Amino acid dipepetide frequency for Lysobacter lycopersici

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.712AlaAla: 17.712 ± 0.227
1.437AlaCys: 1.437 ± 0.047
7.64AlaAsp: 7.64 ± 0.109
7.027AlaGlu: 7.027 ± 0.114
4.61AlaPhe: 4.61 ± 0.076
11.095AlaGly: 11.095 ± 0.141
2.669AlaHis: 2.669 ± 0.062
6.032AlaIle: 6.032 ± 0.087
4.633AlaLys: 4.633 ± 0.096
15.538AlaLeu: 15.538 ± 0.192
3.788AlaMet: 3.788 ± 0.066
3.554AlaAsn: 3.554 ± 0.075
6.156AlaPro: 6.156 ± 0.117
5.069AlaGln: 5.069 ± 0.086
9.86AlaArg: 9.86 ± 0.127
6.808AlaSer: 6.808 ± 0.102
6.568AlaThr: 6.568 ± 0.101
8.192AlaVal: 8.192 ± 0.117
2.329AlaTrp: 2.329 ± 0.068
2.579AlaTyr: 2.579 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
1.123CysAla: 1.123 ± 0.039
0.122CysCys: 0.122 ± 0.013
0.495CysAsp: 0.495 ± 0.028
0.522CysGlu: 0.522 ± 0.026
0.28CysPhe: 0.28 ± 0.018
0.964CysGly: 0.964 ± 0.036
0.211CysHis: 0.211 ± 0.017
0.391CysIle: 0.391 ± 0.024
0.258CysLys: 0.258 ± 0.019
0.773CysLeu: 0.773 ± 0.034
0.17CysMet: 0.17 ± 0.014
0.25CysAsn: 0.25 ± 0.015
0.425CysPro: 0.425 ± 0.026
0.24CysGln: 0.24 ± 0.018
0.601CysArg: 0.601 ± 0.032
0.49CysSer: 0.49 ± 0.025
0.536CysThr: 0.536 ± 0.028
0.702CysVal: 0.702 ± 0.03
0.131CysTrp: 0.131 ± 0.012
0.198CysTyr: 0.198 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
10.379AspAla: 10.379 ± 0.129
0.493AspCys: 0.493 ± 0.024
3.92AspAsp: 3.92 ± 0.071
3.569AspGlu: 3.569 ± 0.083
2.284AspPhe: 2.284 ± 0.059
6.327AspGly: 6.327 ± 0.098
1.169AspHis: 1.169 ± 0.037
2.596AspIle: 2.596 ± 0.051
1.979AspLys: 1.979 ± 0.063
5.469AspLeu: 5.469 ± 0.091
1.237AspMet: 1.237 ± 0.041
1.404AspAsn: 1.404 ± 0.04
3.802AspPro: 3.802 ± 0.075
1.445AspGln: 1.445 ± 0.046
3.981AspArg: 3.981 ± 0.075
2.627AspSer: 2.627 ± 0.06
2.571AspThr: 2.571 ± 0.058
4.411AspVal: 4.411 ± 0.079
1.126AspTrp: 1.126 ± 0.045
1.711AspTyr: 1.711 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
7.265GluAla: 7.265 ± 0.122
0.435GluCys: 0.435 ± 0.023
2.548GluAsp: 2.548 ± 0.068
2.321GluGlu: 2.321 ± 0.077
1.885GluPhe: 1.885 ± 0.05
3.954GluGly: 3.954 ± 0.068
1.451GluHis: 1.451 ± 0.052
2.552GluIle: 2.552 ± 0.059
1.655GluLys: 1.655 ± 0.059
6.079GluLeu: 6.079 ± 0.112
1.087GluMet: 1.087 ± 0.041
1.27GluAsn: 1.27 ± 0.038
2.426GluPro: 2.426 ± 0.064
2.269GluGln: 2.269 ± 0.057
5.435GluArg: 5.435 ± 0.097
2.789GluSer: 2.789 ± 0.066
2.755GluThr: 2.755 ± 0.064
3.758GluVal: 3.758 ± 0.08
0.767GluTrp: 0.767 ± 0.032
1.196GluTyr: 1.196 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
5.12PheAla: 5.12 ± 0.099
0.362PheCys: 0.362 ± 0.022
3.042PheAsp: 3.042 ± 0.073
2.049PheGlu: 2.049 ± 0.058
1.244PhePhe: 1.244 ± 0.044
3.55PheGly: 3.55 ± 0.074
0.761PheHis: 0.761 ± 0.026
1.184PheIle: 1.184 ± 0.037
0.939PheLys: 0.939 ± 0.033
3.162PheLeu: 3.162 ± 0.061
0.618PheMet: 0.618 ± 0.03
0.993PheAsn: 0.993 ± 0.035
1.549PhePro: 1.549 ± 0.044
0.876PheGln: 0.876 ± 0.033
2.279PheArg: 2.279 ± 0.05
1.868PheSer: 1.868 ± 0.047
1.553PheThr: 1.553 ± 0.049
2.809PheVal: 2.809 ± 0.061
0.553PheTrp: 0.553 ± 0.029
0.821PheTyr: 0.821 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
9.033GlyAla: 9.033 ± 0.119
0.847GlyCys: 0.847 ± 0.035
5.48GlyAsp: 5.48 ± 0.103
5.431GlyGlu: 5.431 ± 0.093
3.606GlyPhe: 3.606 ± 0.069
7.48GlyGly: 7.48 ± 0.122
2.051GlyHis: 2.051 ± 0.054
4.419GlyIle: 4.419 ± 0.072
3.534GlyLys: 3.534 ± 0.073
8.324GlyLeu: 8.324 ± 0.125
2.354GlyMet: 2.354 ± 0.055
2.603GlyAsn: 2.603 ± 0.069
2.964GlyPro: 2.964 ± 0.056
2.745GlyGln: 2.745 ± 0.068
5.862GlyArg: 5.862 ± 0.117
4.639GlySer: 4.639 ± 0.09
4.378GlyThr: 4.378 ± 0.084
6.254GlyVal: 6.254 ± 0.084
1.636GlyTrp: 1.636 ± 0.047
2.404GlyTyr: 2.404 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
3.371HisAla: 3.371 ± 0.074
0.245HisCys: 0.245 ± 0.018
1.416HisAsp: 1.416 ± 0.043
1.186HisGlu: 1.186 ± 0.039
0.845HisPhe: 0.845 ± 0.034
2.332HisGly: 2.332 ± 0.057
0.564HisHis: 0.564 ± 0.028
0.698HisIle: 0.698 ± 0.031
0.502HisLys: 0.502 ± 0.022
1.992HisLeu: 1.992 ± 0.054
0.48HisMet: 0.48 ± 0.024
0.431HisAsn: 0.431 ± 0.025
1.454HisPro: 1.454 ± 0.047
0.589HisGln: 0.589 ± 0.03
1.697HisArg: 1.697 ± 0.058
1.001HisSer: 1.001 ± 0.037
0.797HisThr: 0.797 ± 0.037
1.64HisVal: 1.64 ± 0.048
0.429HisTrp: 0.429 ± 0.026
0.629HisTyr: 0.629 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
7.136IleAla: 7.136 ± 0.101
0.374IleCys: 0.374 ± 0.021
3.619IleAsp: 3.619 ± 0.071
2.966IleGlu: 2.966 ± 0.07
1.006IlePhe: 1.006 ± 0.041
4.424IleGly: 4.424 ± 0.08
0.808IleHis: 0.808 ± 0.03
1.135IleIle: 1.135 ± 0.039
1.078IleLys: 1.078 ± 0.042
3.087IleLeu: 3.087 ± 0.072
0.55IleMet: 0.55 ± 0.029
0.997IleAsn: 0.997 ± 0.037
2.271IlePro: 2.271 ± 0.058
0.952IleGln: 0.952 ± 0.037
2.726IleArg: 2.726 ± 0.065
2.012IleSer: 2.012 ± 0.055
1.818IleThr: 1.818 ± 0.057
3.502IleVal: 3.502 ± 0.072
0.367IleTrp: 0.367 ± 0.025
0.77IleTyr: 0.77 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
3.843LysAla: 3.843 ± 0.091
0.171LysCys: 0.171 ± 0.014
1.732LysAsp: 1.732 ± 0.048
1.198LysGlu: 1.198 ± 0.051
0.964LysPhe: 0.964 ± 0.032
2.185LysGly: 2.185 ± 0.056
0.686LysHis: 0.686 ± 0.028
1.241LysIle: 1.241 ± 0.049
1.175LysLys: 1.175 ± 0.066
3.709LysLeu: 3.709 ± 0.08
0.656LysMet: 0.656 ± 0.033
0.703LysAsn: 0.703 ± 0.03
2.472LysPro: 2.472 ± 0.075
1.409LysGln: 1.409 ± 0.047
2.53LysArg: 2.53 ± 0.061
1.694LysSer: 1.694 ± 0.05
1.735LysThr: 1.735 ± 0.053
2.345LysVal: 2.345 ± 0.061
0.382LysTrp: 0.382 ± 0.022
0.672LysTyr: 0.672 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
15.112LeuAla: 15.112 ± 0.194
0.932LeuCys: 0.932 ± 0.036
6.999LeuAsp: 6.999 ± 0.111
5.154LeuGlu: 5.154 ± 0.112
3.551LeuPhe: 3.551 ± 0.082
8.527LeuGly: 8.527 ± 0.124
2.48LeuHis: 2.48 ± 0.055
3.227LeuIle: 3.227 ± 0.08
3.017LeuLys: 3.017 ± 0.061
11.743LeuLeu: 11.743 ± 0.202
1.923LeuMet: 1.923 ± 0.058
2.151LeuAsn: 2.151 ± 0.054
6.378LeuPro: 6.378 ± 0.088
3.853LeuGln: 3.853 ± 0.071
9.122LeuArg: 9.122 ± 0.134
5.439LeuSer: 5.439 ± 0.086
3.983LeuThr: 3.983 ± 0.075
7.936LeuVal: 7.936 ± 0.109
1.363LeuTrp: 1.363 ± 0.053
2.137LeuTyr: 2.137 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.743MetAla: 2.743 ± 0.057
0.15MetCys: 0.15 ± 0.014
1.183MetAsp: 1.183 ± 0.041
0.91MetGlu: 0.91 ± 0.032
0.674MetPhe: 0.674 ± 0.033
1.501MetGly: 1.501 ± 0.048
0.553MetHis: 0.553 ± 0.023
0.773MetIle: 0.773 ± 0.034
0.862MetLys: 0.862 ± 0.033
2.547MetLeu: 2.547 ± 0.057
0.405MetMet: 0.405 ± 0.025
0.714MetAsn: 0.714 ± 0.032
1.655MetPro: 1.655 ± 0.044
0.971MetGln: 0.971 ± 0.038
1.957MetArg: 1.957 ± 0.044
1.402MetSer: 1.402 ± 0.04
1.242MetThr: 1.242 ± 0.038
1.393MetVal: 1.393 ± 0.044
0.208MetTrp: 0.208 ± 0.017
0.345MetTyr: 0.345 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.795AsnAla: 3.795 ± 0.073
0.238AsnCys: 0.238 ± 0.019
1.541AsnAsp: 1.541 ± 0.041
1.227AsnGlu: 1.227 ± 0.041
0.93AsnPhe: 0.93 ± 0.03
2.574AsnGly: 2.574 ± 0.061
0.488AsnHis: 0.488 ± 0.022
1.114AsnIle: 1.114 ± 0.038
0.725AsnLys: 0.725 ± 0.036
2.364AsnLeu: 2.364 ± 0.052
0.451AsnMet: 0.451 ± 0.022
0.661AsnAsn: 0.661 ± 0.029
1.868AsnPro: 1.868 ± 0.049
0.668AsnGln: 0.668 ± 0.031
1.745AsnArg: 1.745 ± 0.049
1.113AsnSer: 1.113 ± 0.033
1.243AsnThr: 1.243 ± 0.042
1.858AsnVal: 1.858 ± 0.057
0.39AsnTrp: 0.39 ± 0.023
0.623AsnTyr: 0.623 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
7.418ProAla: 7.418 ± 0.134
0.323ProCys: 0.323 ± 0.019
3.676ProAsp: 3.676 ± 0.065
3.307ProGlu: 3.307 ± 0.064
1.76ProPhe: 1.76 ± 0.05
4.895ProGly: 4.895 ± 0.082
1.108ProHis: 1.108 ± 0.031
1.847ProIle: 1.847 ± 0.05
1.711ProLys: 1.711 ± 0.05
5.034ProLeu: 5.034 ± 0.085
1.307ProMet: 1.307 ± 0.045
1.316ProAsn: 1.316 ± 0.038
2.959ProPro: 2.959 ± 0.084
2.153ProGln: 2.153 ± 0.052
3.715ProArg: 3.715 ± 0.081
2.66ProSer: 2.66 ± 0.061
2.417ProThr: 2.417 ± 0.067
4.138ProVal: 4.138 ± 0.081
0.86ProTrp: 0.86 ± 0.035
1.174ProTyr: 1.174 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
4.878GlnAla: 4.878 ± 0.092
0.247GlnCys: 0.247 ± 0.018
1.49GlnAsp: 1.49 ± 0.042
1.3GlnGlu: 1.3 ± 0.052
1.06GlnPhe: 1.06 ± 0.04
2.605GlnGly: 2.605 ± 0.061
0.743GlnHis: 0.743 ± 0.03
1.206GlnIle: 1.206 ± 0.04
1.035GlnLys: 1.035 ± 0.04
3.912GlnLeu: 3.912 ± 0.072
0.765GlnMet: 0.765 ± 0.032
0.681GlnAsn: 0.681 ± 0.035
2.196GlnPro: 2.196 ± 0.066
1.644GlnGln: 1.644 ± 0.073
3.338GlnArg: 3.338 ± 0.069
1.674GlnSer: 1.674 ± 0.049
1.34GlnThr: 1.34 ± 0.047
2.745GlnVal: 2.745 ± 0.072
0.55GlnTrp: 0.55 ± 0.029
0.761GlnTyr: 0.761 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
8.754ArgAla: 8.754 ± 0.135
0.562ArgCys: 0.562 ± 0.031
5.325ArgAsp: 5.325 ± 0.09
5.13ArgGlu: 5.13 ± 0.101
3.093ArgPhe: 3.093 ± 0.059
5.764ArgGly: 5.764 ± 0.095
1.931ArgHis: 1.931 ± 0.059
4.298ArgIle: 4.298 ± 0.082
2.431ArgLys: 2.431 ± 0.06
7.745ArgLeu: 7.745 ± 0.116
2.076ArgMet: 2.076 ± 0.056
2.211ArgAsn: 2.211 ± 0.043
3.285ArgPro: 3.285 ± 0.079
2.445ArgGln: 2.445 ± 0.07
5.86ArgArg: 5.86 ± 0.136
3.529ArgSer: 3.529 ± 0.065
3.168ArgThr: 3.168 ± 0.073
5.097ArgVal: 5.097 ± 0.09
1.359ArgTrp: 1.359 ± 0.046
2.073ArgTyr: 2.073 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
6.122SerAla: 6.122 ± 0.081
0.451SerCys: 0.451 ± 0.026
2.868SerAsp: 2.868 ± 0.059
2.53SerGlu: 2.53 ± 0.055
1.823SerPhe: 1.823 ± 0.053
5.142SerGly: 5.142 ± 0.096
1.164SerHis: 1.164 ± 0.04
2.346SerIle: 2.346 ± 0.052
1.591SerLys: 1.591 ± 0.049
5.35SerLeu: 5.35 ± 0.087
1.088SerMet: 1.088 ± 0.039
1.413SerAsn: 1.413 ± 0.049
2.883SerPro: 2.883 ± 0.059
1.591SerGln: 1.591 ± 0.053
3.625SerArg: 3.625 ± 0.073
2.705SerSer: 2.705 ± 0.077
2.707SerThr: 2.707 ± 0.06
3.468SerVal: 3.468 ± 0.071
0.727SerTrp: 0.727 ± 0.026
1.131SerTyr: 1.131 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
5.315ThrAla: 5.315 ± 0.088
0.48ThrCys: 0.48 ± 0.028
2.596ThrAsp: 2.596 ± 0.063
1.949ThrGlu: 1.949 ± 0.049
1.476ThrPhe: 1.476 ± 0.046
4.269ThrGly: 4.269 ± 0.094
1.021ThrHis: 1.021 ± 0.034
2.137ThrIle: 2.137 ± 0.054
1.232ThrLys: 1.232 ± 0.045
5.629ThrLeu: 5.629 ± 0.098
0.942ThrMet: 0.942 ± 0.033
1.16ThrAsn: 1.16 ± 0.045
3.235ThrPro: 3.235 ± 0.077
1.522ThrGln: 1.522 ± 0.051
3.167ThrArg: 3.167 ± 0.062
2.378ThrSer: 2.378 ± 0.07
2.732ThrThr: 2.732 ± 0.095
3.525ThrVal: 3.525 ± 0.077
0.656ThrTrp: 0.656 ± 0.033
1.055ThrTyr: 1.055 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
9.878ValAla: 9.878 ± 0.125
0.652ValCys: 0.652 ± 0.028
4.782ValAsp: 4.782 ± 0.082
4.457ValGlu: 4.457 ± 0.085
2.634ValPhe: 2.634 ± 0.059
5.517ValGly: 5.517 ± 0.091
1.556ValHis: 1.556 ± 0.048
2.892ValIle: 2.892 ± 0.057
1.958ValLys: 1.958 ± 0.055
7.976ValLeu: 7.976 ± 0.112
1.406ValMet: 1.406 ± 0.042
1.915ValAsn: 1.915 ± 0.057
3.831ValPro: 3.831 ± 0.084
2.384ValGln: 2.384 ± 0.059
5.287ValArg: 5.287 ± 0.099
3.771ValSer: 3.771 ± 0.066
3.098ValThr: 3.098 ± 0.071
6.211ValVal: 6.211 ± 0.104
0.784ValTrp: 0.784 ± 0.035
1.459ValTyr: 1.459 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.235TrpAla: 1.235 ± 0.044
0.153TrpCys: 0.153 ± 0.014
0.7TrpAsp: 0.7 ± 0.03
0.547TrpGlu: 0.547 ± 0.026
0.678TrpPhe: 0.678 ± 0.036
0.894TrpGly: 0.894 ± 0.038
0.411TrpHis: 0.411 ± 0.023
0.774TrpIle: 0.774 ± 0.035
0.6TrpLys: 0.6 ± 0.025
2.26TrpLeu: 2.26 ± 0.068
0.455TrpMet: 0.455 ± 0.024
0.591TrpAsn: 0.591 ± 0.031
0.813TrpPro: 0.813 ± 0.034
0.625TrpGln: 0.625 ± 0.03
1.391TrpArg: 1.391 ± 0.043
0.903TrpSer: 0.903 ± 0.035
0.739TrpThr: 0.739 ± 0.032
0.872TrpVal: 0.872 ± 0.034
0.344TrpTrp: 0.344 ± 0.023
0.374TrpTyr: 0.374 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.066TyrAla: 3.066 ± 0.059
0.208TyrCys: 0.208 ± 0.016
1.449TyrAsp: 1.449 ± 0.045
1.116TyrGlu: 1.116 ± 0.039
0.929TyrPhe: 0.929 ± 0.04
2.045TyrGly: 2.045 ± 0.055
0.473TyrHis: 0.473 ± 0.026
0.736TyrIle: 0.736 ± 0.029
0.587TyrLys: 0.587 ± 0.028
2.332TyrLeu: 2.332 ± 0.051
0.43TyrMet: 0.43 ± 0.025
0.598TyrAsn: 0.598 ± 0.029
1.155TyrPro: 1.155 ± 0.044
0.721TyrGln: 0.721 ± 0.032
1.957TyrArg: 1.957 ± 0.054
1.225TyrSer: 1.225 ± 0.039
1.097TyrThr: 1.097 ± 0.041
1.588TyrVal: 1.588 ± 0.048
0.401TyrTrp: 0.401 ± 0.021
0.61TyrTyr: 0.61 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2491 proteins (793208 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski