Amino acid dipepetide frequency for Streptomyces alboflavus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.636AlaAla: 22.636 ± 0.14	1.157AlaCys: 1.157 ± 0.022	9.132AlaAsp: 9.132 ± 0.076	8.813AlaGlu: 8.813 ± 0.087	3.487AlaPhe: 3.487 ± 0.035	13.133AlaGly: 13.133 ± 0.085	3.116AlaHis: 3.116 ± 0.036	3.228AlaIle: 3.228 ± 0.033	3.011AlaLys: 3.011 ± 0.05	14.599AlaLeu: 14.599 ± 0.101	2.482AlaMet: 2.482 ± 0.032	1.787AlaAsn: 1.787 ± 0.029	7.939AlaPro: 7.939 ± 0.07	3.679AlaGln: 3.679 ± 0.045	11.023AlaArg: 11.023 ± 0.083	6.064AlaSer: 6.064 ± 0.056	7.131AlaThr: 7.131 ± 0.058	12.4AlaVal: 12.4 ± 0.091	1.952AlaTrp: 1.952 ± 0.029	2.857AlaTyr: 2.857 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.249CysAla: 1.249 ± 0.023	0.121CysCys: 0.121 ± 0.006	0.482CysAsp: 0.482 ± 0.014	0.386CysGlu: 0.386 ± 0.012	0.213CysPhe: 0.213 ± 0.009	1.053CysGly: 1.053 ± 0.022	0.197CysHis: 0.197 ± 0.009	0.138CysIle: 0.138 ± 0.008	0.125CysLys: 0.125 ± 0.007	0.729CysLeu: 0.729 ± 0.016	0.137CysMet: 0.137 ± 0.007	0.113CysAsn: 0.113 ± 0.006	0.535CysPro: 0.535 ± 0.014	0.172CysGln: 0.172 ± 0.008	0.683CysArg: 0.683 ± 0.017	0.503CysSer: 0.503 ± 0.015	0.51CysThr: 0.51 ± 0.013	0.7CysVal: 0.7 ± 0.017	0.125CysTrp: 0.125 ± 0.007	0.144CysTyr: 0.144 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	8.23AspAla: 8.23 ± 0.077	0.425AspCys: 0.425 ± 0.014	3.902AspAsp: 3.902 ± 0.046	3.901AspGlu: 3.901 ± 0.042	1.628AspPhe: 1.628 ± 0.025	6.759AspGly: 6.759 ± 0.061	1.439AspHis: 1.439 ± 0.023	1.841AspIle: 1.841 ± 0.025	1.383AspLys: 1.383 ± 0.033	6.244AspLeu: 6.244 ± 0.057	0.836AspMet: 0.836 ± 0.019	0.897AspAsn: 0.897 ± 0.018	4.503AspPro: 4.503 ± 0.038	1.541AspGln: 1.541 ± 0.029	4.92AspArg: 4.92 ± 0.055	2.575AspSer: 2.575 ± 0.028	3.285AspThr: 3.285 ± 0.036	4.93AspVal: 4.93 ± 0.042	1.037AspTrp: 1.037 ± 0.019	1.076AspTyr: 1.076 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.357GluAla: 7.357 ± 0.082	0.372GluCys: 0.372 ± 0.011	2.705GluAsp: 2.705 ± 0.031	3.193GluGlu: 3.193 ± 0.042	1.424GluPhe: 1.424 ± 0.021	4.457GluGly: 4.457 ± 0.042	1.518GluHis: 1.518 ± 0.024	2.002GluIle: 2.002 ± 0.029	1.442GluLys: 1.442 ± 0.029	6.678GluLeu: 6.678 ± 0.052	0.806GluMet: 0.806 ± 0.016	0.927GluAsn: 0.927 ± 0.019	3.403GluPro: 3.403 ± 0.035	2.232GluGln: 2.232 ± 0.032	5.653GluArg: 5.653 ± 0.049	2.596GluSer: 2.596 ± 0.035	2.654GluThr: 2.654 ± 0.034	4.271GluVal: 4.271 ± 0.045	0.726GluTrp: 0.726 ± 0.016	1.037GluTyr: 1.037 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.627PheAla: 3.627 ± 0.043	0.241PheCys: 0.241 ± 0.009	1.914PheAsp: 1.914 ± 0.029	1.363PheGlu: 1.363 ± 0.026	0.82PhePhe: 0.82 ± 0.021	2.99PheGly: 2.99 ± 0.038	0.606PheHis: 0.606 ± 0.015	0.683PheIle: 0.683 ± 0.015	0.536PheLys: 0.536 ± 0.017	2.521PheLeu: 2.521 ± 0.033	0.398PheMet: 0.398 ± 0.012	0.543PheAsn: 0.543 ± 0.015	1.365PhePro: 1.365 ± 0.022	0.653PheGln: 0.653 ± 0.015	1.788PheArg: 1.788 ± 0.023	1.4PheSer: 1.4 ± 0.024	1.932PheThr: 1.932 ± 0.026	2.211PheVal: 2.211 ± 0.035	0.412PheTrp: 0.412 ± 0.012	0.517PheTyr: 0.517 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	12.135GlyAla: 12.135 ± 0.083	0.872GlyCys: 0.872 ± 0.019	5.484GlyAsp: 5.484 ± 0.05	5.245GlyGlu: 5.245 ± 0.039	2.806GlyPhe: 2.806 ± 0.033	9.432GlyGly: 9.432 ± 0.085	2.388GlyHis: 2.388 ± 0.03	3.124GlyIle: 3.124 ± 0.033	2.674GlyLys: 2.674 ± 0.049	9.366GlyLeu: 9.366 ± 0.067	1.937GlyMet: 1.937 ± 0.03	1.625GlyAsn: 1.625 ± 0.033	5.454GlyPro: 5.454 ± 0.051	2.698GlyGln: 2.698 ± 0.041	7.923GlyArg: 7.923 ± 0.063	5.464GlySer: 5.464 ± 0.055	6.402GlyThr: 6.402 ± 0.061	7.759GlyVal: 7.759 ± 0.068	1.649GlyTrp: 1.649 ± 0.028	2.131GlyTyr: 2.131 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.825HisAla: 2.825 ± 0.041	0.218HisCys: 0.218 ± 0.009	1.415HisAsp: 1.415 ± 0.021	1.22HisGlu: 1.22 ± 0.022	0.634HisPhe: 0.634 ± 0.015	2.456HisGly: 2.456 ± 0.029	0.706HisHis: 0.706 ± 0.019	0.667HisIle: 0.667 ± 0.016	0.375HisLys: 0.375 ± 0.012	2.428HisLeu: 2.428 ± 0.034	0.33HisMet: 0.33 ± 0.01	0.35HisAsn: 0.35 ± 0.012	1.826HisPro: 1.826 ± 0.024	0.676HisGln: 0.676 ± 0.016	2.176HisArg: 2.176 ± 0.03	1.009HisSer: 1.009 ± 0.02	1.403HisThr: 1.403 ± 0.026	1.763HisVal: 1.763 ± 0.027	0.37HisTrp: 0.37 ± 0.011	0.467HisTyr: 0.467 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.444IleAla: 4.444 ± 0.044	0.275IleCys: 0.275 ± 0.008	2.022IleAsp: 2.022 ± 0.028	1.81IleGlu: 1.81 ± 0.023	0.634IlePhe: 0.634 ± 0.017	3.302IleGly: 3.302 ± 0.042	0.587IleHis: 0.587 ± 0.014	0.735IleIle: 0.735 ± 0.018	0.781IleLys: 0.781 ± 0.019	2.193IleLeu: 2.193 ± 0.032	0.406IleMet: 0.406 ± 0.013	0.594IleAsn: 0.594 ± 0.016	1.594IlePro: 1.594 ± 0.026	0.66IleGln: 0.66 ± 0.014	2.061IleArg: 2.061 ± 0.029	1.549IleSer: 1.549 ± 0.024	1.99IleThr: 1.99 ± 0.028	2.475IleVal: 2.475 ± 0.033	0.367IleTrp: 0.367 ± 0.011	0.472IleTyr: 0.472 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	3.092LysAla: 3.092 ± 0.05	0.133LysCys: 0.133 ± 0.007	1.495LysAsp: 1.495 ± 0.032	1.27LysGlu: 1.27 ± 0.025	0.501LysPhe: 0.501 ± 0.017	2.016LysGly: 2.016 ± 0.037	0.457LysHis: 0.457 ± 0.015	0.832LysIle: 0.832 ± 0.022	1.063LysLys: 1.063 ± 0.034	2.044LysLeu: 2.044 ± 0.034	0.413LysMet: 0.413 ± 0.014	0.563LysAsn: 0.563 ± 0.016	1.503LysPro: 1.503 ± 0.032	0.723LysGln: 0.723 ± 0.019	1.485LysArg: 1.485 ± 0.028	1.316LysSer: 1.316 ± 0.025	1.33LysThr: 1.33 ± 0.031	1.945LysVal: 1.945 ± 0.03	0.302LysTrp: 0.302 ± 0.012	0.48LysTyr: 0.48 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.102LeuAla: 15.102 ± 0.108	0.86LeuCys: 0.86 ± 0.018	6.641LeuAsp: 6.641 ± 0.06	4.277LeuGlu: 4.277 ± 0.044	2.578LeuPhe: 2.578 ± 0.034	9.14LeuGly: 9.14 ± 0.071	2.308LeuHis: 2.308 ± 0.033	3.087LeuIle: 3.087 ± 0.038	2.118LeuLys: 2.118 ± 0.033	10.897LeuLeu: 10.897 ± 0.093	1.584LeuMet: 1.584 ± 0.025	1.62LeuAsn: 1.62 ± 0.025	6.428LeuPro: 6.428 ± 0.053	2.015LeuGln: 2.015 ± 0.026	8.739LeuArg: 8.739 ± 0.068	5.171LeuSer: 5.171 ± 0.05	6.893LeuThr: 6.893 ± 0.057	8.495LeuVal: 8.495 ± 0.058	1.334LeuTrp: 1.334 ± 0.024	1.773LeuTyr: 1.773 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.258MetAla: 2.258 ± 0.03	0.145MetCys: 0.145 ± 0.007	0.92MetAsp: 0.92 ± 0.018	0.705MetGlu: 0.705 ± 0.017	0.444MetPhe: 0.444 ± 0.015	1.282MetGly: 1.282 ± 0.025	0.343MetHis: 0.343 ± 0.012	0.633MetIle: 0.633 ± 0.017	0.444MetLys: 0.444 ± 0.014	1.653MetLeu: 1.653 ± 0.029	0.278MetMet: 0.278 ± 0.012	0.418MetAsn: 0.418 ± 0.013	1.118MetPro: 1.118 ± 0.022	0.396MetGln: 0.396 ± 0.014	1.394MetArg: 1.394 ± 0.022	1.26MetSer: 1.26 ± 0.021	1.475MetThr: 1.475 ± 0.025	1.295MetVal: 1.295 ± 0.02	0.22MetTrp: 0.22 ± 0.01	0.339MetTyr: 0.339 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.072AsnAla: 2.072 ± 0.027	0.158AsnCys: 0.158 ± 0.007	0.883AsnAsp: 0.883 ± 0.021	0.749AsnGlu: 0.749 ± 0.017	0.426AsnPhe: 0.426 ± 0.012	1.757AsnGly: 1.757 ± 0.033	0.375AsnHis: 0.375 ± 0.012	0.577AsnIle: 0.577 ± 0.014	0.432AsnLys: 0.432 ± 0.016	1.507AsnLeu: 1.507 ± 0.025	0.271AsnMet: 0.271 ± 0.01	0.375AsnAsn: 0.375 ± 0.013	1.267AsnPro: 1.267 ± 0.024	0.475AsnGln: 0.475 ± 0.013	1.177AsnArg: 1.177 ± 0.021	0.896AsnSer: 0.896 ± 0.021	1.025AsnThr: 1.025 ± 0.025	1.287AsnVal: 1.287 ± 0.022	0.283AsnTrp: 0.283 ± 0.011	0.381AsnTyr: 0.381 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	8.733ProAla: 8.733 ± 0.072	0.423ProCys: 0.423 ± 0.013	4.791ProAsp: 4.791 ± 0.046	4.266ProGlu: 4.266 ± 0.045	1.466ProPhe: 1.466 ± 0.024	7.069ProGly: 7.069 ± 0.06	1.532ProHis: 1.532 ± 0.024	1.197ProIle: 1.197 ± 0.019	1.38ProLys: 1.38 ± 0.026	5.35ProLeu: 5.35 ± 0.05	1.021ProMet: 1.021 ± 0.018	0.858ProAsn: 0.858 ± 0.018	3.938ProPro: 3.938 ± 0.057	1.77ProGln: 1.77 ± 0.031	4.411ProArg: 4.411 ± 0.048	3.386ProSer: 3.386 ± 0.04	3.477ProThr: 3.477 ± 0.041	5.302ProVal: 5.302 ± 0.042	0.95ProTrp: 0.95 ± 0.018	1.327ProTyr: 1.327 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.623GlnAla: 3.623 ± 0.041	0.171GlnCys: 0.171 ± 0.008	1.439GlnAsp: 1.439 ± 0.026	1.478GlnGlu: 1.478 ± 0.026	0.68GlnPhe: 0.68 ± 0.017	2.37GlnGly: 2.37 ± 0.039	0.668GlnHis: 0.668 ± 0.015	0.973GlnIle: 0.973 ± 0.02	0.594GlnLys: 0.594 ± 0.017	2.941GlnLeu: 2.941 ± 0.036	0.469GlnMet: 0.469 ± 0.013	0.447GlnAsn: 0.447 ± 0.014	1.664GlnPro: 1.664 ± 0.028	1.181GlnGln: 1.181 ± 0.025	2.394GlnArg: 2.394 ± 0.034	1.222GlnSer: 1.222 ± 0.024	1.234GlnThr: 1.234 ± 0.024	2.255GlnVal: 2.255 ± 0.03	0.444GlnTrp: 0.444 ± 0.013	0.572GlnTyr: 0.572 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	10.868ArgAla: 10.868 ± 0.083	0.707ArgCys: 0.707 ± 0.018	4.456ArgAsp: 4.456 ± 0.037	4.7ArgGlu: 4.7 ± 0.046	2.293ArgPhe: 2.293 ± 0.026	6.384ArgGly: 6.384 ± 0.055	2.214ArgHis: 2.214 ± 0.029	2.817ArgIle: 2.817 ± 0.032	1.664ArgLys: 1.664 ± 0.028	8.693ArgLeu: 8.693 ± 0.075	1.733ArgMet: 1.733 ± 0.025	1.236ArgAsn: 1.236 ± 0.024	5.214ArgPro: 5.214 ± 0.056	2.29ArgGln: 2.29 ± 0.031	7.997ArgArg: 7.997 ± 0.068	4.118ArgSer: 4.118 ± 0.048	5.584ArgThr: 5.584 ± 0.048	6.19ArgVal: 6.19 ± 0.052	1.422ArgTrp: 1.422 ± 0.026	1.693ArgTyr: 1.693 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.996SerAla: 6.996 ± 0.052	0.481SerCys: 0.481 ± 0.013	2.69SerAsp: 2.69 ± 0.032	2.268SerGlu: 2.268 ± 0.032	1.464SerPhe: 1.464 ± 0.025	6.216SerGly: 6.216 ± 0.055	0.99SerHis: 0.99 ± 0.02	1.304SerIle: 1.304 ± 0.021	1.113SerLys: 1.113 ± 0.024	4.669SerLeu: 4.669 ± 0.043	1.082SerMet: 1.082 ± 0.023	0.828SerAsn: 0.828 ± 0.017	3.416SerPro: 3.416 ± 0.035	1.185SerGln: 1.185 ± 0.018	3.824SerArg: 3.824 ± 0.043	3.024SerSer: 3.024 ± 0.043	3.105SerThr: 3.105 ± 0.039	4.162SerVal: 4.162 ± 0.038	0.909SerTrp: 0.909 ± 0.019	1.19SerTyr: 1.19 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.969ThrAla: 8.969 ± 0.065	0.45ThrCys: 0.45 ± 0.014	3.628ThrAsp: 3.628 ± 0.037	3.086ThrGlu: 3.086 ± 0.033	1.57ThrPhe: 1.57 ± 0.023	6.663ThrGly: 6.663 ± 0.061	1.258ThrHis: 1.258 ± 0.028	1.534ThrIle: 1.534 ± 0.024	1.279ThrLys: 1.279 ± 0.028	5.586ThrLeu: 5.586 ± 0.05	0.942ThrMet: 0.942 ± 0.021	0.951ThrAsn: 0.951 ± 0.021	4.374ThrPro: 4.374 ± 0.044	1.331ThrGln: 1.331 ± 0.021	4.13ThrArg: 4.13 ± 0.037	3.251ThrSer: 3.251 ± 0.037	3.816ThrThr: 3.816 ± 0.049	5.753ThrVal: 5.753 ± 0.056	0.915ThrTrp: 0.915 ± 0.019	1.368ThrTyr: 1.368 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	10.902ValAla: 10.902 ± 0.072	0.77ValCys: 0.77 ± 0.018	5.085ValAsp: 5.085 ± 0.051	4.699ValGlu: 4.699 ± 0.05	2.354ValPhe: 2.354 ± 0.033	6.814ValGly: 6.814 ± 0.055	1.879ValHis: 1.879 ± 0.028	2.652ValIle: 2.652 ± 0.038	1.757ValLys: 1.757 ± 0.028	9.251ValLeu: 9.251 ± 0.069	1.355ValMet: 1.355 ± 0.021	1.526ValAsn: 1.526 ± 0.023	5.262ValPro: 5.262 ± 0.042	2.01ValGln: 2.01 ± 0.027	7.3ValArg: 7.3 ± 0.058	4.213ValSer: 4.213 ± 0.042	5.493ValThr: 5.493 ± 0.053	7.869ValVal: 7.869 ± 0.055	1.122ValTrp: 1.122 ± 0.021	1.429ValTyr: 1.429 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.684TrpAla: 1.684 ± 0.026	0.171TrpCys: 0.171 ± 0.007	0.831TrpAsp: 0.831 ± 0.02	0.724TrpGlu: 0.724 ± 0.015	0.481TrpPhe: 0.481 ± 0.015	1.095TrpGly: 1.095 ± 0.023	0.363TrpHis: 0.363 ± 0.013	0.51TrpIle: 0.51 ± 0.016	0.384TrpLys: 0.384 ± 0.014	1.787TrpLeu: 1.787 ± 0.026	0.302TrpMet: 0.302 ± 0.011	0.369TrpAsn: 0.369 ± 0.012	0.856TrpPro: 0.856 ± 0.019	0.594TrpGln: 0.594 ± 0.015	1.44TrpArg: 1.44 ± 0.025	0.998TrpSer: 0.998 ± 0.019	1.007TrpThr: 1.007 ± 0.02	0.976TrpVal: 0.976 ± 0.02	0.348TrpTrp: 0.348 ± 0.012	0.323TrpTyr: 0.323 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.822TyrAla: 2.822 ± 0.03	0.165TyrCys: 0.165 ± 0.008	1.438TyrAsp: 1.438 ± 0.03	1.301TyrGlu: 1.301 ± 0.021	0.618TyrPhe: 0.618 ± 0.015	2.179TyrGly: 2.179 ± 0.033	0.37TyrHis: 0.37 ± 0.013	0.418TyrIle: 0.418 ± 0.013	0.407TyrLys: 0.407 ± 0.014	1.924TyrLeu: 1.924 ± 0.031	0.235TyrMet: 0.235 ± 0.01	0.349TyrAsn: 0.349 ± 0.012	0.99TyrPro: 0.99 ± 0.021	0.54TyrGln: 0.54 ± 0.015	1.757TyrArg: 1.757 ± 0.029	0.901TyrSer: 0.901 ± 0.018	1.107TyrThr: 1.107 ± 0.023	1.704TyrVal: 1.704 ± 0.03	0.355TyrTrp: 0.355 ± 0.011	0.415TyrTyr: 0.415 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9243 proteins (2826290 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---