: 6.03 ± 1.606
6.238GlyLeu: 6.238 ± 1.942
2.079GlyMet: 2.079 ± 0.611
3.743GlyAsn: 3.743 ± 0.532
1.04GlyPro: 1.04 ± 0.351
1.664GlyGln: 1.664 ± 0.687
2.495GlyArg: 2.495 ± 0.901
3.535GlySer: 3.535 ± 0.784
3.119GlyThr: 3.119 ± 1.639
5.407GlyVal: 5.407 ± 0.607
1.04GlyTrp: 1.04 ± 0.365
2.703GlyTyr: 2.703 ± 0.681
0.0GlyXaa: 0.0 ± 0.0
His
0.624HisAla: 0.624 ± 0.364
0.208HisCys: 0.208 ± 0.205
0.624HisAsp: 0.624 ± 0.333
0.624HisGlu: 0.624 ± 0.254
1.04HisPhe: 1.04 ± 0.349
0.832HisGly: 0.832 ± 0.398
0.208HisHis: 0.208 ± 0.137
2.079HisIle: 2.079 ± 0.553
1.456HisLys: 1.456 ± 0.44
1.04HisLeu: 1.04 ± 0.396
0.208HisMet: 0.208 ± 0.294
2.079HisAsn: 2.079 ± 0.669
0.832HisPro: 0.832 ± 0.372
0.0HisGln: 0.0 ± 0.0
1.871HisArg: 1.871 ± 0.619
0.832HisSer: 0.832 ± 0.401
0.624HisThr: 0.624 ± 0.477
1.248HisVal: 1.248 ± 0.473
0.624HisTrp: 0.624 ± 0.254
1.04HisTyr: 1.04 ± 0.468
0.0HisXaa: 0.0 ± 0.0
Ile
1.871IleAla: 1.871 ± 0.649
0.832IleCys: 0.832 ± 0.388
4.991IleAsp: 4.991 ± 0.881
6.03IleGlu: 6.03 ± 1.422
2.911IlePhe: 2.911 ± 0.577
6.03IleGly: 6.03 ± 1.035
0.624IleHis: 0.624 ± 0.411
5.614IleIle: 5.614 ± 1.387
11.021IleLys: 11.021 ± 2.442
6.446IleLeu: 6.446 ± 1.236
4.159IleMet: 4.159 ± 1.156
7.694IleAsn: 7.694 ± 1.233
4.575IlePro: 4.575 ± 0.796
1.871IleGln: 1.871 ± 0.648
6.03IleArg: 6.03 ± 0.961
5.822IleSer: 5.822 ± 1.334
4.783IleThr: 4.783 ± 1.193
3.535IleVal: 3.535 ± 0.914
0.832IleTrp: 0.832 ± 0.438
3.535IleTyr: 3.535 ± 0.673
0.0IleXaa: 0.0 ± 0.0
Lys
2.287LysAla: 2.287 ± 1.123
2.079LysCys: 2.079 ± 0.661
3.327LysAsp: 3.327 ± 1.017
5.614LysGlu: 5.614 ± 0.802
3.119LysPhe: 3.119 ± 1.222
6.862LysGly: 6.862 ± 1.565
1.456LysHis: 1.456 ± 0.794
8.942LysIle: 8.942 ± 2.021
8.734LysLys: 8.734 ± 1.946
10.397LysLeu: 10.397 ± 1.52
3.535LysMet: 3.535 ± 0.826
5.614LysAsn: 5.614 ± 1.23
3.535LysPro: 3.535 ± 0.803
1.871LysGln: 1.871 ± 0.596
3.743LysArg: 3.743 ± 0.959
5.822LysSer: 5.822 ± 1.084
3.951LysThr: 3.951 ± 0.938
4.575LysVal: 4.575 ± 1.2
1.04LysTrp: 1.04 ± 0.269
2.495LysTyr: 2.495 ± 0.588
0.0LysXaa: 0.0 ± 0.0
Leu
2.079LeuAla: 2.079 ± 0.939
2.495LeuCys: 2.495 ± 1.029
6.654LeuAsp: 6.654 ± 1.21
6.862LeuGlu: 6.862 ± 1.297
3.119LeuPhe: 3.119 ± 0.524
5.199LeuGly: 5.199 ± 0.783
0.832LeuHis: 0.832 ± 0.313
9.357LeuIle: 9.357 ± 2.185
8.734LeuLys: 8.734 ± 1.408
9.357LeuLeu: 9.357 ± 1.918
3.119LeuMet: 3.119 ± 0.94
5.407LeuAsn: 5.407 ± 1.118
2.495LeuPro: 2.495 ± 0.823
3.119LeuGln: 3.119 ± 0.675
4.159LeuArg: 4.159 ± 1.376
8.318LeuSer: 8.318 ± 1.449
3.743LeuThr: 3.743 ± 1.095
4.575LeuVal: 4.575 ± 1.09
1.04LeuTrp: 1.04 ± 0.692
3.119LeuTyr: 3.119 ± 0.832
0.0LeuXaa: 0.0 ± 0.0
Met
1.456MetAla: 1.456 ± 0.583
0.624MetCys: 0.624 ± 0.765
2.495MetAsp: 2.495 ± 0.865
1.664MetGlu: 1.664 ± 0.581
1.664MetPhe: 1.664 ± 0.79
2.287MetGly: 2.287 ± 0.879
0.416MetHis: 0.416 ± 0.485
4.783MetIle: 4.783 ± 0.737
2.911MetLys: 2.911 ± 0.504
1.871MetLeu: 1.871 ± 0.966
0.832MetMet: 0.832 ± 0.665
2.079MetAsn: 2.079 ± 0.762
0.208MetPro: 0.208 ± 0.205
1.248MetGln: 1.248 ± 0.64
0.832MetArg: 0.832 ± 0.541
1.871MetSer: 1.871 ± 0.589
0.416MetThr: 0.416 ± 0.303
0.208MetVal: 0.208 ± 0.137
0.624MetTrp: 0.624 ± 0.47
1.871MetTyr: 1.871 ± 0.671
0.0MetXaa: 0.0 ± 0.0
Asn
2.703AsnAla: 2.703 ± 0.474
1.456AsnCys: 1.456 ± 0.543
3.535AsnAsp: 3.535 ± 0.83
3.535AsnGlu: 3.535 ± 0.765
4.159AsnPhe: 4.159 ± 0.799
3.951AsnGly: 3.951 ± 1.29
1.248AsnHis: 1.248 ± 0.546
6.862AsnIle: 6.862 ± 0.693
4.367AsnLys: 4.367 ± 1.034
5.822AsnLeu: 5.822 ± 0.973
2.079AsnMet: 2.079 ± 0.46
6.446AsnAsn: 6.446 ± 1.075
2.495AsnPro: 2.495 ± 0.834
2.287AsnGln: 2.287 ± 0.519
1.871AsnArg: 1.871 ± 0.808
5.199AsnSer: 5.199 ± 0.681
4.991AsnThr: 4.991 ± 0.673
2.079AsnVal: 2.079 ± 0.592
1.248AsnTrp: 1.248 ± 0.478
3.743AsnTyr: 3.743 ± 0.829
0.0AsnXaa: 0.0 ± 0.0
Pro
0.832ProAla: 0.832 ± 0.246
0.0ProCys: 0.0 ± 0.0
2.287ProAsp: 2.287 ± 0.472
3.119ProGlu: 3.119 ± 1.009
1.456ProPhe: 1.456 ± 0.915
1.871ProGly: 1.871 ± 0.903
0.624ProHis: 0.624 ± 0.254
3.119ProIle: 3.119 ± 1.113
2.079ProLys: 2.079 ± 0.419
4.159ProLeu: 4.159 ± 1.075
0.832ProMet: 0.832 ± 0.628
2.079ProAsn: 2.079 ± 0.453
1.04ProPro: 1.04 ± 0.431
0.832ProGln: 0.832 ± 0.677
1.04ProArg: 1.04 ± 0.519
2.703ProSer: 2.703 ± 0.617
2.495ProThr: 2.495 ± 0.736
1.456ProVal: 1.456 ± 1.015
0.416ProTrp: 0.416 ± 0.216
1.456ProTyr: 1.456 ± 0.526
0.0ProXaa: 0.0 ± 0.0
Gln
0.832GlnAla: 0.832 ± 0.423
1.04GlnCys: 1.04 ± 0.577
1.456GlnAsp: 1.456 ± 0.47
1.456GlnGlu: 1.456 ± 0.461
1.248GlnPhe: 1.248 ± 0.36
2.287GlnGly: 2.287 ± 0.694
0.416GlnHis: 0.416 ± 0.316
1.456GlnIle: 1.456 ± 0.588
1.871GlnLys: 1.871 ± 0.695
1.871GlnLeu: 1.871 ± 0.558
0.624GlnMet: 0.624 ± 0.359
2.287GlnAsn: 2.287 ± 0.536
0.416GlnPro: 0.416 ± 0.28
0.832GlnGln: 0.832 ± 0.401
0.624GlnArg: 0.624 ± 0.269
2.079GlnSer: 2.079 ± 0.683
2.079GlnThr: 2.079 ± 0.491
1.04GlnVal: 1.04 ± 0.468
0.624GlnTrp: 0.624 ± 0.254
0.416GlnTyr: 0.416 ± 0.587
0.0GlnXaa: 0.0 ± 0.0
Arg
1.04ArgAla: 1.04 ± 0.397
0.832ArgCys: 0.832 ± 0.389
1.871ArgAsp: 1.871 ± 0.648
3.951ArgGlu: 3.951 ± 0.704
2.495ArgPhe: 2.495 ± 0.607
1.664ArgGly: 1.664 ± 0.748
0.832ArgHis: 0.832 ± 0.422
4.367ArgIle: 4.367 ± 0.474
2.079ArgLys: 2.079 ± 0.576
3.535ArgLeu: 3.535 ± 0.555
0.832ArgMet: 0.832 ± 0.5
3.119ArgAsn: 3.119 ± 0.745
1.456ArgPro: 1.456 ± 0.442
0.416ArgGln: 0.416 ± 0.246
2.495ArgArg: 2.495 ± 0.535
3.535ArgSer: 3.535 ± 0.946
3.119ArgThr: 3.119 ± 0.837
2.495ArgVal: 2.495 ± 0.597
0.416ArgTrp: 0.416 ± 0.186
2.079ArgTyr: 2.079 ± 0.677
0.0ArgXaa: 0.0 ± 0.0
Ser
2.703SerAla: 2.703 ± 0.655
1.664SerCys: 1.664 ± 0.582
3.119SerAsp: 3.119 ± 0.868
5.199SerGlu: 5.199 ± 1.196
2.911SerPhe: 2.911 ± 0.525
3.743SerGly: 3.743 ± 0.962
1.248SerHis: 1.248 ± 0.485
4.575SerIle: 4.575 ± 0.818
5.614SerLys: 5.614 ± 1.116
7.694SerLeu: 7.694 ± 1.167
2.703SerMet: 2.703 ± 0.477
3.743SerAsn: 3.743 ± 1.33
3.119SerPro: 3.119 ± 0.705
1.248SerGln: 1.248 ± 0.617
2.703SerArg: 2.703 ± 0.66
4.159SerSer: 4.159 ± 0.631
2.703SerThr: 2.703 ± 0.659
3.119SerVal: 3.119 ± 0.676
2.287SerTrp: 2.287 ± 0.678
3.119SerTyr: 3.119 ± 0.972
0.0SerXaa: 0.0 ± 0.0
Thr
0.832ThrAla: 0.832 ± 0.468
0.832ThrCys: 0.832 ± 0.442
2.703ThrAsp: 2.703 ± 1.074
3.743ThrGlu: 3.743 ± 0.914
1.456ThrPhe: 1.456 ± 0.638
2.495ThrGly: 2.495 ± 0.501
1.664ThrHis: 1.664 ± 0.568
4.159ThrIle: 4.159 ± 0.929
4.575ThrLys: 4.575 ± 0.943
4.783ThrLeu: 4.783 ± 0.69
1.248ThrMet: 1.248 ± 0.64
2.079ThrAsn: 2.079 ± 0.532
1.456ThrPro: 1.456 ± 0.853
1.04ThrGln: 1.04 ± 0.478
2.495ThrArg: 2.495 ± 0.8
3.327ThrSer: 3.327 ± 0.858
2.703ThrThr: 2.703 ± 0.842
3.743ThrVal: 3.743 ± 0.731
1.456ThrTrp: 1.456 ± 0.438
3.119ThrTyr: 3.119 ± 0.954
0.0ThrXaa: 0.0 ± 0.0
Val
1.664ValAla: 1.664 ± 1.068
2.079ValCys: 2.079 ± 0.708
4.575ValAsp: 4.575 ± 0.851
1.871ValGlu: 1.871 ± 0.672
1.04ValPhe: 1.04 ± 0.312
2.911ValGly: 2.911 ± 0.746
0.832ValHis: 0.832 ± 0.358
7.07ValIle: 7.07 ± 1.08
5.199ValLys: 5.199 ± 1.142
3.951ValLeu: 3.951 ± 1.019
1.456ValMet: 1.456 ± 0.571
4.575ValAsn: 4.575 ± 0.963
1.456ValPro: 1.456 ± 0.468
1.248ValGln: 1.248 ± 0.413
1.664ValArg: 1.664 ± 0.676
2.911ValSer: 2.911 ± 1.277
2.911ValThr: 2.911 ± 0.98
2.495ValVal: 2.495 ± 1.04
0.832ValTrp: 0.832 ± 0.389
2.287ValTyr: 2.287 ± 0.402
0.0ValXaa: 0.0 ± 0.0
Trp
0.208TrpAla: 0.208 ± 0.294
0.208TrpCys: 0.208 ± 0.137
1.456TrpAsp: 1.456 ± 0.467
2.079TrpGlu: 2.079 ± 0.531
1.664TrpPhe: 1.664 ± 0.499
1.248TrpGly: 1.248 ± 0.296
0.208TrpHis: 0.208 ± 0.137
1.456TrpIle: 1.456 ± 0.311
1.04TrpLys: 1.04 ± 0.396
1.04TrpLeu: 1.04 ± 0.503
0.832TrpMet: 0.832 ± 0.296
0.832TrpAsn: 0.832 ± 0.401
0.832TrpPro: 0.832 ± 0.424
0.0TrpGln: 0.0 ± 0.0
0.624TrpArg: 0.624 ± 0.412
1.456TrpSer: 1.456 ± 0.473
0.832TrpThr: 0.832 ± 0.364
0.832TrpVal: 0.832 ± 0.509
0.416TrpTrp: 0.416 ± 0.316
0.208TrpTyr: 0.208 ± 0.205
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.456TyrAla: 1.456 ± 0.524
0.624TyrCys: 0.624 ± 0.269
3.535TyrAsp: 3.535 ± 1.059
3.535TyrGlu: 3.535 ± 0.85
1.248TyrPhe: 1.248 ± 0.416
2.079TyrGly: 2.079 ± 0.893
1.04TyrHis: 1.04 ± 0.312
2.495TyrIle: 2.495 ± 0.526
5.199TyrLys: 5.199 ± 1.567
4.575TyrLeu: 4.575 ± 1.633
0.832TyrMet: 0.832 ± 0.297
2.495TyrAsn: 2.495 ± 0.927
1.248TyrPro: 1.248 ± 0.642
1.871TyrGln: 1.871 ± 0.626
2.287TyrArg: 2.287 ± 0.844
2.495TyrSer: 2.495 ± 0.478
2.079TyrThr: 2.079 ± 0.59
1.456TyrVal: 1.456 ± 0.468
0.416TyrTrp: 0.416 ± 0.316
1.248TyrTyr: 1.248 ± 0.442
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (4810 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski