Amino acid dipepetide frequency for Poophage SC_4_H6H8_2017

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.926AlaAla: 7.926 ± 3.356
0.0AlaCys: 0.0 ± 0.0
1.321AlaAsp: 1.321 ± 0.946
1.321AlaGlu: 1.321 ± 0.946
2.642AlaPhe: 2.642 ± 0.086
3.963AlaGly: 3.963 ± 0.774
1.321AlaHis: 1.321 ± 0.86
1.321AlaIle: 1.321 ± 0.946
2.642AlaLys: 2.642 ± 0.086
5.284AlaLeu: 5.284 ± 1.979
0.0AlaMet: 0.0 ± 0.0
0.0AlaAsn: 0.0 ± 0.0
3.963AlaPro: 3.963 ± 2.839
0.0AlaGln: 0.0 ± 0.0
0.0AlaArg: 0.0 ± 0.0
7.926AlaSer: 7.926 ± 0.258
6.605AlaThr: 6.605 ± 4.302
6.605AlaVal: 6.605 ± 1.118
1.321AlaTrp: 1.321 ± 0.946
2.642AlaTyr: 2.642 ± 0.086
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
1.321CysGlu: 1.321 ± 0.946
1.321CysPhe: 1.321 ± 0.946
1.321CysGly: 1.321 ± 0.946
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
2.642CysLeu: 2.642 ± 1.893
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.321CysPro: 1.321 ± 0.86
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
1.321CysTyr: 1.321 ± 0.86
0.0CysXaa: 0.0 ± 0.0
Asp
1.321AspAla: 1.321 ± 0.946
1.321AspCys: 1.321 ± 0.946
0.0AspAsp: 0.0 ± 0.0
3.963AspGlu: 3.963 ± 0.774
11.889AspPhe: 11.889 ± 3.097
0.0AspGly: 0.0 ± 0.0
0.0AspHis: 0.0 ± 0.0
1.321AspIle: 1.321 ± 0.86
2.642AspLys: 2.642 ± 1.893
6.605AspLeu: 6.605 ± 2.495
1.321AspMet: 1.321 ± 0.86
1.321AspAsn: 1.321 ± 0.86
1.321AspPro: 1.321 ± 0.946
0.0AspGln: 0.0 ± 0.0
7.926AspArg: 7.926 ± 1.549
2.642AspSer: 2.642 ± 0.086
1.321AspThr: 1.321 ± 0.86
7.926AspVal: 7.926 ± 1.549
2.642AspTrp: 2.642 ± 0.086
5.284AspTyr: 5.284 ± 0.172
0.0AspXaa: 0.0 ± 0.0
Glu
3.963GluAla: 3.963 ± 0.774
1.321GluCys: 1.321 ± 0.946
1.321GluAsp: 1.321 ± 0.86
1.321GluGlu: 1.321 ± 0.946
3.963GluPhe: 3.963 ± 1.032
1.321GluGly: 1.321 ± 0.86
1.321GluHis: 1.321 ± 0.86
2.642GluIle: 2.642 ± 1.721
0.0GluLys: 0.0 ± 0.0
2.642GluLeu: 2.642 ± 0.086
0.0GluMet: 0.0 ± 0.0
0.0GluAsn: 0.0 ± 0.0
5.284GluPro: 5.284 ± 1.635
1.321GluGln: 1.321 ± 0.86
5.284GluArg: 5.284 ± 3.785
0.0GluSer: 0.0 ± 0.0
1.321GluThr: 1.321 ± 0.946
2.642GluVal: 2.642 ± 0.086
0.0GluTrp: 0.0 ± 0.0
3.963GluTyr: 3.963 ± 0.774
0.0GluXaa: 0.0 ± 0.0
Phe
7.926PheAla: 7.926 ± 3.356
0.0PheCys: 0.0 ± 0.0
1.321PheAsp: 1.321 ± 0.86
1.321PheGlu: 1.321 ± 0.946
3.963PhePhe: 3.963 ± 0.774
5.284PheGly: 5.284 ± 3.785
1.321PheHis: 1.321 ± 0.946
3.963PheIle: 3.963 ± 1.032
3.963PheLys: 3.963 ± 1.032
6.605PheLeu: 6.605 ± 2.925
0.0PheMet: 0.0 ± 0.0
6.605PheAsn: 6.605 ± 2.495
1.321PhePro: 1.321 ± 0.86
1.321PheGln: 1.321 ± 0.946
2.642PheArg: 2.642 ± 0.086
5.284PheSer: 5.284 ± 0.172
3.963PheThr: 3.963 ± 0.774
3.963PheVal: 3.963 ± 1.032
3.963PheTrp: 3.963 ± 0.774
2.642PheTyr: 2.642 ± 1.721
0.0PheXaa: 0.0 ± 0.0
Gly
2.642GlyAla: 2.642 ± 0.086
0.0GlyCys: 0.0 ± 0.0
3.963GlyAsp: 3.963 ± 1.032
2.642GlyGlu: 2.642 ± 1.721
5.284GlyPhe: 5.284 ± 1.979
6.605GlyGly: 6.605 ± 0.689
1.321GlyHis: 1.321 ± 0.946
2.642GlyIle: 2.642 ± 0.086
2.642GlyLys: 2.642 ± 1.893
3.963GlyLeu: 3.963 ± 1.032
1.321GlyMet: 1.321 ± 0.674
1.321GlyAsn: 1.321 ± 0.946
1.321GlyPro: 1.321 ± 0.86
2.642GlyGln: 2.642 ± 1.721
2.642GlyArg: 2.642 ± 0.086
5.284GlySer: 5.284 ± 1.635
3.963GlyThr: 3.963 ± 2.581
6.605GlyVal: 6.605 ± 2.925
1.321GlyTrp: 1.321 ± 0.86
3.963GlyTyr: 3.963 ± 2.581
0.0GlyXaa: 0.0 ± 0.0
His
1.321HisAla: 1.321 ± 0.946
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
1.321HisPhe: 1.321 ± 0.946
1.321HisGly: 1.321 ± 0.946
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.0HisLys: 0.0 ± 0.0
0.0HisLeu: 0.0 ± 0.0
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
2.642HisPro: 2.642 ± 0.086
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
2.642HisSer: 2.642 ± 1.893
0.0HisThr: 0.0 ± 0.0
1.321HisVal: 1.321 ± 0.86
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.963IleAla: 3.963 ± 1.032
0.0IleCys: 0.0 ± 0.0
3.963IleAsp: 3.963 ± 1.032
2.642IleGlu: 2.642 ± 1.721
1.321IlePhe: 1.321 ± 0.86
6.605IleGly: 6.605 ± 2.495
0.0IleHis: 0.0 ± 0.0
0.0IleIle: 0.0 ± 0.0
1.321IleLys: 1.321 ± 0.946
1.321IleLeu: 1.321 ± 0.86
1.321IleMet: 1.321 ± 0.946
0.0IleAsn: 0.0 ± 0.0
2.642IlePro: 2.642 ± 0.086
0.0IleGln: 0.0 ± 0.0
9.247IleArg: 9.247 ± 3.011
5.284IleSer: 5.284 ± 0.172
3.963IleThr: 3.963 ± 2.839
1.321IleVal: 1.321 ± 0.946
1.321IleTrp: 1.321 ± 0.946
1.321IleTyr: 1.321 ± 0.86
0.0IleXaa: 0.0 ± 0.0
Lys
2.642LysAla: 2.642 ± 0.086
0.0LysCys: 0.0 ± 0.0
3.963LysAsp: 3.963 ± 1.032
2.642LysGlu: 2.642 ± 1.721
1.321LysPhe: 1.321 ± 0.946
3.963LysGly: 3.963 ± 0.774
1.321LysHis: 1.321 ± 0.946
5.284LysIle: 5.284 ± 0.172
0.0LysLys: 0.0 ± 0.0
5.284LysLeu: 5.284 ± 0.172
0.0LysMet: 0.0 ± 0.0
0.0LysAsn: 0.0 ± 0.0
0.0LysPro: 0.0 ± 0.0
0.0LysGln: 0.0 ± 0.0
1.321LysArg: 1.321 ± 0.946
6.605LysSer: 6.605 ± 1.118
2.642LysThr: 2.642 ± 0.086
6.605LysVal: 6.605 ± 0.689
0.0LysTrp: 0.0 ± 0.0
5.284LysTyr: 5.284 ± 3.785
0.0LysXaa: 0.0 ± 0.0
Leu
6.605LeuAla: 6.605 ± 1.118
0.0LeuCys: 0.0 ± 0.0
0.0LeuAsp: 0.0 ± 0.0
3.963LeuGlu: 3.963 ± 0.774
5.284LeuPhe: 5.284 ± 3.442
9.247LeuGly: 9.247 ± 1.204
1.321LeuHis: 1.321 ± 0.946
1.321LeuIle: 1.321 ± 0.86
0.0LeuLys: 0.0 ± 0.0
3.963LeuLeu: 3.963 ± 0.774
2.642LeuMet: 2.642 ± 0.086
2.642LeuAsn: 2.642 ± 0.086
1.321LeuPro: 1.321 ± 0.946
7.926LeuGln: 7.926 ± 1.549
7.926LeuArg: 7.926 ± 3.871
6.605LeuSer: 6.605 ± 0.689
5.284LeuThr: 5.284 ± 1.635
3.963LeuVal: 3.963 ± 1.032
3.963LeuTrp: 3.963 ± 2.839
3.963LeuTyr: 3.963 ± 1.032
0.0LeuXaa: 0.0 ± 0.0
Met
1.321MetAla: 1.321 ± 0.86
1.321MetCys: 1.321 ± 0.946
1.321MetAsp: 1.321 ± 0.946
0.0MetGlu: 0.0 ± 0.0
2.642MetPhe: 2.642 ± 1.721
1.321MetGly: 1.321 ± 0.86
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
2.642MetLeu: 2.642 ± 1.721
0.0MetMet: 0.0 ± 0.0
2.642MetAsn: 2.642 ± 0.086
1.321MetPro: 1.321 ± 0.86
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
1.321MetSer: 1.321 ± 0.86
1.321MetThr: 1.321 ± 0.86
2.642MetVal: 2.642 ± 0.086
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.321AsnAla: 1.321 ± 0.946
0.0AsnCys: 0.0 ± 0.0
2.642AsnAsp: 2.642 ± 0.086
3.963AsnGlu: 3.963 ± 0.774
1.321AsnPhe: 1.321 ± 0.86
1.321AsnGly: 1.321 ± 0.86
0.0AsnHis: 0.0 ± 0.0
1.321AsnIle: 1.321 ± 0.86
5.284AsnLys: 5.284 ± 1.635
2.642AsnLeu: 2.642 ± 0.086
1.321AsnMet: 1.321 ± 0.86
2.642AsnAsn: 2.642 ± 1.721
5.284AsnPro: 5.284 ± 0.172
1.321AsnGln: 1.321 ± 0.86
3.963AsnArg: 3.963 ± 1.032
6.605AsnSer: 6.605 ± 0.689
1.321AsnThr: 1.321 ± 0.946
2.642AsnVal: 2.642 ± 1.721
1.321AsnTrp: 1.321 ± 0.86
1.321AsnTyr: 1.321 ± 0.86
0.0AsnXaa: 0.0 ± 0.0
Pro
1.321ProAla: 1.321 ± 0.86
2.642ProCys: 2.642 ± 0.086
5.284ProAsp: 5.284 ± 3.442
2.642ProGlu: 2.642 ± 1.893
5.284ProPhe: 5.284 ± 1.635
3.963ProGly: 3.963 ± 0.774
1.321ProHis: 1.321 ± 0.946
3.963ProIle: 3.963 ± 1.032
3.963ProLys: 3.963 ± 2.581
1.321ProLeu: 1.321 ± 0.86
1.321ProMet: 1.321 ± 0.86
0.0ProAsn: 0.0 ± 0.0
1.321ProPro: 1.321 ± 0.86
2.642ProGln: 2.642 ± 1.721
3.963ProArg: 3.963 ± 1.032
10.568ProSer: 10.568 ± 0.344
0.0ProThr: 0.0 ± 0.0
1.321ProVal: 1.321 ± 0.86
1.321ProTrp: 1.321 ± 0.946
1.321ProTyr: 1.321 ± 0.86
0.0ProXaa: 0.0 ± 0.0
Gln
1.321GlnAla: 1.321 ± 0.86
0.0GlnCys: 0.0 ± 0.0
2.642GlnAsp: 2.642 ± 0.086
3.963GlnGlu: 3.963 ± 0.774
0.0GlnPhe: 0.0 ± 0.0
0.0GlnGly: 0.0 ± 0.0
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
1.321GlnLys: 1.321 ± 0.946
1.321GlnLeu: 1.321 ± 0.86
2.642GlnMet: 2.642 ± 1.721
3.963GlnAsn: 3.963 ± 1.032
0.0GlnPro: 0.0 ± 0.0
2.642GlnGln: 2.642 ± 0.086
3.963GlnArg: 3.963 ± 1.032
5.284GlnSer: 5.284 ± 3.442
1.321GlnThr: 1.321 ± 0.86
1.321GlnVal: 1.321 ± 0.86
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
1.321ArgAla: 1.321 ± 0.946
1.321ArgCys: 1.321 ± 0.946
3.963ArgAsp: 3.963 ± 2.581
6.605ArgGlu: 6.605 ± 2.925
2.642ArgPhe: 2.642 ± 0.086
1.321ArgGly: 1.321 ± 0.86
0.0ArgHis: 0.0 ± 0.0
5.284ArgIle: 5.284 ± 1.979
5.284ArgLys: 5.284 ± 1.979
10.568ArgLeu: 10.568 ± 2.15
0.0ArgMet: 0.0 ± 0.645
3.963ArgAsn: 3.963 ± 2.839
7.926ArgPro: 7.926 ± 0.258
1.321ArgGln: 1.321 ± 0.946
3.963ArgArg: 3.963 ± 2.839
5.284ArgSer: 5.284 ± 1.635
1.321ArgThr: 1.321 ± 0.946
2.642ArgVal: 2.642 ± 1.893
0.0ArgTrp: 0.0 ± 0.0
5.284ArgTyr: 5.284 ± 1.979
0.0ArgXaa: 0.0 ± 0.0
Ser
5.284SerAla: 5.284 ± 3.785
0.0SerCys: 0.0 ± 0.0
9.247SerAsp: 9.247 ± 2.409
0.0SerGlu: 0.0 ± 0.0
3.963SerPhe: 3.963 ± 1.032
3.963SerGly: 3.963 ± 0.774
0.0SerHis: 0.0 ± 0.0
5.284SerIle: 5.284 ± 0.172
5.284SerLys: 5.284 ± 0.172
5.284SerLeu: 5.284 ± 1.979
2.642SerMet: 2.642 ± 1.721
3.963SerAsn: 3.963 ± 0.774
3.963SerPro: 3.963 ± 2.581
3.963SerGln: 3.963 ± 0.774
7.926SerArg: 7.926 ± 0.258
10.568SerSer: 10.568 ± 3.27
5.284SerThr: 5.284 ± 1.635
6.605SerVal: 6.605 ± 0.689
0.0SerTrp: 0.0 ± 0.0
6.605SerTyr: 6.605 ± 0.689
0.0SerXaa: 0.0 ± 0.0
Thr
1.321ThrAla: 1.321 ± 0.946
0.0ThrCys: 0.0 ± 0.0
5.284ThrAsp: 5.284 ± 1.979
1.321ThrGlu: 1.321 ± 0.86
1.321ThrPhe: 1.321 ± 0.86
3.963ThrGly: 3.963 ± 0.774
0.0ThrHis: 0.0 ± 0.0
6.605ThrIle: 6.605 ± 1.118
1.321ThrLys: 1.321 ± 0.946
3.963ThrLeu: 3.963 ± 2.581
0.0ThrMet: 0.0 ± 0.0
2.642ThrAsn: 2.642 ± 0.086
3.963ThrPro: 3.963 ± 2.581
1.321ThrGln: 1.321 ± 0.946
2.642ThrArg: 2.642 ± 1.721
2.642ThrSer: 2.642 ± 0.086
0.0ThrThr: 0.0 ± 0.0
5.284ThrVal: 5.284 ± 1.635
1.321ThrTrp: 1.321 ± 0.86
2.642ThrTyr: 2.642 ± 0.086
0.0ThrXaa: 0.0 ± 0.0
Val
3.963ValAla: 3.963 ± 0.774
1.321ValCys: 1.321 ± 0.86
5.284ValAsp: 5.284 ± 1.635
0.0ValGlu: 0.0 ± 0.0
3.963ValPhe: 3.963 ± 2.839
3.963ValGly: 3.963 ± 2.839
1.321ValHis: 1.321 ± 0.946
1.321ValIle: 1.321 ± 0.946
9.247ValLys: 9.247 ± 3.011
6.605ValLeu: 6.605 ± 1.118
2.642ValMet: 2.642 ± 1.721
7.926ValAsn: 7.926 ± 5.162
7.926ValPro: 7.926 ± 1.549
2.642ValGln: 2.642 ± 1.721
0.0ValArg: 0.0 ± 0.0
0.0ValSer: 0.0 ± 0.0
2.642ValThr: 2.642 ± 1.893
7.926ValVal: 7.926 ± 0.258
1.321ValTrp: 1.321 ± 0.946
6.605ValTyr: 6.605 ± 1.118
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
2.642TrpAsp: 2.642 ± 1.893
0.0TrpGlu: 0.0 ± 0.0
1.321TrpPhe: 1.321 ± 0.946
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
2.642TrpIle: 2.642 ± 1.893
1.321TrpLys: 1.321 ± 0.86
1.321TrpLeu: 1.321 ± 0.86
0.0TrpMet: 0.0 ± 0.0
2.642TrpAsn: 2.642 ± 1.721
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.321TrpArg: 1.321 ± 0.86
1.321TrpSer: 1.321 ± 0.946
2.642TrpThr: 2.642 ± 0.086
2.642TrpVal: 2.642 ± 0.086
0.0TrpTrp: 0.0 ± 0.0
1.321TrpTyr: 1.321 ± 0.946
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.321TyrAla: 1.321 ± 0.946
0.0TyrCys: 0.0 ± 0.0
6.605TyrAsp: 6.605 ± 1.118
0.0TyrGlu: 0.0 ± 0.0
6.605TyrPhe: 6.605 ± 2.495
2.642TyrGly: 2.642 ± 0.086
0.0TyrHis: 0.0 ± 0.0
2.642TyrIle: 2.642 ± 0.086
2.642TyrLys: 2.642 ± 1.721
3.963TyrLeu: 3.963 ± 1.032
1.321TyrMet: 1.321 ± 0.946
5.284TyrAsn: 5.284 ± 1.635
2.642TyrPro: 2.642 ± 1.721
2.642TyrGln: 2.642 ± 0.086
6.605TyrArg: 6.605 ± 2.925
3.963TyrSer: 3.963 ± 0.774
2.642TyrThr: 2.642 ± 0.086
2.642TyrVal: 2.642 ± 1.893
1.321TyrTrp: 1.321 ± 0.86
3.963TyrTyr: 3.963 ± 1.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (758 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski