Amino acid dipepetide frequency for Rubellimicrobium rubrum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.431AlaAla: 17.431 ± 0.153	1.084AlaCys: 1.084 ± 0.031	6.797AlaAsp: 6.797 ± 0.075	8.608AlaGlu: 8.608 ± 0.11	4.247AlaPhe: 4.247 ± 0.063	11.144AlaGly: 11.144 ± 0.105	2.315AlaHis: 2.315 ± 0.046	5.487AlaIle: 5.487 ± 0.065	2.899AlaLys: 2.899 ± 0.057	14.594AlaLeu: 14.594 ± 0.16	3.714AlaMet: 3.714 ± 0.062	2.476AlaAsn: 2.476 ± 0.044	5.985AlaPro: 5.985 ± 0.091	4.86AlaGln: 4.86 ± 0.067	10.351AlaArg: 10.351 ± 0.119	6.195AlaSer: 6.195 ± 0.061	6.408AlaThr: 6.408 ± 0.074	9.268AlaVal: 9.268 ± 0.1	1.812AlaTrp: 1.812 ± 0.04	2.352AlaTyr: 2.352 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.906CysAla: 0.906 ± 0.025	0.099CysCys: 0.099 ± 0.009	0.521CysAsp: 0.521 ± 0.02	0.444CysGlu: 0.444 ± 0.02	0.27CysPhe: 0.27 ± 0.015	0.871CysGly: 0.871 ± 0.031	0.244CysHis: 0.244 ± 0.013	0.338CysIle: 0.338 ± 0.016	0.109CysLys: 0.109 ± 0.009	0.831CysLeu: 0.831 ± 0.023	0.135CysMet: 0.135 ± 0.011	0.173CysAsn: 0.173 ± 0.012	0.466CysPro: 0.466 ± 0.02	0.218CysGln: 0.218 ± 0.011	0.614CysArg: 0.614 ± 0.02	0.38CysSer: 0.38 ± 0.02	0.353CysThr: 0.353 ± 0.017	0.568CysVal: 0.568 ± 0.023	0.123CysTrp: 0.123 ± 0.009	0.138CysTyr: 0.138 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.053AspAla: 7.053 ± 0.088	0.428AspCys: 0.428 ± 0.018	3.18AspAsp: 3.18 ± 0.071	3.516AspGlu: 3.516 ± 0.052	2.051AspPhe: 2.051 ± 0.035	5.731AspGly: 5.731 ± 0.082	1.346AspHis: 1.346 ± 0.033	2.504AspIle: 2.504 ± 0.042	1.083AspLys: 1.083 ± 0.028	7.189AspLeu: 7.189 ± 0.084	1.335AspMet: 1.335 ± 0.032	1.037AspAsn: 1.037 ± 0.031	4.092AspPro: 4.092 ± 0.063	1.828AspGln: 1.828 ± 0.038	5.214AspArg: 5.214 ± 0.072	2.09AspSer: 2.09 ± 0.04	2.673AspThr: 2.673 ± 0.054	4.078AspVal: 4.078 ± 0.058	1.186AspTrp: 1.186 ± 0.034	1.287AspTyr: 1.287 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	9.499GluAla: 9.499 ± 0.117	0.299GluCys: 0.299 ± 0.016	3.329GluAsp: 3.329 ± 0.054	4.011GluGlu: 4.011 ± 0.068	1.658GluPhe: 1.658 ± 0.035	5.553GluGly: 5.553 ± 0.069	1.17GluHis: 1.17 ± 0.032	2.989GluIle: 2.989 ± 0.045	1.35GluLys: 1.35 ± 0.037	5.006GluLeu: 5.006 ± 0.072	1.645GluMet: 1.645 ± 0.036	1.345GluAsn: 1.345 ± 0.029	3.11GluPro: 3.11 ± 0.063	2.037GluGln: 2.037 ± 0.044	5.298GluArg: 5.298 ± 0.088	2.332GluSer: 2.332 ± 0.047	3.283GluThr: 3.283 ± 0.055	5.049GluVal: 5.049 ± 0.068	0.782GluTrp: 0.782 ± 0.027	0.862GluTyr: 0.862 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.28PheAla: 4.28 ± 0.055	0.347PheCys: 0.347 ± 0.017	2.529PheAsp: 2.529 ± 0.046	2.044PheGlu: 2.044 ± 0.042	1.177PhePhe: 1.177 ± 0.035	3.448PheGly: 3.448 ± 0.059	0.75PheHis: 0.75 ± 0.024	1.34PheIle: 1.34 ± 0.029	0.634PheLys: 0.634 ± 0.025	3.358PheLeu: 3.358 ± 0.06	0.675PheMet: 0.675 ± 0.026	0.824PheAsn: 0.824 ± 0.026	1.5PhePro: 1.5 ± 0.035	1.044PheGln: 1.044 ± 0.028	2.358PheArg: 2.358 ± 0.042	1.743PheSer: 1.743 ± 0.038	1.764PheThr: 1.764 ± 0.037	2.684PheVal: 2.684 ± 0.043	0.592PheTrp: 0.592 ± 0.023	0.772PheTyr: 0.772 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.094GlyAla: 10.094 ± 0.115	0.792GlyCys: 0.792 ± 0.024	4.656GlyAsp: 4.656 ± 0.069	5.197GlyGlu: 5.197 ± 0.066	3.478GlyPhe: 3.478 ± 0.052	8.114GlyGly: 8.114 ± 0.124	2.096GlyHis: 2.096 ± 0.043	4.009GlyIle: 4.009 ± 0.063	2.18GlyLys: 2.18 ± 0.048	10.228GlyLeu: 10.228 ± 0.112	2.294GlyMet: 2.294 ± 0.043	2.046GlyAsn: 2.046 ± 0.06	4.595GlyPro: 4.595 ± 0.066	3.612GlyGln: 3.612 ± 0.053	7.536GlyArg: 7.536 ± 0.081	4.783GlySer: 4.783 ± 0.068	5.25GlyThr: 5.25 ± 0.076	6.622GlyVal: 6.622 ± 0.078	1.568GlyTrp: 1.568 ± 0.037	2.1GlyTyr: 2.1 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.378HisAla: 2.378 ± 0.053	0.191HisCys: 0.191 ± 0.013	1.381HisAsp: 1.381 ± 0.035	1.212HisGlu: 1.212 ± 0.029	0.733HisPhe: 0.733 ± 0.024	2.117HisGly: 2.117 ± 0.038	0.579HisHis: 0.579 ± 0.022	0.722HisIle: 0.722 ± 0.027	0.396HisLys: 0.396 ± 0.019	2.312HisLeu: 2.312 ± 0.04	0.485HisMet: 0.485 ± 0.019	0.404HisAsn: 0.404 ± 0.016	1.507HisPro: 1.507 ± 0.042	0.569HisGln: 0.569 ± 0.022	1.571HisArg: 1.571 ± 0.037	0.814HisSer: 0.814 ± 0.028	0.732HisThr: 0.732 ± 0.025	1.608HisVal: 1.608 ± 0.038	0.359HisTrp: 0.359 ± 0.018	0.491HisTyr: 0.491 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.898IleAla: 5.898 ± 0.071	0.448IleCys: 0.448 ± 0.021	3.027IleAsp: 3.027 ± 0.044	3.295IleGlu: 3.295 ± 0.051	1.402IlePhe: 1.402 ± 0.04	4.297IleGly: 4.297 ± 0.066	0.871IleHis: 0.871 ± 0.024	1.628IleIle: 1.628 ± 0.039	0.887IleLys: 0.887 ± 0.027	4.533IleLeu: 4.533 ± 0.066	0.779IleMet: 0.779 ± 0.026	1.057IleAsn: 1.057 ± 0.032	2.243IlePro: 2.243 ± 0.044	1.154IleGln: 1.154 ± 0.028	3.235IleArg: 3.235 ± 0.055	2.075IleSer: 2.075 ± 0.047	2.419IleThr: 2.419 ± 0.051	3.513IleVal: 3.513 ± 0.058	0.601IleTrp: 0.601 ± 0.023	0.939IleTyr: 0.939 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.077LysAla: 3.077 ± 0.054	0.096LysCys: 0.096 ± 0.008	1.292LysAsp: 1.292 ± 0.035	1.074LysGlu: 1.074 ± 0.029	0.511LysPhe: 0.511 ± 0.021	2.182LysGly: 2.182 ± 0.05	0.429LysHis: 0.429 ± 0.02	0.959LysIle: 0.959 ± 0.028	0.583LysLys: 0.583 ± 0.026	2.051LysLeu: 2.051 ± 0.048	0.462LysMet: 0.462 ± 0.018	0.443LysAsn: 0.443 ± 0.019	1.344LysPro: 1.344 ± 0.035	0.607LysGln: 0.607 ± 0.024	1.659LysArg: 1.659 ± 0.035	1.122LysSer: 1.122 ± 0.032	1.206LysThr: 1.206 ± 0.034	1.779LysVal: 1.779 ± 0.047	0.238LysTrp: 0.238 ± 0.014	0.374LysTyr: 0.374 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.833LeuAla: 14.833 ± 0.154	0.901LeuCys: 0.901 ± 0.025	6.573LeuAsp: 6.573 ± 0.079	5.349LeuGlu: 5.349 ± 0.079	3.282LeuPhe: 3.282 ± 0.055	9.815LeuGly: 9.815 ± 0.102	2.055LeuHis: 2.055 ± 0.046	4.473LeuIle: 4.473 ± 0.07	2.291LeuLys: 2.291 ± 0.05	10.53LeuLeu: 10.53 ± 0.171	2.402LeuMet: 2.402 ± 0.041	2.343LeuAsn: 2.343 ± 0.044	6.062LeuPro: 6.062 ± 0.083	2.809LeuGln: 2.809 ± 0.048	8.771LeuArg: 8.771 ± 0.097	6.754LeuSer: 6.754 ± 0.071	5.826LeuThr: 5.826 ± 0.069	8.102LeuVal: 8.102 ± 0.1	1.531LeuTrp: 1.531 ± 0.038	1.857LeuTyr: 1.857 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.512MetAla: 3.512 ± 0.049	0.134MetCys: 0.134 ± 0.01	1.281MetAsp: 1.281 ± 0.029	1.221MetGlu: 1.221 ± 0.031	0.619MetPhe: 0.619 ± 0.023	2.153MetGly: 2.153 ± 0.046	0.377MetHis: 0.377 ± 0.018	1.212MetIle: 1.212 ± 0.031	0.621MetLys: 0.621 ± 0.02	2.272MetLeu: 2.272 ± 0.044	0.63MetMet: 0.63 ± 0.025	0.669MetAsn: 0.669 ± 0.023	1.476MetPro: 1.476 ± 0.034	0.76MetGln: 0.76 ± 0.021	1.907MetArg: 1.907 ± 0.036	1.421MetSer: 1.421 ± 0.034	1.951MetThr: 1.951 ± 0.037	1.672MetVal: 1.672 ± 0.039	0.225MetTrp: 0.225 ± 0.014	0.259MetTyr: 0.259 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.687AsnAla: 2.687 ± 0.044	0.204AsnCys: 0.204 ± 0.013	1.412AsnAsp: 1.412 ± 0.05	1.09AsnGlu: 1.09 ± 0.034	0.776AsnPhe: 0.776 ± 0.026	2.098AsnGly: 2.098 ± 0.048	0.426AsnHis: 0.426 ± 0.018	0.965AsnIle: 0.965 ± 0.028	0.388AsnLys: 0.388 ± 0.017	2.396AsnLeu: 2.396 ± 0.046	0.5AsnMet: 0.5 ± 0.019	0.545AsnAsn: 0.545 ± 0.025	1.591AsnPro: 1.591 ± 0.034	0.657AsnGln: 0.657 ± 0.025	1.591AsnArg: 1.591 ± 0.036	0.981AsnSer: 0.981 ± 0.029	1.02AsnThr: 1.02 ± 0.03	1.672AsnVal: 1.672 ± 0.036	0.37AsnTrp: 0.37 ± 0.017	0.497AsnTyr: 0.497 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.559ProAla: 6.559 ± 0.08	0.364ProCys: 0.364 ± 0.02	4.207ProAsp: 4.207 ± 0.061	4.483ProGlu: 4.483 ± 0.063	2.021ProPhe: 2.021 ± 0.038	5.054ProGly: 5.054 ± 0.069	1.108ProHis: 1.108 ± 0.028	2.156ProIle: 2.156 ± 0.045	1.184ProLys: 1.184 ± 0.032	5.247ProLeu: 5.247 ± 0.068	1.261ProMet: 1.261 ± 0.024	1.15ProAsn: 1.15 ± 0.032	2.897ProPro: 2.897 ± 0.06	1.761ProGln: 1.761 ± 0.032	3.628ProArg: 3.628 ± 0.076	3.064ProSer: 3.064 ± 0.056	2.718ProThr: 2.718 ± 0.051	4.624ProVal: 4.624 ± 0.067	0.841ProTrp: 0.841 ± 0.028	1.041ProTyr: 1.041 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.841GlnAla: 4.841 ± 0.065	0.157GlnCys: 0.157 ± 0.01	1.834GlnAsp: 1.834 ± 0.038	1.806GlnGlu: 1.806 ± 0.04	0.988GlnPhe: 0.988 ± 0.026	3.233GlnGly: 3.233 ± 0.057	0.577GlnHis: 0.577 ± 0.024	1.615GlnIle: 1.615 ± 0.038	0.722GlnLys: 0.722 ± 0.023	2.748GlnLeu: 2.748 ± 0.049	0.844GlnMet: 0.844 ± 0.026	0.695GlnAsn: 0.695 ± 0.024	1.838GlnPro: 1.838 ± 0.039	1.04GlnGln: 1.04 ± 0.035	2.436GlnArg: 2.436 ± 0.049	1.645GlnSer: 1.645 ± 0.036	1.662GlnThr: 1.662 ± 0.039	2.617GlnVal: 2.617 ± 0.045	0.404GlnTrp: 0.404 ± 0.018	0.471GlnTyr: 0.471 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.394ArgAla: 9.394 ± 0.101	0.479ArgCys: 0.479 ± 0.017	4.619ArgAsp: 4.619 ± 0.061	4.634ArgGlu: 4.634 ± 0.067	2.849ArgPhe: 2.849 ± 0.049	5.38ArgGly: 5.38 ± 0.072	1.835ArgHis: 1.835 ± 0.041	4.155ArgIle: 4.155 ± 0.053	1.737ArgLys: 1.737 ± 0.044	9.477ArgLeu: 9.477 ± 0.099	2.111ArgMet: 2.111 ± 0.039	1.649ArgAsn: 1.649 ± 0.037	4.404ArgPro: 4.404 ± 0.068	2.611ArgGln: 2.611 ± 0.05	6.573ArgArg: 6.573 ± 0.098	4.009ArgSer: 4.009 ± 0.067	3.838ArgThr: 3.838 ± 0.053	5.617ArgVal: 5.617 ± 0.062	1.215ArgTrp: 1.215 ± 0.034	1.511ArgTyr: 1.511 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.667SerAla: 5.667 ± 0.07	0.413SerCys: 0.413 ± 0.018	2.997SerAsp: 2.997 ± 0.051	2.912SerGlu: 2.912 ± 0.052	2.014SerPhe: 2.014 ± 0.037	5.447SerGly: 5.447 ± 0.068	1.063SerHis: 1.063 ± 0.028	2.214SerIle: 2.214 ± 0.042	1.056SerLys: 1.056 ± 0.031	5.399SerLeu: 5.399 ± 0.065	1.223SerMet: 1.223 ± 0.032	1.136SerAsn: 1.136 ± 0.028	2.923SerPro: 2.923 ± 0.048	1.602SerGln: 1.602 ± 0.035	3.688SerArg: 3.688 ± 0.053	2.597SerSer: 2.597 ± 0.058	2.515SerThr: 2.515 ± 0.047	3.75SerVal: 3.75 ± 0.058	0.797SerTrp: 0.797 ± 0.028	1.146SerTyr: 1.146 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.057ThrAla: 6.057 ± 0.074	0.418ThrCys: 0.418 ± 0.017	3.06ThrAsp: 3.06 ± 0.048	2.97ThrGlu: 2.97 ± 0.048	1.895ThrPhe: 1.895 ± 0.039	5.564ThrGly: 5.564 ± 0.07	1.067ThrHis: 1.067 ± 0.031	2.441ThrIle: 2.441 ± 0.045	1.054ThrLys: 1.054 ± 0.029	6.205ThrLeu: 6.205 ± 0.075	1.182ThrMet: 1.182 ± 0.029	1.146ThrAsn: 1.146 ± 0.035	3.371ThrPro: 3.371 ± 0.054	1.51ThrGln: 1.51 ± 0.034	3.576ThrArg: 3.576 ± 0.058	2.675ThrSer: 2.675 ± 0.047	2.798ThrThr: 2.798 ± 0.048	4.395ThrVal: 4.395 ± 0.071	0.828ThrTrp: 0.828 ± 0.029	1.143ThrTyr: 1.143 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.942ValAla: 9.942 ± 0.113	0.627ValCys: 0.627 ± 0.025	4.016ValAsp: 4.016 ± 0.059	4.827ValGlu: 4.827 ± 0.067	2.601ValPhe: 2.601 ± 0.045	5.922ValGly: 5.922 ± 0.083	1.453ValHis: 1.453 ± 0.034	3.699ValIle: 3.699 ± 0.051	1.571ValLys: 1.571 ± 0.041	8.401ValLeu: 8.401 ± 0.093	1.923ValMet: 1.923 ± 0.04	1.792ValAsn: 1.792 ± 0.036	4.144ValPro: 4.144 ± 0.065	2.305ValGln: 2.305 ± 0.043	5.294ValArg: 5.294 ± 0.064	4.02ValSer: 4.02 ± 0.056	5.041ValThr: 5.041 ± 0.068	6.353ValVal: 6.353 ± 0.083	1.06ValTrp: 1.06 ± 0.032	1.359ValTyr: 1.359 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.588TrpAla: 1.588 ± 0.035	0.115TrpCys: 0.115 ± 0.009	0.842TrpAsp: 0.842 ± 0.027	0.733TrpGlu: 0.733 ± 0.026	0.586TrpPhe: 0.586 ± 0.023	1.166TrpGly: 1.166 ± 0.032	0.349TrpHis: 0.349 ± 0.018	0.702TrpIle: 0.702 ± 0.025	0.36TrpLys: 0.36 ± 0.016	1.761TrpLeu: 1.761 ± 0.043	0.39TrpMet: 0.39 ± 0.018	0.449TrpAsn: 0.449 ± 0.021	0.826TrpPro: 0.826 ± 0.025	0.556TrpGln: 0.556 ± 0.023	1.329TrpArg: 1.329 ± 0.034	0.914TrpSer: 0.914 ± 0.023	0.993TrpThr: 0.993 ± 0.031	0.957TrpVal: 0.957 ± 0.03	0.271TrpTrp: 0.271 ± 0.014	0.245TrpTyr: 0.245 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.333TyrAla: 2.333 ± 0.037	0.203TyrCys: 0.203 ± 0.012	1.348TyrAsp: 1.348 ± 0.031	1.182TyrGlu: 1.182 ± 0.032	0.702TyrPhe: 0.702 ± 0.027	1.96TyrGly: 1.96 ± 0.048	0.451TyrHis: 0.451 ± 0.02	0.691TyrIle: 0.691 ± 0.025	0.383TyrLys: 0.383 ± 0.02	2.02TyrLeu: 2.02 ± 0.043	0.387TyrMet: 0.387 ± 0.018	0.487TyrAsn: 0.487 ± 0.02	0.997TyrPro: 0.997 ± 0.029	0.633TyrGln: 0.633 ± 0.024	1.469TyrArg: 1.469 ± 0.033	0.945TyrSer: 0.945 ± 0.028	0.904TyrThr: 0.904 ± 0.031	1.421TyrVal: 1.421 ± 0.035	0.329TyrTrp: 0.329 ± 0.017	0.517TyrTyr: 0.517 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4087 proteins (1295680 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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