Amino acid dipepetide frequency for Kern Canyon virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.969AlaAla: 2.969 ± 1.293
1.35AlaCys: 1.35 ± 0.387
3.509AlaAsp: 3.509 ± 1.316
2.429AlaGlu: 2.429 ± 1.194
1.08AlaPhe: 1.08 ± 0.415
1.619AlaGly: 1.619 ± 0.657
0.54AlaHis: 0.54 ± 0.42
3.779AlaIle: 3.779 ± 0.618
2.699AlaLys: 2.699 ± 0.917
3.509AlaLeu: 3.509 ± 0.318
0.27AlaMet: 0.27 ± 0.47
1.889AlaAsn: 1.889 ± 1.014
1.35AlaPro: 1.35 ± 0.734
1.889AlaGln: 1.889 ± 1.025
2.699AlaArg: 2.699 ± 0.97
1.889AlaSer: 1.889 ± 0.642
3.779AlaThr: 3.779 ± 0.768
2.969AlaVal: 2.969 ± 0.636
0.0AlaTrp: 0.0 ± 0.0
2.429AlaTyr: 2.429 ± 1.231
0.0AlaXaa: 0.0 ± 0.0
Cys
0.54CysAla: 0.54 ± 0.303
0.54CysCys: 0.54 ± 1.261
1.08CysAsp: 1.08 ± 0.54
1.35CysGlu: 1.35 ± 0.663
0.54CysPhe: 0.54 ± 0.27
1.08CysGly: 1.08 ± 0.371
1.08CysHis: 1.08 ± 1.103
1.619CysIle: 1.619 ± 0.63
1.619CysLys: 1.619 ± 1.128
2.429CysLeu: 2.429 ± 0.266
0.0CysMet: 0.0 ± 0.0
0.81CysAsn: 0.81 ± 0.366
0.81CysPro: 0.81 ± 0.284
0.27CysGln: 0.27 ± 0.156
0.0CysArg: 0.0 ± 0.0
1.35CysSer: 1.35 ± 0.492
1.08CysThr: 1.08 ± 0.463
0.81CysVal: 0.81 ± 0.284
0.27CysTrp: 0.27 ± 0.156
0.54CysTyr: 0.54 ± 0.603
0.0CysXaa: 0.0 ± 0.0
Asp
1.08AspAla: 1.08 ± 0.291
1.35AspCys: 1.35 ± 0.793
5.668AspAsp: 5.668 ± 1.936
5.668AspGlu: 5.668 ± 2.425
3.509AspPhe: 3.509 ± 0.666
3.239AspGly: 3.239 ± 0.947
1.619AspHis: 1.619 ± 0.63
5.128AspIle: 5.128 ± 1.591
5.128AspLys: 5.128 ± 1.729
5.668AspLeu: 5.668 ± 1.986
2.429AspMet: 2.429 ± 0.621
2.699AspAsn: 2.699 ± 1.154
3.779AspPro: 3.779 ± 1.009
1.35AspGln: 1.35 ± 0.595
3.779AspArg: 3.779 ± 0.535
5.398AspSer: 5.398 ± 1.317
2.969AspThr: 2.969 ± 1.571
1.889AspVal: 1.889 ± 0.795
1.619AspTrp: 1.619 ± 0.53
1.619AspTyr: 1.619 ± 0.715
0.0AspXaa: 0.0 ± 0.0
Glu
2.699GluAla: 2.699 ± 1.389
1.08GluCys: 1.08 ± 0.54
5.668GluAsp: 5.668 ± 3.19
5.398GluGlu: 5.398 ± 3.225
2.969GluPhe: 2.969 ± 0.939
2.699GluGly: 2.699 ± 0.83
1.889GluHis: 1.889 ± 1.122
7.018GluIle: 7.018 ± 1.55
5.128GluLys: 5.128 ± 1.121
3.509GluLeu: 3.509 ± 0.663
2.699GluMet: 2.699 ± 0.929
2.429GluAsn: 2.429 ± 0.653
2.159GluPro: 2.159 ± 0.863
2.159GluGln: 2.159 ± 1.406
3.239GluArg: 3.239 ± 1.002
5.398GluSer: 5.398 ± 0.855
2.429GluThr: 2.429 ± 1.231
4.588GluVal: 4.588 ± 1.516
1.35GluTrp: 1.35 ± 0.291
2.969GluTyr: 2.969 ± 0.776
0.0GluXaa: 0.0 ± 0.0
Phe
1.08PheAla: 1.08 ± 0.606
0.54PheCys: 0.54 ± 0.481
2.699PheAsp: 2.699 ± 0.672
3.239PheGlu: 3.239 ± 0.776
2.159PhePhe: 2.159 ± 0.713
2.969PheGly: 2.969 ± 0.871
2.159PheHis: 2.159 ± 0.741
2.159PheIle: 2.159 ± 0.716
4.588PheLys: 4.588 ± 0.482
3.239PheLeu: 3.239 ± 1.516
1.619PheMet: 1.619 ± 0.438
1.619PheAsn: 1.619 ± 0.397
2.429PhePro: 2.429 ± 0.418
2.159PheGln: 2.159 ± 0.833
2.699PheArg: 2.699 ± 0.876
3.239PheSer: 3.239 ± 1.231
1.889PheThr: 1.889 ± 0.735
2.699PheVal: 2.699 ± 0.736
0.54PheTrp: 0.54 ± 0.303
0.81PheTyr: 0.81 ± 0.87
0.0PheXaa: 0.0 ± 0.0
Gly
2.159GlyAla: 2.159 ± 0.56
0.81GlyCys: 0.81 ± 0.366
3.239GlyAsp: 3.239 ± 0.906
4.318GlyGlu: 4.318 ± 1.12
1.889GlyPhe: 1.889 ± 0.656
4.588GlyGly: 4.588 ± 0.972
0.54GlyHis: 0.54 ± 0.303
3.779GlyIle: 3.779 ± 0.71
3.239GlyLys: 3.239 ± 0.705
7.827GlyLeu: 7.827 ± 1.097
1.889GlyMet: 1.889 ± 0.774
2.969GlyAsn: 2.969 ± 0.746
3.239GlyPro: 3.239 ± 0.636
1.889GlyGln: 1.889 ± 0.778
2.159GlyArg: 2.159 ± 0.482
4.858GlySer: 4.858 ± 0.921
2.429GlyThr: 2.429 ± 0.803
3.239GlyVal: 3.239 ± 1.301
0.54GlyTrp: 0.54 ± 0.408
2.699GlyTyr: 2.699 ± 0.517
0.0GlyXaa: 0.0 ± 0.0
His
1.35HisAla: 1.35 ± 0.642
0.81HisCys: 0.81 ± 0.401
1.08HisAsp: 1.08 ± 1.062
0.81HisGlu: 0.81 ± 0.432
1.08HisPhe: 1.08 ± 0.624
0.54HisGly: 0.54 ± 0.312
1.35HisHis: 1.35 ± 0.532
2.969HisIle: 2.969 ± 0.793
1.619HisLys: 1.619 ± 0.811
3.779HisLeu: 3.779 ± 0.871
0.27HisMet: 0.27 ± 0.47
0.54HisAsn: 0.54 ± 0.312
1.889HisPro: 1.889 ± 0.534
0.81HisGln: 0.81 ± 0.591
1.889HisArg: 1.889 ± 0.607
1.35HisSer: 1.35 ± 0.291
0.54HisThr: 0.54 ± 0.303
1.35HisVal: 1.35 ± 0.663
0.54HisTrp: 0.54 ± 0.312
1.08HisTyr: 1.08 ± 0.415
0.0HisXaa: 0.0 ± 0.0
Ile
2.969IleAla: 2.969 ± 0.946
1.889IleCys: 1.889 ± 0.813
4.049IleAsp: 4.049 ± 1.377
4.588IleGlu: 4.588 ± 1.395
2.699IlePhe: 2.699 ± 0.946
4.588IleGly: 4.588 ± 0.858
2.699IleHis: 2.699 ± 1.065
6.208IleIle: 6.208 ± 2.186
6.208IleLys: 6.208 ± 1.379
6.208IleLeu: 6.208 ± 0.92
2.429IleMet: 2.429 ± 0.544
2.969IleAsn: 2.969 ± 1.205
3.239IlePro: 3.239 ± 0.874
1.889IleGln: 1.889 ± 0.623
4.588IleArg: 4.588 ± 0.976
6.478IleSer: 6.478 ± 0.885
4.318IleThr: 4.318 ± 1.086
2.969IleVal: 2.969 ± 0.549
1.889IleTrp: 1.889 ± 0.534
2.429IleTyr: 2.429 ± 0.943
0.0IleXaa: 0.0 ± 0.0
Lys
3.239LysAla: 3.239 ± 1.391
0.54LysCys: 0.54 ± 0.27
6.748LysAsp: 6.748 ± 1.975
4.858LysGlu: 4.858 ± 2.535
2.159LysPhe: 2.159 ± 0.438
4.588LysGly: 4.588 ± 0.377
0.54LysHis: 0.54 ± 0.42
4.588LysIle: 4.588 ± 1.047
5.938LysLys: 5.938 ± 1.444
7.827LysLeu: 7.827 ± 1.722
1.08LysMet: 1.08 ± 0.575
2.969LysAsn: 2.969 ± 1.281
3.779LysPro: 3.779 ± 0.561
2.159LysGln: 2.159 ± 0.741
3.509LysArg: 3.509 ± 0.871
4.588LysSer: 4.588 ± 1.101
5.668LysThr: 5.668 ± 1.607
5.398LysVal: 5.398 ± 1.483
2.429LysTrp: 2.429 ± 0.939
2.429LysTyr: 2.429 ± 0.669
0.0LysXaa: 0.0 ± 0.0
Leu
4.049LeuAla: 4.049 ± 0.865
1.889LeuCys: 1.889 ± 1.035
7.557LeuAsp: 7.557 ± 2.145
6.748LeuGlu: 6.748 ± 1.993
4.318LeuPhe: 4.318 ± 1.268
7.018LeuGly: 7.018 ± 0.72
2.699LeuHis: 2.699 ± 1.393
7.557LeuIle: 7.557 ± 1.374
5.398LeuLys: 5.398 ± 1.298
8.097LeuLeu: 8.097 ± 1.516
2.699LeuMet: 2.699 ± 1.56
4.049LeuAsn: 4.049 ± 2.026
3.779LeuPro: 3.779 ± 1.958
2.429LeuGln: 2.429 ± 1.118
3.779LeuArg: 3.779 ± 1.509
8.907LeuSer: 8.907 ± 1.277
6.478LeuThr: 6.478 ± 1.186
4.318LeuVal: 4.318 ± 0.918
0.81LeuTrp: 0.81 ± 0.752
2.969LeuTyr: 2.969 ± 1.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.429MetAla: 2.429 ± 0.418
1.08MetCys: 1.08 ± 0.291
0.81MetAsp: 0.81 ± 0.366
1.889MetGlu: 1.889 ± 0.299
1.08MetPhe: 1.08 ± 0.606
0.54MetGly: 0.54 ± 0.312
0.27MetHis: 0.27 ± 0.156
1.35MetIle: 1.35 ± 0.595
1.889MetLys: 1.889 ± 0.805
2.699MetLeu: 2.699 ± 0.637
0.27MetMet: 0.27 ± 0.352
1.619MetAsn: 1.619 ± 1.12
0.27MetPro: 0.27 ± 0.352
0.54MetGln: 0.54 ± 0.303
1.08MetArg: 1.08 ± 0.606
2.159MetSer: 2.159 ± 0.71
2.159MetThr: 2.159 ± 0.901
2.159MetVal: 2.159 ± 0.798
0.27MetTrp: 0.27 ± 0.337
0.81MetTyr: 0.81 ± 0.51
0.0MetXaa: 0.0 ± 0.0
Asn
2.429AsnAla: 2.429 ± 0.635
0.27AsnCys: 0.27 ± 0.156
1.889AsnAsp: 1.889 ± 0.642
2.699AsnGlu: 2.699 ± 0.988
1.889AsnPhe: 1.889 ± 0.813
3.509AsnGly: 3.509 ± 1.606
2.159AsnHis: 2.159 ± 0.684
2.969AsnIle: 2.969 ± 0.854
1.619AsnLys: 1.619 ± 0.823
4.049AsnLeu: 4.049 ± 1.401
1.08AsnMet: 1.08 ± 0.575
2.159AsnAsn: 2.159 ± 0.612
3.509AsnPro: 3.509 ± 0.644
1.889AsnGln: 1.889 ± 0.8
0.81AsnArg: 0.81 ± 0.468
2.969AsnSer: 2.969 ± 0.644
1.35AsnThr: 1.35 ± 0.492
1.35AsnVal: 1.35 ± 0.773
1.619AsnTrp: 1.619 ± 0.57
1.35AsnTyr: 1.35 ± 0.492
0.0AsnXaa: 0.0 ± 0.0
Pro
3.779ProAla: 3.779 ± 0.471
0.27ProCys: 0.27 ± 0.463
4.049ProAsp: 4.049 ± 1.322
3.239ProGlu: 3.239 ± 1.436
1.619ProPhe: 1.619 ± 0.518
2.429ProGly: 2.429 ± 0.38
0.81ProHis: 0.81 ± 0.284
2.969ProIle: 2.969 ± 0.962
3.509ProLys: 3.509 ± 1.002
4.858ProLeu: 4.858 ± 1.175
0.54ProMet: 0.54 ± 0.912
2.159ProAsn: 2.159 ± 0.49
4.049ProPro: 4.049 ± 1.262
1.08ProGln: 1.08 ± 0.929
3.239ProArg: 3.239 ± 0.621
5.128ProSer: 5.128 ± 0.485
1.619ProThr: 1.619 ± 0.366
2.429ProVal: 2.429 ± 1.501
0.81ProTrp: 0.81 ± 0.329
1.619ProTyr: 1.619 ± 0.731
0.0ProXaa: 0.0 ± 0.0
Gln
1.619GlnAla: 1.619 ± 0.938
0.81GlnCys: 0.81 ± 0.591
0.54GlnAsp: 0.54 ± 0.598
1.619GlnGlu: 1.619 ± 1.091
0.81GlnPhe: 0.81 ± 0.329
2.699GlnGly: 2.699 ± 0.787
0.81GlnHis: 0.81 ± 0.284
2.969GlnIle: 2.969 ± 0.588
1.35GlnLys: 1.35 ± 0.469
2.429GlnLeu: 2.429 ± 0.635
0.54GlnMet: 0.54 ± 0.704
1.619GlnAsn: 1.619 ± 0.811
2.159GlnPro: 2.159 ± 0.423
0.81GlnGln: 0.81 ± 0.504
1.08GlnArg: 1.08 ± 0.701
2.159GlnSer: 2.159 ± 0.798
2.159GlnThr: 2.159 ± 0.731
1.889GlnVal: 1.889 ± 1.213
0.27GlnTrp: 0.27 ± 0.352
0.81GlnTyr: 0.81 ± 0.366
0.0GlnXaa: 0.0 ± 0.0
Arg
2.699ArgAla: 2.699 ± 1.024
1.08ArgCys: 1.08 ± 0.451
2.699ArgAsp: 2.699 ± 0.611
2.699ArgGlu: 2.699 ± 0.876
3.239ArgPhe: 3.239 ± 0.817
2.699ArgGly: 2.699 ± 0.733
1.35ArgHis: 1.35 ± 0.291
1.619ArgIle: 1.619 ± 0.463
2.969ArgLys: 2.969 ± 0.863
5.398ArgLeu: 5.398 ± 1.806
1.08ArgMet: 1.08 ± 0.44
2.969ArgAsn: 2.969 ± 0.844
4.049ArgPro: 4.049 ± 0.816
1.619ArgGln: 1.619 ± 0.473
2.159ArgArg: 2.159 ± 0.339
3.509ArgSer: 3.509 ± 1.229
2.429ArgThr: 2.429 ± 0.756
2.429ArgVal: 2.429 ± 0.739
0.27ArgTrp: 0.27 ± 0.337
1.619ArgTyr: 1.619 ± 0.658
0.0ArgXaa: 0.0 ± 0.0
Ser
3.509SerAla: 3.509 ± 0.902
0.81SerCys: 0.81 ± 0.468
5.128SerAsp: 5.128 ± 1.734
5.668SerGlu: 5.668 ± 1.395
5.668SerPhe: 5.668 ± 1.194
2.699SerGly: 2.699 ± 0.952
1.619SerHis: 1.619 ± 0.671
5.938SerIle: 5.938 ± 1.834
7.557SerLys: 7.557 ± 1.098
7.287SerLeu: 7.287 ± 1.305
1.35SerMet: 1.35 ± 0.581
1.889SerAsn: 1.889 ± 0.852
2.429SerPro: 2.429 ± 0.512
2.429SerGln: 2.429 ± 1.319
4.588SerArg: 4.588 ± 1.004
7.827SerSer: 7.827 ± 0.823
4.858SerThr: 4.858 ± 0.914
4.318SerVal: 4.318 ± 0.946
1.619SerTrp: 1.619 ± 0.366
1.619SerTyr: 1.619 ± 0.366
0.0SerXaa: 0.0 ± 0.0
Thr
0.81ThrAla: 0.81 ± 0.366
0.27ThrCys: 0.27 ± 0.47
2.969ThrAsp: 2.969 ± 0.549
3.509ThrGlu: 3.509 ± 0.868
1.889ThrPhe: 1.889 ± 0.798
2.699ThrGly: 2.699 ± 0.539
1.35ThrHis: 1.35 ± 0.387
4.049ThrIle: 4.049 ± 0.893
4.588ThrLys: 4.588 ± 0.519
5.128ThrLeu: 5.128 ± 1.3
1.35ThrMet: 1.35 ± 0.492
1.889ThrAsn: 1.889 ± 0.572
2.699ThrPro: 2.699 ± 1.084
1.35ThrGln: 1.35 ± 0.668
2.429ThrArg: 2.429 ± 1.072
4.588ThrSer: 4.588 ± 1.352
2.159ThrThr: 2.159 ± 1.248
4.588ThrVal: 4.588 ± 1.743
1.08ThrTrp: 1.08 ± 0.446
2.429ThrTyr: 2.429 ± 0.465
0.0ThrXaa: 0.0 ± 0.0
Val
1.35ValAla: 1.35 ± 0.581
1.08ValCys: 1.08 ± 0.624
3.239ValAsp: 3.239 ± 0.793
2.969ValGlu: 2.969 ± 1.581
1.889ValPhe: 1.889 ± 0.851
4.588ValGly: 4.588 ± 0.709
1.35ValHis: 1.35 ± 0.469
5.128ValIle: 5.128 ± 0.871
5.668ValLys: 5.668 ± 1.754
7.018ValLeu: 7.018 ± 1.239
1.619ValMet: 1.619 ± 0.981
2.159ValAsn: 2.159 ± 0.339
2.159ValPro: 2.159 ± 0.798
1.889ValGln: 1.889 ± 0.805
2.429ValArg: 2.429 ± 0.55
4.858ValSer: 4.858 ± 1.936
1.08ValThr: 1.08 ± 1.216
2.159ValVal: 2.159 ± 0.893
0.81ValTrp: 0.81 ± 0.504
1.619ValTyr: 1.619 ± 0.671
0.0ValXaa: 0.0 ± 0.0
Trp
0.81TrpAla: 0.81 ± 0.366
0.27TrpCys: 0.27 ± 0.631
1.619TrpAsp: 1.619 ± 0.57
1.35TrpGlu: 1.35 ± 0.536
1.889TrpPhe: 1.889 ± 0.608
1.619TrpGly: 1.619 ± 0.936
0.27TrpHis: 0.27 ± 0.156
1.619TrpIle: 1.619 ± 0.811
1.08TrpLys: 1.08 ± 0.624
0.54TrpLeu: 0.54 ± 0.704
1.08TrpMet: 1.08 ± 0.44
0.54TrpAsn: 0.54 ± 0.312
0.54TrpPro: 0.54 ± 0.312
0.27TrpGln: 0.27 ± 0.337
0.27TrpArg: 0.27 ± 0.337
1.08TrpSer: 1.08 ± 0.371
0.54TrpThr: 0.54 ± 0.603
1.619TrpVal: 1.619 ± 0.973
0.0TrpTrp: 0.0 ± 0.0
0.27TrpTyr: 0.27 ± 0.337
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.08TyrAla: 1.08 ± 0.451
1.08TyrCys: 1.08 ± 0.665
1.35TyrAsp: 1.35 ± 0.492
2.429TyrGlu: 2.429 ± 0.614
2.159TyrPhe: 2.159 ± 0.922
1.889TyrGly: 1.889 ± 1.252
0.54TyrHis: 0.54 ± 0.481
1.889TyrIle: 1.889 ± 0.982
3.239TyrLys: 3.239 ± 0.731
4.049TyrLeu: 4.049 ± 0.668
0.81TyrMet: 0.81 ± 0.872
1.619TyrAsn: 1.619 ± 0.486
2.159TyrPro: 2.159 ± 0.445
0.27TyrGln: 0.27 ± 0.156
2.159TyrArg: 2.159 ± 0.547
1.08TyrSer: 1.08 ± 0.291
1.889TyrThr: 1.889 ± 0.572
1.889TyrVal: 1.889 ± 0.845
0.54TyrTrp: 0.54 ± 0.27
2.159TyrTyr: 2.159 ± 0.689
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (3706 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski