Amino acid dipepetide frequency for Halorhodospira halochloris (Ectothiorhodospira halochloris)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.939AlaAla: 12.939 ± 0.193	1.042AlaCys: 1.042 ± 0.04	6.357AlaAsp: 6.357 ± 0.082	8.782AlaGlu: 8.782 ± 0.13	3.095AlaPhe: 3.095 ± 0.062	8.533AlaGly: 8.533 ± 0.12	2.158AlaHis: 2.158 ± 0.049	5.347AlaIle: 5.347 ± 0.094	3.019AlaLys: 3.019 ± 0.068	11.32AlaLeu: 11.32 ± 0.14	2.439AlaMet: 2.439 ± 0.064	2.85AlaAsn: 2.85 ± 0.074	3.853AlaPro: 3.853 ± 0.08	4.689AlaGln: 4.689 ± 0.083	7.041AlaArg: 7.041 ± 0.104	5.245AlaSer: 5.245 ± 0.082	4.662AlaThr: 4.662 ± 0.089	7.45AlaVal: 7.45 ± 0.101	1.481AlaTrp: 1.481 ± 0.042	2.494AlaTyr: 2.494 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.967CysAla: 0.967 ± 0.036	0.136CysCys: 0.136 ± 0.013	0.553CysAsp: 0.553 ± 0.029	0.624CysGlu: 0.624 ± 0.035	0.303CysPhe: 0.303 ± 0.018	0.943CysGly: 0.943 ± 0.037	0.337CysHis: 0.337 ± 0.028	0.41CysIle: 0.41 ± 0.027	0.256CysLys: 0.256 ± 0.016	0.872CysLeu: 0.872 ± 0.03	0.183CysMet: 0.183 ± 0.014	0.272CysAsn: 0.272 ± 0.017	0.58CysPro: 0.58 ± 0.03	0.412CysGln: 0.412 ± 0.023	0.766CysArg: 0.766 ± 0.031	0.622CysSer: 0.622 ± 0.032	0.478CysThr: 0.478 ± 0.026	0.581CysVal: 0.581 ± 0.028	0.123CysTrp: 0.123 ± 0.013	0.285CysTyr: 0.285 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.33AspAla: 5.33 ± 0.093	0.569AspCys: 0.569 ± 0.029	3.912AspAsp: 3.912 ± 0.107	4.966AspGlu: 4.966 ± 0.092	2.196AspPhe: 2.196 ± 0.057	4.919AspGly: 4.919 ± 0.092	1.337AspHis: 1.337 ± 0.043	3.239AspIle: 3.239 ± 0.071	1.822AspLys: 1.822 ± 0.054	6.301AspLeu: 6.301 ± 0.093	1.231AspMet: 1.231 ± 0.04	1.794AspAsn: 1.794 ± 0.05	3.489AspPro: 3.489 ± 0.069	2.397AspGln: 2.397 ± 0.058	3.937AspArg: 3.937 ± 0.074	3.551AspSer: 3.551 ± 0.075	2.466AspThr: 2.466 ± 0.063	3.632AspVal: 3.632 ± 0.072	1.126AspTrp: 1.126 ± 0.043	1.938AspTyr: 1.938 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	7.472GluAla: 7.472 ± 0.096	0.509GluCys: 0.509 ± 0.026	4.025GluAsp: 4.025 ± 0.088	5.397GluGlu: 5.397 ± 0.122	1.928GluPhe: 1.928 ± 0.05	5.216GluGly: 5.216 ± 0.096	2.17GluHis: 2.17 ± 0.05	3.748GluIle: 3.748 ± 0.069	2.225GluLys: 2.225 ± 0.051	8.537GluLeu: 8.537 ± 0.116	1.671GluMet: 1.671 ± 0.049	1.706GluAsn: 1.706 ± 0.043	3.504GluPro: 3.504 ± 0.084	5.602GluGln: 5.602 ± 0.1	7.285GluArg: 7.285 ± 0.111	3.831GluSer: 3.831 ± 0.076	3.087GluThr: 3.087 ± 0.072	5.189GluVal: 5.189 ± 0.09	0.933GluTrp: 0.933 ± 0.034	1.677GluTyr: 1.677 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.495PheAla: 3.495 ± 0.067	0.375PheCys: 0.375 ± 0.02	2.368PheAsp: 2.368 ± 0.056	2.309PheGlu: 2.309 ± 0.058	1.329PhePhe: 1.329 ± 0.047	2.822PheGly: 2.822 ± 0.064	0.771PheHis: 0.771 ± 0.029	1.624PheIle: 1.624 ± 0.041	0.849PheLys: 0.849 ± 0.031	2.892PheLeu: 2.892 ± 0.064	0.758PheMet: 0.758 ± 0.03	1.034PheAsn: 1.034 ± 0.036	1.26PhePro: 1.26 ± 0.039	1.012PheGln: 1.012 ± 0.036	2.003PheArg: 2.003 ± 0.056	2.035PheSer: 2.035 ± 0.048	1.764PheThr: 1.764 ± 0.046	2.184PheVal: 2.184 ± 0.057	0.443PheTrp: 0.443 ± 0.027	0.993PheTyr: 0.993 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	7.385GlyAla: 7.385 ± 0.109	0.982GlyCys: 0.982 ± 0.034	4.627GlyAsp: 4.627 ± 0.09	6.04GlyGlu: 6.04 ± 0.089	3.051GlyPhe: 3.051 ± 0.063	6.5GlyGly: 6.5 ± 0.11	1.972GlyHis: 1.972 ± 0.051	4.251GlyIle: 4.251 ± 0.089	2.844GlyLys: 2.844 ± 0.064	8.205GlyLeu: 8.205 ± 0.099	2.008GlyMet: 2.008 ± 0.052	2.118GlyAsn: 2.118 ± 0.051	2.622GlyPro: 2.622 ± 0.061	3.264GlyGln: 3.264 ± 0.065	5.571GlyArg: 5.571 ± 0.087	5.037GlySer: 5.037 ± 0.079	3.644GlyThr: 3.644 ± 0.065	6.117GlyVal: 6.117 ± 0.104	1.22GlyTrp: 1.22 ± 0.039	2.7GlyTyr: 2.7 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	2.113HisAla: 2.113 ± 0.054	0.296HisCys: 0.296 ± 0.018	1.424HisAsp: 1.424 ± 0.043	1.634HisGlu: 1.634 ± 0.043	0.793HisPhe: 0.793 ± 0.032	2.132HisGly: 2.132 ± 0.059	0.685HisHis: 0.685 ± 0.03	1.207HisIle: 1.207 ± 0.039	0.699HisLys: 0.699 ± 0.029	2.375HisLeu: 2.375 ± 0.055	0.434HisMet: 0.434 ± 0.024	0.747HisAsn: 0.747 ± 0.036	1.557HisPro: 1.557 ± 0.05	1.005HisGln: 1.005 ± 0.036	1.786HisArg: 1.786 ± 0.044	1.423HisSer: 1.423 ± 0.037	1.092HisThr: 1.092 ± 0.039	1.376HisVal: 1.376 ± 0.046	0.427HisTrp: 0.427 ± 0.024	0.816HisTyr: 0.816 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.758IleAla: 5.758 ± 0.091	0.536IleCys: 0.536 ± 0.024	4.068IleAsp: 4.068 ± 0.082	4.321IleGlu: 4.321 ± 0.076	1.605IlePhe: 1.605 ± 0.045	4.478IleGly: 4.478 ± 0.083	1.183IleHis: 1.183 ± 0.04	2.458IleIle: 2.458 ± 0.069	1.669IleLys: 1.669 ± 0.046	4.127IleLeu: 4.127 ± 0.075	0.855IleMet: 0.855 ± 0.034	1.877IleAsn: 1.877 ± 0.045	2.342IlePro: 2.342 ± 0.059	1.512IleGln: 1.512 ± 0.038	3.344IleArg: 3.344 ± 0.065	3.178IleSer: 3.178 ± 0.069	2.821IleThr: 2.821 ± 0.06	3.141IleVal: 3.141 ± 0.074	0.592IleTrp: 0.592 ± 0.027	1.369IleTyr: 1.369 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	2.963LysAla: 2.963 ± 0.064	0.205LysCys: 0.205 ± 0.017	1.499LysAsp: 1.499 ± 0.05	2.022LysGlu: 2.022 ± 0.058	0.675LysPhe: 0.675 ± 0.032	2.132LysGly: 2.132 ± 0.064	0.659LysHis: 0.659 ± 0.029	1.407LysIle: 1.407 ± 0.042	1.049LysLys: 1.049 ± 0.043	2.908LysLeu: 2.908 ± 0.066	0.62LysMet: 0.62 ± 0.027	0.801LysAsn: 0.801 ± 0.032	1.507LysPro: 1.507 ± 0.046	1.374LysGln: 1.374 ± 0.047	2.593LysArg: 2.593 ± 0.062	1.814LysSer: 1.814 ± 0.047	1.419LysThr: 1.419 ± 0.034	2.024LysVal: 2.024 ± 0.054	0.318LysTrp: 0.318 ± 0.022	0.617LysTyr: 0.617 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.78LeuAla: 11.78 ± 0.148	0.957LeuCys: 0.957 ± 0.037	6.508LeuAsp: 6.508 ± 0.091	8.4LeuGlu: 8.4 ± 0.115	3.448LeuPhe: 3.448 ± 0.074	8.242LeuGly: 8.242 ± 0.105	2.509LeuHis: 2.509 ± 0.062	5.432LeuIle: 5.432 ± 0.088	2.805LeuLys: 2.805 ± 0.059	10.689LeuLeu: 10.689 ± 0.167	1.998LeuMet: 1.998 ± 0.049	3.051LeuAsn: 3.051 ± 0.061	5.338LeuPro: 5.338 ± 0.094	3.929LeuGln: 3.929 ± 0.077	8.03LeuArg: 8.03 ± 0.117	6.303LeuSer: 6.303 ± 0.095	4.944LeuThr: 4.944 ± 0.07	6.689LeuVal: 6.689 ± 0.102	1.213LeuTrp: 1.213 ± 0.043	2.466LeuTyr: 2.466 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.587MetAla: 2.587 ± 0.069	0.126MetCys: 0.126 ± 0.012	1.186MetAsp: 1.186 ± 0.044	1.312MetGlu: 1.312 ± 0.043	0.535MetPhe: 0.535 ± 0.028	1.626MetGly: 1.626 ± 0.048	0.496MetHis: 0.496 ± 0.023	1.077MetIle: 1.077 ± 0.041	0.568MetLys: 0.568 ± 0.028	2.456MetLeu: 2.456 ± 0.056	0.447MetMet: 0.447 ± 0.023	0.532MetAsn: 0.532 ± 0.025	1.225MetPro: 1.225 ± 0.04	0.933MetGln: 0.933 ± 0.039	1.734MetArg: 1.734 ± 0.047	1.341MetSer: 1.341 ± 0.043	1.171MetThr: 1.171 ± 0.037	1.531MetVal: 1.531 ± 0.045	0.187MetTrp: 0.187 ± 0.016	0.347MetTyr: 0.347 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.617AsnAla: 2.617 ± 0.058	0.325AsnCys: 0.325 ± 0.022	1.517AsnAsp: 1.517 ± 0.046	1.827AsnGlu: 1.827 ± 0.049	0.867AsnPhe: 0.867 ± 0.034	2.004AsnGly: 2.004 ± 0.06	0.668AsnHis: 0.668 ± 0.031	1.584AsnIle: 1.584 ± 0.045	0.893AsnLys: 0.893 ± 0.035	3.015AsnLeu: 3.015 ± 0.062	0.616AsnMet: 0.616 ± 0.03	0.884AsnAsn: 0.884 ± 0.036	1.797AsnPro: 1.797 ± 0.043	1.136AsnGln: 1.136 ± 0.034	2.126AsnArg: 2.126 ± 0.053	1.634AsnSer: 1.634 ± 0.049	1.315AsnThr: 1.315 ± 0.041	1.76AsnVal: 1.76 ± 0.051	0.434AsnTrp: 0.434 ± 0.021	0.738AsnTyr: 0.738 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.5ProAla: 4.5 ± 0.078	0.36ProCys: 0.36 ± 0.023	3.312ProAsp: 3.312 ± 0.064	4.307ProGlu: 4.307 ± 0.083	1.604ProPhe: 1.604 ± 0.052	4.088ProGly: 4.088 ± 0.073	1.12ProHis: 1.12 ± 0.035	2.123ProIle: 2.123 ± 0.048	1.192ProLys: 1.192 ± 0.046	4.599ProLeu: 4.599 ± 0.093	0.939ProMet: 0.939 ± 0.037	1.231ProAsn: 1.231 ± 0.04	2.268ProPro: 2.268 ± 0.07	2.305ProGln: 2.305 ± 0.057	2.988ProArg: 2.988 ± 0.07	2.576ProSer: 2.576 ± 0.055	2.018ProThr: 2.018 ± 0.054	3.538ProVal: 3.538 ± 0.066	0.757ProTrp: 0.757 ± 0.035	1.241ProTyr: 1.241 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	5.197GlnAla: 5.197 ± 0.084	0.31GlnCys: 0.31 ± 0.018	2.002GlnAsp: 2.002 ± 0.055	3.004GlnGlu: 3.004 ± 0.069	1.008GlnPhe: 1.008 ± 0.035	3.373GlnGly: 3.373 ± 0.064	0.994GlnHis: 0.994 ± 0.038	2.314GlnIle: 2.314 ± 0.054	1.115GlnLys: 1.115 ± 0.041	4.903GlnLeu: 4.903 ± 0.092	1.049GlnMet: 1.049 ± 0.034	0.981GlnAsn: 0.981 ± 0.035	2.223GlnPro: 2.223 ± 0.06	2.908GlnGln: 2.908 ± 0.08	4.316GlnArg: 4.316 ± 0.084	2.298GlnSer: 2.298 ± 0.057	1.749GlnThr: 1.749 ± 0.049	3.081GlnVal: 3.081 ± 0.058	0.611GlnTrp: 0.611 ± 0.025	0.851GlnTyr: 0.851 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	6.87ArgAla: 6.87 ± 0.102	0.787ArgCys: 0.787 ± 0.035	4.266ArgAsp: 4.266 ± 0.079	5.752ArgGlu: 5.752 ± 0.095	2.879ArgPhe: 2.879 ± 0.06	5.188ArgGly: 5.188 ± 0.085	2.022ArgHis: 2.022 ± 0.05	4.104ArgIle: 4.104 ± 0.081	2.031ArgLys: 2.031 ± 0.055	9.016ArgLeu: 9.016 ± 0.12	1.762ArgMet: 1.762 ± 0.046	1.964ArgAsn: 1.964 ± 0.05	3.069ArgPro: 3.069 ± 0.059	3.665ArgGln: 3.665 ± 0.076	6.072ArgArg: 6.072 ± 0.107	4.177ArgSer: 4.177 ± 0.07	2.901ArgThr: 2.901 ± 0.063	5.078ArgVal: 5.078 ± 0.076	1.135ArgTrp: 1.135 ± 0.042	2.247ArgTyr: 2.247 ± 0.058	0.0ArgXaa: 0.0 ± 0.0
Ser	6.347SerAla: 6.347 ± 0.091	0.634SerCys: 0.634 ± 0.029	3.213SerAsp: 3.213 ± 0.064	3.985SerGlu: 3.985 ± 0.066	1.948SerPhe: 1.948 ± 0.057	5.744SerGly: 5.744 ± 0.089	1.284SerHis: 1.284 ± 0.04	2.666SerIle: 2.666 ± 0.06	1.573SerLys: 1.573 ± 0.049	5.835SerLeu: 5.835 ± 0.089	1.263SerMet: 1.263 ± 0.037	1.643SerAsn: 1.643 ± 0.049	2.708SerPro: 2.708 ± 0.056	2.167SerGln: 2.167 ± 0.057	4.135SerArg: 4.135 ± 0.072	3.98SerSer: 3.98 ± 0.081	2.649SerThr: 2.649 ± 0.056	3.896SerVal: 3.896 ± 0.078	0.838SerTrp: 0.838 ± 0.033	1.534SerTyr: 1.534 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.104ThrAla: 5.104 ± 0.101	0.424ThrCys: 0.424 ± 0.025	2.716ThrAsp: 2.716 ± 0.056	2.938ThrGlu: 2.938 ± 0.058	1.466ThrPhe: 1.466 ± 0.042	4.141ThrGly: 4.141 ± 0.08	1.009ThrHis: 1.009 ± 0.033	2.386ThrIle: 2.386 ± 0.059	1.144ThrLys: 1.144 ± 0.042	5.165ThrLeu: 5.165 ± 0.088	0.851ThrMet: 0.851 ± 0.032	1.22ThrAsn: 1.22 ± 0.039	2.756ThrPro: 2.756 ± 0.061	1.661ThrGln: 1.661 ± 0.046	2.92ThrArg: 2.92 ± 0.064	2.467ThrSer: 2.467 ± 0.06	2.361ThrThr: 2.361 ± 0.056	3.446ThrVal: 3.446 ± 0.073	0.553ThrTrp: 0.553 ± 0.028	1.175ThrTyr: 1.175 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.721ValAla: 7.721 ± 0.113	0.722ValCys: 0.722 ± 0.03	4.405ValAsp: 4.405 ± 0.071	5.569ValGlu: 5.569 ± 0.093	2.246ValPhe: 2.246 ± 0.061	5.082ValGly: 5.082 ± 0.103	1.556ValHis: 1.556 ± 0.047	3.906ValIle: 3.906 ± 0.079	1.91ValLys: 1.91 ± 0.055	6.695ValLeu: 6.695 ± 0.106	1.512ValMet: 1.512 ± 0.048	1.992ValAsn: 1.992 ± 0.056	3.05ValPro: 3.05 ± 0.073	2.104ValGln: 2.104 ± 0.055	4.773ValArg: 4.773 ± 0.091	4.09ValSer: 4.09 ± 0.072	3.681ValThr: 3.681 ± 0.066	5.575ValVal: 5.575 ± 0.104	0.727ValTrp: 0.727 ± 0.027	1.716ValTyr: 1.716 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.128TrpAla: 1.128 ± 0.038	0.123TrpCys: 0.123 ± 0.013	0.641TrpAsp: 0.641 ± 0.033	0.838TrpGlu: 0.838 ± 0.034	0.388TrpPhe: 0.388 ± 0.021	0.9TrpGly: 0.9 ± 0.036	0.431TrpHis: 0.431 ± 0.027	0.774TrpIle: 0.774 ± 0.031	0.254TrpLys: 0.254 ± 0.016	1.994TrpLeu: 1.994 ± 0.06	0.275TrpMet: 0.275 ± 0.019	0.311TrpAsn: 0.311 ± 0.02	0.613TrpPro: 0.613 ± 0.032	0.999TrpGln: 0.999 ± 0.041	1.252TrpArg: 1.252 ± 0.04	0.746TrpSer: 0.746 ± 0.028	0.456TrpThr: 0.456 ± 0.025	1.08TrpVal: 1.08 ± 0.037	0.227TrpTrp: 0.227 ± 0.018	0.349TrpTyr: 0.349 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.522TyrAla: 2.522 ± 0.057	0.286TyrCys: 0.286 ± 0.019	1.553TyrAsp: 1.553 ± 0.036	1.684TyrGlu: 1.684 ± 0.047	0.96TyrPhe: 0.96 ± 0.034	2.096TyrGly: 2.096 ± 0.058	0.658TyrHis: 0.658 ± 0.032	1.179TyrIle: 1.179 ± 0.037	0.688TyrLys: 0.688 ± 0.027	2.827TyrLeu: 2.827 ± 0.056	0.504TyrMet: 0.504 ± 0.026	0.746TyrAsn: 0.746 ± 0.032	1.304TyrPro: 1.304 ± 0.038	1.214TyrGln: 1.214 ± 0.041	2.311TyrArg: 2.311 ± 0.056	1.693TyrSer: 1.693 ± 0.048	1.23TyrThr: 1.23 ± 0.043	1.661TyrVal: 1.661 ± 0.045	0.436TyrTrp: 0.436 ± 0.026	0.743TyrTyr: 0.743 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2566 proteins (818812 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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