Amino acid dipepetide frequency for Desulfosporosinus acidiphilus (strain DSM 22704 / JCM 16185 / SJ4)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.918AlaAla: 6.918 ± 0.1	0.9AlaCys: 0.9 ± 0.025	3.459AlaAsp: 3.459 ± 0.053	4.996AlaGlu: 4.996 ± 0.07	3.019AlaPhe: 3.019 ± 0.058	6.116AlaGly: 6.116 ± 0.087	1.282AlaHis: 1.282 ± 0.03	5.517AlaIle: 5.517 ± 0.077	4.643AlaLys: 4.643 ± 0.063	8.535AlaLeu: 8.535 ± 0.092	2.049AlaMet: 2.049 ± 0.041	2.959AlaAsn: 2.959 ± 0.051	2.297AlaPro: 2.297 ± 0.045	3.213AlaGln: 3.213 ± 0.06	3.342AlaArg: 3.342 ± 0.053	4.342AlaSer: 4.342 ± 0.072	3.588AlaThr: 3.588 ± 0.112	5.637AlaVal: 5.637 ± 0.064	0.768AlaTrp: 0.768 ± 0.026	2.295AlaTyr: 2.295 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.67CysAla: 0.67 ± 0.023	0.196CysCys: 0.196 ± 0.014	0.486CysAsp: 0.486 ± 0.019	0.581CysGlu: 0.581 ± 0.021	0.443CysPhe: 0.443 ± 0.018	1.119CysGly: 1.119 ± 0.033	0.308CysHis: 0.308 ± 0.021	0.687CysIle: 0.687 ± 0.024	0.531CysLys: 0.531 ± 0.02	1.133CysLeu: 1.133 ± 0.029	0.257CysMet: 0.257 ± 0.013	0.423CysAsn: 0.423 ± 0.02	0.626CysPro: 0.626 ± 0.025	0.499CysGln: 0.499 ± 0.019	0.557CysArg: 0.557 ± 0.02	0.784CysSer: 0.784 ± 0.024	0.558CysThr: 0.558 ± 0.024	0.608CysVal: 0.608 ± 0.028	0.125CysTrp: 0.125 ± 0.01	0.348CysTyr: 0.348 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.122AspAla: 3.122 ± 0.045	0.542AspCys: 0.542 ± 0.021	2.088AspAsp: 2.088 ± 0.043	3.25AspGlu: 3.25 ± 0.057	2.364AspPhe: 2.364 ± 0.049	3.041AspGly: 3.041 ± 0.047	0.991AspHis: 0.991 ± 0.025	3.742AspIle: 3.742 ± 0.058	2.873AspLys: 2.873 ± 0.053	5.434AspLeu: 5.434 ± 0.069	1.184AspMet: 1.184 ± 0.035	1.85AspAsn: 1.85 ± 0.04	2.208AspPro: 2.208 ± 0.04	1.905AspGln: 1.905 ± 0.038	2.208AspArg: 2.208 ± 0.043	2.841AspSer: 2.841 ± 0.046	2.235AspThr: 2.235 ± 0.051	3.295AspVal: 3.295 ± 0.047	0.642AspTrp: 0.642 ± 0.022	2.032AspTyr: 2.032 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	4.876GluAla: 4.876 ± 0.075	0.602GluCys: 0.602 ± 0.022	3.173GluAsp: 3.173 ± 0.058	5.387GluGlu: 5.387 ± 0.093	2.453GluPhe: 2.453 ± 0.051	4.139GluGly: 4.139 ± 0.057	1.2GluHis: 1.2 ± 0.032	5.463GluIle: 5.463 ± 0.069	4.804GluLys: 4.804 ± 0.072	6.759GluLeu: 6.759 ± 0.088	1.931GluMet: 1.931 ± 0.038	3.11GluAsn: 3.11 ± 0.051	1.816GluPro: 1.816 ± 0.038	2.737GluGln: 2.737 ± 0.054	3.679GluArg: 3.679 ± 0.07	3.373GluSer: 3.373 ± 0.058	3.422GluThr: 3.422 ± 0.063	4.659GluVal: 4.659 ± 0.071	0.663GluTrp: 0.663 ± 0.023	1.867GluTyr: 1.867 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.004PheAla: 3.004 ± 0.051	0.533PheCys: 0.533 ± 0.022	2.024PheAsp: 2.024 ± 0.044	2.409PheGlu: 2.409 ± 0.046	1.871PhePhe: 1.871 ± 0.044	3.332PheGly: 3.332 ± 0.057	0.779PheHis: 0.779 ± 0.025	2.98PheIle: 2.98 ± 0.059	2.163PheLys: 2.163 ± 0.042	4.434PheLeu: 4.434 ± 0.071	1.088PheMet: 1.088 ± 0.03	1.775PheAsn: 1.775 ± 0.039	1.708PhePro: 1.708 ± 0.035	1.44PheGln: 1.44 ± 0.035	1.786PheArg: 1.786 ± 0.04	3.049PheSer: 3.049 ± 0.055	2.164PheThr: 2.164 ± 0.048	2.7PheVal: 2.7 ± 0.048	0.55PheTrp: 0.55 ± 0.021	1.502PheTyr: 1.502 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.471GlyAla: 5.471 ± 0.124	0.992GlyCys: 0.992 ± 0.031	3.155GlyAsp: 3.155 ± 0.055	4.301GlyGlu: 4.301 ± 0.061	3.32GlyPhe: 3.32 ± 0.057	5.503GlyGly: 5.503 ± 0.113	1.402GlyHis: 1.402 ± 0.035	6.499GlyIle: 6.499 ± 0.072	4.93GlyLys: 4.93 ± 0.06	7.561GlyLeu: 7.561 ± 0.084	2.126GlyMet: 2.126 ± 0.049	2.964GlyAsn: 2.964 ± 0.058	2.004GlyPro: 2.004 ± 0.04	2.694GlyGln: 2.694 ± 0.046	3.165GlyArg: 3.165 ± 0.049	4.442GlySer: 4.442 ± 0.077	4.488GlyThr: 4.488 ± 0.086	5.513GlyVal: 5.513 ± 0.08	0.876GlyTrp: 0.876 ± 0.027	2.902GlyTyr: 2.902 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.129HisAla: 1.129 ± 0.033	0.281HisCys: 0.281 ± 0.015	0.873HisAsp: 0.873 ± 0.029	1.176HisGlu: 1.176 ± 0.034	0.838HisPhe: 0.838 ± 0.027	1.352HisGly: 1.352 ± 0.034	0.509HisHis: 0.509 ± 0.022	1.17HisIle: 1.17 ± 0.027	0.949HisLys: 0.949 ± 0.024	2.05HisLeu: 2.05 ± 0.04	0.44HisMet: 0.44 ± 0.017	0.753HisAsn: 0.753 ± 0.026	1.092HisPro: 1.092 ± 0.031	0.77HisGln: 0.77 ± 0.024	0.892HisArg: 0.892 ± 0.027	1.167HisSer: 1.167 ± 0.028	0.91HisThr: 0.91 ± 0.026	1.133HisVal: 1.133 ± 0.035	0.293HisTrp: 0.293 ± 0.018	0.708HisTyr: 0.708 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.052IleAla: 6.052 ± 0.078	0.804IleCys: 0.804 ± 0.026	3.686IleAsp: 3.686 ± 0.056	4.5IleGlu: 4.5 ± 0.067	3.0IlePhe: 3.0 ± 0.053	5.539IleGly: 5.539 ± 0.069	1.372IleHis: 1.372 ± 0.035	5.624IleIle: 5.624 ± 0.079	4.268IleLys: 4.268 ± 0.061	7.864IleLeu: 7.864 ± 0.089	1.795IleMet: 1.795 ± 0.034	3.237IleAsn: 3.237 ± 0.054	3.64IlePro: 3.64 ± 0.046	2.737IleGln: 2.737 ± 0.052	3.329IleArg: 3.329 ± 0.048	5.226IleSer: 5.226 ± 0.066	4.131IleThr: 4.131 ± 0.064	5.19IleVal: 5.19 ± 0.076	0.664IleTrp: 0.664 ± 0.024	2.335IleTyr: 2.335 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.763LysAla: 4.763 ± 0.061	0.526LysCys: 0.526 ± 0.023	3.209LysAsp: 3.209 ± 0.056	4.789LysGlu: 4.789 ± 0.063	1.904LysPhe: 1.904 ± 0.036	4.091LysGly: 4.091 ± 0.056	1.014LysHis: 1.014 ± 0.03	4.765LysIle: 4.765 ± 0.061	3.875LysLys: 3.875 ± 0.058	5.559LysLeu: 5.559 ± 0.076	1.708LysMet: 1.708 ± 0.032	2.829LysAsn: 2.829 ± 0.052	2.28LysPro: 2.28 ± 0.043	2.309LysGln: 2.309 ± 0.043	3.023LysArg: 3.023 ± 0.058	3.438LysSer: 3.438 ± 0.052	3.499LysThr: 3.499 ± 0.052	4.527LysVal: 4.527 ± 0.063	0.516LysTrp: 0.516 ± 0.02	1.841LysTyr: 1.841 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	8.852LeuAla: 8.852 ± 0.089	1.042LeuCys: 1.042 ± 0.029	5.018LeuAsp: 5.018 ± 0.07	7.014LeuGlu: 7.014 ± 0.086	4.113LeuPhe: 4.113 ± 0.068	8.001LeuGly: 8.001 ± 0.098	1.75LeuHis: 1.75 ± 0.036	7.339LeuIle: 7.339 ± 0.084	6.774LeuLys: 6.774 ± 0.081	10.641LeuLeu: 10.641 ± 0.139	2.612LeuMet: 2.612 ± 0.05	4.757LeuAsn: 4.757 ± 0.072	4.5LeuPro: 4.5 ± 0.067	3.727LeuGln: 3.727 ± 0.055	5.002LeuArg: 5.002 ± 0.07	7.139LeuSer: 7.139 ± 0.075	6.065LeuThr: 6.065 ± 0.07	6.638LeuVal: 6.638 ± 0.072	1.088LeuTrp: 1.088 ± 0.035	2.765LeuTyr: 2.765 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.318MetAla: 2.318 ± 0.046	0.197MetCys: 0.197 ± 0.012	1.328MetAsp: 1.328 ± 0.027	1.692MetGlu: 1.692 ± 0.037	0.921MetPhe: 0.921 ± 0.028	2.119MetGly: 2.119 ± 0.04	0.422MetHis: 0.422 ± 0.02	1.878MetIle: 1.878 ± 0.039	1.72MetLys: 1.72 ± 0.037	2.44MetLeu: 2.44 ± 0.044	0.709MetMet: 0.709 ± 0.03	1.292MetAsn: 1.292 ± 0.033	1.063MetPro: 1.063 ± 0.032	0.818MetGln: 0.818 ± 0.028	1.207MetArg: 1.207 ± 0.029	1.712MetSer: 1.712 ± 0.04	1.529MetThr: 1.529 ± 0.035	1.824MetVal: 1.824 ± 0.039	0.162MetTrp: 0.162 ± 0.009	0.6MetTyr: 0.6 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.775AsnAla: 2.775 ± 0.052	0.542AsnCys: 0.542 ± 0.021	2.032AsnAsp: 2.032 ± 0.041	2.369AsnGlu: 2.369 ± 0.043	1.76AsnPhe: 1.76 ± 0.036	3.013AsnGly: 3.013 ± 0.064	0.876AsnHis: 0.876 ± 0.026	3.23AsnIle: 3.23 ± 0.055	2.438AsnLys: 2.438 ± 0.049	4.607AsnLeu: 4.607 ± 0.059	1.055AsnMet: 1.055 ± 0.028	2.043AsnAsn: 2.043 ± 0.049	2.439AsnPro: 2.439 ± 0.047	1.808AsnGln: 1.808 ± 0.045	1.925AsnArg: 1.925 ± 0.041	2.916AsnSer: 2.916 ± 0.052	2.226AsnThr: 2.226 ± 0.051	3.02AsnVal: 3.02 ± 0.046	0.482AsnTrp: 0.482 ± 0.02	1.715AsnTyr: 1.715 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.692ProAla: 2.692 ± 0.054	0.357ProCys: 0.357 ± 0.017	2.15ProAsp: 2.15 ± 0.044	3.24ProGlu: 3.24 ± 0.051	1.764ProPhe: 1.764 ± 0.043	2.978ProGly: 2.978 ± 0.056	0.768ProHis: 0.768 ± 0.022	2.746ProIle: 2.746 ± 0.046	2.253ProLys: 2.253 ± 0.038	4.079ProLeu: 4.079 ± 0.057	0.897ProMet: 0.897 ± 0.024	1.748ProAsn: 1.748 ± 0.041	1.324ProPro: 1.324 ± 0.039	1.619ProGln: 1.619 ± 0.036	1.522ProArg: 1.522 ± 0.037	2.651ProSer: 2.651 ± 0.055	2.061ProThr: 2.061 ± 0.042	3.081ProVal: 3.081 ± 0.051	0.481ProTrp: 0.481 ± 0.022	1.319ProTyr: 1.319 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.255GlnAla: 3.255 ± 0.056	0.349GlnCys: 0.349 ± 0.016	1.821GlnAsp: 1.821 ± 0.041	3.071GlnGlu: 3.071 ± 0.058	1.331GlnPhe: 1.331 ± 0.038	2.93GlnGly: 2.93 ± 0.053	0.633GlnHis: 0.633 ± 0.022	2.724GlnIle: 2.724 ± 0.046	2.486GlnLys: 2.486 ± 0.042	3.584GlnLeu: 3.584 ± 0.055	1.071GlnMet: 1.071 ± 0.027	1.765GlnAsn: 1.765 ± 0.039	1.244GlnPro: 1.244 ± 0.031	1.641GlnGln: 1.641 ± 0.046	2.04GlnArg: 2.04 ± 0.043	2.255GlnSer: 2.255 ± 0.046	2.253GlnThr: 2.253 ± 0.05	2.713GlnVal: 2.713 ± 0.05	0.476GlnTrp: 0.476 ± 0.019	1.106GlnTyr: 1.106 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.971ArgAla: 2.971 ± 0.051	0.51ArgCys: 0.51 ± 0.02	2.272ArgAsp: 2.272 ± 0.043	3.603ArgGlu: 3.603 ± 0.061	2.014ArgPhe: 2.014 ± 0.043	2.867ArgGly: 2.867 ± 0.045	0.898ArgHis: 0.898 ± 0.03	3.529ArgIle: 3.529 ± 0.057	3.108ArgLys: 3.108 ± 0.049	4.961ArgLeu: 4.961 ± 0.066	1.246ArgMet: 1.246 ± 0.027	1.98ArgAsn: 1.98 ± 0.039	1.686ArgPro: 1.686 ± 0.044	2.012ArgGln: 2.012 ± 0.048	2.499ArgArg: 2.499 ± 0.055	2.59ArgSer: 2.59 ± 0.045	2.256ArgThr: 2.256 ± 0.043	3.143ArgVal: 3.143 ± 0.055	0.576ArgTrp: 0.576 ± 0.021	1.641ArgTyr: 1.641 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.588SerAla: 4.588 ± 0.073	0.663SerCys: 0.663 ± 0.024	2.939SerAsp: 2.939 ± 0.048	3.887SerGlu: 3.887 ± 0.06	2.827SerPhe: 2.827 ± 0.054	5.162SerGly: 5.162 ± 0.09	1.163SerHis: 1.163 ± 0.031	4.521SerIle: 4.521 ± 0.057	3.477SerLys: 3.477 ± 0.052	7.094SerLeu: 7.094 ± 0.082	1.692SerMet: 1.692 ± 0.036	2.666SerAsn: 2.666 ± 0.056	2.539SerPro: 2.539 ± 0.047	2.52SerGln: 2.52 ± 0.049	2.744SerArg: 2.744 ± 0.045	4.652SerSer: 4.652 ± 0.084	3.288SerThr: 3.288 ± 0.073	4.275SerVal: 4.275 ± 0.058	0.728SerTrp: 0.728 ± 0.026	2.104SerTyr: 2.104 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.279ThrAla: 4.279 ± 0.082	0.558ThrCys: 0.558 ± 0.027	2.513ThrAsp: 2.513 ± 0.047	3.066ThrGlu: 3.066 ± 0.056	2.293ThrPhe: 2.293 ± 0.047	4.749ThrGly: 4.749 ± 0.129	0.968ThrHis: 0.968 ± 0.03	4.153ThrIle: 4.153 ± 0.059	2.837ThrLys: 2.837 ± 0.054	5.74ThrLeu: 5.74 ± 0.063	1.395ThrMet: 1.395 ± 0.032	2.241ThrAsn: 2.241 ± 0.054	2.527ThrPro: 2.527 ± 0.052	1.903ThrGln: 1.903 ± 0.041	2.075ThrArg: 2.075 ± 0.037	3.433ThrSer: 3.433 ± 0.071	3.031ThrThr: 3.031 ± 0.071	4.049ThrVal: 4.049 ± 0.069	0.584ThrTrp: 0.584 ± 0.025	1.649ThrTyr: 1.649 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.127ValAla: 5.127 ± 0.08	0.837ValCys: 0.837 ± 0.029	3.404ValAsp: 3.404 ± 0.049	4.197ValGlu: 4.197 ± 0.064	3.037ValPhe: 3.037 ± 0.052	4.835ValGly: 4.835 ± 0.067	1.237ValHis: 1.237 ± 0.033	5.572ValIle: 5.572 ± 0.065	4.04ValLys: 4.04 ± 0.06	7.481ValLeu: 7.481 ± 0.081	1.746ValMet: 1.746 ± 0.037	3.037ValAsn: 3.037 ± 0.051	2.897ValPro: 2.897 ± 0.05	2.46ValGln: 2.46 ± 0.048	3.094ValArg: 3.094 ± 0.053	4.728ValSer: 4.728 ± 0.068	4.151ValThr: 4.151 ± 0.073	5.183ValVal: 5.183 ± 0.071	0.731ValTrp: 0.731 ± 0.026	2.072ValTyr: 2.072 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.759TrpAla: 0.759 ± 0.027	0.101TrpCys: 0.101 ± 0.008	0.546TrpAsp: 0.546 ± 0.018	0.718TrpGlu: 0.718 ± 0.026	0.444TrpPhe: 0.444 ± 0.02	0.891TrpGly: 0.891 ± 0.03	0.196TrpHis: 0.196 ± 0.013	0.736TrpIle: 0.736 ± 0.027	0.608TrpLys: 0.608 ± 0.02	1.267TrpLeu: 1.267 ± 0.039	0.293TrpMet: 0.293 ± 0.014	0.485TrpAsn: 0.485 ± 0.018	0.385TrpPro: 0.385 ± 0.019	0.545TrpGln: 0.545 ± 0.02	0.582TrpArg: 0.582 ± 0.019	0.665TrpSer: 0.665 ± 0.024	0.514TrpThr: 0.514 ± 0.023	0.752TrpVal: 0.752 ± 0.027	0.137TrpTrp: 0.137 ± 0.01	0.308TrpTyr: 0.308 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.254TyrAla: 2.254 ± 0.042	0.405TyrCys: 0.405 ± 0.018	1.671TyrAsp: 1.671 ± 0.038	1.865TyrGlu: 1.865 ± 0.042	1.575TyrPhe: 1.575 ± 0.04	2.531TyrGly: 2.531 ± 0.054	0.718TyrHis: 0.718 ± 0.023	2.12TyrIle: 2.12 ± 0.048	1.687TyrLys: 1.687 ± 0.036	3.616TyrLeu: 3.616 ± 0.061	0.658TyrMet: 0.658 ± 0.022	1.355TyrAsn: 1.355 ± 0.034	1.455TyrPro: 1.455 ± 0.03	1.391TyrGln: 1.391 ± 0.04	1.691TyrArg: 1.691 ± 0.042	2.128TyrSer: 2.128 ± 0.042	1.676TyrThr: 1.676 ± 0.041	1.925TyrVal: 1.925 ± 0.037	0.389TyrTrp: 0.389 ± 0.016	1.304TyrTyr: 1.304 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4469 proteins (1329414 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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