Amino acid dipepetide frequency for Aquimixticola soesokkakensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.744AlaAla: 16.744 ± 0.174	1.204AlaCys: 1.204 ± 0.036	6.89AlaAsp: 6.89 ± 0.106	6.796AlaGlu: 6.796 ± 0.097	4.449AlaPhe: 4.449 ± 0.071	11.039AlaGly: 11.039 ± 0.119	2.358AlaHis: 2.358 ± 0.048	5.857AlaIle: 5.857 ± 0.088	4.326AlaLys: 4.326 ± 0.08	14.736AlaLeu: 14.736 ± 0.172	3.737AlaMet: 3.737 ± 0.063	2.844AlaAsn: 2.844 ± 0.056	6.391AlaPro: 6.391 ± 0.124	6.726AlaGln: 6.726 ± 0.103	9.467AlaArg: 9.467 ± 0.127	6.195AlaSer: 6.195 ± 0.085	6.648AlaThr: 6.648 ± 0.088	8.475AlaVal: 8.475 ± 0.096	1.377AlaTrp: 1.377 ± 0.04	2.643AlaTyr: 2.643 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.328CysAla: 1.328 ± 0.042	0.1CysCys: 0.1 ± 0.009	0.696CysAsp: 0.696 ± 0.028	0.493CysGlu: 0.493 ± 0.023	0.352CysPhe: 0.352 ± 0.019	0.918CysGly: 0.918 ± 0.035	0.254CysHis: 0.254 ± 0.015	0.384CysIle: 0.384 ± 0.019	0.198CysLys: 0.198 ± 0.016	0.855CysLeu: 0.855 ± 0.031	0.166CysMet: 0.166 ± 0.012	0.178CysAsn: 0.178 ± 0.011	0.471CysPro: 0.471 ± 0.025	0.219CysGln: 0.219 ± 0.015	0.504CysArg: 0.504 ± 0.021	0.407CysSer: 0.407 ± 0.018	0.47CysThr: 0.47 ± 0.022	0.71CysVal: 0.71 ± 0.025	0.089CysTrp: 0.089 ± 0.009	0.177CysTyr: 0.177 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.661AspAla: 7.661 ± 0.098	0.536AspCys: 0.536 ± 0.025	3.271AspAsp: 3.271 ± 0.085	3.224AspGlu: 3.224 ± 0.066	2.48AspPhe: 2.48 ± 0.048	5.102AspGly: 5.102 ± 0.093	1.347AspHis: 1.347 ± 0.042	3.432AspIle: 3.432 ± 0.055	1.704AspLys: 1.704 ± 0.038	6.794AspLeu: 6.794 ± 0.083	1.736AspMet: 1.736 ± 0.043	1.243AspAsn: 1.243 ± 0.035	3.49AspPro: 3.49 ± 0.059	1.857AspGln: 1.857 ± 0.044	3.6AspArg: 3.6 ± 0.059	2.53AspSer: 2.53 ± 0.05	3.496AspThr: 3.496 ± 0.072	4.444AspVal: 4.444 ± 0.069	1.17AspTrp: 1.17 ± 0.035	1.586AspTyr: 1.586 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.671GluAla: 7.671 ± 0.108	0.345GluCys: 0.345 ± 0.017	3.199GluAsp: 3.199 ± 0.061	3.011GluGlu: 3.011 ± 0.072	1.781GluPhe: 1.781 ± 0.043	4.627GluGly: 4.627 ± 0.075	1.056GluHis: 1.056 ± 0.033	3.316GluIle: 3.316 ± 0.058	2.06GluLys: 2.06 ± 0.051	4.601GluLeu: 4.601 ± 0.082	1.686GluMet: 1.686 ± 0.051	1.66GluAsn: 1.66 ± 0.037	2.094GluPro: 2.094 ± 0.054	1.797GluGln: 1.797 ± 0.044	4.02GluArg: 4.02 ± 0.08	2.118GluSer: 2.118 ± 0.049	3.681GluThr: 3.681 ± 0.059	4.298GluVal: 4.298 ± 0.069	0.595GluTrp: 0.595 ± 0.026	0.964GluTyr: 0.964 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.881PheAla: 4.881 ± 0.068	0.468PheCys: 0.468 ± 0.02	3.113PheAsp: 3.113 ± 0.054	2.354PheGlu: 2.354 ± 0.046	1.463PhePhe: 1.463 ± 0.048	3.818PheGly: 3.818 ± 0.056	0.729PheHis: 0.729 ± 0.029	1.617PheIle: 1.617 ± 0.039	1.025PheLys: 1.025 ± 0.036	3.298PheLeu: 3.298 ± 0.065	0.847PheMet: 0.847 ± 0.03	1.128PheAsn: 1.128 ± 0.035	1.521PhePro: 1.521 ± 0.037	0.959PheGln: 0.959 ± 0.027	1.908PheArg: 1.908 ± 0.046	2.277PheSer: 2.277 ± 0.052	2.173PheThr: 2.173 ± 0.049	2.825PheVal: 2.825 ± 0.055	0.516PheTrp: 0.516 ± 0.027	0.942PheTyr: 0.942 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.55GlyAla: 10.55 ± 0.119	0.821GlyCys: 0.821 ± 0.033	4.784GlyAsp: 4.784 ± 0.093	4.523GlyGlu: 4.523 ± 0.072	3.657GlyPhe: 3.657 ± 0.064	7.091GlyGly: 7.091 ± 0.102	1.749GlyHis: 1.749 ± 0.036	4.292GlyIle: 4.292 ± 0.068	3.215GlyLys: 3.215 ± 0.055	8.964GlyLeu: 8.964 ± 0.109	2.488GlyMet: 2.488 ± 0.053	2.021GlyAsn: 2.021 ± 0.054	3.375GlyPro: 3.375 ± 0.057	3.047GlyGln: 3.047 ± 0.056	5.11GlyArg: 5.11 ± 0.071	4.044GlySer: 4.044 ± 0.069	4.967GlyThr: 4.967 ± 0.077	6.683GlyVal: 6.683 ± 0.093	1.291GlyTrp: 1.291 ± 0.036	2.277GlyTyr: 2.277 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.311HisAla: 2.311 ± 0.05	0.217HisCys: 0.217 ± 0.017	1.229HisAsp: 1.229 ± 0.039	0.965HisGlu: 0.965 ± 0.03	0.841HisPhe: 0.841 ± 0.023	1.696HisGly: 1.696 ± 0.047	0.557HisHis: 0.557 ± 0.03	0.997HisIle: 0.997 ± 0.032	0.57HisLys: 0.57 ± 0.025	2.055HisLeu: 2.055 ± 0.046	0.542HisMet: 0.542 ± 0.025	0.479HisAsn: 0.479 ± 0.019	1.338HisPro: 1.338 ± 0.041	0.568HisGln: 0.568 ± 0.022	1.28HisArg: 1.28 ± 0.034	1.009HisSer: 1.009 ± 0.033	0.84HisThr: 0.84 ± 0.029	1.423HisVal: 1.423 ± 0.034	0.32HisTrp: 0.32 ± 0.017	0.521HisTyr: 0.521 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.2IleAla: 7.2 ± 0.087	0.636IleCys: 0.636 ± 0.026	3.579IleAsp: 3.579 ± 0.066	3.451IleGlu: 3.451 ± 0.066	1.766IlePhe: 1.766 ± 0.048	4.731IleGly: 4.731 ± 0.079	0.906IleHis: 0.906 ± 0.028	2.074IleIle: 2.074 ± 0.058	1.489IleLys: 1.489 ± 0.038	4.516IleLeu: 4.516 ± 0.079	1.06IleMet: 1.06 ± 0.034	1.402IleAsn: 1.402 ± 0.038	2.2IlePro: 2.2 ± 0.047	1.128IleGln: 1.128 ± 0.034	2.908IleArg: 2.908 ± 0.052	3.041IleSer: 3.041 ± 0.079	3.016IleThr: 3.016 ± 0.055	3.75IleVal: 3.75 ± 0.064	0.672IleTrp: 0.672 ± 0.029	1.157IleTyr: 1.157 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.125LysAla: 4.125 ± 0.073	0.165LysCys: 0.165 ± 0.013	1.796LysAsp: 1.796 ± 0.049	1.53LysGlu: 1.53 ± 0.054	1.047LysPhe: 1.047 ± 0.035	2.824LysGly: 2.824 ± 0.055	0.656LysHis: 0.656 ± 0.028	1.817LysIle: 1.817 ± 0.041	1.239LysLys: 1.239 ± 0.043	3.106LysLeu: 3.106 ± 0.051	0.933LysMet: 0.933 ± 0.03	0.882LysAsn: 0.882 ± 0.028	1.834LysPro: 1.834 ± 0.044	0.918LysGln: 0.918 ± 0.031	2.381LysArg: 2.381 ± 0.05	2.07LysSer: 2.07 ± 0.052	2.109LysThr: 2.109 ± 0.046	2.348LysVal: 2.348 ± 0.053	0.375LysTrp: 0.375 ± 0.021	0.666LysTyr: 0.666 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	13.158LeuAla: 13.158 ± 0.136	1.041LeuCys: 1.041 ± 0.032	6.222LeuAsp: 6.222 ± 0.092	5.295LeuGlu: 5.295 ± 0.066	3.548LeuPhe: 3.548 ± 0.072	8.625LeuGly: 8.625 ± 0.118	1.839LeuHis: 1.839 ± 0.05	5.031LeuIle: 5.031 ± 0.094	3.422LeuLys: 3.422 ± 0.061	8.576LeuLeu: 8.576 ± 0.115	2.739LeuMet: 2.739 ± 0.053	2.494LeuAsn: 2.494 ± 0.055	5.296LeuPro: 5.296 ± 0.08	2.648LeuGln: 2.648 ± 0.047	6.877LeuArg: 6.877 ± 0.087	6.872LeuSer: 6.872 ± 0.083	5.889LeuThr: 5.889 ± 0.083	7.237LeuVal: 7.237 ± 0.097	1.313LeuTrp: 1.313 ± 0.045	2.025LeuTyr: 2.025 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.434MetAla: 3.434 ± 0.052	0.197MetCys: 0.197 ± 0.014	1.397MetAsp: 1.397 ± 0.035	1.232MetGlu: 1.232 ± 0.038	0.839MetPhe: 0.839 ± 0.026	2.33MetGly: 2.33 ± 0.045	0.449MetHis: 0.449 ± 0.023	1.532MetIle: 1.532 ± 0.036	0.991MetLys: 0.991 ± 0.033	2.469MetLeu: 2.469 ± 0.045	0.802MetMet: 0.802 ± 0.026	0.836MetAsn: 0.836 ± 0.026	1.499MetPro: 1.499 ± 0.036	0.976MetGln: 0.976 ± 0.03	1.886MetArg: 1.886 ± 0.047	1.958MetSer: 1.958 ± 0.047	2.092MetThr: 2.092 ± 0.048	1.957MetVal: 1.957 ± 0.045	0.25MetTrp: 0.25 ± 0.014	0.327MetTyr: 0.327 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.297AsnAla: 3.297 ± 0.063	0.238AsnCys: 0.238 ± 0.013	1.434AsnAsp: 1.434 ± 0.05	1.171AsnGlu: 1.171 ± 0.039	0.997AsnPhe: 0.997 ± 0.032	2.409AsnGly: 2.409 ± 0.055	0.527AsnHis: 0.527 ± 0.025	1.362AsnIle: 1.362 ± 0.034	0.697AsnLys: 0.697 ± 0.025	2.452AsnLeu: 2.452 ± 0.053	0.675AsnMet: 0.675 ± 0.022	0.648AsnAsn: 0.648 ± 0.03	1.729AsnPro: 1.729 ± 0.037	0.662AsnGln: 0.662 ± 0.025	1.65AsnArg: 1.65 ± 0.04	1.274AsnSer: 1.274 ± 0.041	1.385AsnThr: 1.385 ± 0.036	1.83AsnVal: 1.83 ± 0.044	0.437AsnTrp: 0.437 ± 0.022	0.613AsnTyr: 0.613 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.204ProAla: 6.204 ± 0.093	0.373ProCys: 0.373 ± 0.019	3.866ProAsp: 3.866 ± 0.071	3.661ProGlu: 3.661 ± 0.059	1.933ProPhe: 1.933 ± 0.043	2.857ProGly: 2.857 ± 0.051	1.041ProHis: 1.041 ± 0.029	2.064ProIle: 2.064 ± 0.045	1.783ProLys: 1.783 ± 0.044	4.975ProLeu: 4.975 ± 0.062	1.372ProMet: 1.372 ± 0.034	1.264ProAsn: 1.264 ± 0.036	2.125ProPro: 2.125 ± 0.057	2.213ProGln: 2.213 ± 0.048	2.839ProArg: 2.839 ± 0.069	2.52ProSer: 2.52 ± 0.047	2.483ProThr: 2.483 ± 0.059	4.226ProVal: 4.226 ± 0.063	0.616ProTrp: 0.616 ± 0.022	1.138ProTyr: 1.138 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.894GlnAla: 4.894 ± 0.081	0.196GlnCys: 0.196 ± 0.014	1.837GlnAsp: 1.837 ± 0.046	1.671GlnGlu: 1.671 ± 0.044	1.171GlnPhe: 1.171 ± 0.036	2.888GlnGly: 2.888 ± 0.049	0.588GlnHis: 0.588 ± 0.027	2.177GlnIle: 2.177 ± 0.047	1.176GlnLys: 1.176 ± 0.036	2.905GlnLeu: 2.905 ± 0.052	1.131GlnMet: 1.131 ± 0.036	1.081GlnAsn: 1.081 ± 0.033	1.506GlnPro: 1.506 ± 0.044	1.065GlnGln: 1.065 ± 0.033	2.17GlnArg: 2.17 ± 0.045	2.139GlnSer: 2.139 ± 0.051	2.121GlnThr: 2.121 ± 0.044	2.508GlnVal: 2.508 ± 0.052	0.406GlnTrp: 0.406 ± 0.019	0.593GlnTyr: 0.593 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.738ArgAla: 8.738 ± 0.111	0.486ArgCys: 0.486 ± 0.026	4.405ArgAsp: 4.405 ± 0.073	3.631ArgGlu: 3.631 ± 0.063	2.683ArgPhe: 2.683 ± 0.051	4.514ArgGly: 4.514 ± 0.064	1.428ArgHis: 1.428 ± 0.04	3.471ArgIle: 3.471 ± 0.065	2.269ArgLys: 2.269 ± 0.05	6.895ArgLeu: 6.895 ± 0.093	1.829ArgMet: 1.829 ± 0.04	1.599ArgAsn: 1.599 ± 0.042	2.89ArgPro: 2.89 ± 0.049	2.019ArgGln: 2.019 ± 0.046	4.331ArgArg: 4.331 ± 0.072	3.204ArgSer: 3.204 ± 0.058	2.855ArgThr: 2.855 ± 0.05	4.584ArgVal: 4.584 ± 0.071	0.818ArgTrp: 0.818 ± 0.028	1.451ArgTyr: 1.451 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.662SerAla: 6.662 ± 0.093	0.463SerCys: 0.463 ± 0.023	3.637SerAsp: 3.637 ± 0.07	2.891SerGlu: 2.891 ± 0.063	2.354SerPhe: 2.354 ± 0.05	5.728SerGly: 5.728 ± 0.093	1.085SerHis: 1.085 ± 0.03	2.471SerIle: 2.471 ± 0.055	1.653SerLys: 1.653 ± 0.044	5.362SerLeu: 5.362 ± 0.084	1.314SerMet: 1.314 ± 0.04	1.341SerAsn: 1.341 ± 0.038	2.701SerPro: 2.701 ± 0.077	1.842SerGln: 1.842 ± 0.042	3.124SerArg: 3.124 ± 0.058	2.782SerSer: 2.782 ± 0.084	2.731SerThr: 2.731 ± 0.075	3.977SerVal: 3.977 ± 0.073	0.668SerTrp: 0.668 ± 0.027	1.344SerTyr: 1.344 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.722ThrAla: 6.722 ± 0.083	0.504ThrCys: 0.504 ± 0.024	2.951ThrAsp: 2.951 ± 0.058	2.555ThrGlu: 2.555 ± 0.058	2.083ThrPhe: 2.083 ± 0.047	5.406ThrGly: 5.406 ± 0.086	1.126ThrHis: 1.126 ± 0.036	2.725ThrIle: 2.725 ± 0.057	1.637ThrLys: 1.637 ± 0.04	6.454ThrLeu: 6.454 ± 0.087	1.346ThrMet: 1.346 ± 0.029	1.32ThrAsn: 1.32 ± 0.036	3.898ThrPro: 3.898 ± 0.066	2.168ThrGln: 2.168 ± 0.045	3.629ThrArg: 3.629 ± 0.068	3.163ThrSer: 3.163 ± 0.068	3.139ThrThr: 3.139 ± 0.064	4.211ThrVal: 4.211 ± 0.073	0.631ThrTrp: 0.631 ± 0.022	1.303ThrTyr: 1.303 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.466ValAla: 9.466 ± 0.106	0.601ValCys: 0.601 ± 0.022	4.106ValAsp: 4.106 ± 0.072	4.291ValGlu: 4.291 ± 0.066	2.974ValPhe: 2.974 ± 0.062	5.259ValGly: 5.259 ± 0.088	1.27ValHis: 1.27 ± 0.037	4.411ValIle: 4.411 ± 0.076	2.383ValLys: 2.383 ± 0.052	7.525ValLeu: 7.525 ± 0.108	2.171ValMet: 2.171 ± 0.053	2.04ValAsn: 2.04 ± 0.045	3.529ValPro: 3.529 ± 0.07	2.177ValGln: 2.177 ± 0.048	3.915ValArg: 3.915 ± 0.068	4.559ValSer: 4.559 ± 0.066	4.961ValThr: 4.961 ± 0.078	5.879ValVal: 5.879 ± 0.076	0.868ValTrp: 0.868 ± 0.031	1.433ValTyr: 1.433 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.289TrpAla: 1.289 ± 0.036	0.139TrpCys: 0.139 ± 0.013	0.798TrpAsp: 0.798 ± 0.028	0.609TrpGlu: 0.609 ± 0.023	0.504TrpPhe: 0.504 ± 0.025	0.983TrpGly: 0.983 ± 0.031	0.324TrpHis: 0.324 ± 0.017	0.679TrpIle: 0.679 ± 0.024	0.41TrpLys: 0.41 ± 0.018	1.398TrpLeu: 1.398 ± 0.034	0.391TrpMet: 0.391 ± 0.02	0.404TrpAsn: 0.404 ± 0.022	0.619TrpPro: 0.619 ± 0.024	0.547TrpGln: 0.547 ± 0.022	1.011TrpArg: 1.011 ± 0.035	0.771TrpSer: 0.771 ± 0.029	0.699TrpThr: 0.699 ± 0.027	0.936TrpVal: 0.936 ± 0.029	0.186TrpTrp: 0.186 ± 0.014	0.256TrpTyr: 0.256 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.568TyrAla: 2.568 ± 0.049	0.239TyrCys: 0.239 ± 0.014	1.491TyrAsp: 1.491 ± 0.039	1.224TyrGlu: 1.224 ± 0.037	0.94TyrPhe: 0.94 ± 0.029	2.104TyrGly: 2.104 ± 0.05	0.471TyrHis: 0.471 ± 0.021	0.974TyrIle: 0.974 ± 0.031	0.575TyrLys: 0.575 ± 0.021	2.21TyrLeu: 2.21 ± 0.047	0.488TyrMet: 0.488 ± 0.021	0.623TyrAsn: 0.623 ± 0.028	1.049TyrPro: 1.049 ± 0.031	0.686TyrGln: 0.686 ± 0.024	1.49TyrArg: 1.49 ± 0.042	1.198TyrSer: 1.198 ± 0.04	1.215TyrThr: 1.215 ± 0.038	1.515TyrVal: 1.515 ± 0.039	0.355TyrTrp: 0.355 ± 0.021	0.521TyrTyr: 0.521 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3316 proteins (1038695 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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