Amino acid dipepetide frequency for Actinobaculum massiliense ACS-171-V-Col2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.756AlaAla: 14.756 ± 0.255	0.819AlaCys: 0.819 ± 0.04	6.984AlaAsp: 6.984 ± 0.135	8.153AlaGlu: 8.153 ± 0.129	3.399AlaPhe: 3.399 ± 0.08	11.547AlaGly: 11.547 ± 0.184	2.12AlaHis: 2.12 ± 0.056	5.969AlaIle: 5.969 ± 0.117	4.269AlaLys: 4.269 ± 0.113	11.352AlaLeu: 11.352 ± 0.157	2.563AlaMet: 2.563 ± 0.064	3.349AlaAsn: 3.349 ± 0.081	5.408AlaPro: 5.408 ± 0.108	4.906AlaGln: 4.906 ± 0.11	8.236AlaArg: 8.236 ± 0.155	7.167AlaSer: 7.167 ± 0.135	6.156AlaThr: 6.156 ± 0.113	9.003AlaVal: 9.003 ± 0.151	1.518AlaTrp: 1.518 ± 0.056	2.553AlaTyr: 2.553 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.885CysAla: 0.885 ± 0.043	0.062CysCys: 0.062 ± 0.01	0.396CysAsp: 0.396 ± 0.025	0.428CysGlu: 0.428 ± 0.03	0.233CysPhe: 0.233 ± 0.022	0.768CysGly: 0.768 ± 0.039	0.15CysHis: 0.15 ± 0.017	0.3CysIle: 0.3 ± 0.025	0.16CysLys: 0.16 ± 0.016	0.701CysLeu: 0.701 ± 0.035	0.13CysMet: 0.13 ± 0.017	0.158CysAsn: 0.158 ± 0.016	0.334CysPro: 0.334 ± 0.028	0.189CysGln: 0.189 ± 0.016	0.349CysArg: 0.349 ± 0.026	0.428CysSer: 0.428 ± 0.027	0.34CysThr: 0.34 ± 0.028	0.568CysVal: 0.568 ± 0.034	0.106CysTrp: 0.106 ± 0.013	0.15CysTyr: 0.15 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.23AspAla: 7.23 ± 0.124	0.32AspCys: 0.32 ± 0.023	3.269AspAsp: 3.269 ± 0.106	4.055AspGlu: 4.055 ± 0.093	2.221AspPhe: 2.221 ± 0.066	5.167AspGly: 5.167 ± 0.107	1.073AspHis: 1.073 ± 0.04	2.658AspIle: 2.658 ± 0.07	1.495AspLys: 1.495 ± 0.066	5.477AspLeu: 5.477 ± 0.102	0.979AspMet: 0.979 ± 0.035	1.35AspAsn: 1.35 ± 0.047	3.765AspPro: 3.765 ± 0.094	1.593AspGln: 1.593 ± 0.055	3.172AspArg: 3.172 ± 0.068	3.411AspSer: 3.411 ± 0.085	2.555AspThr: 2.555 ± 0.071	4.778AspVal: 4.778 ± 0.092	0.817AspTrp: 0.817 ± 0.045	1.481AspTyr: 1.481 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.964GluAla: 7.964 ± 0.118	0.372GluCys: 0.372 ± 0.029	3.8GluAsp: 3.8 ± 0.089	5.18GluGlu: 5.18 ± 0.113	2.059GluPhe: 2.059 ± 0.062	4.845GluGly: 4.845 ± 0.088	1.458GluHis: 1.458 ± 0.053	4.011GluIle: 4.011 ± 0.08	2.912GluLys: 2.912 ± 0.083	6.815GluLeu: 6.815 ± 0.128	1.466GluMet: 1.466 ± 0.051	2.597GluAsn: 2.597 ± 0.07	3.126GluPro: 3.126 ± 0.078	2.523GluGln: 2.523 ± 0.067	4.884GluArg: 4.884 ± 0.111	3.618GluSer: 3.618 ± 0.08	3.539GluThr: 3.539 ± 0.086	5.169GluVal: 5.169 ± 0.095	0.807GluTrp: 0.807 ± 0.039	1.448GluTyr: 1.448 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.807PheAla: 3.807 ± 0.09	0.241PheCys: 0.241 ± 0.022	2.218PheAsp: 2.218 ± 0.066	2.1PheGlu: 2.1 ± 0.065	1.244PhePhe: 1.244 ± 0.057	3.317PheGly: 3.317 ± 0.089	0.639PheHis: 0.639 ± 0.032	1.717PheIle: 1.717 ± 0.054	0.866PheLys: 0.866 ± 0.039	2.804PheLeu: 2.804 ± 0.076	0.622PheMet: 0.622 ± 0.034	0.897PheAsn: 0.897 ± 0.04	1.502PhePro: 1.502 ± 0.053	0.912PheGln: 0.912 ± 0.037	1.613PheArg: 1.613 ± 0.056	2.435PheSer: 2.435 ± 0.063	2.117PheThr: 2.117 ± 0.06	2.572PheVal: 2.572 ± 0.068	0.541PheTrp: 0.541 ± 0.031	0.812PheTyr: 0.812 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	9.569GlyAla: 9.569 ± 0.155	0.624GlyCys: 0.624 ± 0.032	4.479GlyAsp: 4.479 ± 0.097	6.16GlyGlu: 6.16 ± 0.119	3.129GlyPhe: 3.129 ± 0.078	7.149GlyGly: 7.149 ± 0.154	1.598GlyHis: 1.598 ± 0.054	5.074GlyIle: 5.074 ± 0.106	3.974GlyLys: 3.974 ± 0.087	7.506GlyLeu: 7.506 ± 0.134	2.117GlyMet: 2.117 ± 0.068	2.744GlyAsn: 2.744 ± 0.084	3.241GlyPro: 3.241 ± 0.085	2.941GlyGln: 2.941 ± 0.074	5.216GlyArg: 5.216 ± 0.102	5.341GlySer: 5.341 ± 0.096	5.106GlyThr: 5.106 ± 0.104	6.667GlyVal: 6.667 ± 0.106	1.392GlyTrp: 1.392 ± 0.052	2.462GlyTyr: 2.462 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.064HisAla: 2.064 ± 0.062	0.163HisCys: 0.163 ± 0.014	1.085HisAsp: 1.085 ± 0.05	1.144HisGlu: 1.144 ± 0.051	0.627HisPhe: 0.627 ± 0.03	1.667HisGly: 1.667 ± 0.055	0.529HisHis: 0.529 ± 0.035	0.915HisIle: 0.915 ± 0.04	0.504HisLys: 0.504 ± 0.029	1.8HisLeu: 1.8 ± 0.059	0.329HisMet: 0.329 ± 0.029	0.489HisAsn: 0.489 ± 0.028	1.298HisPro: 1.298 ± 0.046	0.578HisGln: 0.578 ± 0.03	1.333HisArg: 1.333 ± 0.055	1.048HisSer: 1.048 ± 0.046	1.008HisThr: 1.008 ± 0.043	1.461HisVal: 1.461 ± 0.048	0.254HisTrp: 0.254 ± 0.024	0.504HisTyr: 0.504 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.449IleAla: 6.449 ± 0.106	0.489IleCys: 0.489 ± 0.029	3.443IleAsp: 3.443 ± 0.083	3.478IleGlu: 3.478 ± 0.07	1.852IlePhe: 1.852 ± 0.069	4.614IleGly: 4.614 ± 0.112	0.998IleHis: 0.998 ± 0.041	2.644IleIle: 2.644 ± 0.091	1.323IleLys: 1.323 ± 0.055	4.437IleLeu: 4.437 ± 0.102	0.998IleMet: 0.998 ± 0.047	1.427IleAsn: 1.427 ± 0.059	2.784IlePro: 2.784 ± 0.077	1.335IleGln: 1.335 ± 0.051	3.023IleArg: 3.023 ± 0.067	3.51IleSer: 3.51 ± 0.076	3.091IleThr: 3.091 ± 0.086	4.23IleVal: 4.23 ± 0.095	0.62IleTrp: 0.62 ± 0.033	1.202IleTyr: 1.202 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	3.536LysAla: 3.536 ± 0.094	0.13LysCys: 0.13 ± 0.015	1.844LysAsp: 1.844 ± 0.062	2.064LysGlu: 2.064 ± 0.069	1.035LysPhe: 1.035 ± 0.038	2.083LysGly: 2.083 ± 0.064	0.624LysHis: 0.624 ± 0.029	2.194LysIle: 2.194 ± 0.065	1.652LysLys: 1.652 ± 0.077	3.037LysLeu: 3.037 ± 0.071	0.843LysMet: 0.843 ± 0.037	1.352LysAsn: 1.352 ± 0.057	1.835LysPro: 1.835 ± 0.077	1.158LysGln: 1.158 ± 0.053	2.201LysArg: 2.201 ± 0.072	1.842LysSer: 1.842 ± 0.061	2.051LysThr: 2.051 ± 0.068	2.615LysVal: 2.615 ± 0.086	0.404LysTrp: 0.404 ± 0.028	0.903LysTyr: 0.903 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	12.42LeuAla: 12.42 ± 0.173	0.725LeuCys: 0.725 ± 0.035	5.555LeuAsp: 5.555 ± 0.1	6.016LeuGlu: 6.016 ± 0.113	2.739LeuPhe: 2.739 ± 0.089	8.123LeuGly: 8.123 ± 0.128	1.552LeuHis: 1.552 ± 0.058	4.484LeuIle: 4.484 ± 0.107	2.519LeuLys: 2.519 ± 0.073	8.404LeuLeu: 8.404 ± 0.163	1.751LeuMet: 1.751 ± 0.058	2.339LeuAsn: 2.339 ± 0.059	4.791LeuPro: 4.791 ± 0.102	2.432LeuGln: 2.432 ± 0.071	6.576LeuArg: 6.576 ± 0.125	5.849LeuSer: 5.849 ± 0.099	5.716LeuThr: 5.716 ± 0.113	7.305LeuVal: 7.305 ± 0.131	1.073LeuTrp: 1.073 ± 0.045	1.866LeuTyr: 1.866 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.46MetAla: 2.46 ± 0.075	0.133MetCys: 0.133 ± 0.013	1.077MetAsp: 1.077 ± 0.049	1.114MetGlu: 1.114 ± 0.043	0.684MetPhe: 0.684 ± 0.038	1.633MetGly: 1.633 ± 0.059	0.379MetHis: 0.379 ± 0.027	1.07MetIle: 1.07 ± 0.048	0.802MetLys: 0.802 ± 0.035	1.941MetLeu: 1.941 ± 0.056	0.408MetMet: 0.408 ± 0.032	0.701MetAsn: 0.701 ± 0.033	1.095MetPro: 1.095 ± 0.043	0.632MetGln: 0.632 ± 0.031	1.574MetArg: 1.574 ± 0.052	1.561MetSer: 1.561 ± 0.05	1.33MetThr: 1.33 ± 0.052	1.493MetVal: 1.493 ± 0.054	0.258MetTrp: 0.258 ± 0.02	0.396MetTyr: 0.396 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.325AsnAla: 3.325 ± 0.09	0.179AsnCys: 0.179 ± 0.018	1.52AsnAsp: 1.52 ± 0.049	1.694AsnGlu: 1.694 ± 0.064	0.994AsnPhe: 0.994 ± 0.045	2.567AsnGly: 2.567 ± 0.077	0.533AsnHis: 0.533 ± 0.032	1.432AsnIle: 1.432 ± 0.049	0.886AsnLys: 0.886 ± 0.035	2.808AsnLeu: 2.808 ± 0.071	0.649AsnMet: 0.649 ± 0.033	0.913AsnAsn: 0.913 ± 0.048	2.127AsnPro: 2.127 ± 0.06	1.031AsnGln: 1.031 ± 0.048	1.813AsnArg: 1.813 ± 0.061	1.869AsnSer: 1.869 ± 0.067	1.54AsnThr: 1.54 ± 0.058	2.125AsnVal: 2.125 ± 0.06	0.472AsnTrp: 0.472 ± 0.026	0.878AsnTyr: 0.878 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	6.412ProAla: 6.412 ± 0.136	0.256ProCys: 0.256 ± 0.021	2.993ProAsp: 2.993 ± 0.074	4.5ProGlu: 4.5 ± 0.099	1.601ProPhe: 1.601 ± 0.059	4.656ProGly: 4.656 ± 0.084	0.989ProHis: 0.989 ± 0.044	2.275ProIle: 2.275 ± 0.059	1.439ProLys: 1.439 ± 0.049	4.036ProLeu: 4.036 ± 0.083	0.843ProMet: 0.843 ± 0.038	1.466ProAsn: 1.466 ± 0.049	1.623ProPro: 1.623 ± 0.057	1.776ProGln: 1.776 ± 0.059	3.012ProArg: 3.012 ± 0.073	3.146ProSer: 3.146 ± 0.076	2.757ProThr: 2.757 ± 0.076	3.964ProVal: 3.964 ± 0.092	0.723ProTrp: 0.723 ± 0.036	1.213ProTyr: 1.213 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	4.107GlnAla: 4.107 ± 0.091	0.185GlnCys: 0.185 ± 0.018	1.397GlnAsp: 1.397 ± 0.048	2.017GlnGlu: 2.017 ± 0.071	1.004GlnPhe: 1.004 ± 0.041	2.268GlnGly: 2.268 ± 0.07	0.6GlnHis: 0.6 ± 0.035	1.968GlnIle: 1.968 ± 0.056	1.267GlnLys: 1.267 ± 0.047	3.269GlnLeu: 3.269 ± 0.083	0.88GlnMet: 0.88 ± 0.038	0.976GlnAsn: 0.976 ± 0.039	1.786GlnPro: 1.786 ± 0.067	1.242GlnGln: 1.242 ± 0.056	2.577GlnArg: 2.577 ± 0.07	1.729GlnSer: 1.729 ± 0.048	1.796GlnThr: 1.796 ± 0.055	2.627GlnVal: 2.627 ± 0.071	0.47GlnTrp: 0.47 ± 0.029	0.715GlnTyr: 0.715 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	7.91ArgAla: 7.91 ± 0.158	0.394ArgCys: 0.394 ± 0.03	3.485ArgAsp: 3.485 ± 0.085	5.432ArgGlu: 5.432 ± 0.112	2.132ArgPhe: 2.132 ± 0.064	5.317ArgGly: 5.317 ± 0.118	1.249ArgHis: 1.249 ± 0.042	3.468ArgIle: 3.468 ± 0.088	2.241ArgLys: 2.241 ± 0.063	5.883ArgLeu: 5.883 ± 0.105	1.589ArgMet: 1.589 ± 0.054	1.857ArgAsn: 1.857 ± 0.05	2.801ArgPro: 2.801 ± 0.088	2.321ArgGln: 2.321 ± 0.061	5.359ArgArg: 5.359 ± 0.11	3.536ArgSer: 3.536 ± 0.089	3.382ArgThr: 3.382 ± 0.064	5.098ArgVal: 5.098 ± 0.094	1.004ArgTrp: 1.004 ± 0.041	1.707ArgTyr: 1.707 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	7.614SerAla: 7.614 ± 0.143	0.359SerCys: 0.359 ± 0.026	3.29SerAsp: 3.29 ± 0.078	4.092SerGlu: 4.092 ± 0.09	2.155SerPhe: 2.155 ± 0.06	6.256SerGly: 6.256 ± 0.108	1.151SerHis: 1.151 ± 0.043	2.932SerIle: 2.932 ± 0.074	1.837SerLys: 1.837 ± 0.065	5.548SerLeu: 5.548 ± 0.099	1.244SerMet: 1.244 ± 0.05	1.667SerAsn: 1.667 ± 0.055	2.924SerPro: 2.924 ± 0.074	2.083SerGln: 2.083 ± 0.061	3.901SerArg: 3.901 ± 0.095	3.836SerSer: 3.836 ± 0.092	3.317SerThr: 3.317 ± 0.073	4.346SerVal: 4.346 ± 0.087	0.891SerTrp: 0.891 ± 0.038	1.523SerTyr: 1.523 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	6.215ThrAla: 6.215 ± 0.132	0.371ThrCys: 0.371 ± 0.024	3.163ThrAsp: 3.163 ± 0.077	3.279ThrGlu: 3.279 ± 0.085	1.867ThrPhe: 1.867 ± 0.059	5.184ThrGly: 5.184 ± 0.103	1.087ThrHis: 1.087 ± 0.045	2.87ThrIle: 2.87 ± 0.092	1.655ThrLys: 1.655 ± 0.061	5.241ThrLeu: 5.241 ± 0.103	1.011ThrMet: 1.011 ± 0.041	1.662ThrAsn: 1.662 ± 0.054	3.45ThrPro: 3.45 ± 0.083	1.817ThrGln: 1.817 ± 0.058	3.436ThrArg: 3.436 ± 0.081	3.47ThrSer: 3.47 ± 0.081	3.317ThrThr: 3.317 ± 0.099	4.741ThrVal: 4.741 ± 0.117	0.747ThrTrp: 0.747 ± 0.034	1.409ThrTyr: 1.409 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	9.481ValAla: 9.481 ± 0.135	0.689ValCys: 0.689 ± 0.037	4.821ValAsp: 4.821 ± 0.105	5.3ValGlu: 5.3 ± 0.103	2.572ValPhe: 2.572 ± 0.076	6.067ValGly: 6.067 ± 0.12	1.35ValHis: 1.35 ± 0.048	4.159ValIle: 4.159 ± 0.098	2.403ValLys: 2.403 ± 0.07	7.466ValLeu: 7.466 ± 0.126	1.534ValMet: 1.534 ± 0.054	2.164ValAsn: 2.164 ± 0.068	4.001ValPro: 4.001 ± 0.081	2.029ValGln: 2.029 ± 0.049	5.113ValArg: 5.113 ± 0.093	5.007ValSer: 5.007 ± 0.097	4.862ValThr: 4.862 ± 0.111	6.884ValVal: 6.884 ± 0.101	0.915ValTrp: 0.915 ± 0.041	1.633ValTyr: 1.633 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	1.353TrpAla: 1.353 ± 0.045	0.126TrpCys: 0.126 ± 0.015	0.716TrpAsp: 0.716 ± 0.04	0.819TrpGlu: 0.819 ± 0.037	0.551TrpPhe: 0.551 ± 0.035	1.015TrpGly: 1.015 ± 0.042	0.312TrpHis: 0.312 ± 0.023	0.755TrpIle: 0.755 ± 0.037	0.501TrpLys: 0.501 ± 0.03	1.355TrpLeu: 1.355 ± 0.052	0.334TrpMet: 0.334 ± 0.027	0.568TrpAsn: 0.568 ± 0.03	0.588TrpPro: 0.588 ± 0.035	0.551TrpGln: 0.551 ± 0.034	1.021TrpArg: 1.021 ± 0.047	0.735TrpSer: 0.735 ± 0.037	0.73TrpThr: 0.73 ± 0.034	0.999TrpVal: 0.999 ± 0.043	0.29TrpTrp: 0.29 ± 0.022	0.33TrpTyr: 0.33 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.668TyrAla: 2.668 ± 0.068	0.197TyrCys: 0.197 ± 0.019	1.33TyrAsp: 1.33 ± 0.052	1.571TyrGlu: 1.571 ± 0.058	0.875TyrPhe: 0.875 ± 0.043	2.245TyrGly: 2.245 ± 0.064	0.411TyrHis: 0.411 ± 0.029	1.05TyrIle: 1.05 ± 0.044	0.696TyrLys: 0.696 ± 0.037	2.356TyrLeu: 2.356 ± 0.07	0.453TyrMet: 0.453 ± 0.032	0.681TyrAsn: 0.681 ± 0.032	1.203TyrPro: 1.203 ± 0.047	0.836TyrGln: 0.836 ± 0.034	1.758TyrArg: 1.758 ± 0.061	1.427TyrSer: 1.427 ± 0.049	1.281TyrThr: 1.281 ± 0.049	1.805TyrVal: 1.805 ± 0.058	0.344TyrTrp: 0.344 ± 0.023	0.57TyrTyr: 0.57 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1696 proteins (593390 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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