Amino acid dipepetide frequency for Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.354AlaAla: 10.354 ± 0.13	1.176AlaCys: 1.176 ± 0.032	5.095AlaAsp: 5.095 ± 0.059	5.889AlaGlu: 5.889 ± 0.077	3.656AlaPhe: 3.656 ± 0.046	7.797AlaGly: 7.797 ± 0.106	1.857AlaHis: 1.857 ± 0.034	5.886AlaIle: 5.886 ± 0.07	3.785AlaLys: 3.785 ± 0.057	11.951AlaLeu: 11.951 ± 0.122	2.975AlaMet: 2.975 ± 0.048	3.112AlaAsn: 3.112 ± 0.05	3.737AlaPro: 3.737 ± 0.064	4.536AlaGln: 4.536 ± 0.063	5.886AlaArg: 5.886 ± 0.077	5.668AlaSer: 5.668 ± 0.064	4.98AlaThr: 4.98 ± 0.077	6.758AlaVal: 6.758 ± 0.083	1.673AlaTrp: 1.673 ± 0.039	1.967AlaTyr: 1.967 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.064CysAla: 1.064 ± 0.03	0.169CysCys: 0.169 ± 0.011	0.629CysAsp: 0.629 ± 0.02	0.623CysGlu: 0.623 ± 0.02	0.462CysPhe: 0.462 ± 0.017	1.089CysGly: 1.089 ± 0.032	0.343CysHis: 0.343 ± 0.02	0.603CysIle: 0.603 ± 0.022	0.363CysLys: 0.363 ± 0.015	1.02CysLeu: 1.02 ± 0.029	0.25CysMet: 0.25 ± 0.014	0.343CysAsn: 0.343 ± 0.015	0.541CysPro: 0.541 ± 0.023	0.458CysGln: 0.458 ± 0.016	0.711CysArg: 0.711 ± 0.023	0.702CysSer: 0.702 ± 0.023	0.494CysThr: 0.494 ± 0.019	0.751CysVal: 0.751 ± 0.023	0.205CysTrp: 0.205 ± 0.013	0.341CysTyr: 0.341 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.26AspAla: 5.26 ± 0.07	0.519AspCys: 0.519 ± 0.018	2.977AspAsp: 2.977 ± 0.058	3.62AspGlu: 3.62 ± 0.057	2.04AspPhe: 2.04 ± 0.038	3.915AspGly: 3.915 ± 0.06	0.935AspHis: 0.935 ± 0.027	3.522AspIle: 3.522 ± 0.051	2.526AspLys: 2.526 ± 0.045	4.483AspLeu: 4.483 ± 0.05	1.329AspMet: 1.329 ± 0.036	2.261AspAsn: 2.261 ± 0.036	2.166AspPro: 2.166 ± 0.04	1.402AspGln: 1.402 ± 0.032	2.718AspArg: 2.718 ± 0.053	2.86AspSer: 2.86 ± 0.048	2.641AspThr: 2.641 ± 0.057	3.652AspVal: 3.652 ± 0.055	0.83AspTrp: 0.83 ± 0.021	1.902AspTyr: 1.902 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.473GluAla: 5.473 ± 0.067	0.504GluCys: 0.504 ± 0.016	2.285GluAsp: 2.285 ± 0.043	3.431GluGlu: 3.431 ± 0.064	1.811GluPhe: 1.811 ± 0.039	3.715GluGly: 3.715 ± 0.054	1.328GluHis: 1.328 ± 0.03	3.347GluIle: 3.347 ± 0.047	3.448GluLys: 3.448 ± 0.056	5.873GluLeu: 5.873 ± 0.064	1.791GluMet: 1.791 ± 0.036	2.451GluAsn: 2.451 ± 0.042	2.041GluPro: 2.041 ± 0.039	3.354GluGln: 3.354 ± 0.055	3.727GluArg: 3.727 ± 0.059	2.957GluSer: 2.957 ± 0.05	2.985GluThr: 2.985 ± 0.048	3.852GluVal: 3.852 ± 0.066	0.798GluTrp: 0.798 ± 0.025	1.529GluTyr: 1.529 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.704PheAla: 3.704 ± 0.054	0.547PheCys: 0.547 ± 0.02	2.253PheAsp: 2.253 ± 0.035	1.716PheGlu: 1.716 ± 0.037	1.748PhePhe: 1.748 ± 0.043	3.085PheGly: 3.085 ± 0.053	0.797PheHis: 0.797 ± 0.024	2.578PheIle: 2.578 ± 0.043	1.292PheLys: 1.292 ± 0.033	3.306PheLeu: 3.306 ± 0.061	0.982PheMet: 0.982 ± 0.028	1.745PheAsn: 1.745 ± 0.033	1.546PhePro: 1.546 ± 0.036	1.091PheGln: 1.091 ± 0.03	1.96PheArg: 1.96 ± 0.038	3.174PheSer: 3.174 ± 0.05	2.479PheThr: 2.479 ± 0.037	2.465PheVal: 2.465 ± 0.046	0.647PheTrp: 0.647 ± 0.022	1.216PheTyr: 1.216 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.362GlyAla: 6.362 ± 0.082	1.03GlyCys: 1.03 ± 0.028	3.846GlyAsp: 3.846 ± 0.059	4.767GlyGlu: 4.767 ± 0.06	3.199GlyPhe: 3.199 ± 0.049	5.633GlyGly: 5.633 ± 0.095	1.608GlyHis: 1.608 ± 0.036	5.047GlyIle: 5.047 ± 0.069	3.995GlyLys: 3.995 ± 0.06	7.356GlyLeu: 7.356 ± 0.087	2.389GlyMet: 2.389 ± 0.043	2.917GlyAsn: 2.917 ± 0.076	1.964GlyPro: 1.964 ± 0.04	2.886GlyGln: 2.886 ± 0.05	3.846GlyArg: 3.846 ± 0.058	4.334GlySer: 4.334 ± 0.088	3.869GlyThr: 3.869 ± 0.085	5.917GlyVal: 5.917 ± 0.071	1.285GlyTrp: 1.285 ± 0.03	2.661GlyTyr: 2.661 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.872HisAla: 1.872 ± 0.035	0.341HisCys: 0.341 ± 0.014	1.135HisAsp: 1.135 ± 0.029	1.083HisGlu: 1.083 ± 0.029	1.012HisPhe: 1.012 ± 0.028	1.685HisGly: 1.685 ± 0.036	0.74HisHis: 0.74 ± 0.026	1.308HisIle: 1.308 ± 0.03	0.743HisLys: 0.743 ± 0.025	2.214HisLeu: 2.214 ± 0.043	0.501HisMet: 0.501 ± 0.018	0.838HisAsn: 0.838 ± 0.023	1.292HisPro: 1.292 ± 0.028	1.056HisGln: 1.056 ± 0.028	1.216HisArg: 1.216 ± 0.027	1.246HisSer: 1.246 ± 0.029	1.108HisThr: 1.108 ± 0.027	1.241HisVal: 1.241 ± 0.027	0.373HisTrp: 0.373 ± 0.015	0.912HisTyr: 0.912 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.53IleAla: 6.53 ± 0.069	0.689IleCys: 0.689 ± 0.026	3.484IleAsp: 3.484 ± 0.052	3.208IleGlu: 3.208 ± 0.047	2.156IlePhe: 2.156 ± 0.046	4.477IleGly: 4.477 ± 0.062	1.185IleHis: 1.185 ± 0.027	3.45IleIle: 3.45 ± 0.059	2.364IleLys: 2.364 ± 0.048	5.024IleLeu: 5.024 ± 0.075	1.338IleMet: 1.338 ± 0.034	2.718IleAsn: 2.718 ± 0.053	2.767IlePro: 2.767 ± 0.045	1.847IleGln: 1.847 ± 0.042	3.113IleArg: 3.113 ± 0.041	3.914IleSer: 3.914 ± 0.058	3.563IleThr: 3.563 ± 0.057	4.015IleVal: 4.015 ± 0.056	0.7IleTrp: 0.7 ± 0.021	1.579IleTyr: 1.579 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.342LysAla: 4.342 ± 0.075	0.318LysCys: 0.318 ± 0.016	2.018LysAsp: 2.018 ± 0.041	2.563LysGlu: 2.563 ± 0.053	1.123LysPhe: 1.123 ± 0.026	3.028LysGly: 3.028 ± 0.055	0.832LysHis: 0.832 ± 0.026	2.439LysIle: 2.439 ± 0.047	2.42LysLys: 2.42 ± 0.049	4.211LysLeu: 4.211 ± 0.072	1.295LysMet: 1.295 ± 0.032	1.899LysAsn: 1.899 ± 0.051	2.046LysPro: 2.046 ± 0.039	1.927LysGln: 1.927 ± 0.039	2.601LysArg: 2.601 ± 0.041	2.35LysSer: 2.35 ± 0.048	2.567LysThr: 2.567 ± 0.049	2.879LysVal: 2.879 ± 0.049	0.452LysTrp: 0.452 ± 0.016	1.2LysTyr: 1.2 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	11.418LeuAla: 11.418 ± 0.13	1.338LeuCys: 1.338 ± 0.032	5.175LeuAsp: 5.175 ± 0.059	5.397LeuGlu: 5.397 ± 0.065	4.213LeuPhe: 4.213 ± 0.072	7.077LeuGly: 7.077 ± 0.081	2.215LeuHis: 2.215 ± 0.042	5.814LeuIle: 5.814 ± 0.078	4.548LeuLys: 4.548 ± 0.066	11.826LeuLeu: 11.826 ± 0.15	2.91LeuMet: 2.91 ± 0.047	4.379LeuAsn: 4.379 ± 0.06	5.647LeuPro: 5.647 ± 0.08	3.952LeuGln: 3.952 ± 0.056	6.25LeuArg: 6.25 ± 0.077	7.422LeuSer: 7.422 ± 0.084	6.541LeuThr: 6.541 ± 0.083	6.776LeuVal: 6.776 ± 0.081	1.467LeuTrp: 1.467 ± 0.036	2.646LeuTyr: 2.646 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.919MetAla: 2.919 ± 0.044	0.215MetCys: 0.215 ± 0.012	1.16MetAsp: 1.16 ± 0.025	1.255MetGlu: 1.255 ± 0.032	0.879MetPhe: 0.879 ± 0.026	1.883MetGly: 1.883 ± 0.038	0.494MetHis: 0.494 ± 0.017	1.483MetIle: 1.483 ± 0.033	1.423MetLys: 1.423 ± 0.034	3.132MetLeu: 3.132 ± 0.051	0.911MetMet: 0.911 ± 0.028	1.133MetAsn: 1.133 ± 0.029	1.325MetPro: 1.325 ± 0.031	1.219MetGln: 1.219 ± 0.029	1.474MetArg: 1.474 ± 0.026	1.851MetSer: 1.851 ± 0.037	1.78MetThr: 1.78 ± 0.034	1.881MetVal: 1.881 ± 0.037	0.265MetTrp: 0.265 ± 0.014	0.535MetTyr: 0.535 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.73AsnAla: 3.73 ± 0.067	0.341AsnCys: 0.341 ± 0.015	2.013AsnAsp: 2.013 ± 0.036	1.984AsnGlu: 1.984 ± 0.041	1.374AsnPhe: 1.374 ± 0.032	3.287AsnGly: 3.287 ± 0.067	0.848AsnHis: 0.848 ± 0.025	2.458AsnIle: 2.458 ± 0.043	1.66AsnLys: 1.66 ± 0.043	3.456AsnLeu: 3.456 ± 0.049	0.914AsnMet: 0.914 ± 0.028	1.746AsnAsn: 1.746 ± 0.044	2.087AsnPro: 2.087 ± 0.036	1.522AsnGln: 1.522 ± 0.037	2.058AsnArg: 2.058 ± 0.042	2.212AsnSer: 2.212 ± 0.061	2.038AsnThr: 2.038 ± 0.047	2.725AsnVal: 2.725 ± 0.048	0.571AsnTrp: 0.571 ± 0.019	1.195AsnTyr: 1.195 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.608ProAla: 4.608 ± 0.067	0.395ProCys: 0.395 ± 0.015	2.843ProAsp: 2.843 ± 0.046	3.402ProGlu: 3.402 ± 0.052	1.819ProPhe: 1.819 ± 0.035	3.526ProGly: 3.526 ± 0.053	0.998ProHis: 0.998 ± 0.025	1.667ProIle: 1.667 ± 0.032	1.421ProLys: 1.421 ± 0.033	5.101ProLeu: 5.101 ± 0.066	1.04ProMet: 1.04 ± 0.026	1.125ProAsn: 1.125 ± 0.028	1.697ProPro: 1.697 ± 0.043	2.349ProGln: 2.349 ± 0.04	2.022ProArg: 2.022 ± 0.044	2.096ProSer: 2.096 ± 0.04	2.079ProThr: 2.079 ± 0.04	4.155ProVal: 4.155 ± 0.055	0.758ProTrp: 0.758 ± 0.023	1.186ProTyr: 1.186 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.636GlnAla: 4.636 ± 0.071	0.395GlnCys: 0.395 ± 0.017	1.778GlnAsp: 1.778 ± 0.033	2.26GlnGlu: 2.26 ± 0.044	1.435GlnPhe: 1.435 ± 0.028	2.96GlnGly: 2.96 ± 0.049	1.159GlnHis: 1.159 ± 0.03	2.226GlnIle: 2.226 ± 0.04	1.839GlnLys: 1.839 ± 0.036	4.843GlnLeu: 4.843 ± 0.062	1.16GlnMet: 1.16 ± 0.03	1.493GlnAsn: 1.493 ± 0.037	2.189GlnPro: 2.189 ± 0.047	3.157GlnGln: 3.157 ± 0.059	3.029GlnArg: 3.029 ± 0.055	2.31GlnSer: 2.31 ± 0.042	2.232GlnThr: 2.232 ± 0.043	2.759GlnVal: 2.759 ± 0.044	0.682GlnTrp: 0.682 ± 0.022	1.21GlnTyr: 1.21 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	4.715ArgAla: 4.715 ± 0.059	0.627ArgCys: 0.627 ± 0.022	3.062ArgAsp: 3.062 ± 0.045	3.86ArgGlu: 3.86 ± 0.056	2.601ArgPhe: 2.601 ± 0.045	3.502ArgGly: 3.502 ± 0.059	1.612ArgHis: 1.612 ± 0.039	3.505ArgIle: 3.505 ± 0.055	2.494ArgLys: 2.494 ± 0.039	6.549ArgLeu: 6.549 ± 0.081	1.584ArgMet: 1.584 ± 0.033	2.144ArgAsn: 2.144 ± 0.043	2.281ArgPro: 2.281 ± 0.037	3.222ArgGln: 3.222 ± 0.052	3.709ArgArg: 3.709 ± 0.066	2.862ArgSer: 2.862 ± 0.045	2.557ArgThr: 2.557 ± 0.04	3.818ArgVal: 3.818 ± 0.049	1.022ArgTrp: 1.022 ± 0.025	2.215ArgTyr: 2.215 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.966SerAla: 5.966 ± 0.07	0.626SerCys: 0.626 ± 0.021	3.14SerAsp: 3.14 ± 0.046	3.226SerGlu: 3.226 ± 0.053	2.272SerPhe: 2.272 ± 0.042	5.49SerGly: 5.49 ± 0.091	1.357SerHis: 1.357 ± 0.03	2.982SerIle: 2.982 ± 0.053	2.037SerLys: 2.037 ± 0.042	6.791SerLeu: 6.791 ± 0.084	1.48SerMet: 1.48 ± 0.032	1.83SerAsn: 1.83 ± 0.045	2.639SerPro: 2.639 ± 0.041	2.571SerGln: 2.571 ± 0.041	3.666SerArg: 3.666 ± 0.056	3.56SerSer: 3.56 ± 0.064	2.934SerThr: 2.934 ± 0.056	4.47SerVal: 4.47 ± 0.054	0.971SerTrp: 0.971 ± 0.028	1.625SerTyr: 1.625 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.126ThrAla: 5.126 ± 0.088	0.531ThrCys: 0.531 ± 0.018	2.713ThrAsp: 2.713 ± 0.048	2.648ThrGlu: 2.648 ± 0.041	2.132ThrPhe: 2.132 ± 0.045	4.721ThrGly: 4.721 ± 0.077	1.232ThrHis: 1.232 ± 0.031	2.988ThrIle: 2.988 ± 0.062	1.484ThrLys: 1.484 ± 0.032	7.437ThrLeu: 7.437 ± 0.082	1.134ThrMet: 1.134 ± 0.026	1.571ThrAsn: 1.571 ± 0.042	3.327ThrPro: 3.327 ± 0.063	2.148ThrGln: 2.148 ± 0.041	3.148ThrArg: 3.148 ± 0.044	2.934ThrSer: 2.934 ± 0.052	2.974ThrThr: 2.974 ± 0.068	4.077ThrVal: 4.077 ± 0.079	0.804ThrTrp: 0.804 ± 0.022	1.155ThrTyr: 1.155 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	7.131ValAla: 7.131 ± 0.084	0.801ValCys: 0.801 ± 0.023	3.726ValAsp: 3.726 ± 0.058	3.895ValGlu: 3.895 ± 0.056	2.514ValPhe: 2.514 ± 0.046	4.815ValGly: 4.815 ± 0.065	1.23ValHis: 1.23 ± 0.03	4.584ValIle: 4.584 ± 0.066	3.111ValLys: 3.111 ± 0.057	7.059ValLeu: 7.059 ± 0.088	2.206ValMet: 2.206 ± 0.041	2.918ValAsn: 2.918 ± 0.048	3.006ValPro: 3.006 ± 0.049	2.355ValGln: 2.355 ± 0.04	3.758ValArg: 3.758 ± 0.056	4.549ValSer: 4.549 ± 0.06	4.376ValThr: 4.376 ± 0.077	5.483ValVal: 5.483 ± 0.072	0.988ValTrp: 0.988 ± 0.026	1.763ValTyr: 1.763 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.982TrpAla: 0.982 ± 0.024	0.201TrpCys: 0.201 ± 0.012	0.629TrpAsp: 0.629 ± 0.024	0.605TrpGlu: 0.605 ± 0.02	0.697TrpPhe: 0.697 ± 0.022	0.957TrpGly: 0.957 ± 0.026	0.443TrpHis: 0.443 ± 0.016	0.751TrpIle: 0.751 ± 0.023	0.556TrpLys: 0.556 ± 0.02	2.359TrpLeu: 2.359 ± 0.039	0.452TrpMet: 0.452 ± 0.02	0.502TrpAsn: 0.502 ± 0.018	0.657TrpPro: 0.657 ± 0.024	1.166TrpGln: 1.166 ± 0.03	1.169TrpArg: 1.169 ± 0.032	0.844TrpSer: 0.844 ± 0.026	0.617TrpThr: 0.617 ± 0.022	0.911TrpVal: 0.911 ± 0.023	0.24TrpTrp: 0.24 ± 0.012	0.448TrpTyr: 0.448 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.544TyrAla: 2.544 ± 0.04	0.397TyrCys: 0.397 ± 0.016	1.6TyrAsp: 1.6 ± 0.035	1.265TyrGlu: 1.265 ± 0.03	1.185TyrPhe: 1.185 ± 0.029	2.269TyrGly: 2.269 ± 0.047	0.701TyrHis: 0.701 ± 0.023	1.483TyrIle: 1.483 ± 0.035	1.002TyrLys: 1.002 ± 0.031	3.018TyrLeu: 3.018 ± 0.051	0.577TyrMet: 0.577 ± 0.023	1.097TyrAsn: 1.097 ± 0.033	1.331TyrPro: 1.331 ± 0.033	1.535TyrGln: 1.535 ± 0.037	1.879TyrArg: 1.879 ± 0.035	1.789TyrSer: 1.789 ± 0.035	1.472TyrThr: 1.472 ± 0.036	1.683TyrVal: 1.683 ± 0.038	0.458TyrTrp: 0.458 ± 0.017	0.966TyrTyr: 0.966 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4792 proteins (1494618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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