Amino acid dipepetide frequency for Nocardioides euryhalodurans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.027AlaAla: 19.027 ± 0.185	0.977AlaCys: 0.977 ± 0.032	8.412AlaAsp: 8.412 ± 0.094	8.378AlaGlu: 8.378 ± 0.105	3.377AlaPhe: 3.377 ± 0.059	12.714AlaGly: 12.714 ± 0.127	2.489AlaHis: 2.489 ± 0.051	4.001AlaIle: 4.001 ± 0.064	1.972AlaLys: 1.972 ± 0.053	13.43AlaLeu: 13.43 ± 0.149	2.641AlaMet: 2.641 ± 0.045	1.764AlaAsn: 1.764 ± 0.042	5.928AlaPro: 5.928 ± 0.085	3.245AlaGln: 3.245 ± 0.051	9.744AlaArg: 9.744 ± 0.111	6.252AlaSer: 6.252 ± 0.071	7.886AlaThr: 7.886 ± 0.09	11.937AlaVal: 11.937 ± 0.135	2.08AlaTrp: 2.08 ± 0.045	2.666AlaTyr: 2.666 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.85CysAla: 0.85 ± 0.029	0.08CysCys: 0.08 ± 0.008	0.499CysAsp: 0.499 ± 0.021	0.409CysGlu: 0.409 ± 0.02	0.235CysPhe: 0.235 ± 0.014	0.872CysGly: 0.872 ± 0.029	0.19CysHis: 0.19 ± 0.012	0.163CysIle: 0.163 ± 0.011	0.091CysLys: 0.091 ± 0.009	0.66CysLeu: 0.66 ± 0.023	0.101CysMet: 0.101 ± 0.009	0.133CysAsn: 0.133 ± 0.012	0.435CysPro: 0.435 ± 0.02	0.164CysGln: 0.164 ± 0.012	0.62CysArg: 0.62 ± 0.022	0.4CysSer: 0.4 ± 0.018	0.432CysThr: 0.432 ± 0.019	0.605CysVal: 0.605 ± 0.023	0.109CysTrp: 0.109 ± 0.009	0.154CysTyr: 0.154 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.972AspAla: 7.972 ± 0.09	0.401AspCys: 0.401 ± 0.018	4.825AspAsp: 4.825 ± 0.071	4.656AspGlu: 4.656 ± 0.069	1.737AspPhe: 1.737 ± 0.044	6.52AspGly: 6.52 ± 0.088	1.72AspHis: 1.72 ± 0.042	1.677AspIle: 1.677 ± 0.043	0.952AspLys: 0.952 ± 0.028	7.6AspLeu: 7.6 ± 0.083	0.813AspMet: 0.813 ± 0.028	0.909AspAsn: 0.909 ± 0.032	4.949AspPro: 4.949 ± 0.077	1.908AspGln: 1.908 ± 0.039	5.442AspArg: 5.442 ± 0.081	2.449AspSer: 2.449 ± 0.042	3.026AspThr: 3.026 ± 0.052	6.398AspVal: 6.398 ± 0.067	1.011AspTrp: 1.011 ± 0.03	1.254AspTyr: 1.254 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.614GluAla: 7.614 ± 0.104	0.351GluCys: 0.351 ± 0.018	3.502GluAsp: 3.502 ± 0.058	3.967GluGlu: 3.967 ± 0.073	1.414GluPhe: 1.414 ± 0.033	4.816GluGly: 4.816 ± 0.072	1.686GluHis: 1.686 ± 0.044	2.257GluIle: 2.257 ± 0.046	1.177GluLys: 1.177 ± 0.039	6.762GluLeu: 6.762 ± 0.082	1.078GluMet: 1.078 ± 0.028	0.844GluAsn: 0.844 ± 0.029	3.518GluPro: 3.518 ± 0.064	2.694GluGln: 2.694 ± 0.05	5.284GluArg: 5.284 ± 0.072	2.752GluSer: 2.752 ± 0.05	3.021GluThr: 3.021 ± 0.049	6.196GluVal: 6.196 ± 0.075	0.843GluTrp: 0.843 ± 0.031	0.922GluTyr: 0.922 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.529PheAla: 3.529 ± 0.052	0.262PheCys: 0.262 ± 0.015	2.093PheAsp: 2.093 ± 0.049	1.61PheGlu: 1.61 ± 0.036	0.905PhePhe: 0.905 ± 0.033	2.956PheGly: 2.956 ± 0.055	0.601PheHis: 0.601 ± 0.023	0.727PheIle: 0.727 ± 0.024	0.401PheLys: 0.401 ± 0.017	2.665PheLeu: 2.665 ± 0.05	0.427PheMet: 0.427 ± 0.021	0.529PheAsn: 0.529 ± 0.023	1.316PhePro: 1.316 ± 0.032	0.599PheGln: 0.599 ± 0.024	1.852PheArg: 1.852 ± 0.037	1.473PheSer: 1.473 ± 0.038	1.845PheThr: 1.845 ± 0.044	2.773PheVal: 2.773 ± 0.048	0.445PheTrp: 0.445 ± 0.019	0.559PheTyr: 0.559 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.215GlyAla: 10.215 ± 0.108	0.849GlyCys: 0.849 ± 0.028	5.786GlyAsp: 5.786 ± 0.082	5.652GlyGlu: 5.652 ± 0.073	3.105GlyPhe: 3.105 ± 0.05	8.47GlyGly: 8.47 ± 0.129	2.294GlyHis: 2.294 ± 0.041	3.607GlyIle: 3.607 ± 0.059	1.788GlyLys: 1.788 ± 0.047	9.944GlyLeu: 9.944 ± 0.108	2.093GlyMet: 2.093 ± 0.041	1.642GlyAsn: 1.642 ± 0.05	4.69GlyPro: 4.69 ± 0.07	2.605GlyGln: 2.605 ± 0.045	7.699GlyArg: 7.699 ± 0.1	5.534GlySer: 5.534 ± 0.074	5.778GlyThr: 5.778 ± 0.072	8.208GlyVal: 8.208 ± 0.087	1.852GlyTrp: 1.852 ± 0.045	2.092GlyTyr: 2.092 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.637HisAla: 2.637 ± 0.052	0.185HisCys: 0.185 ± 0.012	1.751HisAsp: 1.751 ± 0.042	1.34HisGlu: 1.34 ± 0.03	0.564HisPhe: 0.564 ± 0.019	2.3HisGly: 2.3 ± 0.049	0.765HisHis: 0.765 ± 0.026	0.422HisIle: 0.422 ± 0.018	0.263HisLys: 0.263 ± 0.013	2.529HisLeu: 2.529 ± 0.045	0.29HisMet: 0.29 ± 0.017	0.336HisAsn: 0.336 ± 0.017	1.635HisPro: 1.635 ± 0.036	0.598HisGln: 0.598 ± 0.024	2.015HisArg: 2.015 ± 0.045	0.834HisSer: 0.834 ± 0.029	1.034HisThr: 1.034 ± 0.032	2.121HisVal: 2.121 ± 0.046	0.355HisTrp: 0.355 ± 0.015	0.472HisTyr: 0.472 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.456IleAla: 4.456 ± 0.062	0.252IleCys: 0.252 ± 0.015	2.368IleAsp: 2.368 ± 0.047	2.121IleGlu: 2.121 ± 0.045	0.792IlePhe: 0.792 ± 0.035	3.578IleGly: 3.578 ± 0.061	0.569IleHis: 0.569 ± 0.02	0.901IleIle: 0.901 ± 0.032	0.609IleLys: 0.609 ± 0.028	2.449IleLeu: 2.449 ± 0.049	0.439IleMet: 0.439 ± 0.019	0.657IleAsn: 0.657 ± 0.026	1.654IlePro: 1.654 ± 0.045	0.664IleGln: 0.664 ± 0.024	2.208IleArg: 2.208 ± 0.038	1.701IleSer: 1.701 ± 0.043	1.998IleThr: 1.998 ± 0.039	2.892IleVal: 2.892 ± 0.052	0.359IleTrp: 0.359 ± 0.018	0.537IleTyr: 0.537 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.131LysAla: 2.131 ± 0.056	0.085LysCys: 0.085 ± 0.008	0.888LysAsp: 0.888 ± 0.032	0.884LysGlu: 0.884 ± 0.034	0.389LysPhe: 0.389 ± 0.018	1.393LysGly: 1.393 ± 0.043	0.36LysHis: 0.36 ± 0.016	0.626LysIle: 0.626 ± 0.024	0.606LysLys: 0.606 ± 0.033	1.424LysLeu: 1.424 ± 0.043	0.308LysMet: 0.308 ± 0.019	0.342LysAsn: 0.342 ± 0.017	0.979LysPro: 0.979 ± 0.032	0.622LysGln: 0.622 ± 0.023	1.227LysArg: 1.227 ± 0.037	0.861LysSer: 0.861 ± 0.03	0.939LysThr: 0.939 ± 0.031	1.63LysVal: 1.63 ± 0.041	0.176LysTrp: 0.176 ± 0.011	0.346LysTyr: 0.346 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.61LeuAla: 15.61 ± 0.173	0.695LeuCys: 0.695 ± 0.024	7.44LeuAsp: 7.44 ± 0.088	5.835LeuGlu: 5.835 ± 0.081	2.47LeuPhe: 2.47 ± 0.054	10.117LeuGly: 10.117 ± 0.101	2.181LeuHis: 2.181 ± 0.044	2.604LeuIle: 2.604 ± 0.052	1.443LeuLys: 1.443 ± 0.041	11.607LeuLeu: 11.607 ± 0.157	1.692LeuMet: 1.692 ± 0.042	1.436LeuAsn: 1.436 ± 0.035	5.994LeuPro: 5.994 ± 0.071	2.331LeuGln: 2.331 ± 0.041	8.036LeuArg: 8.036 ± 0.095	5.101LeuSer: 5.101 ± 0.066	6.584LeuThr: 6.584 ± 0.063	11.335LeuVal: 11.335 ± 0.119	1.238LeuTrp: 1.238 ± 0.033	1.436LeuTyr: 1.436 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.289MetAla: 2.289 ± 0.044	0.121MetCys: 0.121 ± 0.01	0.853MetAsp: 0.853 ± 0.028	0.811MetGlu: 0.811 ± 0.026	0.505MetPhe: 0.505 ± 0.02	1.411MetGly: 1.411 ± 0.033	0.323MetHis: 0.323 ± 0.016	0.633MetIle: 0.633 ± 0.021	0.409MetLys: 0.409 ± 0.02	1.909MetLeu: 1.909 ± 0.041	0.345MetMet: 0.345 ± 0.019	0.376MetAsn: 0.376 ± 0.017	1.094MetPro: 1.094 ± 0.032	0.465MetGln: 0.465 ± 0.018	1.453MetArg: 1.453 ± 0.034	1.436MetSer: 1.436 ± 0.033	1.713MetThr: 1.713 ± 0.04	1.679MetVal: 1.679 ± 0.043	0.217MetTrp: 0.217 ± 0.013	0.27MetTyr: 0.27 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	1.968AsnAla: 1.968 ± 0.046	0.131AsnCys: 0.131 ± 0.01	0.916AsnAsp: 0.916 ± 0.028	0.748AsnGlu: 0.748 ± 0.027	0.46AsnPhe: 0.46 ± 0.021	1.533AsnGly: 1.533 ± 0.048	0.333AsnHis: 0.333 ± 0.018	0.563AsnIle: 0.563 ± 0.024	0.302AsnLys: 0.302 ± 0.019	1.727AsnLeu: 1.727 ± 0.036	0.239AsnMet: 0.239 ± 0.015	0.349AsnAsn: 0.349 ± 0.018	1.259AsnPro: 1.259 ± 0.036	0.504AsnGln: 0.504 ± 0.023	1.194AsnArg: 1.194 ± 0.035	0.681AsnSer: 0.681 ± 0.025	0.929AsnThr: 0.929 ± 0.033	1.345AsnVal: 1.345 ± 0.036	0.232AsnTrp: 0.232 ± 0.014	0.348AsnTyr: 0.348 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.334ProAla: 7.334 ± 0.09	0.286ProCys: 0.286 ± 0.016	4.595ProAsp: 4.595 ± 0.064	4.225ProGlu: 4.225 ± 0.061	1.467ProPhe: 1.467 ± 0.039	5.92ProGly: 5.92 ± 0.081	1.215ProHis: 1.215 ± 0.034	1.505ProIle: 1.505 ± 0.037	0.788ProLys: 0.788 ± 0.029	4.899ProLeu: 4.899 ± 0.075	1.034ProMet: 1.034 ± 0.03	0.77ProAsn: 0.77 ± 0.028	2.991ProPro: 2.991 ± 0.061	1.408ProGln: 1.408 ± 0.034	3.912ProArg: 3.912 ± 0.058	2.904ProSer: 2.904 ± 0.05	3.487ProThr: 3.487 ± 0.062	5.477ProVal: 5.477 ± 0.074	0.957ProTrp: 0.957 ± 0.029	1.144ProTyr: 1.144 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.502GlnAla: 3.502 ± 0.06	0.14GlnCys: 0.14 ± 0.011	1.376GlnAsp: 1.376 ± 0.038	1.423GlnGlu: 1.423 ± 0.035	0.674GlnPhe: 0.674 ± 0.024	2.134GlnGly: 2.134 ± 0.041	0.61GlnHis: 0.61 ± 0.023	0.966GlnIle: 0.966 ± 0.032	0.462GlnLys: 0.462 ± 0.02	3.122GlnLeu: 3.122 ± 0.053	0.562GlnMet: 0.562 ± 0.024	0.391GlnAsn: 0.391 ± 0.018	1.632GlnPro: 1.632 ± 0.037	1.268GlnGln: 1.268 ± 0.037	2.537GlnArg: 2.537 ± 0.045	1.17GlnSer: 1.17 ± 0.029	1.391GlnThr: 1.391 ± 0.032	2.974GlnVal: 2.974 ± 0.05	0.416GlnTrp: 0.416 ± 0.018	0.477GlnTyr: 0.477 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.132ArgAla: 9.132 ± 0.105	0.572ArgCys: 0.572 ± 0.023	4.975ArgAsp: 4.975 ± 0.065	4.926ArgGlu: 4.926 ± 0.075	2.292ArgPhe: 2.292 ± 0.04	6.156ArgGly: 6.156 ± 0.072	2.075ArgHis: 2.075 ± 0.041	2.978ArgIle: 2.978 ± 0.046	1.367ArgLys: 1.367 ± 0.038	8.616ArgLeu: 8.616 ± 0.109	1.867ArgMet: 1.867 ± 0.04	1.243ArgAsn: 1.243 ± 0.038	4.521ArgPro: 4.521 ± 0.069	2.263ArgGln: 2.263 ± 0.046	7.902ArgArg: 7.902 ± 0.109	4.351ArgSer: 4.351 ± 0.067	4.857ArgThr: 4.857 ± 0.066	6.624ArgVal: 6.624 ± 0.079	1.44ArgTrp: 1.44 ± 0.032	1.553ArgTyr: 1.553 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.837SerAla: 5.837 ± 0.066	0.385SerCys: 0.385 ± 0.017	2.962SerAsp: 2.962 ± 0.054	2.57SerGlu: 2.57 ± 0.055	1.647SerPhe: 1.647 ± 0.043	5.604SerGly: 5.604 ± 0.074	1.082SerHis: 1.082 ± 0.032	1.662SerIle: 1.662 ± 0.043	0.787SerLys: 0.787 ± 0.027	5.219SerLeu: 5.219 ± 0.075	1.22SerMet: 1.22 ± 0.035	0.849SerAsn: 0.849 ± 0.025	3.025SerPro: 3.025 ± 0.055	1.341SerGln: 1.341 ± 0.036	4.035SerArg: 4.035 ± 0.065	2.944SerSer: 2.944 ± 0.055	3.194SerThr: 3.194 ± 0.059	4.439SerVal: 4.439 ± 0.066	0.943SerTrp: 0.943 ± 0.028	1.241SerTyr: 1.241 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.267ThrAla: 7.267 ± 0.086	0.447ThrCys: 0.447 ± 0.018	3.689ThrAsp: 3.689 ± 0.054	3.228ThrGlu: 3.228 ± 0.057	1.834ThrPhe: 1.834 ± 0.038	6.251ThrGly: 6.251 ± 0.09	1.197ThrHis: 1.197 ± 0.033	2.085ThrIle: 2.085 ± 0.047	0.897ThrLys: 0.897 ± 0.033	6.003ThrLeu: 6.003 ± 0.078	1.088ThrMet: 1.088 ± 0.028	1.017ThrAsn: 1.017 ± 0.029	3.697ThrPro: 3.697 ± 0.068	1.353ThrGln: 1.353 ± 0.032	4.339ThrArg: 4.339 ± 0.067	3.413ThrSer: 3.413 ± 0.054	4.275ThrThr: 4.275 ± 0.07	5.933ThrVal: 5.933 ± 0.087	1.07ThrTrp: 1.07 ± 0.031	1.459ThrTyr: 1.459 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	13.232ValAla: 13.232 ± 0.116	0.69ValCys: 0.69 ± 0.022	6.649ValAsp: 6.649 ± 0.078	6.017ValGlu: 6.017 ± 0.069	2.521ValPhe: 2.521 ± 0.051	8.185ValGly: 8.185 ± 0.094	2.069ValHis: 2.069 ± 0.042	2.916ValIle: 2.916 ± 0.057	1.382ValLys: 1.382 ± 0.038	10.626ValLeu: 10.626 ± 0.109	1.607ValMet: 1.607 ± 0.037	1.551ValAsn: 1.551 ± 0.039	5.294ValPro: 5.294 ± 0.069	2.115ValGln: 2.115 ± 0.045	7.36ValArg: 7.36 ± 0.077	4.821ValSer: 4.821 ± 0.065	6.209ValThr: 6.209 ± 0.078	11.073ValVal: 11.073 ± 0.127	1.227ValTrp: 1.227 ± 0.038	1.354ValTyr: 1.354 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.633TrpAla: 1.633 ± 0.042	0.151TrpCys: 0.151 ± 0.011	0.91TrpAsp: 0.91 ± 0.027	0.822TrpGlu: 0.822 ± 0.026	0.586TrpPhe: 0.586 ± 0.021	1.13TrpGly: 1.13 ± 0.03	0.356TrpHis: 0.356 ± 0.016	0.54TrpIle: 0.54 ± 0.024	0.267TrpLys: 0.267 ± 0.015	1.962TrpLeu: 1.962 ± 0.043	0.287TrpMet: 0.287 ± 0.016	0.303TrpAsn: 0.303 ± 0.017	0.789TrpPro: 0.789 ± 0.028	0.59TrpGln: 0.59 ± 0.021	1.325TrpArg: 1.325 ± 0.034	1.034TrpSer: 1.034 ± 0.028	0.985TrpThr: 0.985 ± 0.028	1.322TrpVal: 1.322 ± 0.035	0.406TrpTrp: 0.406 ± 0.019	0.29TrpTyr: 0.29 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.686TyrAla: 2.686 ± 0.049	0.144TyrCys: 0.144 ± 0.01	1.73TyrAsp: 1.73 ± 0.042	1.072TyrGlu: 1.072 ± 0.033	0.593TyrPhe: 0.593 ± 0.023	1.843TyrGly: 1.843 ± 0.043	0.332TyrHis: 0.332 ± 0.019	0.37TyrIle: 0.37 ± 0.019	0.255TyrLys: 0.255 ± 0.015	2.035TyrLeu: 2.035 ± 0.046	0.181TyrMet: 0.181 ± 0.015	0.32TyrAsn: 0.32 ± 0.017	0.921TyrPro: 0.921 ± 0.027	0.491TyrGln: 0.491 ± 0.022	1.524TyrArg: 1.524 ± 0.042	0.873TyrSer: 0.873 ± 0.029	0.957TyrThr: 0.957 ± 0.034	1.937TyrVal: 1.937 ± 0.044	0.313TyrTrp: 0.313 ± 0.017	0.417TyrTyr: 0.417 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3773 proteins (1218950 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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