Amino acid dipepetide frequency for Caenispirillum salinarum AK4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.614AlaAla: 20.614 ± 0.209	1.293AlaCys: 1.293 ± 0.035	8.044AlaAsp: 8.044 ± 0.109	9.376AlaGlu: 9.376 ± 0.115	4.225AlaPhe: 4.225 ± 0.055	11.622AlaGly: 11.622 ± 0.114	2.48AlaHis: 2.48 ± 0.047	4.757AlaIle: 4.757 ± 0.061	3.111AlaLys: 3.111 ± 0.053	14.271AlaLeu: 14.271 ± 0.149	3.617AlaMet: 3.617 ± 0.053	2.38AlaAsn: 2.38 ± 0.043	6.946AlaPro: 6.946 ± 0.104	3.517AlaGln: 3.517 ± 0.058	9.791AlaArg: 9.791 ± 0.105	5.093AlaSer: 5.093 ± 0.064	5.976AlaThr: 5.976 ± 0.068	11.101AlaVal: 11.101 ± 0.122	1.746AlaTrp: 1.746 ± 0.038	2.371AlaTyr: 2.371 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.075CysAla: 1.075 ± 0.028	0.103CysCys: 0.103 ± 0.009	0.579CysAsp: 0.579 ± 0.018	0.42CysGlu: 0.42 ± 0.019	0.291CysPhe: 0.291 ± 0.013	0.982CysGly: 0.982 ± 0.028	0.293CysHis: 0.293 ± 0.017	0.375CysIle: 0.375 ± 0.017	0.218CysLys: 0.218 ± 0.013	0.796CysLeu: 0.796 ± 0.025	0.178CysMet: 0.178 ± 0.011	0.193CysAsn: 0.193 ± 0.011	0.528CysPro: 0.528 ± 0.021	0.222CysGln: 0.222 ± 0.012	0.726CysArg: 0.726 ± 0.022	0.381CysSer: 0.381 ± 0.016	0.437CysThr: 0.437 ± 0.019	0.648CysVal: 0.648 ± 0.022	0.104CysTrp: 0.104 ± 0.009	0.206CysTyr: 0.206 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.427AspAla: 8.427 ± 0.112	0.503AspCys: 0.503 ± 0.02	3.961AspAsp: 3.961 ± 0.064	3.736AspGlu: 3.736 ± 0.057	1.936AspPhe: 1.936 ± 0.039	5.985AspGly: 5.985 ± 0.093	1.467AspHis: 1.467 ± 0.033	2.797AspIle: 2.797 ± 0.042	1.479AspLys: 1.479 ± 0.039	6.651AspLeu: 6.651 ± 0.084	1.647AspMet: 1.647 ± 0.036	1.171AspAsn: 1.171 ± 0.035	3.926AspPro: 3.926 ± 0.053	1.615AspGln: 1.615 ± 0.039	4.968AspArg: 4.968 ± 0.066	2.277AspSer: 2.277 ± 0.047	3.22AspThr: 3.22 ± 0.059	4.825AspVal: 4.825 ± 0.067	1.03AspTrp: 1.03 ± 0.029	1.37AspTyr: 1.37 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	8.942GluAla: 8.942 ± 0.102	0.383GluCys: 0.383 ± 0.018	3.979GluAsp: 3.979 ± 0.068	3.778GluGlu: 3.778 ± 0.065	1.449GluPhe: 1.449 ± 0.029	5.035GluGly: 5.035 ± 0.065	1.37GluHis: 1.37 ± 0.031	2.753GluIle: 2.753 ± 0.046	2.123GluLys: 2.123 ± 0.046	4.599GluLeu: 4.599 ± 0.07	1.788GluMet: 1.788 ± 0.038	1.459GluAsn: 1.459 ± 0.033	3.218GluPro: 3.218 ± 0.058	2.182GluGln: 2.182 ± 0.05	5.01GluArg: 5.01 ± 0.066	2.401GluSer: 2.401 ± 0.042	4.013GluThr: 4.013 ± 0.06	4.43GluVal: 4.43 ± 0.064	0.686GluTrp: 0.686 ± 0.021	1.045GluTyr: 1.045 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.852PheAla: 3.852 ± 0.058	0.37PheCys: 0.37 ± 0.02	2.332PheAsp: 2.332 ± 0.044	1.84PheGlu: 1.84 ± 0.037	1.176PhePhe: 1.176 ± 0.034	3.228PheGly: 3.228 ± 0.05	0.759PheHis: 0.759 ± 0.022	1.444PheIle: 1.444 ± 0.035	0.893PheLys: 0.893 ± 0.025	3.241PheLeu: 3.241 ± 0.058	0.773PheMet: 0.773 ± 0.025	0.895PheAsn: 0.895 ± 0.024	1.456PhePro: 1.456 ± 0.037	0.952PheGln: 0.952 ± 0.024	2.195PheArg: 2.195 ± 0.043	1.725PheSer: 1.725 ± 0.037	1.958PheThr: 1.958 ± 0.042	2.393PheVal: 2.393 ± 0.047	0.5PheTrp: 0.5 ± 0.02	0.813PheTyr: 0.813 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.197GlyAla: 10.197 ± 0.104	0.922GlyCys: 0.922 ± 0.033	4.911GlyAsp: 4.911 ± 0.065	4.952GlyGlu: 4.952 ± 0.059	3.221GlyPhe: 3.221 ± 0.051	8.48GlyGly: 8.48 ± 0.118	2.004GlyHis: 2.004 ± 0.039	4.063GlyIle: 4.063 ± 0.061	2.714GlyLys: 2.714 ± 0.052	9.394GlyLeu: 9.394 ± 0.096	2.628GlyMet: 2.628 ± 0.045	1.853GlyAsn: 1.853 ± 0.043	4.105GlyPro: 4.105 ± 0.066	2.618GlyGln: 2.618 ± 0.051	7.098GlyArg: 7.098 ± 0.075	3.993GlySer: 3.993 ± 0.066	5.05GlyThr: 5.05 ± 0.08	6.709GlyVal: 6.709 ± 0.064	1.427GlyTrp: 1.427 ± 0.037	2.096GlyTyr: 2.096 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.66HisAla: 2.66 ± 0.047	0.249HisCys: 0.249 ± 0.013	1.468HisAsp: 1.468 ± 0.036	1.144HisGlu: 1.144 ± 0.026	0.753HisPhe: 0.753 ± 0.023	2.177HisGly: 2.177 ± 0.043	0.639HisHis: 0.639 ± 0.025	0.833HisIle: 0.833 ± 0.023	0.511HisLys: 0.511 ± 0.019	2.172HisLeu: 2.172 ± 0.044	0.543HisMet: 0.543 ± 0.021	0.43HisAsn: 0.43 ± 0.017	1.491HisPro: 1.491 ± 0.035	0.575HisGln: 0.575 ± 0.02	1.601HisArg: 1.601 ± 0.039	0.79HisSer: 0.79 ± 0.022	0.949HisThr: 0.949 ± 0.027	1.621HisVal: 1.621 ± 0.031	0.334HisTrp: 0.334 ± 0.014	0.507HisTyr: 0.507 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.586IleAla: 5.586 ± 0.07	0.389IleCys: 0.389 ± 0.018	3.016IleAsp: 3.016 ± 0.051	2.592IleGlu: 2.592 ± 0.045	1.252IlePhe: 1.252 ± 0.035	4.276IleGly: 4.276 ± 0.066	0.835IleHis: 0.835 ± 0.025	1.835IleIle: 1.835 ± 0.041	1.129IleLys: 1.129 ± 0.031	3.915IleLeu: 3.915 ± 0.061	0.967IleMet: 0.967 ± 0.027	1.149IleAsn: 1.149 ± 0.03	2.064IlePro: 2.064 ± 0.04	1.093IleGln: 1.093 ± 0.028	2.747IleArg: 2.747 ± 0.049	2.019IleSer: 2.019 ± 0.046	2.453IleThr: 2.453 ± 0.043	3.459IleVal: 3.459 ± 0.052	0.457IleTrp: 0.457 ± 0.02	0.876IleTyr: 0.876 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.881LysAla: 3.881 ± 0.067	0.158LysCys: 0.158 ± 0.01	1.708LysAsp: 1.708 ± 0.046	1.567LysGlu: 1.567 ± 0.038	0.664LysPhe: 0.664 ± 0.024	2.578LysGly: 2.578 ± 0.046	0.554LysHis: 0.554 ± 0.022	1.121LysIle: 1.121 ± 0.03	1.103LysLys: 1.103 ± 0.035	2.425LysLeu: 2.425 ± 0.045	0.721LysMet: 0.721 ± 0.027	0.612LysAsn: 0.612 ± 0.02	1.781LysPro: 1.781 ± 0.035	0.849LysGln: 0.849 ± 0.025	2.172LysArg: 2.172 ± 0.043	1.284LysSer: 1.284 ± 0.031	1.724LysThr: 1.724 ± 0.038	2.338LysVal: 2.338 ± 0.048	0.296LysTrp: 0.296 ± 0.016	0.539LysTyr: 0.539 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.567LeuAla: 13.567 ± 0.142	0.882LeuCys: 0.882 ± 0.028	6.381LeuAsp: 6.381 ± 0.074	5.95LeuGlu: 5.95 ± 0.072	3.456LeuPhe: 3.456 ± 0.057	8.306LeuGly: 8.306 ± 0.098	1.991LeuHis: 1.991 ± 0.036	4.009LeuIle: 4.009 ± 0.055	3.298LeuLys: 3.298 ± 0.055	9.434LeuLeu: 9.434 ± 0.13	2.489LeuMet: 2.489 ± 0.046	2.325LeuAsn: 2.325 ± 0.041	5.971LeuPro: 5.971 ± 0.077	2.241LeuGln: 2.241 ± 0.037	7.461LeuArg: 7.461 ± 0.087	5.838LeuSer: 5.838 ± 0.062	6.163LeuThr: 6.163 ± 0.08	7.69LeuVal: 7.69 ± 0.081	1.262LeuTrp: 1.262 ± 0.036	1.97LeuTyr: 1.97 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.503MetAla: 3.503 ± 0.053	0.154MetCys: 0.154 ± 0.011	1.537MetAsp: 1.537 ± 0.034	1.437MetGlu: 1.437 ± 0.035	0.646MetPhe: 0.646 ± 0.023	2.045MetGly: 2.045 ± 0.042	0.505MetHis: 0.505 ± 0.019	1.193MetIle: 1.193 ± 0.029	0.93MetLys: 0.93 ± 0.028	2.52MetLeu: 2.52 ± 0.04	0.701MetMet: 0.701 ± 0.026	0.676MetAsn: 0.676 ± 0.022	1.66MetPro: 1.66 ± 0.032	0.736MetGln: 0.736 ± 0.021	1.85MetArg: 1.85 ± 0.04	1.441MetSer: 1.441 ± 0.038	2.161MetThr: 2.161 ± 0.038	2.092MetVal: 2.092 ± 0.041	0.231MetTrp: 0.231 ± 0.012	0.338MetTyr: 0.338 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.735AsnAla: 2.735 ± 0.046	0.211AsnCys: 0.211 ± 0.014	1.241AsnAsp: 1.241 ± 0.034	1.063AsnGlu: 1.063 ± 0.026	0.666AsnPhe: 0.666 ± 0.023	2.083AsnGly: 2.083 ± 0.045	0.438AsnHis: 0.438 ± 0.019	1.072AsnIle: 1.072 ± 0.03	0.555AsnLys: 0.555 ± 0.021	2.192AsnLeu: 2.192 ± 0.039	0.565AsnMet: 0.565 ± 0.02	0.533AsnAsn: 0.533 ± 0.022	1.605AsnPro: 1.605 ± 0.03	0.628AsnGln: 0.628 ± 0.02	1.637AsnArg: 1.637 ± 0.034	0.825AsnSer: 0.825 ± 0.029	1.227AsnThr: 1.227 ± 0.033	1.737AsnVal: 1.737 ± 0.037	0.313AsnTrp: 0.313 ± 0.015	0.505AsnTyr: 0.505 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.691ProAla: 7.691 ± 0.103	0.372ProCys: 0.372 ± 0.017	4.382ProAsp: 4.382 ± 0.06	4.588ProGlu: 4.588 ± 0.056	1.934ProPhe: 1.934 ± 0.038	5.098ProGly: 5.098 ± 0.069	1.186ProHis: 1.186 ± 0.029	1.808ProIle: 1.808 ± 0.036	1.464ProLys: 1.464 ± 0.044	5.193ProLeu: 5.193 ± 0.085	1.284ProMet: 1.284 ± 0.033	1.077ProAsn: 1.077 ± 0.03	3.521ProPro: 3.521 ± 0.07	1.573ProGln: 1.573 ± 0.039	3.522ProArg: 3.522 ± 0.058	2.438ProSer: 2.438 ± 0.039	2.611ProThr: 2.611 ± 0.049	4.84ProVal: 4.84 ± 0.055	0.812ProTrp: 0.812 ± 0.028	1.121ProTyr: 1.121 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.141GlnAla: 4.141 ± 0.06	0.201GlnCys: 0.201 ± 0.012	1.572GlnAsp: 1.572 ± 0.034	1.598GlnGlu: 1.598 ± 0.036	0.781GlnPhe: 0.781 ± 0.025	2.482GlnGly: 2.482 ± 0.045	0.536GlnHis: 0.536 ± 0.021	1.218GlnIle: 1.218 ± 0.031	0.834GlnLys: 0.834 ± 0.028	2.207GlnLeu: 2.207 ± 0.046	0.864GlnMet: 0.864 ± 0.027	0.612GlnAsn: 0.612 ± 0.021	1.687GlnPro: 1.687 ± 0.04	1.08GlnGln: 1.08 ± 0.045	2.163GlnArg: 2.163 ± 0.038	1.287GlnSer: 1.287 ± 0.031	1.567GlnThr: 1.567 ± 0.038	2.34GlnVal: 2.34 ± 0.044	0.386GlnTrp: 0.386 ± 0.017	0.517GlnTyr: 0.517 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.005ArgAla: 9.005 ± 0.105	0.605ArgCys: 0.605 ± 0.025	4.802ArgAsp: 4.802 ± 0.056	4.462ArgGlu: 4.462 ± 0.065	2.731ArgPhe: 2.731 ± 0.047	5.053ArgGly: 5.053 ± 0.072	2.006ArgHis: 2.006 ± 0.038	3.329ArgIle: 3.329 ± 0.046	2.287ArgLys: 2.287 ± 0.048	8.789ArgLeu: 8.789 ± 0.096	2.161ArgMet: 2.161 ± 0.038	1.565ArgAsn: 1.565 ± 0.033	4.287ArgPro: 4.287 ± 0.06	2.399ArgGln: 2.399 ± 0.043	6.965ArgArg: 6.965 ± 0.101	2.947ArgSer: 2.947 ± 0.05	3.677ArgThr: 3.677 ± 0.05	5.422ArgVal: 5.422 ± 0.064	1.09ArgTrp: 1.09 ± 0.031	1.559ArgTyr: 1.559 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.442SerAla: 5.442 ± 0.061	0.387SerCys: 0.387 ± 0.017	2.626SerAsp: 2.626 ± 0.048	2.274SerGlu: 2.274 ± 0.044	1.671SerPhe: 1.671 ± 0.034	4.777SerGly: 4.777 ± 0.067	0.969SerHis: 0.969 ± 0.026	1.982SerIle: 1.982 ± 0.039	1.146SerLys: 1.146 ± 0.03	4.647SerLeu: 4.647 ± 0.057	1.21SerMet: 1.21 ± 0.029	0.959SerAsn: 0.959 ± 0.028	2.424SerPro: 2.424 ± 0.042	1.245SerGln: 1.245 ± 0.03	3.261SerArg: 3.261 ± 0.051	1.934SerSer: 1.934 ± 0.045	2.309SerThr: 2.309 ± 0.043	3.618SerVal: 3.618 ± 0.053	0.616SerTrp: 0.616 ± 0.02	1.047SerTyr: 1.047 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	7.324ThrAla: 7.324 ± 0.084	0.489ThrCys: 0.489 ± 0.018	3.381ThrAsp: 3.381 ± 0.061	2.999ThrGlu: 2.999 ± 0.045	1.946ThrPhe: 1.946 ± 0.041	5.424ThrGly: 5.424 ± 0.068	1.044ThrHis: 1.044 ± 0.028	2.416ThrIle: 2.416 ± 0.045	1.127ThrLys: 1.127 ± 0.028	6.119ThrLeu: 6.119 ± 0.068	1.22ThrMet: 1.22 ± 0.026	1.116ThrAsn: 1.116 ± 0.032	3.636ThrPro: 3.636 ± 0.06	1.339ThrGln: 1.339 ± 0.031	3.47ThrArg: 3.47 ± 0.05	2.245ThrSer: 2.245 ± 0.044	2.842ThrThr: 2.842 ± 0.059	5.256ThrVal: 5.256 ± 0.075	0.804ThrTrp: 0.804 ± 0.026	1.174ThrTyr: 1.174 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.031ValAla: 10.031 ± 0.091	0.714ValCys: 0.714 ± 0.021	4.889ValAsp: 4.889 ± 0.063	5.107ValGlu: 5.107 ± 0.059	2.789ValPhe: 2.789 ± 0.046	5.911ValGly: 5.911 ± 0.07	1.556ValHis: 1.556 ± 0.034	3.673ValIle: 3.673 ± 0.053	2.171ValLys: 2.171 ± 0.044	8.454ValLeu: 8.454 ± 0.078	2.116ValMet: 2.116 ± 0.04	1.924ValAsn: 1.924 ± 0.038	4.442ValPro: 4.442 ± 0.059	2.051ValGln: 2.051 ± 0.038	5.556ValArg: 5.556 ± 0.066	4.022ValSer: 4.022 ± 0.059	5.089ValThr: 5.089 ± 0.071	6.977ValVal: 6.977 ± 0.091	0.947ValTrp: 0.947 ± 0.029	1.5ValTyr: 1.5 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.342TrpAla: 1.342 ± 0.036	0.146TrpCys: 0.146 ± 0.011	0.737TrpAsp: 0.737 ± 0.024	0.639TrpGlu: 0.639 ± 0.021	0.475TrpPhe: 0.475 ± 0.02	0.923TrpGly: 0.923 ± 0.027	0.349TrpHis: 0.349 ± 0.016	0.61TrpIle: 0.61 ± 0.023	0.406TrpLys: 0.406 ± 0.016	1.691TrpLeu: 1.691 ± 0.041	0.411TrpMet: 0.411 ± 0.018	0.373TrpAsn: 0.373 ± 0.017	0.738TrpPro: 0.738 ± 0.028	0.539TrpGln: 0.539 ± 0.019	1.308TrpArg: 1.308 ± 0.032	0.68TrpSer: 0.68 ± 0.023	0.827TrpThr: 0.827 ± 0.025	0.9TrpVal: 0.9 ± 0.031	0.254TrpTrp: 0.254 ± 0.017	0.284TrpTyr: 0.284 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.318TyrAla: 2.318 ± 0.041	0.223TyrCys: 0.223 ± 0.013	1.447TyrAsp: 1.447 ± 0.038	1.122TyrGlu: 1.122 ± 0.028	0.735TyrPhe: 0.735 ± 0.026	1.971TyrGly: 1.971 ± 0.043	0.465TyrHis: 0.465 ± 0.019	0.819TyrIle: 0.819 ± 0.025	0.574TyrLys: 0.574 ± 0.021	1.977TyrLeu: 1.977 ± 0.043	0.47TyrMet: 0.47 ± 0.018	0.529TyrAsn: 0.529 ± 0.02	1.028TyrPro: 1.028 ± 0.027	0.618TyrGln: 0.618 ± 0.024	1.64TyrArg: 1.64 ± 0.036	0.924TyrSer: 0.924 ± 0.024	1.118TyrThr: 1.118 ± 0.031	1.523TyrVal: 1.523 ± 0.034	0.336TyrTrp: 0.336 ± 0.013	0.511TyrTyr: 0.511 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4574 proteins (1438899 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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