Amino acid dipepetide frequency for Rhodoplanes elegans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.43AlaAla: 22.43 ± 0.215	1.273AlaCys: 1.273 ± 0.029	7.291AlaAsp: 7.291 ± 0.072	8.093AlaGlu: 8.093 ± 0.08	4.568AlaPhe: 4.568 ± 0.062	12.293AlaGly: 12.293 ± 0.113	2.306AlaHis: 2.306 ± 0.041	6.258AlaIle: 6.258 ± 0.063	3.997AlaLys: 3.997 ± 0.068	14.436AlaLeu: 14.436 ± 0.127	3.433AlaMet: 3.433 ± 0.044	2.392AlaAsn: 2.392 ± 0.042	7.121AlaPro: 7.121 ± 0.083	3.757AlaGln: 3.757 ± 0.059	10.282AlaArg: 10.282 ± 0.1	6.145AlaSer: 6.145 ± 0.07	7.476AlaThr: 7.476 ± 0.077	11.493AlaVal: 11.493 ± 0.107	1.68AlaTrp: 1.68 ± 0.032	2.462AlaTyr: 2.462 ± 0.043	0.001AlaXaa: 0.001 ± 0.001
Cys	1.033CysAla: 1.033 ± 0.026	0.13CysCys: 0.13 ± 0.009	0.523CysAsp: 0.523 ± 0.019	0.428CysGlu: 0.428 ± 0.016	0.297CysPhe: 0.297 ± 0.014	0.932CysGly: 0.932 ± 0.025	0.229CysHis: 0.229 ± 0.012	0.325CysIle: 0.325 ± 0.013	0.18CysLys: 0.18 ± 0.011	0.719CysLeu: 0.719 ± 0.021	0.161CysMet: 0.161 ± 0.01	0.189CysAsn: 0.189 ± 0.011	0.508CysPro: 0.508 ± 0.019	0.176CysGln: 0.176 ± 0.01	0.735CysArg: 0.735 ± 0.025	0.402CysSer: 0.402 ± 0.018	0.423CysThr: 0.423 ± 0.017	0.639CysVal: 0.639 ± 0.021	0.105CysTrp: 0.105 ± 0.008	0.169CysTyr: 0.169 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.398AspAla: 7.398 ± 0.073	0.46AspCys: 0.46 ± 0.017	3.236AspAsp: 3.236 ± 0.051	3.224AspGlu: 3.224 ± 0.045	1.92AspPhe: 1.92 ± 0.035	5.344AspGly: 5.344 ± 0.068	1.254AspHis: 1.254 ± 0.032	2.599AspIle: 2.599 ± 0.045	1.64AspLys: 1.64 ± 0.037	6.088AspLeu: 6.088 ± 0.064	1.1AspMet: 1.1 ± 0.026	0.976AspAsn: 0.976 ± 0.027	3.899AspPro: 3.899 ± 0.05	1.588AspGln: 1.588 ± 0.037	4.882AspArg: 4.882 ± 0.057	1.849AspSer: 1.849 ± 0.032	2.709AspThr: 2.709 ± 0.04	4.46AspVal: 4.46 ± 0.05	0.895AspTrp: 0.895 ± 0.025	1.255AspTyr: 1.255 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.502GluAla: 7.502 ± 0.082	0.324GluCys: 0.324 ± 0.014	2.24GluAsp: 2.24 ± 0.043	2.654GluGlu: 2.654 ± 0.05	1.483GluPhe: 1.483 ± 0.029	3.548GluGly: 3.548 ± 0.049	1.137GluHis: 1.137 ± 0.027	3.321GluIle: 3.321 ± 0.051	1.998GluLys: 1.998 ± 0.043	4.812GluLeu: 4.812 ± 0.053	1.355GluMet: 1.355 ± 0.029	1.184GluAsn: 1.184 ± 0.027	2.913GluPro: 2.913 ± 0.048	1.863GluGln: 1.863 ± 0.031	5.198GluArg: 5.198 ± 0.063	2.145GluSer: 2.145 ± 0.038	3.569GluThr: 3.569 ± 0.048	3.881GluVal: 3.881 ± 0.053	0.583GluTrp: 0.583 ± 0.018	0.814GluTyr: 0.814 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.657PheAla: 4.657 ± 0.054	0.357PheCys: 0.357 ± 0.016	2.435PheAsp: 2.435 ± 0.038	1.924PheGlu: 1.924 ± 0.03	1.304PhePhe: 1.304 ± 0.028	3.675PheGly: 3.675 ± 0.048	0.652PheHis: 0.652 ± 0.021	1.157PheIle: 1.157 ± 0.027	0.921PheLys: 0.921 ± 0.026	3.045PheLeu: 3.045 ± 0.049	0.672PheMet: 0.672 ± 0.021	0.809PheAsn: 0.809 ± 0.02	1.539PhePro: 1.539 ± 0.03	0.841PheGln: 0.841 ± 0.022	2.327PheArg: 2.327 ± 0.041	1.847PheSer: 1.847 ± 0.033	1.832PheThr: 1.832 ± 0.034	3.211PheVal: 3.211 ± 0.045	0.502PheTrp: 0.502 ± 0.018	0.737PheTyr: 0.737 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.438GlyAla: 10.438 ± 0.1	0.888GlyCys: 0.888 ± 0.024	4.421GlyAsp: 4.421 ± 0.063	4.39GlyGlu: 4.39 ± 0.056	3.661GlyPhe: 3.661 ± 0.041	7.657GlyGly: 7.657 ± 0.124	1.933GlyHis: 1.933 ± 0.037	4.248GlyIle: 4.248 ± 0.053	2.825GlyLys: 2.825 ± 0.052	9.313GlyLeu: 9.313 ± 0.092	2.042GlyMet: 2.042 ± 0.034	1.775GlyAsn: 1.775 ± 0.04	4.331GlyPro: 4.331 ± 0.06	2.426GlyGln: 2.426 ± 0.038	7.345GlyArg: 7.345 ± 0.081	4.353GlySer: 4.353 ± 0.063	5.287GlyThr: 5.287 ± 0.073	6.622GlyVal: 6.622 ± 0.06	1.371GlyTrp: 1.371 ± 0.03	2.114GlyTyr: 2.114 ± 0.04	0.001GlyXaa: 0.001 ± 0.001
His	2.491HisAla: 2.491 ± 0.043	0.186HisCys: 0.186 ± 0.011	1.304HisAsp: 1.304 ± 0.032	0.949HisGlu: 0.949 ± 0.023	0.675HisPhe: 0.675 ± 0.017	2.012HisGly: 2.012 ± 0.041	0.564HisHis: 0.564 ± 0.022	0.73HisIle: 0.73 ± 0.02	0.392HisLys: 0.392 ± 0.015	1.898HisLeu: 1.898 ± 0.035	0.417HisMet: 0.417 ± 0.016	0.342HisAsn: 0.342 ± 0.013	1.379HisPro: 1.379 ± 0.03	0.501HisGln: 0.501 ± 0.019	1.558HisArg: 1.558 ± 0.031	0.734HisSer: 0.734 ± 0.022	0.862HisThr: 0.862 ± 0.022	1.737HisVal: 1.737 ± 0.033	0.321HisTrp: 0.321 ± 0.014	0.473HisTyr: 0.473 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.514IleAla: 7.514 ± 0.07	0.379IleCys: 0.379 ± 0.014	3.446IleAsp: 3.446 ± 0.046	3.26IleGlu: 3.26 ± 0.048	1.212IlePhe: 1.212 ± 0.028	5.018IleGly: 5.018 ± 0.061	0.75IleHis: 0.75 ± 0.021	1.444IleIle: 1.444 ± 0.032	1.316IleLys: 1.316 ± 0.033	3.736IleLeu: 3.736 ± 0.048	0.776IleMet: 0.776 ± 0.022	1.021IleAsn: 1.021 ± 0.028	2.17IlePro: 2.17 ± 0.036	0.976IleGln: 0.976 ± 0.025	3.038IleArg: 3.038 ± 0.04	2.125IleSer: 2.125 ± 0.037	2.557IleThr: 2.557 ± 0.037	4.687IleVal: 4.687 ± 0.058	0.455IleTrp: 0.455 ± 0.019	0.853IleTyr: 0.853 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	4.109LysAla: 4.109 ± 0.06	0.161LysCys: 0.161 ± 0.011	1.564LysAsp: 1.564 ± 0.032	1.341LysGlu: 1.341 ± 0.034	0.762LysPhe: 0.762 ± 0.023	2.351LysGly: 2.351 ± 0.047	0.525LysHis: 0.525 ± 0.015	1.545LysIle: 1.545 ± 0.031	1.209LysLys: 1.209 ± 0.039	3.001LysLeu: 3.001 ± 0.053	0.647LysMet: 0.647 ± 0.019	0.739LysAsn: 0.739 ± 0.023	2.03LysPro: 2.03 ± 0.039	0.903LysGln: 0.903 ± 0.026	2.265LysArg: 2.265 ± 0.039	1.563LysSer: 1.563 ± 0.035	1.943LysThr: 1.943 ± 0.036	2.318LysVal: 2.318 ± 0.05	0.288LysTrp: 0.288 ± 0.014	0.519LysTyr: 0.519 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.79LeuAla: 15.79 ± 0.157	0.775LeuCys: 0.775 ± 0.021	6.313LeuAsp: 6.313 ± 0.066	4.494LeuGlu: 4.494 ± 0.06	3.434LeuPhe: 3.434 ± 0.053	8.667LeuGly: 8.667 ± 0.087	1.777LeuHis: 1.777 ± 0.032	4.405LeuIle: 4.405 ± 0.053	3.17LeuLys: 3.17 ± 0.05	9.258LeuLeu: 9.258 ± 0.101	2.093LeuMet: 2.093 ± 0.034	1.893LeuAsn: 1.893 ± 0.04	5.686LeuPro: 5.686 ± 0.064	2.409LeuGln: 2.409 ± 0.039	7.053LeuArg: 7.053 ± 0.069	5.251LeuSer: 5.251 ± 0.064	5.267LeuThr: 5.267 ± 0.063	8.9LeuVal: 8.9 ± 0.086	1.141LeuTrp: 1.141 ± 0.028	1.859LeuTyr: 1.859 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.75MetAla: 2.75 ± 0.043	0.149MetCys: 0.149 ± 0.01	0.95MetAsp: 0.95 ± 0.023	0.883MetGlu: 0.883 ± 0.023	0.654MetPhe: 0.654 ± 0.02	1.52MetGly: 1.52 ± 0.031	0.387MetHis: 0.387 ± 0.015	1.223MetIle: 1.223 ± 0.027	0.793MetLys: 0.793 ± 0.023	2.308MetLeu: 2.308 ± 0.038	0.55MetMet: 0.55 ± 0.02	0.555MetAsn: 0.555 ± 0.015	1.556MetPro: 1.556 ± 0.034	0.664MetGln: 0.664 ± 0.019	1.874MetArg: 1.874 ± 0.031	1.431MetSer: 1.431 ± 0.027	1.806MetThr: 1.806 ± 0.032	1.672MetVal: 1.672 ± 0.03	0.209MetTrp: 0.209 ± 0.011	0.285MetTyr: 0.285 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.691AsnAla: 2.691 ± 0.048	0.192AsnCys: 0.192 ± 0.011	1.141AsnAsp: 1.141 ± 0.031	0.924AsnGlu: 0.924 ± 0.024	0.708AsnPhe: 0.708 ± 0.025	1.946AsnGly: 1.946 ± 0.039	0.384AsnHis: 0.384 ± 0.015	0.978AsnIle: 0.978 ± 0.025	0.556AsnLys: 0.556 ± 0.019	2.12AsnLeu: 2.12 ± 0.033	0.435AsnMet: 0.435 ± 0.015	0.51AsnAsn: 0.51 ± 0.018	1.602AsnPro: 1.602 ± 0.033	0.593AsnGln: 0.593 ± 0.016	1.553AsnArg: 1.553 ± 0.034	0.834AsnSer: 0.834 ± 0.026	1.068AsnThr: 1.068 ± 0.026	1.746AsnVal: 1.746 ± 0.033	0.289AsnTrp: 0.289 ± 0.014	0.491AsnTyr: 0.491 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	8.116ProAla: 8.116 ± 0.08	0.367ProCys: 0.367 ± 0.014	4.038ProAsp: 4.038 ± 0.052	3.561ProGlu: 3.561 ± 0.051	2.019ProPhe: 2.019 ± 0.029	5.294ProGly: 5.294 ± 0.068	1.143ProHis: 1.143 ± 0.029	2.342ProIle: 2.342 ± 0.042	1.652ProLys: 1.652 ± 0.034	4.973ProLeu: 4.973 ± 0.059	1.172ProMet: 1.172 ± 0.026	1.284ProAsn: 1.284 ± 0.025	3.545ProPro: 3.545 ± 0.065	1.495ProGln: 1.495 ± 0.027	3.705ProArg: 3.705 ± 0.049	2.95ProSer: 2.95 ± 0.041	2.976ProThr: 2.976 ± 0.048	4.817ProVal: 4.817 ± 0.053	0.82ProTrp: 0.82 ± 0.02	1.18ProTyr: 1.18 ± 0.031	0.001ProXaa: 0.001 ± 0.001
Gln	3.825GlnAla: 3.825 ± 0.047	0.184GlnCys: 0.184 ± 0.011	1.272GlnAsp: 1.272 ± 0.03	1.281GlnGlu: 1.281 ± 0.027	0.851GlnPhe: 0.851 ± 0.024	2.075GlnGly: 2.075 ± 0.035	0.552GlnHis: 0.552 ± 0.02	1.522GlnIle: 1.522 ± 0.027	0.916GlnLys: 0.916 ± 0.02	2.334GlnLeu: 2.334 ± 0.037	0.661GlnMet: 0.661 ± 0.021	0.702GlnAsn: 0.702 ± 0.021	1.59GlnPro: 1.59 ± 0.033	1.028GlnGln: 1.028 ± 0.03	2.24GlnArg: 2.24 ± 0.038	1.384GlnSer: 1.384 ± 0.029	1.612GlnThr: 1.612 ± 0.033	2.161GlnVal: 2.161 ± 0.039	0.338GlnTrp: 0.338 ± 0.017	0.479GlnTyr: 0.479 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.506ArgAla: 9.506 ± 0.087	0.616ArgCys: 0.616 ± 0.023	4.762ArgAsp: 4.762 ± 0.059	4.172ArgGlu: 4.172 ± 0.061	2.967ArgPhe: 2.967 ± 0.044	5.578ArgGly: 5.578 ± 0.063	1.815ArgHis: 1.815 ± 0.032	4.068ArgIle: 4.068 ± 0.05	2.173ArgLys: 2.173 ± 0.038	8.794ArgLeu: 8.794 ± 0.087	1.898ArgMet: 1.898 ± 0.038	1.635ArgAsn: 1.635 ± 0.03	4.457ArgPro: 4.457 ± 0.06	2.193ArgGln: 2.193 ± 0.038	7.302ArgArg: 7.302 ± 0.081	3.738ArgSer: 3.738 ± 0.047	4.078ArgThr: 4.078 ± 0.048	5.51ArgVal: 5.51 ± 0.055	1.12ArgTrp: 1.12 ± 0.025	1.545ArgTyr: 1.545 ± 0.029	0.001ArgXaa: 0.001 ± 0.001
Ser	5.844SerAla: 5.844 ± 0.066	0.353SerCys: 0.353 ± 0.015	2.583SerAsp: 2.583 ± 0.039	2.376SerGlu: 2.376 ± 0.032	1.916SerPhe: 1.916 ± 0.04	4.886SerGly: 4.886 ± 0.065	0.918SerHis: 0.918 ± 0.026	2.321SerIle: 2.321 ± 0.037	1.278SerLys: 1.278 ± 0.027	4.73SerLeu: 4.73 ± 0.055	1.014SerMet: 1.014 ± 0.026	1.052SerAsn: 1.052 ± 0.025	2.842SerPro: 2.842 ± 0.041	1.286SerGln: 1.286 ± 0.027	3.719SerArg: 3.719 ± 0.047	2.565SerSer: 2.565 ± 0.055	2.662SerThr: 2.662 ± 0.039	3.786SerVal: 3.786 ± 0.046	0.672SerTrp: 0.672 ± 0.02	1.087SerTyr: 1.087 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	7.562ThrAla: 7.562 ± 0.08	0.442ThrCys: 0.442 ± 0.015	2.78ThrAsp: 2.78 ± 0.036	2.57ThrGlu: 2.57 ± 0.041	1.98ThrPhe: 1.98 ± 0.036	5.429ThrGly: 5.429 ± 0.073	0.951ThrHis: 0.951 ± 0.024	3.06ThrIle: 3.06 ± 0.049	1.442ThrLys: 1.442 ± 0.034	6.124ThrLeu: 6.124 ± 0.062	1.155ThrMet: 1.155 ± 0.028	1.177ThrAsn: 1.177 ± 0.028	3.72ThrPro: 3.72 ± 0.05	1.241ThrGln: 1.241 ± 0.03	3.9ThrArg: 3.9 ± 0.047	2.701ThrSer: 2.701 ± 0.041	3.378ThrThr: 3.378 ± 0.051	5.109ThrVal: 5.109 ± 0.058	0.727ThrTrp: 0.727 ± 0.018	1.12ThrTyr: 1.12 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.741ValAla: 11.741 ± 0.097	0.708ValCys: 0.708 ± 0.02	4.566ValAsp: 4.566 ± 0.05	4.521ValGlu: 4.521 ± 0.059	2.831ValPhe: 2.831 ± 0.044	6.245ValGly: 6.245 ± 0.065	1.534ValHis: 1.534 ± 0.03	3.863ValIle: 3.863 ± 0.05	2.381ValLys: 2.381 ± 0.047	8.443ValLeu: 8.443 ± 0.08	1.934ValMet: 1.934 ± 0.031	1.719ValAsn: 1.719 ± 0.034	4.803ValPro: 4.803 ± 0.052	2.044ValGln: 2.044 ± 0.035	5.959ValArg: 5.959 ± 0.058	4.202ValSer: 4.202 ± 0.041	5.211ValThr: 5.211 ± 0.061	7.799ValVal: 7.799 ± 0.085	1.003ValTrp: 1.003 ± 0.026	1.521ValTyr: 1.521 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.287TrpAla: 1.287 ± 0.028	0.143TrpCys: 0.143 ± 0.008	0.601TrpAsp: 0.601 ± 0.019	0.494TrpGlu: 0.494 ± 0.017	0.489TrpPhe: 0.489 ± 0.015	0.928TrpGly: 0.928 ± 0.024	0.328TrpHis: 0.328 ± 0.015	0.654TrpIle: 0.654 ± 0.019	0.394TrpLys: 0.394 ± 0.015	1.592TrpLeu: 1.592 ± 0.031	0.339TrpMet: 0.339 ± 0.015	0.357TrpAsn: 0.357 ± 0.015	0.752TrpPro: 0.752 ± 0.023	0.452TrpGln: 0.452 ± 0.017	1.291TrpArg: 1.291 ± 0.03	0.83TrpSer: 0.83 ± 0.022	0.818TrpThr: 0.818 ± 0.022	0.825TrpVal: 0.825 ± 0.022	0.26TrpTrp: 0.26 ± 0.013	0.242TrpTyr: 0.242 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.504TyrAla: 2.504 ± 0.041	0.215TyrCys: 0.215 ± 0.012	1.309TyrAsp: 1.309 ± 0.025	0.988TyrGlu: 0.988 ± 0.028	0.713TyrPhe: 0.713 ± 0.022	2.039TyrGly: 2.039 ± 0.037	0.387TyrHis: 0.387 ± 0.017	0.669TyrIle: 0.669 ± 0.019	0.548TyrLys: 0.548 ± 0.02	1.91TyrLeu: 1.91 ± 0.04	0.364TyrMet: 0.364 ± 0.016	0.448TyrAsn: 0.448 ± 0.017	1.009TyrPro: 1.009 ± 0.023	0.575TyrGln: 0.575 ± 0.019	1.698TyrArg: 1.698 ± 0.035	0.84TyrSer: 0.84 ± 0.023	1.033TyrThr: 1.033 ± 0.026	1.658TyrVal: 1.658 ± 0.036	0.298TyrTrp: 0.298 ± 0.012	0.505TyrTyr: 0.505 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.008XaaXaa: 0.008 ± 0.003

Statistics based on 5973 proteins (1759521 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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