Amino acid dipepetide frequency for Legionella sp. TUM19329

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.951AlaAla: 5.951 ± 0.112
1.044AlaCys: 1.044 ± 0.036
3.488AlaAsp: 3.488 ± 0.067
4.149AlaGlu: 4.149 ± 0.074
3.058AlaPhe: 3.058 ± 0.068
4.704AlaGly: 4.704 ± 0.102
1.748AlaHis: 1.748 ± 0.044
5.809AlaIle: 5.809 ± 0.079
4.787AlaLys: 4.787 ± 0.075
8.994AlaLeu: 8.994 ± 0.108
2.021AlaMet: 2.021 ± 0.048
3.477AlaAsn: 3.477 ± 0.068
2.376AlaPro: 2.376 ± 0.057
3.433AlaGln: 3.433 ± 0.073
3.311AlaArg: 3.311 ± 0.059
4.596AlaSer: 4.596 ± 0.072
3.898AlaThr: 3.898 ± 0.07
4.778AlaVal: 4.778 ± 0.083
0.732AlaTrp: 0.732 ± 0.027
2.472AlaTyr: 2.472 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.803CysAla: 0.803 ± 0.026
0.18CysCys: 0.18 ± 0.013
0.668CysAsp: 0.668 ± 0.028
0.627CysGlu: 0.627 ± 0.029
0.68CysPhe: 0.68 ± 0.029
0.858CysGly: 0.858 ± 0.035
0.331CysHis: 0.331 ± 0.022
0.845CysIle: 0.845 ± 0.028
0.566CysLys: 0.566 ± 0.027
1.298CysLeu: 1.298 ± 0.036
0.305CysMet: 0.305 ± 0.017
0.515CysAsn: 0.515 ± 0.024
0.479CysPro: 0.479 ± 0.023
0.54CysGln: 0.54 ± 0.025
0.505CysArg: 0.505 ± 0.024
0.796CysSer: 0.796 ± 0.032
0.597CysThr: 0.597 ± 0.025
0.646CysVal: 0.646 ± 0.023
0.17CysTrp: 0.17 ± 0.013
0.466CysTyr: 0.466 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.553AspAla: 3.553 ± 0.064
0.619AspCys: 0.619 ± 0.027
2.382AspAsp: 2.382 ± 0.059
3.669AspGlu: 3.669 ± 0.067
2.452AspPhe: 2.452 ± 0.053
2.721AspGly: 2.721 ± 0.058
1.041AspHis: 1.041 ± 0.031
3.658AspIle: 3.658 ± 0.069
3.566AspLys: 3.566 ± 0.061
5.322AspLeu: 5.322 ± 0.096
1.122AspMet: 1.122 ± 0.033
2.56AspAsn: 2.56 ± 0.052
1.819AspPro: 1.819 ± 0.049
1.777AspGln: 1.777 ± 0.046
1.999AspArg: 1.999 ± 0.055
3.175AspSer: 3.175 ± 0.065
2.544AspThr: 2.544 ± 0.074
3.091AspVal: 3.091 ± 0.067
0.719AspTrp: 0.719 ± 0.03
2.012AspTyr: 2.012 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
4.229GluAla: 4.229 ± 0.068
0.55GluCys: 0.55 ± 0.023
2.521GluAsp: 2.521 ± 0.053
4.084GluGlu: 4.084 ± 0.104
2.416GluPhe: 2.416 ± 0.056
3.054GluGly: 3.054 ± 0.063
1.717GluHis: 1.717 ± 0.05
4.413GluIle: 4.413 ± 0.08
4.45GluLys: 4.45 ± 0.086
6.907GluLeu: 6.907 ± 0.103
1.557GluMet: 1.557 ± 0.045
2.816GluAsn: 2.816 ± 0.062
1.817GluPro: 1.817 ± 0.051
3.728GluGln: 3.728 ± 0.087
2.91GluArg: 2.91 ± 0.071
3.531GluSer: 3.531 ± 0.078
2.975GluThr: 2.975 ± 0.064
3.413GluVal: 3.413 ± 0.075
0.627GluTrp: 0.627 ± 0.028
1.901GluTyr: 1.901 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.227PheAla: 3.227 ± 0.063
0.653PheCys: 0.653 ± 0.025
2.434PheAsp: 2.434 ± 0.053
2.206PheGlu: 2.206 ± 0.06
2.248PhePhe: 2.248 ± 0.06
2.598PheGly: 2.598 ± 0.064
0.978PheHis: 0.978 ± 0.03
3.569PheIle: 3.569 ± 0.063
2.698PheLys: 2.698 ± 0.053
4.205PheLeu: 4.205 ± 0.077
0.958PheMet: 0.958 ± 0.032
2.457PheAsn: 2.457 ± 0.059
1.572PhePro: 1.572 ± 0.041
1.504PheGln: 1.504 ± 0.039
1.483PheArg: 1.483 ± 0.038
3.441PheSer: 3.441 ± 0.072
2.431PheThr: 2.431 ± 0.056
2.44PheVal: 2.44 ± 0.048
0.514PheTrp: 0.514 ± 0.024
1.601PheTyr: 1.601 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
4.202GlyAla: 4.202 ± 0.084
0.82GlyCys: 0.82 ± 0.032
2.744GlyAsp: 2.744 ± 0.055
3.215GlyGlu: 3.215 ± 0.057
3.151GlyPhe: 3.151 ± 0.074
3.949GlyGly: 3.949 ± 0.094
1.534GlyHis: 1.534 ± 0.038
4.822GlyIle: 4.822 ± 0.078
3.87GlyLys: 3.87 ± 0.066
6.533GlyLeu: 6.533 ± 0.095
1.744GlyMet: 1.744 ± 0.052
2.54GlyAsn: 2.54 ± 0.062
1.579GlyPro: 1.579 ± 0.04
2.345GlyGln: 2.345 ± 0.052
2.6GlyArg: 2.6 ± 0.061
3.827GlySer: 3.827 ± 0.086
3.182GlyThr: 3.182 ± 0.087
4.167GlyVal: 4.167 ± 0.084
0.835GlyTrp: 0.835 ± 0.03
2.428GlyTyr: 2.428 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.811HisAla: 1.811 ± 0.043
0.368HisCys: 0.368 ± 0.019
1.189HisAsp: 1.189 ± 0.04
1.407HisGlu: 1.407 ± 0.036
1.233HisPhe: 1.233 ± 0.039
1.559HisGly: 1.559 ± 0.047
0.914HisHis: 0.914 ± 0.031
1.614HisIle: 1.614 ± 0.046
1.164HisLys: 1.164 ± 0.037
2.838HisLeu: 2.838 ± 0.061
0.507HisMet: 0.507 ± 0.023
0.999HisAsn: 0.999 ± 0.036
1.311HisPro: 1.311 ± 0.039
1.446HisGln: 1.446 ± 0.04
1.043HisArg: 1.043 ± 0.038
1.638HisSer: 1.638 ± 0.041
1.129HisThr: 1.129 ± 0.039
1.449HisVal: 1.449 ± 0.036
0.376HisTrp: 0.376 ± 0.022
1.125HisTyr: 1.125 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
6.096IleAla: 6.096 ± 0.086
0.809IleCys: 0.809 ± 0.027
4.359IleAsp: 4.359 ± 0.069
4.878IleGlu: 4.878 ± 0.074
2.62IlePhe: 2.62 ± 0.045
4.465IleGly: 4.465 ± 0.091
1.79IleHis: 1.79 ± 0.04
5.339IleIle: 5.339 ± 0.086
5.211IleLys: 5.211 ± 0.087
6.797IleLeu: 6.797 ± 0.107
1.52IleMet: 1.52 ± 0.042
4.484IleAsn: 4.484 ± 0.073
3.198IlePro: 3.198 ± 0.055
2.817IleGln: 2.817 ± 0.06
3.167IleArg: 3.167 ± 0.074
5.31IleSer: 5.31 ± 0.074
4.211IleThr: 4.211 ± 0.076
3.91IleVal: 3.91 ± 0.062
0.622IleTrp: 0.622 ± 0.027
2.154IleTyr: 2.154 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
4.75LysAla: 4.75 ± 0.084
0.418LysCys: 0.418 ± 0.022
3.11LysAsp: 3.11 ± 0.071
4.582LysGlu: 4.582 ± 0.084
1.76LysPhe: 1.76 ± 0.05
3.353LysGly: 3.353 ± 0.063
1.489LysHis: 1.489 ± 0.041
4.966LysIle: 4.966 ± 0.078
5.348LysLys: 5.348 ± 0.097
6.106LysLeu: 6.106 ± 0.079
1.588LysMet: 1.588 ± 0.038
3.757LysAsn: 3.757 ± 0.069
2.786LysPro: 2.786 ± 0.056
3.354LysGln: 3.354 ± 0.056
3.054LysArg: 3.054 ± 0.057
4.077LysSer: 4.077 ± 0.081
3.851LysThr: 3.851 ± 0.065
3.407LysVal: 3.407 ± 0.07
0.584LysTrp: 0.584 ± 0.023
1.721LysTyr: 1.721 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
8.913LeuAla: 8.913 ± 0.111
1.334LeuCys: 1.334 ± 0.036
5.409LeuAsp: 5.409 ± 0.093
5.905LeuGlu: 5.905 ± 0.145
4.962LeuPhe: 4.962 ± 0.092
6.358LeuGly: 6.358 ± 0.093
2.543LeuHis: 2.543 ± 0.056
8.117LeuIle: 8.117 ± 0.107
6.967LeuLys: 6.967 ± 0.103
11.378LeuLeu: 11.378 ± 0.148
2.629LeuMet: 2.629 ± 0.053
5.774LeuAsn: 5.774 ± 0.082
4.729LeuPro: 4.729 ± 0.085
4.302LeuGln: 4.302 ± 0.075
4.38LeuArg: 4.38 ± 0.079
8.332LeuSer: 8.332 ± 0.111
6.307LeuThr: 6.307 ± 0.09
6.168LeuVal: 6.168 ± 0.088
1.011LeuTrp: 1.011 ± 0.031
3.216LeuTyr: 3.216 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.008MetAla: 2.008 ± 0.047
0.192MetCys: 0.192 ± 0.014
1.286MetAsp: 1.286 ± 0.039
1.26MetGlu: 1.26 ± 0.037
0.774MetPhe: 0.774 ± 0.029
1.618MetGly: 1.618 ± 0.049
0.602MetHis: 0.602 ± 0.025
1.671MetIle: 1.671 ± 0.047
1.523MetLys: 1.523 ± 0.043
2.589MetLeu: 2.589 ± 0.063
0.747MetMet: 0.747 ± 0.03
1.379MetAsn: 1.379 ± 0.043
1.089MetPro: 1.089 ± 0.034
1.138MetGln: 1.138 ± 0.033
1.162MetArg: 1.162 ± 0.033
1.724MetSer: 1.724 ± 0.042
1.479MetThr: 1.479 ± 0.033
1.48MetVal: 1.48 ± 0.041
0.196MetTrp: 0.196 ± 0.014
0.55MetTyr: 0.55 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.528AsnAla: 3.528 ± 0.069
0.586AsnCys: 0.586 ± 0.026
2.447AsnAsp: 2.447 ± 0.052
3.049AsnGlu: 3.049 ± 0.074
1.788AsnPhe: 1.788 ± 0.049
2.738AsnGly: 2.738 ± 0.064
1.36AsnHis: 1.36 ± 0.036
3.405AsnIle: 3.405 ± 0.065
3.659AsnLys: 3.659 ± 0.065
5.124AsnLeu: 5.124 ± 0.092
1.022AsnMet: 1.022 ± 0.035
2.663AsnAsn: 2.663 ± 0.063
2.759AsnPro: 2.759 ± 0.069
2.908AsnGln: 2.908 ± 0.062
2.136AsnArg: 2.136 ± 0.047
3.265AsnSer: 3.265 ± 0.065
2.665AsnThr: 2.665 ± 0.058
2.273AsnVal: 2.273 ± 0.051
0.641AsnTrp: 0.641 ± 0.029
1.908AsnTyr: 1.908 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
2.774ProAla: 2.774 ± 0.061
0.468ProCys: 0.468 ± 0.024
2.312ProAsp: 2.312 ± 0.054
3.047ProGlu: 3.047 ± 0.062
1.766ProPhe: 1.766 ± 0.047
2.573ProGly: 2.573 ± 0.061
0.945ProHis: 0.945 ± 0.035
2.666ProIle: 2.666 ± 0.064
2.19ProLys: 2.19 ± 0.055
4.31ProLeu: 4.31 ± 0.071
0.971ProMet: 0.971 ± 0.03
1.848ProAsn: 1.848 ± 0.051
1.453ProPro: 1.453 ± 0.045
1.817ProGln: 1.817 ± 0.046
1.38ProArg: 1.38 ± 0.044
2.493ProSer: 2.493 ± 0.051
1.981ProThr: 1.981 ± 0.049
3.07ProVal: 3.07 ± 0.056
0.489ProTrp: 0.489 ± 0.024
1.336ProTyr: 1.336 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
3.674GlnAla: 3.674 ± 0.069
0.512GlnCys: 0.512 ± 0.023
1.837GlnAsp: 1.837 ± 0.047
2.724GlnGlu: 2.724 ± 0.082
2.17GlnPhe: 2.17 ± 0.05
2.672GlnGly: 2.672 ± 0.058
1.197GlnHis: 1.197 ± 0.036
3.121GlnIle: 3.121 ± 0.055
2.849GlnLys: 2.849 ± 0.059
5.487GlnLeu: 5.487 ± 0.117
1.08GlnMet: 1.08 ± 0.035
2.219GlnAsn: 2.219 ± 0.056
1.549GlnPro: 1.549 ± 0.048
2.678GlnGln: 2.678 ± 0.076
2.085GlnArg: 2.085 ± 0.057
2.91GlnSer: 2.91 ± 0.059
2.369GlnThr: 2.369 ± 0.055
2.644GlnVal: 2.644 ± 0.05
0.641GlnTrp: 0.641 ± 0.024
1.51GlnTyr: 1.51 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
3.011ArgAla: 3.011 ± 0.057
0.534ArgCys: 0.534 ± 0.025
2.214ArgAsp: 2.214 ± 0.06
2.669ArgGlu: 2.669 ± 0.064
2.144ArgPhe: 2.144 ± 0.047
2.338ArgGly: 2.338 ± 0.052
1.11ArgHis: 1.11 ± 0.034
3.243ArgIle: 3.243 ± 0.059
2.588ArgLys: 2.588 ± 0.059
4.937ArgLeu: 4.937 ± 0.085
1.15ArgMet: 1.15 ± 0.035
1.927ArgAsn: 1.927 ± 0.046
1.429ArgPro: 1.429 ± 0.041
1.973ArgGln: 1.973 ± 0.062
1.956ArgArg: 1.956 ± 0.054
2.475ArgSer: 2.475 ± 0.053
2.101ArgThr: 2.101 ± 0.054
2.797ArgVal: 2.797 ± 0.061
0.555ArgTrp: 0.555 ± 0.028
1.774ArgTyr: 1.774 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
4.584SerAla: 4.584 ± 0.082
0.794SerCys: 0.794 ± 0.031
3.199SerAsp: 3.199 ± 0.07
3.718SerGlu: 3.718 ± 0.075
3.015SerPhe: 3.015 ± 0.06
4.581SerGly: 4.581 ± 0.089
1.754SerHis: 1.754 ± 0.059
4.937SerIle: 4.937 ± 0.085
3.851SerLys: 3.851 ± 0.067
7.916SerLeu: 7.916 ± 0.105
1.807SerMet: 1.807 ± 0.04
3.039SerAsn: 3.039 ± 0.072
2.893SerPro: 2.893 ± 0.059
2.945SerGln: 2.945 ± 0.067
2.811SerArg: 2.811 ± 0.051
5.03SerSer: 5.03 ± 0.09
3.465SerThr: 3.465 ± 0.066
3.964SerVal: 3.964 ± 0.07
0.773SerTrp: 0.773 ± 0.029
2.284SerTyr: 2.284 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
4.054ThrAla: 4.054 ± 0.082
0.574ThrCys: 0.574 ± 0.028
2.68ThrAsp: 2.68 ± 0.053
2.851ThrGlu: 2.851 ± 0.066
2.01ThrPhe: 2.01 ± 0.045
3.722ThrGly: 3.722 ± 0.069
1.44ThrHis: 1.44 ± 0.04
3.944ThrIle: 3.944 ± 0.069
2.828ThrLys: 2.828 ± 0.068
6.215ThrLeu: 6.215 ± 0.103
1.165ThrMet: 1.165 ± 0.033
2.479ThrAsn: 2.479 ± 0.057
2.787ThrPro: 2.787 ± 0.057
2.523ThrGln: 2.523 ± 0.059
2.264ThrArg: 2.264 ± 0.046
3.513ThrSer: 3.513 ± 0.069
2.986ThrThr: 2.986 ± 0.08
3.528ThrVal: 3.528 ± 0.084
0.494ThrTrp: 0.494 ± 0.022
1.714ThrTyr: 1.714 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
4.636ValAla: 4.636 ± 0.081
0.739ValCys: 0.739 ± 0.029
3.318ValAsp: 3.318 ± 0.065
3.332ValGlu: 3.332 ± 0.069
2.648ValPhe: 2.648 ± 0.057
3.466ValGly: 3.466 ± 0.068
1.367ValHis: 1.367 ± 0.037
4.673ValIle: 4.673 ± 0.078
3.508ValLys: 3.508 ± 0.059
6.341ValLeu: 6.341 ± 0.088
1.582ValMet: 1.582 ± 0.043
2.989ValAsn: 2.989 ± 0.055
2.296ValPro: 2.296 ± 0.052
2.012ValGln: 2.012 ± 0.051
2.419ValArg: 2.419 ± 0.055
4.154ValSer: 4.154 ± 0.065
3.52ValThr: 3.52 ± 0.079
3.974ValVal: 3.974 ± 0.085
0.651ValTrp: 0.651 ± 0.027
1.907ValTyr: 1.907 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.709TrpAla: 0.709 ± 0.025
0.149TrpCys: 0.149 ± 0.012
0.552TrpAsp: 0.552 ± 0.029
0.528TrpGlu: 0.528 ± 0.02
0.563TrpPhe: 0.563 ± 0.03
0.642TrpGly: 0.642 ± 0.031
0.324TrpHis: 0.324 ± 0.02
0.823TrpIle: 0.823 ± 0.032
0.562TrpLys: 0.562 ± 0.027
1.423TrpLeu: 1.423 ± 0.041
0.316TrpMet: 0.316 ± 0.02
0.525TrpAsn: 0.525 ± 0.025
0.448TrpPro: 0.448 ± 0.022
0.686TrpGln: 0.686 ± 0.03
0.576TrpArg: 0.576 ± 0.024
0.702TrpSer: 0.702 ± 0.03
0.497TrpThr: 0.497 ± 0.023
0.715TrpVal: 0.715 ± 0.028
0.156TrpTrp: 0.156 ± 0.014
0.392TrpTyr: 0.392 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.312TyrAla: 2.312 ± 0.049
0.533TyrCys: 0.533 ± 0.023
1.653TyrAsp: 1.653 ± 0.045
1.716TyrGlu: 1.716 ± 0.045
1.756TyrPhe: 1.756 ± 0.039
2.119TyrGly: 2.119 ± 0.055
0.936TyrHis: 0.936 ± 0.03
2.12TyrIle: 2.12 ± 0.049
1.875TyrLys: 1.875 ± 0.046
4.01TyrLeu: 4.01 ± 0.068
0.675TyrMet: 0.675 ± 0.026
1.477TyrAsn: 1.477 ± 0.041
1.521TyrPro: 1.521 ± 0.04
1.999TyrGln: 1.999 ± 0.055
1.688TyrArg: 1.688 ± 0.052
2.371TyrSer: 2.371 ± 0.057
1.583TyrThr: 1.583 ± 0.04
1.621TyrVal: 1.621 ± 0.044
0.503TyrTrp: 0.503 ± 0.024
1.35TyrTyr: 1.35 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3144 proteins (953758 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski