Amino acid dipepetide frequency for filamentous cyanobacterium CCP5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.262AlaAla: 11.262 ± 0.121	0.936AlaCys: 0.936 ± 0.027	5.641AlaAsp: 5.641 ± 0.074	6.395AlaGlu: 6.395 ± 0.081	3.249AlaPhe: 3.249 ± 0.042	6.904AlaGly: 6.904 ± 0.09	1.764AlaHis: 1.764 ± 0.041	7.223AlaIle: 7.223 ± 0.081	3.11AlaLys: 3.11 ± 0.053	10.844AlaLeu: 10.844 ± 0.111	2.301AlaMet: 2.301 ± 0.042	3.03AlaAsn: 3.03 ± 0.058	4.169AlaPro: 4.169 ± 0.064	5.305AlaGln: 5.305 ± 0.08	4.685AlaArg: 4.685 ± 0.067	5.562AlaSer: 5.562 ± 0.069	5.285AlaThr: 5.285 ± 0.056	7.041AlaVal: 7.041 ± 0.086	1.315AlaTrp: 1.315 ± 0.032	2.666AlaTyr: 2.666 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.671CysAla: 0.671 ± 0.022	0.152CysCys: 0.152 ± 0.011	0.642CysAsp: 0.642 ± 0.023	0.485CysGlu: 0.485 ± 0.018	0.383CysPhe: 0.383 ± 0.017	0.753CysGly: 0.753 ± 0.023	0.285CysHis: 0.285 ± 0.015	0.471CysIle: 0.471 ± 0.017	0.205CysLys: 0.205 ± 0.012	1.166CysLeu: 1.166 ± 0.029	0.15CysMet: 0.15 ± 0.009	0.256CysAsn: 0.256 ± 0.014	0.556CysPro: 0.556 ± 0.02	0.587CysGln: 0.587 ± 0.022	0.645CysArg: 0.645 ± 0.023	0.538CysSer: 0.538 ± 0.017	0.422CysThr: 0.422 ± 0.018	0.515CysVal: 0.515 ± 0.023	0.159CysTrp: 0.159 ± 0.012	0.306CysTyr: 0.306 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.563AspAla: 4.563 ± 0.064	0.545AspCys: 0.545 ± 0.023	2.693AspAsp: 2.693 ± 0.051	2.815AspGlu: 2.815 ± 0.05	2.344AspPhe: 2.344 ± 0.043	4.119AspGly: 4.119 ± 0.071	1.171AspHis: 1.171 ± 0.031	3.099AspIle: 3.099 ± 0.05	1.312AspLys: 1.312 ± 0.032	6.842AspLeu: 6.842 ± 0.068	1.021AspMet: 1.021 ± 0.028	1.434AspAsn: 1.434 ± 0.035	3.28AspPro: 3.28 ± 0.049	2.901AspGln: 2.901 ± 0.046	4.465AspArg: 4.465 ± 0.057	3.128AspSer: 3.128 ± 0.055	2.578AspThr: 2.578 ± 0.044	3.24AspVal: 3.24 ± 0.053	1.147AspTrp: 1.147 ± 0.028	2.025AspTyr: 2.025 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.088GluAla: 7.088 ± 0.081	0.345GluCys: 0.345 ± 0.018	2.892GluAsp: 2.892 ± 0.055	3.385GluGlu: 3.385 ± 0.063	2.174GluPhe: 2.174 ± 0.033	3.759GluGly: 3.759 ± 0.052	1.076GluHis: 1.076 ± 0.029	3.569GluIle: 3.569 ± 0.058	2.046GluLys: 2.046 ± 0.043	6.103GluLeu: 6.103 ± 0.077	1.358GluMet: 1.358 ± 0.034	1.896GluAsn: 1.896 ± 0.043	2.94GluPro: 2.94 ± 0.047	3.235GluGln: 3.235 ± 0.05	3.601GluArg: 3.601 ± 0.059	3.344GluSer: 3.344 ± 0.058	3.596GluThr: 3.596 ± 0.056	4.14GluVal: 4.14 ± 0.054	0.746GluTrp: 0.746 ± 0.023	1.4GluTyr: 1.4 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.222PheAla: 3.222 ± 0.05	0.479PheCys: 0.479 ± 0.017	2.319PheAsp: 2.319 ± 0.043	2.31PheGlu: 2.31 ± 0.044	1.496PhePhe: 1.496 ± 0.036	2.94PheGly: 2.94 ± 0.049	0.712PheHis: 0.712 ± 0.022	1.789PheIle: 1.789 ± 0.038	1.127PheLys: 1.127 ± 0.028	3.743PheLeu: 3.743 ± 0.056	0.681PheMet: 0.681 ± 0.024	1.329PheAsn: 1.329 ± 0.034	1.775PhePro: 1.775 ± 0.036	1.686PheGln: 1.686 ± 0.034	2.007PheArg: 2.007 ± 0.041	2.688PheSer: 2.688 ± 0.042	2.067PheThr: 2.067 ± 0.041	2.356PheVal: 2.356 ± 0.04	0.778PheTrp: 0.778 ± 0.026	1.109PheTyr: 1.109 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	6.258GlyAla: 6.258 ± 0.085	0.815GlyCys: 0.815 ± 0.024	4.249GlyAsp: 4.249 ± 0.062	4.153GlyGlu: 4.153 ± 0.056	3.19GlyPhe: 3.19 ± 0.052	5.689GlyGly: 5.689 ± 0.09	1.594GlyHis: 1.594 ± 0.038	4.842GlyIle: 4.842 ± 0.064	2.596GlyLys: 2.596 ± 0.039	8.651GlyLeu: 8.651 ± 0.109	1.78GlyMet: 1.78 ± 0.041	2.451GlyAsn: 2.451 ± 0.061	2.569GlyPro: 2.569 ± 0.048	3.976GlyGln: 3.976 ± 0.058	4.254GlyArg: 4.254 ± 0.056	4.774GlySer: 4.774 ± 0.063	4.077GlyThr: 4.077 ± 0.062	5.006GlyVal: 5.006 ± 0.067	1.419GlyTrp: 1.419 ± 0.036	2.44GlyTyr: 2.44 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.311HisAla: 1.311 ± 0.031	0.269HisCys: 0.269 ± 0.014	0.902HisAsp: 0.902 ± 0.023	0.884HisGlu: 0.884 ± 0.023	0.798HisPhe: 0.798 ± 0.023	1.489HisGly: 1.489 ± 0.035	0.716HisHis: 0.716 ± 0.024	0.995HisIle: 0.995 ± 0.027	0.468HisLys: 0.468 ± 0.018	2.537HisLeu: 2.537 ± 0.045	0.337HisMet: 0.337 ± 0.016	0.583HisAsn: 0.583 ± 0.02	1.592HisPro: 1.592 ± 0.033	1.383HisGln: 1.383 ± 0.036	1.558HisArg: 1.558 ± 0.038	1.207HisSer: 1.207 ± 0.032	0.955HisThr: 0.955 ± 0.028	1.017HisVal: 1.017 ± 0.027	0.423HisTrp: 0.423 ± 0.018	0.673HisTyr: 0.673 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.961IleAla: 6.961 ± 0.079	0.607IleCys: 0.607 ± 0.023	3.495IleAsp: 3.495 ± 0.054	3.523IleGlu: 3.523 ± 0.048	1.939IlePhe: 1.939 ± 0.039	4.263IleGly: 4.263 ± 0.069	1.205IleHis: 1.205 ± 0.03	2.38IleIle: 2.38 ± 0.045	1.543IleLys: 1.543 ± 0.035	5.333IleLeu: 5.333 ± 0.07	0.753IleMet: 0.753 ± 0.022	1.872IleAsn: 1.872 ± 0.041	3.094IlePro: 3.094 ± 0.045	2.731IleGln: 2.731 ± 0.04	3.222IleArg: 3.222 ± 0.049	3.6IleSer: 3.6 ± 0.055	2.967IleThr: 2.967 ± 0.047	3.716IleVal: 3.716 ± 0.053	0.758IleTrp: 0.758 ± 0.022	1.53IleTyr: 1.53 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.343LysAla: 3.343 ± 0.05	0.173LysCys: 0.173 ± 0.011	1.565LysAsp: 1.565 ± 0.038	1.559LysGlu: 1.559 ± 0.039	0.98LysPhe: 0.98 ± 0.025	2.08LysGly: 2.08 ± 0.035	0.584LysHis: 0.584 ± 0.021	1.684LysIle: 1.684 ± 0.032	1.009LysLys: 1.009 ± 0.028	3.174LysLeu: 3.174 ± 0.052	0.546LysMet: 0.546 ± 0.018	0.892LysAsn: 0.892 ± 0.026	1.793LysPro: 1.793 ± 0.038	1.738LysGln: 1.738 ± 0.04	1.967LysArg: 1.967 ± 0.044	1.833LysSer: 1.833 ± 0.034	1.956LysThr: 1.956 ± 0.034	2.181LysVal: 2.181 ± 0.039	0.315LysTrp: 0.315 ± 0.013	0.771LysTyr: 0.771 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.413LeuAla: 11.413 ± 0.119	1.005LeuCys: 1.005 ± 0.026	5.974LeuAsp: 5.974 ± 0.072	7.14LeuGlu: 7.14 ± 0.082	3.594LeuPhe: 3.594 ± 0.058	8.631LeuGly: 8.631 ± 0.105	2.016LeuHis: 2.016 ± 0.037	5.849LeuIle: 5.849 ± 0.075	4.183LeuLys: 4.183 ± 0.061	11.789LeuLeu: 11.789 ± 0.124	2.44LeuMet: 2.44 ± 0.042	3.737LeuAsn: 3.737 ± 0.059	6.255LeuPro: 6.255 ± 0.081	5.461LeuGln: 5.461 ± 0.073	6.702LeuArg: 6.702 ± 0.076	7.743LeuSer: 7.743 ± 0.074	6.523LeuThr: 6.523 ± 0.073	7.746LeuVal: 7.746 ± 0.09	1.635LeuTrp: 1.635 ± 0.04	2.722LeuTyr: 2.722 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.729MetAla: 2.729 ± 0.044	0.111MetCys: 0.111 ± 0.008	0.975MetAsp: 0.975 ± 0.026	1.018MetGlu: 1.018 ± 0.029	0.55MetPhe: 0.55 ± 0.022	1.789MetGly: 1.789 ± 0.034	0.338MetHis: 0.338 ± 0.014	0.979MetIle: 0.979 ± 0.027	0.686MetLys: 0.686 ± 0.02	1.963MetLeu: 1.963 ± 0.036	0.45MetMet: 0.45 ± 0.02	0.648MetAsn: 0.648 ± 0.02	1.221MetPro: 1.221 ± 0.03	0.932MetGln: 0.932 ± 0.027	1.06MetArg: 1.06 ± 0.027	1.163MetSer: 1.163 ± 0.03	1.404MetThr: 1.404 ± 0.03	1.724MetVal: 1.724 ± 0.033	0.146MetTrp: 0.146 ± 0.01	0.334MetTyr: 0.334 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.61AsnAla: 2.61 ± 0.047	0.297AsnCys: 0.297 ± 0.015	1.455AsnAsp: 1.455 ± 0.047	1.224AsnGlu: 1.224 ± 0.033	1.242AsnPhe: 1.242 ± 0.03	2.358AsnGly: 2.358 ± 0.052	0.713AsnHis: 0.713 ± 0.024	1.522AsnIle: 1.522 ± 0.034	0.71AsnLys: 0.71 ± 0.026	4.102AsnLeu: 4.102 ± 0.071	0.459AsnMet: 0.459 ± 0.018	0.93AsnAsn: 0.93 ± 0.032	2.49AsnPro: 2.49 ± 0.041	1.976AsnGln: 1.976 ± 0.04	2.274AsnArg: 2.274 ± 0.046	1.844AsnSer: 1.844 ± 0.038	1.478AsnThr: 1.478 ± 0.038	1.743AsnVal: 1.743 ± 0.038	0.54AsnTrp: 0.54 ± 0.023	0.93AsnTyr: 0.93 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.054ProAla: 5.054 ± 0.071	0.434ProCys: 0.434 ± 0.021	3.889ProAsp: 3.889 ± 0.06	4.503ProGlu: 4.503 ± 0.062	1.832ProPhe: 1.832 ± 0.037	3.946ProGly: 3.946 ± 0.062	1.025ProHis: 1.025 ± 0.028	2.72ProIle: 2.72 ± 0.042	1.636ProLys: 1.636 ± 0.038	5.43ProLeu: 5.43 ± 0.062	1.104ProMet: 1.104 ± 0.029	1.734ProAsn: 1.734 ± 0.037	2.841ProPro: 2.841 ± 0.053	2.659ProGln: 2.659 ± 0.044	2.362ProArg: 2.362 ± 0.043	3.147ProSer: 3.147 ± 0.048	2.909ProThr: 2.909 ± 0.046	4.061ProVal: 4.061 ± 0.058	0.84ProTrp: 0.84 ± 0.025	1.416ProTyr: 1.416 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	6.083GlnAla: 6.083 ± 0.087	0.333GlnCys: 0.333 ± 0.015	2.417GlnAsp: 2.417 ± 0.043	2.957GlnGlu: 2.957 ± 0.053	1.777GlnPhe: 1.777 ± 0.033	3.813GlnGly: 3.813 ± 0.056	0.962GlnHis: 0.962 ± 0.024	3.149GlnIle: 3.149 ± 0.044	1.61GlnLys: 1.61 ± 0.035	6.126GlnLeu: 6.126 ± 0.079	1.069GlnMet: 1.069 ± 0.027	1.4GlnAsn: 1.4 ± 0.032	3.158GlnPro: 3.158 ± 0.044	3.77GlnGln: 3.77 ± 0.08	3.894GlnArg: 3.894 ± 0.061	2.98GlnSer: 2.98 ± 0.052	3.082GlnThr: 3.082 ± 0.048	4.276GlnVal: 4.276 ± 0.057	0.785GlnTrp: 0.785 ± 0.023	1.092GlnTyr: 1.092 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	4.57ArgAla: 4.57 ± 0.066	0.629ArgCys: 0.629 ± 0.022	3.154ArgAsp: 3.154 ± 0.047	3.318ArgGlu: 3.318 ± 0.056	2.51ArgPhe: 2.51 ± 0.041	3.642ArgGly: 3.642 ± 0.057	1.389ArgHis: 1.389 ± 0.028	3.317ArgIle: 3.317 ± 0.05	1.651ArgLys: 1.651 ± 0.039	7.583ArgLeu: 7.583 ± 0.084	1.218ArgMet: 1.218 ± 0.033	1.751ArgAsn: 1.751 ± 0.039	3.02ArgPro: 3.02 ± 0.044	4.265ArgGln: 4.265 ± 0.064	4.31ArgArg: 4.31 ± 0.063	4.066ArgSer: 4.066 ± 0.055	2.791ArgThr: 2.791 ± 0.048	3.99ArgVal: 3.99 ± 0.055	1.219ArgTrp: 1.219 ± 0.033	2.163ArgTyr: 2.163 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.407SerAla: 5.407 ± 0.066	0.527SerCys: 0.527 ± 0.021	3.468SerAsp: 3.468 ± 0.055	3.422SerGlu: 3.422 ± 0.061	2.316SerPhe: 2.316 ± 0.044	5.166SerGly: 5.166 ± 0.064	1.352SerHis: 1.352 ± 0.031	2.926SerIle: 2.926 ± 0.05	1.636SerLys: 1.636 ± 0.037	7.349SerLeu: 7.349 ± 0.08	1.259SerMet: 1.259 ± 0.03	1.85SerAsn: 1.85 ± 0.045	3.887SerPro: 3.887 ± 0.065	3.453SerGln: 3.453 ± 0.059	3.76SerArg: 3.76 ± 0.048	4.041SerSer: 4.041 ± 0.065	3.224SerThr: 3.224 ± 0.051	3.973SerVal: 3.973 ± 0.051	0.962SerTrp: 0.962 ± 0.028	1.62SerTyr: 1.62 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.636ThrAla: 5.636 ± 0.063	0.483ThrCys: 0.483 ± 0.018	2.762ThrAsp: 2.762 ± 0.047	2.837ThrGlu: 2.837 ± 0.047	1.943ThrPhe: 1.943 ± 0.038	4.565ThrGly: 4.565 ± 0.064	1.069ThrHis: 1.069 ± 0.031	2.844ThrIle: 2.844 ± 0.051	1.281ThrLys: 1.281 ± 0.033	6.775ThrLeu: 6.775 ± 0.08	0.886ThrMet: 0.886 ± 0.026	1.439ThrAsn: 1.439 ± 0.029	3.31ThrPro: 3.31 ± 0.046	2.601ThrGln: 2.601 ± 0.046	2.672ThrArg: 2.672 ± 0.045	3.019ThrSer: 3.019 ± 0.043	3.119ThrThr: 3.119 ± 0.051	4.473ThrVal: 4.473 ± 0.06	0.827ThrTrp: 0.827 ± 0.024	1.63ThrTyr: 1.63 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.076ValAla: 7.076 ± 0.075	0.705ValCys: 0.705 ± 0.024	3.916ValAsp: 3.916 ± 0.062	4.419ValGlu: 4.419 ± 0.064	2.578ValPhe: 2.578 ± 0.043	5.263ValGly: 5.263 ± 0.067	1.162ValHis: 1.162 ± 0.03	3.966ValIle: 3.966 ± 0.06	2.212ValLys: 2.212 ± 0.041	7.444ValLeu: 7.444 ± 0.069	1.649ValMet: 1.649 ± 0.031	2.4ValAsn: 2.4 ± 0.045	3.472ValPro: 3.472 ± 0.047	3.044ValGln: 3.044 ± 0.047	3.742ValArg: 3.742 ± 0.05	4.279ValSer: 4.279 ± 0.05	3.839ValThr: 3.839 ± 0.053	5.481ValVal: 5.481 ± 0.073	0.98ValTrp: 0.98 ± 0.031	1.8ValTyr: 1.8 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.186TrpAla: 1.186 ± 0.03	0.148TrpCys: 0.148 ± 0.011	0.701TrpAsp: 0.701 ± 0.025	0.801TrpGlu: 0.801 ± 0.024	0.617TrpPhe: 0.617 ± 0.023	1.145TrpGly: 1.145 ± 0.033	0.379TrpHis: 0.379 ± 0.018	0.902TrpIle: 0.902 ± 0.025	0.42TrpLys: 0.42 ± 0.019	2.228TrpLeu: 2.228 ± 0.046	0.36TrpMet: 0.36 ± 0.017	0.515TrpAsn: 0.515 ± 0.021	0.628TrpPro: 0.628 ± 0.021	1.394TrpGln: 1.394 ± 0.034	1.039TrpArg: 1.039 ± 0.029	0.946TrpSer: 0.946 ± 0.026	0.634TrpThr: 0.634 ± 0.026	1.086TrpVal: 1.086 ± 0.025	0.283TrpTrp: 0.283 ± 0.017	0.395TrpTyr: 0.395 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.244TyrAla: 2.244 ± 0.038	0.354TyrCys: 0.354 ± 0.019	1.613TyrAsp: 1.613 ± 0.036	1.545TyrGlu: 1.545 ± 0.038	1.103TyrPhe: 1.103 ± 0.028	2.47TyrGly: 2.47 ± 0.042	0.582TyrHis: 0.582 ± 0.023	1.268TyrIle: 1.268 ± 0.032	0.705TyrLys: 0.705 ± 0.022	3.376TyrLeu: 3.376 ± 0.047	0.397TyrMet: 0.397 ± 0.015	0.75TyrAsn: 0.75 ± 0.025	1.491TyrPro: 1.491 ± 0.029	1.635TyrGln: 1.635 ± 0.032	2.338TyrArg: 2.338 ± 0.044	1.694TyrSer: 1.694 ± 0.036	1.267TyrThr: 1.267 ± 0.033	1.659TyrVal: 1.659 ± 0.033	0.532TyrTrp: 0.532 ± 0.019	0.893TyrTyr: 0.893 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5193 proteins (1436203 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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