Amino acid dipepetide frequency for Moraxella phage Mcat9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.888AlaAla: 5.888 ± 2.216
0.725AlaCys: 0.725 ± 0.377
6.612AlaAsp: 6.612 ± 1.221
5.163AlaGlu: 5.163 ± 0.683
2.989AlaPhe: 2.989 ± 0.52
5.616AlaGly: 5.616 ± 0.588
1.721AlaHis: 1.721 ± 0.405
4.62AlaIle: 4.62 ± 0.55
7.609AlaLys: 7.609 ± 0.979
8.605AlaLeu: 8.605 ± 1.203
2.083AlaMet: 2.083 ± 0.449
4.076AlaAsn: 4.076 ± 0.608
2.627AlaPro: 2.627 ± 0.595
4.257AlaGln: 4.257 ± 0.853
3.895AlaArg: 3.895 ± 0.623
6.975AlaSer: 6.975 ± 1.116
5.525AlaThr: 5.525 ± 0.974
6.431AlaVal: 6.431 ± 0.818
1.268AlaTrp: 1.268 ± 0.348
2.989AlaTyr: 2.989 ± 0.398
0.0AlaXaa: 0.0 ± 0.0
Cys
0.362CysAla: 0.362 ± 0.182
0.091CysCys: 0.091 ± 0.082
0.362CysAsp: 0.362 ± 0.141
0.996CysGlu: 0.996 ± 0.32
0.272CysPhe: 0.272 ± 0.148
1.087CysGly: 1.087 ± 0.494
0.453CysHis: 0.453 ± 0.241
0.091CysIle: 0.091 ± 0.09
0.634CysLys: 0.634 ± 0.3
0.815CysLeu: 0.815 ± 0.363
0.181CysMet: 0.181 ± 0.144
0.181CysAsn: 0.181 ± 0.105
0.362CysPro: 0.362 ± 0.186
0.543CysGln: 0.543 ± 0.22
0.453CysArg: 0.453 ± 0.194
0.634CysSer: 0.634 ± 0.266
0.362CysThr: 0.362 ± 0.245
0.453CysVal: 0.453 ± 0.212
0.181CysTrp: 0.181 ± 0.116
0.272CysTyr: 0.272 ± 0.162
0.0CysXaa: 0.0 ± 0.0
Asp
5.797AspAla: 5.797 ± 0.755
0.362AspCys: 0.362 ± 0.198
5.435AspAsp: 5.435 ± 0.826
4.62AspGlu: 4.62 ± 0.551
3.351AspPhe: 3.351 ± 0.821
6.612AspGly: 6.612 ± 0.969
0.996AspHis: 0.996 ± 0.385
4.891AspIle: 4.891 ± 0.646
4.438AspLys: 4.438 ± 0.516
4.076AspLeu: 4.076 ± 0.527
1.449AspMet: 1.449 ± 0.426
3.17AspAsn: 3.17 ± 0.607
1.449AspPro: 1.449 ± 0.465
1.993AspGln: 1.993 ± 0.417
3.08AspArg: 3.08 ± 0.681
3.442AspSer: 3.442 ± 0.507
3.17AspThr: 3.17 ± 0.543
3.351AspVal: 3.351 ± 0.622
1.268AspTrp: 1.268 ± 0.348
1.449AspTyr: 1.449 ± 0.357
0.0AspXaa: 0.0 ± 0.0
Glu
3.261GluAla: 3.261 ± 0.569
0.815GluCys: 0.815 ± 0.333
1.721GluAsp: 1.721 ± 0.528
1.812GluGlu: 1.812 ± 0.405
2.717GluPhe: 2.717 ± 0.563
1.902GluGly: 1.902 ± 0.45
0.815GluHis: 0.815 ± 0.231
4.801GluIle: 4.801 ± 0.706
3.623GluLys: 3.623 ± 0.612
6.884GluLeu: 6.884 ± 0.587
1.63GluMet: 1.63 ± 0.438
3.17GluAsn: 3.17 ± 0.419
2.174GluPro: 2.174 ± 0.485
3.261GluGln: 3.261 ± 0.555
3.08GluArg: 3.08 ± 0.423
2.989GluSer: 2.989 ± 0.469
1.54GluThr: 1.54 ± 0.358
1.993GluVal: 1.993 ± 0.5
0.906GluTrp: 0.906 ± 0.245
2.174GluTyr: 2.174 ± 0.384
0.0GluXaa: 0.0 ± 0.0
Phe
3.17PheAla: 3.17 ± 0.489
0.272PheCys: 0.272 ± 0.147
2.808PheAsp: 2.808 ± 0.548
2.264PheGlu: 2.264 ± 0.498
1.54PhePhe: 1.54 ± 0.434
3.17PheGly: 3.17 ± 0.426
0.815PheHis: 0.815 ± 0.346
2.536PheIle: 2.536 ± 0.464
1.721PheLys: 1.721 ± 0.425
2.989PheLeu: 2.989 ± 0.73
0.543PheMet: 0.543 ± 0.223
2.536PheAsn: 2.536 ± 0.407
0.996PhePro: 0.996 ± 0.248
0.543PheGln: 0.543 ± 0.242
1.087PheArg: 1.087 ± 0.379
1.721PheSer: 1.721 ± 0.334
2.264PheThr: 2.264 ± 0.362
1.993PheVal: 1.993 ± 0.482
0.725PheTrp: 0.725 ± 0.215
1.359PheTyr: 1.359 ± 0.387
0.0PheXaa: 0.0 ± 0.0
Gly
5.254GlyAla: 5.254 ± 0.889
0.543GlyCys: 0.543 ± 0.234
5.163GlyAsp: 5.163 ± 0.741
3.986GlyGlu: 3.986 ± 0.466
2.899GlyPhe: 2.899 ± 0.475
5.344GlyGly: 5.344 ± 0.87
1.178GlyHis: 1.178 ± 0.363
4.348GlyIle: 4.348 ± 0.702
6.25GlyLys: 6.25 ± 0.66
5.797GlyLeu: 5.797 ± 0.559
1.54GlyMet: 1.54 ± 0.496
2.627GlyAsn: 2.627 ± 0.538
0.181GlyPro: 0.181 ± 0.112
3.623GlyGln: 3.623 ± 0.848
3.17GlyArg: 3.17 ± 0.578
3.442GlySer: 3.442 ± 0.45
2.989GlyThr: 2.989 ± 0.609
5.435GlyVal: 5.435 ± 0.595
0.634GlyTrp: 0.634 ± 0.24
2.446GlyTyr: 2.446 ± 0.369
0.0GlyXaa: 0.0 ± 0.0
His
1.359HisAla: 1.359 ± 0.314
0.272HisCys: 0.272 ± 0.17
1.449HisAsp: 1.449 ± 0.391
0.996HisGlu: 0.996 ± 0.306
0.543HisPhe: 0.543 ± 0.265
1.993HisGly: 1.993 ± 0.426
1.178HisHis: 1.178 ± 0.514
1.359HisIle: 1.359 ± 0.377
1.178HisLys: 1.178 ± 0.297
2.355HisLeu: 2.355 ± 0.554
0.634HisMet: 0.634 ± 0.273
1.178HisAsn: 1.178 ± 0.305
1.178HisPro: 1.178 ± 0.393
0.906HisGln: 0.906 ± 0.221
1.178HisArg: 1.178 ± 0.376
0.815HisSer: 0.815 ± 0.263
1.812HisThr: 1.812 ± 0.342
1.268HisVal: 1.268 ± 0.345
0.272HisTrp: 0.272 ± 0.169
0.543HisTyr: 0.543 ± 0.188
0.0HisXaa: 0.0 ± 0.0
Ile
6.522IleAla: 6.522 ± 1.026
0.725IleCys: 0.725 ± 0.309
5.525IleAsp: 5.525 ± 0.561
3.714IleGlu: 3.714 ± 0.462
1.63IlePhe: 1.63 ± 0.562
5.525IleGly: 5.525 ± 0.728
1.449IleHis: 1.449 ± 0.457
3.714IleIle: 3.714 ± 0.527
4.62IleLys: 4.62 ± 0.776
4.167IleLeu: 4.167 ± 0.672
1.721IleMet: 1.721 ± 0.43
4.348IleAsn: 4.348 ± 1.276
1.902IlePro: 1.902 ± 0.504
2.083IleGln: 2.083 ± 0.525
2.536IleArg: 2.536 ± 0.392
5.525IleSer: 5.525 ± 0.995
5.797IleThr: 5.797 ± 0.761
3.442IleVal: 3.442 ± 0.459
0.543IleTrp: 0.543 ± 0.249
2.083IleTyr: 2.083 ± 0.495
0.0IleXaa: 0.0 ± 0.0
Lys
7.428LysAla: 7.428 ± 0.935
0.453LysCys: 0.453 ± 0.199
3.17LysAsp: 3.17 ± 0.553
3.351LysGlu: 3.351 ± 0.636
1.54LysPhe: 1.54 ± 0.313
3.623LysGly: 3.623 ± 0.454
0.906LysHis: 0.906 ± 0.282
4.438LysIle: 4.438 ± 0.561
4.529LysLys: 4.529 ± 0.545
5.254LysLeu: 5.254 ± 0.622
1.902LysMet: 1.902 ± 0.493
2.717LysAsn: 2.717 ± 0.603
2.717LysPro: 2.717 ± 0.532
4.348LysGln: 4.348 ± 0.73
3.351LysArg: 3.351 ± 0.725
5.072LysSer: 5.072 ± 0.784
5.435LysThr: 5.435 ± 0.52
3.442LysVal: 3.442 ± 0.491
0.634LysTrp: 0.634 ± 0.175
1.63LysTyr: 1.63 ± 0.368
0.0LysXaa: 0.0 ± 0.0
Leu
7.609LeuAla: 7.609 ± 1.31
1.268LeuCys: 1.268 ± 0.345
5.163LeuAsp: 5.163 ± 0.749
4.257LeuGlu: 4.257 ± 0.511
2.083LeuPhe: 2.083 ± 0.461
5.978LeuGly: 5.978 ± 0.688
2.083LeuHis: 2.083 ± 0.457
4.71LeuIle: 4.71 ± 0.655
6.975LeuLys: 6.975 ± 0.64
5.797LeuLeu: 5.797 ± 0.807
2.083LeuMet: 2.083 ± 0.346
4.438LeuAsn: 4.438 ± 0.62
4.076LeuPro: 4.076 ± 0.579
4.62LeuGln: 4.62 ± 0.57
3.08LeuArg: 3.08 ± 0.518
8.243LeuSer: 8.243 ± 0.733
5.978LeuThr: 5.978 ± 0.747
5.072LeuVal: 5.072 ± 0.848
0.906LeuTrp: 0.906 ± 0.225
2.627LeuTyr: 2.627 ± 0.537
0.0LeuXaa: 0.0 ± 0.0
Met
3.08MetAla: 3.08 ± 0.732
0.0MetCys: 0.0 ± 0.0
0.815MetAsp: 0.815 ± 0.312
0.453MetGlu: 0.453 ± 0.169
0.725MetPhe: 0.725 ± 0.241
1.63MetGly: 1.63 ± 0.496
0.272MetHis: 0.272 ± 0.135
1.63MetIle: 1.63 ± 0.408
0.543MetLys: 0.543 ± 0.187
2.808MetLeu: 2.808 ± 0.739
1.178MetMet: 1.178 ± 0.34
1.54MetAsn: 1.54 ± 0.351
1.087MetPro: 1.087 ± 0.344
1.087MetGln: 1.087 ± 0.371
1.63MetArg: 1.63 ± 0.357
2.083MetSer: 2.083 ± 0.404
2.446MetThr: 2.446 ± 0.525
1.268MetVal: 1.268 ± 0.369
0.0MetTrp: 0.0 ± 0.0
0.362MetTyr: 0.362 ± 0.163
0.0MetXaa: 0.0 ± 0.0
Asn
4.62AsnAla: 4.62 ± 0.601
0.362AsnCys: 0.362 ± 0.214
3.623AsnAsp: 3.623 ± 0.53
2.627AsnGlu: 2.627 ± 0.434
1.449AsnPhe: 1.449 ± 0.364
3.261AsnGly: 3.261 ± 0.63
1.54AsnHis: 1.54 ± 0.491
3.17AsnIle: 3.17 ± 0.608
2.446AsnLys: 2.446 ± 0.348
3.895AsnLeu: 3.895 ± 0.572
1.54AsnMet: 1.54 ± 0.372
2.536AsnAsn: 2.536 ± 0.511
2.264AsnPro: 2.264 ± 0.67
2.446AsnGln: 2.446 ± 0.47
2.808AsnArg: 2.808 ± 0.677
3.261AsnSer: 3.261 ± 0.671
3.17AsnThr: 3.17 ± 0.64
2.899AsnVal: 2.899 ± 0.471
0.634AsnTrp: 0.634 ± 0.198
2.083AsnTyr: 2.083 ± 0.446
0.0AsnXaa: 0.0 ± 0.0
Pro
2.989ProAla: 2.989 ± 0.485
0.453ProCys: 0.453 ± 0.164
2.355ProAsp: 2.355 ± 0.408
1.902ProGlu: 1.902 ± 0.449
1.359ProPhe: 1.359 ± 0.29
0.906ProGly: 0.906 ± 0.274
0.906ProHis: 0.906 ± 0.303
3.17ProIle: 3.17 ± 0.544
2.899ProLys: 2.899 ± 0.515
3.351ProLeu: 3.351 ± 0.69
0.815ProMet: 0.815 ± 0.267
2.083ProAsn: 2.083 ± 0.432
0.543ProPro: 0.543 ± 0.241
1.087ProGln: 1.087 ± 0.287
1.268ProArg: 1.268 ± 0.316
2.264ProSer: 2.264 ± 0.47
2.899ProThr: 2.899 ± 0.753
2.536ProVal: 2.536 ± 0.568
0.181ProTrp: 0.181 ± 0.14
0.815ProTyr: 0.815 ± 0.373
0.0ProXaa: 0.0 ± 0.0
Gln
5.344GlnAla: 5.344 ± 0.723
0.181GlnCys: 0.181 ± 0.139
1.812GlnAsp: 1.812 ± 0.499
1.721GlnGlu: 1.721 ± 0.362
1.268GlnPhe: 1.268 ± 0.282
3.351GlnGly: 3.351 ± 0.687
0.906GlnHis: 0.906 ± 0.236
3.895GlnIle: 3.895 ± 0.672
2.899GlnLys: 2.899 ± 0.507
3.442GlnLeu: 3.442 ± 0.554
1.902GlnMet: 1.902 ± 0.448
3.08GlnAsn: 3.08 ± 0.61
1.178GlnPro: 1.178 ± 0.357
2.808GlnGln: 2.808 ± 0.563
1.902GlnArg: 1.902 ± 0.395
3.714GlnSer: 3.714 ± 1.098
4.62GlnThr: 4.62 ± 0.601
2.717GlnVal: 2.717 ± 0.471
0.453GlnTrp: 0.453 ± 0.216
1.449GlnTyr: 1.449 ± 0.28
0.0GlnXaa: 0.0 ± 0.0
Arg
4.801ArgAla: 4.801 ± 0.535
0.272ArgCys: 0.272 ± 0.152
2.446ArgAsp: 2.446 ± 0.394
1.993ArgGlu: 1.993 ± 0.464
2.989ArgPhe: 2.989 ± 0.751
1.178ArgGly: 1.178 ± 0.307
1.812ArgHis: 1.812 ± 0.391
4.076ArgIle: 4.076 ± 0.828
1.902ArgLys: 1.902 ± 0.378
4.801ArgLeu: 4.801 ± 0.656
0.906ArgMet: 0.906 ± 0.336
1.359ArgAsn: 1.359 ± 0.341
1.449ArgPro: 1.449 ± 0.335
2.808ArgGln: 2.808 ± 0.39
2.355ArgArg: 2.355 ± 0.485
2.083ArgSer: 2.083 ± 0.403
3.714ArgThr: 3.714 ± 0.579
2.264ArgVal: 2.264 ± 0.38
0.543ArgTrp: 0.543 ± 0.195
2.264ArgTyr: 2.264 ± 0.509
0.0ArgXaa: 0.0 ± 0.0
Ser
5.344SerAla: 5.344 ± 0.88
0.453SerCys: 0.453 ± 0.183
5.254SerAsp: 5.254 ± 0.725
3.17SerGlu: 3.17 ± 0.531
1.087SerPhe: 1.087 ± 0.239
4.529SerGly: 4.529 ± 0.75
1.63SerHis: 1.63 ± 0.286
4.438SerIle: 4.438 ± 1.071
4.167SerLys: 4.167 ± 0.612
6.069SerLeu: 6.069 ± 0.912
1.087SerMet: 1.087 ± 0.338
3.442SerAsn: 3.442 ± 0.624
1.993SerPro: 1.993 ± 0.474
3.895SerGln: 3.895 ± 0.831
2.627SerArg: 2.627 ± 0.537
3.351SerSer: 3.351 ± 0.885
2.536SerThr: 2.536 ± 0.513
5.254SerVal: 5.254 ± 0.792
0.453SerTrp: 0.453 ± 0.17
2.989SerTyr: 2.989 ± 0.498
0.0SerXaa: 0.0 ± 0.0
Thr
7.609ThrAla: 7.609 ± 1.055
0.362ThrCys: 0.362 ± 0.159
3.986ThrAsp: 3.986 ± 0.616
3.351ThrGlu: 3.351 ± 0.648
2.355ThrPhe: 2.355 ± 0.527
4.257ThrGly: 4.257 ± 0.49
1.087ThrHis: 1.087 ± 0.29
4.076ThrIle: 4.076 ± 0.59
4.257ThrLys: 4.257 ± 0.736
7.156ThrLeu: 7.156 ± 1.154
1.268ThrMet: 1.268 ± 0.262
2.899ThrAsn: 2.899 ± 0.513
4.257ThrPro: 4.257 ± 0.729
2.808ThrGln: 2.808 ± 0.57
2.083ThrArg: 2.083 ± 0.511
3.08ThrSer: 3.08 ± 0.602
5.707ThrThr: 5.707 ± 1.076
4.076ThrVal: 4.076 ± 0.649
0.906ThrTrp: 0.906 ± 0.216
1.449ThrTyr: 1.449 ± 0.52
0.0ThrXaa: 0.0 ± 0.0
Val
5.616ValAla: 5.616 ± 0.845
0.543ValCys: 0.543 ± 0.288
4.076ValAsp: 4.076 ± 0.679
1.993ValGlu: 1.993 ± 0.511
2.989ValPhe: 2.989 ± 0.549
4.438ValGly: 4.438 ± 0.683
1.087ValHis: 1.087 ± 0.371
4.529ValIle: 4.529 ± 0.749
3.714ValLys: 3.714 ± 0.689
4.348ValLeu: 4.348 ± 0.695
1.721ValMet: 1.721 ± 0.443
2.627ValAsn: 2.627 ± 0.44
2.355ValPro: 2.355 ± 0.607
2.808ValGln: 2.808 ± 0.405
3.533ValArg: 3.533 ± 0.574
3.351ValSer: 3.351 ± 0.614
4.348ValThr: 4.348 ± 0.55
4.348ValVal: 4.348 ± 0.689
0.815ValTrp: 0.815 ± 0.237
1.63ValTyr: 1.63 ± 0.469
0.0ValXaa: 0.0 ± 0.0
Trp
1.178TrpAla: 1.178 ± 0.422
0.181TrpCys: 0.181 ± 0.171
0.725TrpAsp: 0.725 ± 0.256
0.725TrpGlu: 0.725 ± 0.248
0.272TrpPhe: 0.272 ± 0.192
0.634TrpGly: 0.634 ± 0.222
0.453TrpHis: 0.453 ± 0.202
0.634TrpIle: 0.634 ± 0.246
0.272TrpLys: 0.272 ± 0.144
1.359TrpLeu: 1.359 ± 0.359
0.272TrpMet: 0.272 ± 0.157
0.272TrpAsn: 0.272 ± 0.127
0.0TrpPro: 0.0 ± 0.0
1.268TrpGln: 1.268 ± 0.371
0.634TrpArg: 0.634 ± 0.3
0.362TrpSer: 0.362 ± 0.206
0.815TrpThr: 0.815 ± 0.236
1.178TrpVal: 1.178 ± 0.31
0.181TrpTrp: 0.181 ± 0.118
0.543TrpTyr: 0.543 ± 0.204
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.446TyrAla: 2.446 ± 0.61
0.453TyrCys: 0.453 ± 0.213
1.902TyrAsp: 1.902 ± 0.383
2.174TyrGlu: 2.174 ± 0.384
0.996TyrPhe: 0.996 ± 0.271
1.812TyrGly: 1.812 ± 0.344
1.178TyrHis: 1.178 ± 0.427
2.446TyrIle: 2.446 ± 0.417
1.268TyrLys: 1.268 ± 0.331
3.08TyrLeu: 3.08 ± 0.646
0.091TyrMet: 0.091 ± 0.095
2.446TyrAsn: 2.446 ± 0.458
1.993TyrPro: 1.993 ± 0.448
1.449TyrGln: 1.449 ± 0.538
2.264TyrArg: 2.264 ± 0.464
1.359TyrSer: 1.359 ± 0.276
1.902TyrThr: 1.902 ± 0.604
1.449TyrVal: 1.449 ± 0.269
0.453TyrTrp: 0.453 ± 0.241
1.449TyrTyr: 1.449 ± 0.432
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 42 proteins (11041 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski