Amino acid dipepetide frequency for Chryseolinea flava

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.913AlaAla: 5.913 ± 0.067
0.722AlaCys: 0.722 ± 0.021
4.034AlaAsp: 4.034 ± 0.042
4.176AlaGlu: 4.176 ± 0.058
3.579AlaPhe: 3.579 ± 0.046
5.376AlaGly: 5.376 ± 0.069
1.325AlaHis: 1.325 ± 0.029
5.305AlaIle: 5.305 ± 0.059
4.471AlaLys: 4.471 ± 0.07
7.167AlaLeu: 7.167 ± 0.066
1.859AlaMet: 1.859 ± 0.034
3.53AlaAsn: 3.53 ± 0.051
2.391AlaPro: 2.391 ± 0.042
2.923AlaGln: 2.923 ± 0.039
2.938AlaArg: 2.938 ± 0.035
5.094AlaSer: 5.094 ± 0.058
4.704AlaThr: 4.704 ± 0.077
4.934AlaVal: 4.934 ± 0.049
0.918AlaTrp: 0.918 ± 0.023
2.788AlaTyr: 2.788 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
0.578CysAla: 0.578 ± 0.018
0.121CysCys: 0.121 ± 0.008
0.414CysAsp: 0.414 ± 0.017
0.41CysGlu: 0.41 ± 0.014
0.406CysPhe: 0.406 ± 0.015
0.586CysGly: 0.586 ± 0.016
0.179CysHis: 0.179 ± 0.01
0.558CysIle: 0.558 ± 0.019
0.424CysLys: 0.424 ± 0.016
0.681CysLeu: 0.681 ± 0.02
0.177CysMet: 0.177 ± 0.011
0.335CysAsn: 0.335 ± 0.015
0.32CysPro: 0.32 ± 0.015
0.222CysGln: 0.222 ± 0.012
0.297CysArg: 0.297 ± 0.013
0.581CysSer: 0.581 ± 0.018
0.426CysThr: 0.426 ± 0.017
0.48CysVal: 0.48 ± 0.017
0.099CysTrp: 0.099 ± 0.007
0.292CysTyr: 0.292 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
4.313AspAla: 4.313 ± 0.053
0.349AspCys: 0.349 ± 0.018
3.201AspAsp: 3.201 ± 0.05
3.576AspGlu: 3.576 ± 0.049
3.193AspPhe: 3.193 ± 0.044
4.204AspGly: 4.204 ± 0.059
1.247AspHis: 1.247 ± 0.025
3.75AspIle: 3.75 ± 0.045
3.511AspLys: 3.511 ± 0.044
5.161AspLeu: 5.161 ± 0.061
1.079AspMet: 1.079 ± 0.023
2.723AspAsn: 2.723 ± 0.044
2.324AspPro: 2.324 ± 0.034
2.045AspGln: 2.045 ± 0.036
2.473AspArg: 2.473 ± 0.038
3.027AspSer: 3.027 ± 0.045
2.47AspThr: 2.47 ± 0.047
4.002AspVal: 4.002 ± 0.052
0.739AspTrp: 0.739 ± 0.018
2.37AspTyr: 2.37 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
4.315GluAla: 4.315 ± 0.054
0.336GluCys: 0.336 ± 0.012
2.964GluAsp: 2.964 ± 0.045
3.876GluGlu: 3.876 ± 0.051
2.699GluPhe: 2.699 ± 0.044
3.6GluGly: 3.6 ± 0.048
1.222GluHis: 1.222 ± 0.024
4.502GluIle: 4.502 ± 0.047
4.899GluLys: 4.899 ± 0.055
5.341GluLeu: 5.341 ± 0.061
1.5GluMet: 1.5 ± 0.028
3.164GluAsn: 3.164 ± 0.038
1.601GluPro: 1.601 ± 0.029
2.26GluGln: 2.26 ± 0.042
2.885GluArg: 2.885 ± 0.039
3.348GluSer: 3.348 ± 0.036
3.036GluThr: 3.036 ± 0.04
3.986GluVal: 3.986 ± 0.056
0.701GluTrp: 0.701 ± 0.021
2.113GluTyr: 2.113 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.364PheAla: 3.364 ± 0.04
0.447PheCys: 0.447 ± 0.017
3.245PheAsp: 3.245 ± 0.047
2.931PheGlu: 2.931 ± 0.038
2.59PhePhe: 2.59 ± 0.044
3.418PheGly: 3.418 ± 0.046
1.038PheHis: 1.038 ± 0.024
3.379PheIle: 3.379 ± 0.051
3.134PheLys: 3.134 ± 0.042
4.479PheLeu: 4.479 ± 0.067
1.112PheMet: 1.112 ± 0.025
2.879PheAsn: 2.879 ± 0.045
1.729PhePro: 1.729 ± 0.028
1.777PheGln: 1.777 ± 0.033
2.048PheArg: 2.048 ± 0.038
3.769PheSer: 3.769 ± 0.048
3.226PheThr: 3.226 ± 0.046
3.367PheVal: 3.367 ± 0.043
0.6PheTrp: 0.6 ± 0.018
2.045PheTyr: 2.045 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
4.747GlyAla: 4.747 ± 0.068
0.582GlyCys: 0.582 ± 0.025
3.583GlyAsp: 3.583 ± 0.046
3.692GlyGlu: 3.692 ± 0.05
3.53GlyPhe: 3.53 ± 0.05
4.94GlyGly: 4.94 ± 0.082
1.225GlyHis: 1.225 ± 0.029
4.946GlyIle: 4.946 ± 0.049
5.039GlyLys: 5.039 ± 0.058
5.783GlyLeu: 5.783 ± 0.07
1.62GlyMet: 1.62 ± 0.029
3.606GlyAsn: 3.606 ± 0.057
1.663GlyPro: 1.663 ± 0.032
2.201GlyGln: 2.201 ± 0.036
2.591GlyArg: 2.591 ± 0.037
4.32GlySer: 4.32 ± 0.079
4.579GlyThr: 4.579 ± 0.096
4.857GlyVal: 4.857 ± 0.066
0.985GlyTrp: 0.985 ± 0.024
2.89GlyTyr: 2.89 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
1.539HisAla: 1.539 ± 0.032
0.185HisCys: 0.185 ± 0.009
1.163HisAsp: 1.163 ± 0.024
1.27HisGlu: 1.27 ± 0.027
1.229HisPhe: 1.229 ± 0.027
1.419HisGly: 1.419 ± 0.031
0.663HisHis: 0.663 ± 0.021
1.186HisIle: 1.186 ± 0.026
0.955HisLys: 0.955 ± 0.022
1.816HisLeu: 1.816 ± 0.032
0.391HisMet: 0.391 ± 0.015
0.925HisAsn: 0.925 ± 0.022
1.053HisPro: 1.053 ± 0.025
0.88HisGln: 0.88 ± 0.021
0.989HisArg: 0.989 ± 0.024
1.063HisSer: 1.063 ± 0.024
1.039HisThr: 1.039 ± 0.025
1.299HisVal: 1.299 ± 0.029
0.314HisTrp: 0.314 ± 0.013
0.961HisTyr: 0.961 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.804IleAla: 5.804 ± 0.06
0.607IleCys: 0.607 ± 0.021
4.379IleAsp: 4.379 ± 0.046
4.316IleGlu: 4.316 ± 0.05
3.382IlePhe: 3.382 ± 0.053
4.706IleGly: 4.706 ± 0.06
1.45IleHis: 1.45 ± 0.029
4.59IleIle: 4.59 ± 0.058
4.281IleLys: 4.281 ± 0.053
5.968IleLeu: 5.968 ± 0.07
1.329IleMet: 1.329 ± 0.027
3.566IleAsn: 3.566 ± 0.049
2.916IlePro: 2.916 ± 0.039
2.511IleGln: 2.511 ± 0.04
3.105IleArg: 3.105 ± 0.043
4.839IleSer: 4.839 ± 0.042
4.688IleThr: 4.688 ± 0.061
4.946IleVal: 4.946 ± 0.059
0.664IleTrp: 0.664 ± 0.021
2.358IleTyr: 2.358 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
4.611LysAla: 4.611 ± 0.062
0.319LysCys: 0.319 ± 0.013
3.789LysAsp: 3.789 ± 0.047
4.342LysGlu: 4.342 ± 0.058
2.868LysPhe: 2.868 ± 0.039
4.024LysGly: 4.024 ± 0.052
1.329LysHis: 1.329 ± 0.026
4.974LysIle: 4.974 ± 0.055
5.155LysLys: 5.155 ± 0.072
5.952LysLeu: 5.952 ± 0.057
1.739LysMet: 1.739 ± 0.031
3.699LysAsn: 3.699 ± 0.044
2.389LysPro: 2.389 ± 0.036
2.429LysGln: 2.429 ± 0.039
3.026LysArg: 3.026 ± 0.044
4.168LysSer: 4.168 ± 0.054
3.777LysThr: 3.777 ± 0.053
4.567LysVal: 4.567 ± 0.052
0.672LysTrp: 0.672 ± 0.019
2.348LysTyr: 2.348 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
6.659LeuAla: 6.659 ± 0.072
0.742LeuCys: 0.742 ± 0.019
4.815LeuAsp: 4.815 ± 0.05
5.05LeuGlu: 5.05 ± 0.051
4.359LeuPhe: 4.359 ± 0.062
5.611LeuGly: 5.611 ± 0.053
1.895LeuHis: 1.895 ± 0.034
6.296LeuIle: 6.296 ± 0.083
6.524LeuLys: 6.524 ± 0.068
8.619LeuLeu: 8.619 ± 0.1
2.15LeuMet: 2.15 ± 0.037
4.831LeuAsn: 4.831 ± 0.06
3.769LeuPro: 3.769 ± 0.047
3.583LeuGln: 3.583 ± 0.048
4.238LeuArg: 4.238 ± 0.049
6.823LeuSer: 6.823 ± 0.064
5.639LeuThr: 5.639 ± 0.062
5.654LeuVal: 5.654 ± 0.058
1.027LeuTrp: 1.027 ± 0.029
3.118LeuTyr: 3.118 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
1.71MetAla: 1.71 ± 0.032
0.147MetCys: 0.147 ± 0.01
1.077MetAsp: 1.077 ± 0.024
1.318MetGlu: 1.318 ± 0.028
0.936MetPhe: 0.936 ± 0.02
1.347MetGly: 1.347 ± 0.025
0.443MetHis: 0.443 ± 0.015
1.697MetIle: 1.697 ± 0.034
2.104MetLys: 2.104 ± 0.033
2.148MetLeu: 2.148 ± 0.037
0.687MetMet: 0.687 ± 0.022
1.296MetAsn: 1.296 ± 0.026
0.944MetPro: 0.944 ± 0.022
0.819MetGln: 0.819 ± 0.02
1.173MetArg: 1.173 ± 0.023
1.452MetSer: 1.452 ± 0.028
1.293MetThr: 1.293 ± 0.03
1.401MetVal: 1.401 ± 0.029
0.199MetTrp: 0.199 ± 0.011
0.684MetTyr: 0.684 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
4.077AsnAla: 4.077 ± 0.047
0.342AsnCys: 0.342 ± 0.015
2.9AsnAsp: 2.9 ± 0.059
2.911AsnGlu: 2.911 ± 0.045
2.713AsnPhe: 2.713 ± 0.038
3.999AsnGly: 3.999 ± 0.067
1.023AsnHis: 1.023 ± 0.024
3.697AsnIle: 3.697 ± 0.053
2.918AsnLys: 2.918 ± 0.039
4.677AsnLeu: 4.677 ± 0.058
1.027AsnMet: 1.027 ± 0.024
2.809AsnAsn: 2.809 ± 0.047
2.438AsnPro: 2.438 ± 0.041
1.78AsnGln: 1.78 ± 0.038
2.267AsnArg: 2.267 ± 0.038
2.908AsnSer: 2.908 ± 0.045
3.171AsnThr: 3.171 ± 0.055
3.678AsnVal: 3.678 ± 0.048
0.627AsnTrp: 0.627 ± 0.02
2.224AsnTyr: 2.224 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
2.874ProAla: 2.874 ± 0.051
0.209ProCys: 0.209 ± 0.011
2.278ProAsp: 2.278 ± 0.035
2.573ProGlu: 2.573 ± 0.034
1.931ProPhe: 1.931 ± 0.034
2.619ProGly: 2.619 ± 0.047
0.723ProHis: 0.723 ± 0.022
2.438ProIle: 2.438 ± 0.036
2.055ProLys: 2.055 ± 0.032
3.212ProLeu: 3.212 ± 0.04
0.872ProMet: 0.872 ± 0.022
1.881ProAsn: 1.881 ± 0.036
1.147ProPro: 1.147 ± 0.03
1.277ProGln: 1.277 ± 0.026
1.299ProArg: 1.299 ± 0.029
2.557ProSer: 2.557 ± 0.039
2.338ProThr: 2.338 ± 0.038
2.95ProVal: 2.95 ± 0.046
0.468ProTrp: 0.468 ± 0.016
1.398ProTyr: 1.398 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
2.547GlnAla: 2.547 ± 0.04
0.234GlnCys: 0.234 ± 0.012
1.773GlnAsp: 1.773 ± 0.031
2.22GlnGlu: 2.22 ± 0.037
1.773GlnPhe: 1.773 ± 0.029
2.147GlnGly: 2.147 ± 0.034
0.91GlnHis: 0.91 ± 0.023
2.34GlnIle: 2.34 ± 0.038
2.492GlnLys: 2.492 ± 0.035
3.392GlnLeu: 3.392 ± 0.041
0.867GlnMet: 0.867 ± 0.022
1.849GlnAsn: 1.849 ± 0.032
1.301GlnPro: 1.301 ± 0.027
1.867GlnGln: 1.867 ± 0.041
1.889GlnArg: 1.889 ± 0.033
2.31GlnSer: 2.31 ± 0.036
2.023GlnThr: 2.023 ± 0.031
2.313GlnVal: 2.313 ± 0.04
0.555GlnTrp: 0.555 ± 0.019
1.569GlnTyr: 1.569 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
2.935ArgAla: 2.935 ± 0.04
0.278ArgCys: 0.278 ± 0.013
2.454ArgAsp: 2.454 ± 0.039
2.815ArgGlu: 2.815 ± 0.041
2.246ArgPhe: 2.246 ± 0.039
2.483ArgGly: 2.483 ± 0.044
0.861ArgHis: 0.861 ± 0.024
3.335ArgIle: 3.335 ± 0.046
3.218ArgLys: 3.218 ± 0.047
3.948ArgLeu: 3.948 ± 0.044
1.244ArgMet: 1.244 ± 0.026
2.342ArgAsn: 2.342 ± 0.038
1.386ArgPro: 1.386 ± 0.027
1.573ArgGln: 1.573 ± 0.033
1.901ArgArg: 1.901 ± 0.038
2.61ArgSer: 2.61 ± 0.039
2.378ArgThr: 2.378 ± 0.034
2.907ArgVal: 2.907 ± 0.042
0.635ArgTrp: 0.635 ± 0.021
1.974ArgTyr: 1.974 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
4.799SerAla: 4.799 ± 0.057
0.574SerCys: 0.574 ± 0.017
3.468SerAsp: 3.468 ± 0.049
3.373SerGlu: 3.373 ± 0.043
3.72SerPhe: 3.72 ± 0.052
4.85SerGly: 4.85 ± 0.075
1.256SerHis: 1.256 ± 0.025
4.901SerIle: 4.901 ± 0.059
3.91SerLys: 3.91 ± 0.044
6.45SerLeu: 6.45 ± 0.071
1.436SerMet: 1.436 ± 0.028
3.23SerAsn: 3.23 ± 0.05
2.556SerPro: 2.556 ± 0.043
2.113SerGln: 2.113 ± 0.035
2.682SerArg: 2.682 ± 0.038
4.528SerSer: 4.528 ± 0.06
3.978SerThr: 3.978 ± 0.064
4.4SerVal: 4.4 ± 0.051
0.833SerTrp: 0.833 ± 0.021
2.568SerTyr: 2.568 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
4.568ThrAla: 4.568 ± 0.064
0.418ThrCys: 0.418 ± 0.014
3.226ThrAsp: 3.226 ± 0.046
2.979ThrGlu: 2.979 ± 0.045
3.227ThrPhe: 3.227 ± 0.043
4.444ThrGly: 4.444 ± 0.078
1.118ThrHis: 1.118 ± 0.025
4.556ThrIle: 4.556 ± 0.057
3.403ThrLys: 3.403 ± 0.043
5.916ThrLeu: 5.916 ± 0.061
1.146ThrMet: 1.146 ± 0.024
2.897ThrAsn: 2.897 ± 0.054
2.789ThrPro: 2.789 ± 0.049
1.966ThrGln: 1.966 ± 0.028
2.283ThrArg: 2.283 ± 0.038
4.06ThrSer: 4.06 ± 0.056
4.186ThrThr: 4.186 ± 0.066
4.312ThrVal: 4.312 ± 0.074
0.777ThrTrp: 0.777 ± 0.024
2.304ThrTyr: 2.304 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
5.22ValAla: 5.22 ± 0.057
0.534ValCys: 0.534 ± 0.017
3.987ValAsp: 3.987 ± 0.054
3.765ValGlu: 3.765 ± 0.052
3.315ValPhe: 3.315 ± 0.048
4.282ValGly: 4.282 ± 0.046
1.252ValHis: 1.252 ± 0.031
4.834ValIle: 4.834 ± 0.055
4.495ValLys: 4.495 ± 0.055
6.135ValLeu: 6.135 ± 0.059
1.599ValMet: 1.599 ± 0.031
3.757ValAsn: 3.757 ± 0.057
2.508ValPro: 2.508 ± 0.041
2.09ValGln: 2.09 ± 0.035
2.891ValArg: 2.891 ± 0.042
4.893ValSer: 4.893 ± 0.066
4.425ValThr: 4.425 ± 0.073
5.37ValVal: 5.37 ± 0.068
0.784ValTrp: 0.784 ± 0.021
2.417ValTyr: 2.417 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
0.77TrpAla: 0.77 ± 0.02
0.111TrpCys: 0.111 ± 0.007
0.672TrpAsp: 0.672 ± 0.019
0.668TrpGlu: 0.668 ± 0.019
0.619TrpPhe: 0.619 ± 0.018
0.778TrpGly: 0.778 ± 0.022
0.267TrpHis: 0.267 ± 0.012
0.937TrpIle: 0.937 ± 0.028
0.881TrpLys: 0.881 ± 0.024
1.091TrpLeu: 1.091 ± 0.026
0.337TrpMet: 0.337 ± 0.015
0.759TrpAsn: 0.759 ± 0.024
0.355TrpPro: 0.355 ± 0.014
0.47TrpGln: 0.47 ± 0.016
0.599TrpArg: 0.599 ± 0.02
0.83TrpSer: 0.83 ± 0.022
0.791TrpThr: 0.791 ± 0.023
0.731TrpVal: 0.731 ± 0.022
0.199TrpTrp: 0.199 ± 0.011
0.475TrpTyr: 0.475 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.799TyrAla: 2.799 ± 0.043
0.33TyrCys: 0.33 ± 0.012
2.334TyrAsp: 2.334 ± 0.041
2.088TyrGlu: 2.088 ± 0.033
2.26TyrPhe: 2.26 ± 0.039
2.549TyrGly: 2.549 ± 0.044
0.917TyrHis: 0.917 ± 0.022
2.183TyrIle: 2.183 ± 0.033
2.307TyrLys: 2.307 ± 0.035
3.464TyrLeu: 3.464 ± 0.046
0.705TyrMet: 0.705 ± 0.021
2.107TyrAsn: 2.107 ± 0.037
1.521TyrPro: 1.521 ± 0.03
1.586TyrGln: 1.586 ± 0.034
1.948TyrArg: 1.948 ± 0.034
2.446TyrSer: 2.446 ± 0.043
2.408TyrThr: 2.408 ± 0.046
2.397TyrVal: 2.397 ± 0.034
0.546TyrTrp: 0.546 ± 0.017
1.838TyrTyr: 1.838 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5446 proteins (1947148 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski