Amino acid dipepetide frequency for Mycetocola miduiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.957AlaAla: 17.957 ± 0.222
0.655AlaCys: 0.655 ± 0.031
7.556AlaAsp: 7.556 ± 0.099
7.884AlaGlu: 7.884 ± 0.104
3.884AlaPhe: 3.884 ± 0.064
11.427AlaGly: 11.427 ± 0.114
2.128AlaHis: 2.128 ± 0.045
6.159AlaIle: 6.159 ± 0.083
2.932AlaLys: 2.932 ± 0.065
13.276AlaLeu: 13.276 ± 0.149
2.556AlaMet: 2.556 ± 0.059
2.642AlaAsn: 2.642 ± 0.056
5.626AlaPro: 5.626 ± 0.099
3.563AlaGln: 3.563 ± 0.059
8.205AlaArg: 8.205 ± 0.109
7.876AlaSer: 7.876 ± 0.099
7.293AlaThr: 7.293 ± 0.092
10.967AlaVal: 10.967 ± 0.121
1.735AlaTrp: 1.735 ± 0.046
2.183AlaTyr: 2.183 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.635CysAla: 0.635 ± 0.029
0.049CysCys: 0.049 ± 0.008
0.318CysAsp: 0.318 ± 0.021
0.255CysGlu: 0.255 ± 0.015
0.166CysPhe: 0.166 ± 0.014
0.531CysGly: 0.531 ± 0.027
0.113CysHis: 0.113 ± 0.011
0.217CysIle: 0.217 ± 0.015
0.073CysLys: 0.073 ± 0.009
0.445CysLeu: 0.445 ± 0.023
0.068CysMet: 0.068 ± 0.009
0.119CysAsn: 0.119 ± 0.012
0.275CysPro: 0.275 ± 0.019
0.129CysGln: 0.129 ± 0.012
0.313CysArg: 0.313 ± 0.02
0.371CysSer: 0.371 ± 0.022
0.329CysThr: 0.329 ± 0.017
0.448CysVal: 0.448 ± 0.022
0.085CysTrp: 0.085 ± 0.008
0.109CysTyr: 0.109 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.394AspAla: 8.394 ± 0.113
0.227AspCys: 0.227 ± 0.017
4.018AspAsp: 4.018 ± 0.085
4.196AspGlu: 4.196 ± 0.075
1.815AspPhe: 1.815 ± 0.048
5.562AspGly: 5.562 ± 0.095
1.069AspHis: 1.069 ± 0.033
2.761AspIle: 2.761 ± 0.049
1.152AspLys: 1.152 ± 0.041
6.2AspLeu: 6.2 ± 0.087
0.851AspMet: 0.851 ± 0.032
1.256AspAsn: 1.256 ± 0.054
3.721AspPro: 3.721 ± 0.061
1.587AspGln: 1.587 ± 0.04
4.195AspArg: 4.195 ± 0.077
3.149AspSer: 3.149 ± 0.066
2.991AspThr: 2.991 ± 0.058
5.528AspVal: 5.528 ± 0.08
0.902AspTrp: 0.902 ± 0.028
1.276AspTyr: 1.276 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
6.658GluAla: 6.658 ± 0.104
0.226GluCys: 0.226 ± 0.015
2.754GluAsp: 2.754 ± 0.059
3.083GluGlu: 3.083 ± 0.071
1.767GluPhe: 1.767 ± 0.051
3.755GluGly: 3.755 ± 0.065
1.471GluHis: 1.471 ± 0.043
2.98GluIle: 2.98 ± 0.063
1.751GluLys: 1.751 ± 0.045
6.706GluLeu: 6.706 ± 0.101
0.981GluMet: 0.981 ± 0.038
1.624GluAsn: 1.624 ± 0.04
3.087GluPro: 3.087 ± 0.058
2.249GluGln: 2.249 ± 0.051
4.772GluArg: 4.772 ± 0.079
3.444GluSer: 3.444 ± 0.062
3.216GluThr: 3.216 ± 0.064
4.324GluVal: 4.324 ± 0.08
0.788GluTrp: 0.788 ± 0.034
1.227GluTyr: 1.227 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
4.141PheAla: 4.141 ± 0.067
0.183PheCys: 0.183 ± 0.015
2.477PheAsp: 2.477 ± 0.043
1.861PheGlu: 1.861 ± 0.047
1.164PhePhe: 1.164 ± 0.043
3.484PheGly: 3.484 ± 0.065
0.558PheHis: 0.558 ± 0.025
1.317PheIle: 1.317 ± 0.043
0.554PheLys: 0.554 ± 0.024
3.043PheLeu: 3.043 ± 0.063
0.468PheMet: 0.468 ± 0.025
0.74PheAsn: 0.74 ± 0.029
1.415PhePro: 1.415 ± 0.041
0.776PheGln: 0.776 ± 0.027
1.808PheArg: 1.808 ± 0.041
2.113PheSer: 2.113 ± 0.053
2.182PheThr: 2.182 ± 0.05
2.916PheVal: 2.916 ± 0.059
0.454PheTrp: 0.454 ± 0.024
0.698PheTyr: 0.698 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
9.719GlyAla: 9.719 ± 0.148
0.556GlyCys: 0.556 ± 0.025
4.787GlyAsp: 4.787 ± 0.086
4.788GlyGlu: 4.788 ± 0.07
3.223GlyPhe: 3.223 ± 0.05
7.203GlyGly: 7.203 ± 0.107
1.811GlyHis: 1.811 ± 0.046
5.124GlyIle: 5.124 ± 0.085
2.527GlyLys: 2.527 ± 0.062
8.592GlyLeu: 8.592 ± 0.097
2.024GlyMet: 2.024 ± 0.048
2.06GlyAsn: 2.06 ± 0.057
3.613GlyPro: 3.613 ± 0.071
2.631GlyGln: 2.631 ± 0.06
5.729GlyArg: 5.729 ± 0.085
5.734GlySer: 5.734 ± 0.088
5.719GlyThr: 5.719 ± 0.083
7.595GlyVal: 7.595 ± 0.1
1.488GlyTrp: 1.488 ± 0.043
2.292GlyTyr: 2.292 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.156HisAla: 2.156 ± 0.045
0.126HisCys: 0.126 ± 0.01
1.202HisAsp: 1.202 ± 0.036
1.181HisGlu: 1.181 ± 0.045
0.554HisPhe: 0.554 ± 0.025
1.815HisGly: 1.815 ± 0.042
0.52HisHis: 0.52 ± 0.026
0.802HisIle: 0.802 ± 0.029
0.344HisLys: 0.344 ± 0.018
1.947HisLeu: 1.947 ± 0.047
0.312HisMet: 0.312 ± 0.016
0.395HisAsn: 0.395 ± 0.016
1.449HisPro: 1.449 ± 0.04
0.541HisGln: 0.541 ± 0.022
1.466HisArg: 1.466 ± 0.043
1.136HisSer: 1.136 ± 0.032
1.051HisThr: 1.051 ± 0.032
1.543HisVal: 1.543 ± 0.041
0.284HisTrp: 0.284 ± 0.015
0.413HisTyr: 0.413 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.734IleAla: 6.734 ± 0.093
0.281IleCys: 0.281 ± 0.018
3.56IleAsp: 3.56 ± 0.061
2.978IleGlu: 2.978 ± 0.058
1.412IlePhe: 1.412 ± 0.042
4.827IleGly: 4.827 ± 0.079
0.746IleHis: 0.746 ± 0.029
2.045IleIle: 2.045 ± 0.056
0.941IleLys: 0.941 ± 0.04
4.603IleLeu: 4.603 ± 0.077
0.638IleMet: 0.638 ± 0.027
1.128IleAsn: 1.128 ± 0.035
2.51IlePro: 2.51 ± 0.061
1.096IleGln: 1.096 ± 0.033
3.018IleArg: 3.018 ± 0.056
2.78IleSer: 2.78 ± 0.051
2.963IleThr: 2.963 ± 0.054
4.736IleVal: 4.736 ± 0.086
0.549IleTrp: 0.549 ± 0.027
0.882IleTyr: 0.882 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
2.862LysAla: 2.862 ± 0.071
0.074LysCys: 0.074 ± 0.009
1.219LysAsp: 1.219 ± 0.04
1.145LysGlu: 1.145 ± 0.041
0.568LysPhe: 0.568 ± 0.025
1.718LysGly: 1.718 ± 0.049
0.555LysHis: 0.555 ± 0.027
1.108LysIle: 1.108 ± 0.036
1.02LysLys: 1.02 ± 0.051
2.311LysLeu: 2.311 ± 0.055
0.459LysMet: 0.459 ± 0.022
0.742LysAsn: 0.742 ± 0.029
1.474LysPro: 1.474 ± 0.046
0.843LysGln: 0.843 ± 0.034
1.822LysArg: 1.822 ± 0.046
1.492LysSer: 1.492 ± 0.043
1.574LysThr: 1.574 ± 0.042
1.832LysVal: 1.832 ± 0.049
0.286LysTrp: 0.286 ± 0.017
0.537LysTyr: 0.537 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
14.161LeuAla: 14.161 ± 0.149
0.552LeuCys: 0.552 ± 0.029
6.655LeuAsp: 6.655 ± 0.099
5.507LeuGlu: 5.507 ± 0.086
3.136LeuPhe: 3.136 ± 0.068
9.303LeuGly: 9.303 ± 0.128
1.883LeuHis: 1.883 ± 0.048
4.766LeuIle: 4.766 ± 0.089
2.174LeuLys: 2.174 ± 0.057
10.511LeuLeu: 10.511 ± 0.148
1.672LeuMet: 1.672 ± 0.041
2.225LeuAsn: 2.225 ± 0.048
5.422LeuPro: 5.422 ± 0.075
2.656LeuGln: 2.656 ± 0.057
6.709LeuArg: 6.709 ± 0.097
6.439LeuSer: 6.439 ± 0.095
6.534LeuThr: 6.534 ± 0.087
9.356LeuVal: 9.356 ± 0.126
1.277LeuTrp: 1.277 ± 0.041
1.723LeuTyr: 1.723 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.177MetAla: 2.177 ± 0.045
0.085MetCys: 0.085 ± 0.011
0.833MetAsp: 0.833 ± 0.029
0.706MetGlu: 0.706 ± 0.027
0.593MetPhe: 0.593 ± 0.025
1.307MetGly: 1.307 ± 0.038
0.327MetHis: 0.327 ± 0.018
0.863MetIle: 0.863 ± 0.035
0.526MetLys: 0.526 ± 0.024
1.959MetLeu: 1.959 ± 0.04
0.352MetMet: 0.352 ± 0.026
0.564MetAsn: 0.564 ± 0.024
1.183MetPro: 1.183 ± 0.033
0.554MetGln: 0.554 ± 0.026
1.259MetArg: 1.259 ± 0.036
1.574MetSer: 1.574 ± 0.037
1.691MetThr: 1.691 ± 0.038
1.389MetVal: 1.389 ± 0.039
0.19MetTrp: 0.19 ± 0.013
0.272MetTyr: 0.272 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.873AsnAla: 2.873 ± 0.056
0.143AsnCys: 0.143 ± 0.012
1.438AsnAsp: 1.438 ± 0.046
1.254AsnGlu: 1.254 ± 0.041
0.744AsnPhe: 0.744 ± 0.031
2.29AsnGly: 2.29 ± 0.059
0.402AsnHis: 0.402 ± 0.021
1.069AsnIle: 1.069 ± 0.035
0.516AsnLys: 0.516 ± 0.027
2.282AsnLeu: 2.282 ± 0.048
0.398AsnMet: 0.398 ± 0.021
0.6AsnAsn: 0.6 ± 0.028
1.801AsnPro: 1.801 ± 0.042
0.671AsnGln: 0.671 ± 0.025
1.579AsnArg: 1.579 ± 0.043
1.296AsnSer: 1.296 ± 0.059
1.381AsnThr: 1.381 ± 0.041
1.964AsnVal: 1.964 ± 0.043
0.338AsnTrp: 0.338 ± 0.018
0.549AsnTyr: 0.549 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
6.738ProAla: 6.738 ± 0.099
0.193ProCys: 0.193 ± 0.014
3.765ProAsp: 3.765 ± 0.075
3.847ProGlu: 3.847 ± 0.076
1.757ProPhe: 1.757 ± 0.041
4.859ProGly: 4.859 ± 0.08
1.024ProHis: 1.024 ± 0.03
2.274ProIle: 2.274 ± 0.053
1.227ProLys: 1.227 ± 0.034
4.788ProLeu: 4.788 ± 0.081
0.856ProMet: 0.856 ± 0.031
1.203ProAsn: 1.203 ± 0.034
2.289ProPro: 2.289 ± 0.065
1.438ProGln: 1.438 ± 0.036
2.99ProArg: 2.99 ± 0.057
3.361ProSer: 3.361 ± 0.053
3.355ProThr: 3.355 ± 0.07
4.862ProVal: 4.862 ± 0.074
0.754ProTrp: 0.754 ± 0.029
1.056ProTyr: 1.056 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.513GlnAla: 3.513 ± 0.065
0.133GlnCys: 0.133 ± 0.014
1.342GlnAsp: 1.342 ± 0.042
1.284GlnGlu: 1.284 ± 0.036
0.977GlnPhe: 0.977 ± 0.031
1.989GlnGly: 1.989 ± 0.045
0.568GlnHis: 0.568 ± 0.025
1.435GlnIle: 1.435 ± 0.041
0.802GlnLys: 0.802 ± 0.031
3.198GlnLeu: 3.198 ± 0.064
0.574GlnMet: 0.574 ± 0.026
0.737GlnAsn: 0.737 ± 0.024
1.662GlnPro: 1.662 ± 0.048
1.122GlnGln: 1.122 ± 0.039
2.241GlnArg: 2.241 ± 0.047
1.74GlnSer: 1.74 ± 0.045
1.528GlnThr: 1.528 ± 0.043
2.458GlnVal: 2.458 ± 0.051
0.407GlnTrp: 0.407 ± 0.022
0.652GlnTyr: 0.652 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
7.653ArgAla: 7.653 ± 0.113
0.305ArgCys: 0.305 ± 0.017
3.919ArgAsp: 3.919 ± 0.073
3.956ArgGlu: 3.956 ± 0.069
2.338ArgPhe: 2.338 ± 0.054
4.86ArgGly: 4.86 ± 0.073
1.394ArgHis: 1.394 ± 0.035
3.61ArgIle: 3.61 ± 0.057
1.694ArgLys: 1.694 ± 0.043
6.975ArgLeu: 6.975 ± 0.102
1.795ArgMet: 1.795 ± 0.046
1.681ArgAsn: 1.681 ± 0.035
3.325ArgPro: 3.325 ± 0.074
2.1ArgGln: 2.1 ± 0.042
5.574ArgArg: 5.574 ± 0.094
4.384ArgSer: 4.384 ± 0.072
3.988ArgThr: 3.988 ± 0.072
5.645ArgVal: 5.645 ± 0.079
1.062ArgTrp: 1.062 ± 0.038
1.582ArgTyr: 1.582 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
7.704SerAla: 7.704 ± 0.095
0.293SerCys: 0.293 ± 0.019
3.639SerAsp: 3.639 ± 0.073
3.096SerGlu: 3.096 ± 0.064
2.161SerPhe: 2.161 ± 0.052
6.381SerGly: 6.381 ± 0.083
1.233SerHis: 1.233 ± 0.037
3.132SerIle: 3.132 ± 0.062
1.367SerLys: 1.367 ± 0.041
5.951SerLeu: 5.951 ± 0.084
1.298SerMet: 1.298 ± 0.036
1.449SerAsn: 1.449 ± 0.042
3.318SerPro: 3.318 ± 0.054
1.631SerGln: 1.631 ± 0.04
4.121SerArg: 4.121 ± 0.067
4.107SerSer: 4.107 ± 0.076
3.975SerThr: 3.975 ± 0.068
5.361SerVal: 5.361 ± 0.084
0.935SerTrp: 0.935 ± 0.032
1.351SerTyr: 1.351 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
7.754ThrAla: 7.754 ± 0.107
0.283ThrCys: 0.283 ± 0.017
3.77ThrAsp: 3.77 ± 0.071
3.387ThrGlu: 3.387 ± 0.066
1.905ThrPhe: 1.905 ± 0.047
5.949ThrGly: 5.949 ± 0.087
1.096ThrHis: 1.096 ± 0.029
3.013ThrIle: 3.013 ± 0.051
1.412ThrLys: 1.412 ± 0.046
6.055ThrLeu: 6.055 ± 0.08
1.032ThrMet: 1.032 ± 0.037
1.421ThrAsn: 1.421 ± 0.044
3.941ThrPro: 3.941 ± 0.076
1.449ThrGln: 1.449 ± 0.044
3.638ThrArg: 3.638 ± 0.061
3.729ThrSer: 3.729 ± 0.073
3.956ThrThr: 3.956 ± 0.073
5.903ThrVal: 5.903 ± 0.085
0.843ThrTrp: 0.843 ± 0.03
1.145ThrTyr: 1.145 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
10.944ValAla: 10.944 ± 0.13
0.472ValCys: 0.472 ± 0.02
5.669ValAsp: 5.669 ± 0.069
4.719ValGlu: 4.719 ± 0.063
2.855ValPhe: 2.855 ± 0.053
7.054ValGly: 7.054 ± 0.096
1.682ValHis: 1.682 ± 0.04
4.314ValIle: 4.314 ± 0.065
1.895ValLys: 1.895 ± 0.048
9.679ValLeu: 9.679 ± 0.143
1.48ValMet: 1.48 ± 0.04
2.052ValAsn: 2.052 ± 0.047
4.712ValPro: 4.712 ± 0.063
2.219ValGln: 2.219 ± 0.042
5.685ValArg: 5.685 ± 0.088
5.531ValSer: 5.531 ± 0.072
5.935ValThr: 5.935 ± 0.088
8.327ValVal: 8.327 ± 0.114
1.067ValTrp: 1.067 ± 0.032
1.534ValTyr: 1.534 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.511TrpAla: 1.511 ± 0.038
0.089TrpCys: 0.089 ± 0.01
0.685TrpAsp: 0.685 ± 0.029
0.609TrpGlu: 0.609 ± 0.024
0.544TrpPhe: 0.544 ± 0.023
0.99TrpGly: 0.99 ± 0.031
0.34TrpHis: 0.34 ± 0.02
0.667TrpIle: 0.667 ± 0.026
0.358TrpLys: 0.358 ± 0.022
1.748TrpLeu: 1.748 ± 0.051
0.323TrpMet: 0.323 ± 0.021
0.424TrpAsn: 0.424 ± 0.019
0.705TrpPro: 0.705 ± 0.028
0.54TrpGln: 0.54 ± 0.02
1.097TrpArg: 1.097 ± 0.031
0.892TrpSer: 0.892 ± 0.033
0.896TrpThr: 0.896 ± 0.03
1.073TrpVal: 1.073 ± 0.035
0.352TrpTrp: 0.352 ± 0.019
0.286TrpTyr: 0.286 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.218TyrAla: 2.218 ± 0.046
0.124TyrCys: 0.124 ± 0.011
1.246TyrAsp: 1.246 ± 0.041
1.127TyrGlu: 1.127 ± 0.036
0.789TyrPhe: 0.789 ± 0.029
1.91TyrGly: 1.91 ± 0.049
0.316TyrHis: 0.316 ± 0.018
0.773TyrIle: 0.773 ± 0.027
0.378TyrLys: 0.378 ± 0.019
2.391TyrLeu: 2.391 ± 0.058
0.265TyrMet: 0.265 ± 0.018
0.526TyrAsn: 0.526 ± 0.026
1.111TyrPro: 1.111 ± 0.033
0.568TyrGln: 0.568 ± 0.025
1.619TyrArg: 1.619 ± 0.039
1.356TyrSer: 1.356 ± 0.039
1.124TyrThr: 1.124 ± 0.04
1.593TyrVal: 1.593 ± 0.037
0.334TyrTrp: 0.334 ± 0.018
0.471TyrTyr: 0.471 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3145 proteins (983503 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski