Amino acid dipepetide frequency for Vibrio nigripulchritudo

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.053AlaAla: 7.053 ± 0.075
0.898AlaCys: 0.898 ± 0.021
4.143AlaAsp: 4.143 ± 0.057
5.316AlaGlu: 5.316 ± 0.06
3.488AlaPhe: 3.488 ± 0.045
5.757AlaGly: 5.757 ± 0.065
1.683AlaHis: 1.683 ± 0.027
5.886AlaIle: 5.886 ± 0.065
4.821AlaLys: 4.821 ± 0.054
9.473AlaLeu: 9.473 ± 0.089
2.656AlaMet: 2.656 ± 0.04
3.466AlaAsn: 3.466 ± 0.049
2.746AlaPro: 2.746 ± 0.043
3.46AlaGln: 3.46 ± 0.048
3.451AlaArg: 3.451 ± 0.051
5.666AlaSer: 5.666 ± 0.053
4.309AlaThr: 4.309 ± 0.05
5.68AlaVal: 5.68 ± 0.058
0.95AlaTrp: 0.95 ± 0.021
2.342AlaTyr: 2.342 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
0.775CysAla: 0.775 ± 0.024
0.158CysCys: 0.158 ± 0.011
0.618CysAsp: 0.618 ± 0.02
0.656CysGlu: 0.656 ± 0.02
0.452CysPhe: 0.452 ± 0.016
0.897CysGly: 0.897 ± 0.024
0.34CysHis: 0.34 ± 0.013
0.615CysIle: 0.615 ± 0.02
0.441CysLys: 0.441 ± 0.016
0.946CysLeu: 0.946 ± 0.025
0.232CysMet: 0.232 ± 0.012
0.383CysAsn: 0.383 ± 0.014
0.412CysPro: 0.412 ± 0.016
0.473CysGln: 0.473 ± 0.018
0.445CysArg: 0.445 ± 0.017
0.73CysSer: 0.73 ± 0.021
0.467CysThr: 0.467 ± 0.02
0.694CysVal: 0.694 ± 0.02
0.134CysTrp: 0.134 ± 0.008
0.331CysTyr: 0.331 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.392AspAla: 4.392 ± 0.058
0.518AspCys: 0.518 ± 0.017
2.784AspAsp: 2.784 ± 0.056
3.959AspGlu: 3.959 ± 0.061
2.543AspPhe: 2.543 ± 0.038
3.736AspGly: 3.736 ± 0.06
1.129AspHis: 1.129 ± 0.026
3.968AspIle: 3.968 ± 0.048
3.116AspLys: 3.116 ± 0.04
5.296AspLeu: 5.296 ± 0.062
1.423AspMet: 1.423 ± 0.026
2.381AspAsn: 2.381 ± 0.035
2.091AspPro: 2.091 ± 0.041
2.001AspGln: 2.001 ± 0.033
2.294AspArg: 2.294 ± 0.035
3.546AspSer: 3.546 ± 0.054
2.744AspThr: 2.744 ± 0.044
4.086AspVal: 4.086 ± 0.05
0.881AspTrp: 0.881 ± 0.026
1.933AspTyr: 1.933 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
5.212GluAla: 5.212 ± 0.059
0.579GluCys: 0.579 ± 0.019
3.168GluAsp: 3.168 ± 0.053
4.515GluGlu: 4.515 ± 0.068
2.685GluPhe: 2.685 ± 0.042
3.85GluGly: 3.85 ± 0.044
1.691GluHis: 1.691 ± 0.031
3.887GluIle: 3.887 ± 0.051
4.194GluLys: 4.194 ± 0.05
7.179GluLeu: 7.179 ± 0.07
1.781GluMet: 1.781 ± 0.038
2.972GluAsn: 2.972 ± 0.039
2.275GluPro: 2.275 ± 0.056
3.638GluGln: 3.638 ± 0.056
3.43GluArg: 3.43 ± 0.051
4.495GluSer: 4.495 ± 0.051
3.322GluThr: 3.322 ± 0.048
4.496GluVal: 4.496 ± 0.049
0.902GluTrp: 0.902 ± 0.022
1.942GluTyr: 1.942 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.528PheAla: 3.528 ± 0.053
0.515PheCys: 0.515 ± 0.017
2.75PheAsp: 2.75 ± 0.044
2.817PheGlu: 2.817 ± 0.036
1.787PhePhe: 1.787 ± 0.04
3.324PheGly: 3.324 ± 0.043
0.884PheHis: 0.884 ± 0.02
2.599PheIle: 2.599 ± 0.04
1.998PheLys: 1.998 ± 0.033
3.598PheLeu: 3.598 ± 0.05
0.977PheMet: 0.977 ± 0.024
1.99PheAsn: 1.99 ± 0.036
1.557PhePro: 1.557 ± 0.03
1.459PheGln: 1.459 ± 0.028
1.62PheArg: 1.62 ± 0.028
3.461PheSer: 3.461 ± 0.043
2.308PheThr: 2.308 ± 0.042
3.018PheVal: 3.018 ± 0.042
0.535PheTrp: 0.535 ± 0.019
1.368PheTyr: 1.368 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
5.251GlyAla: 5.251 ± 0.069
0.878GlyCys: 0.878 ± 0.025
3.622GlyAsp: 3.622 ± 0.049
4.593GlyGlu: 4.593 ± 0.047
3.322GlyPhe: 3.322 ± 0.046
4.877GlyGly: 4.877 ± 0.068
1.524GlyHis: 1.524 ± 0.03
4.832GlyIle: 4.832 ± 0.06
4.13GlyLys: 4.13 ± 0.056
6.876GlyLeu: 6.876 ± 0.078
2.013GlyMet: 2.013 ± 0.037
2.688GlyAsn: 2.688 ± 0.041
1.593GlyPro: 1.593 ± 0.035
2.731GlyGln: 2.731 ± 0.042
3.004GlyArg: 3.004 ± 0.04
4.344GlySer: 4.344 ± 0.06
3.525GlyThr: 3.525 ± 0.058
5.331GlyVal: 5.331 ± 0.067
0.995GlyTrp: 0.995 ± 0.025
2.658GlyTyr: 2.658 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
1.627HisAla: 1.627 ± 0.026
0.342HisCys: 0.342 ± 0.015
1.163HisAsp: 1.163 ± 0.028
1.207HisGlu: 1.207 ± 0.03
1.115HisPhe: 1.115 ± 0.024
1.55HisGly: 1.55 ± 0.03
0.747HisHis: 0.747 ± 0.022
1.42HisIle: 1.42 ± 0.026
1.067HisLys: 1.067 ± 0.023
2.345HisLeu: 2.345 ± 0.036
0.495HisMet: 0.495 ± 0.016
0.884HisAsn: 0.884 ± 0.02
1.197HisPro: 1.197 ± 0.024
1.208HisGln: 1.208 ± 0.027
1.031HisArg: 1.031 ± 0.024
1.569HisSer: 1.569 ± 0.029
1.12HisThr: 1.12 ± 0.022
1.324HisVal: 1.324 ± 0.029
0.385HisTrp: 0.385 ± 0.014
0.85HisTyr: 0.85 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.166IleAla: 6.166 ± 0.065
0.676IleCys: 0.676 ± 0.022
3.996IleAsp: 3.996 ± 0.051
4.84IleGlu: 4.84 ± 0.058
2.23IlePhe: 2.23 ± 0.038
4.645IleGly: 4.645 ± 0.056
1.345IleHis: 1.345 ± 0.025
3.289IleIle: 3.289 ± 0.054
3.109IleLys: 3.109 ± 0.043
5.386IleLeu: 5.386 ± 0.061
1.309IleMet: 1.309 ± 0.03
2.726IleAsn: 2.726 ± 0.042
2.711IlePro: 2.711 ± 0.041
2.514IleGln: 2.514 ± 0.04
2.948IleArg: 2.948 ± 0.042
4.625IleSer: 4.625 ± 0.056
3.533IleThr: 3.533 ± 0.044
4.094IleVal: 4.094 ± 0.056
0.676IleTrp: 0.676 ± 0.019
1.666IleTyr: 1.666 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
4.815LysAla: 4.815 ± 0.059
0.31LysCys: 0.31 ± 0.016
2.915LysAsp: 2.915 ± 0.039
3.725LysGlu: 3.725 ± 0.055
1.632LysPhe: 1.632 ± 0.031
3.53LysGly: 3.53 ± 0.044
1.334LysHis: 1.334 ± 0.028
2.908LysIle: 2.908 ± 0.038
3.168LysLys: 3.168 ± 0.051
5.506LysLeu: 5.506 ± 0.062
1.394LysMet: 1.394 ± 0.031
2.264LysAsn: 2.264 ± 0.038
2.474LysPro: 2.474 ± 0.033
2.677LysGln: 2.677 ± 0.038
2.694LysArg: 2.694 ± 0.039
3.494LysSer: 3.494 ± 0.05
2.914LysThr: 2.914 ± 0.038
4.07LysVal: 4.07 ± 0.054
0.635LysTrp: 0.635 ± 0.021
1.432LysTyr: 1.432 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
9.229LeuAla: 9.229 ± 0.086
1.076LeuCys: 1.076 ± 0.025
5.853LeuAsp: 5.853 ± 0.058
6.537LeuGlu: 6.537 ± 0.066
4.325LeuPhe: 4.325 ± 0.066
6.974LeuGly: 6.974 ± 0.076
1.964LeuHis: 1.964 ± 0.033
6.108LeuIle: 6.108 ± 0.069
5.637LeuLys: 5.637 ± 0.052
9.807LeuLeu: 9.807 ± 0.09
2.673LeuMet: 2.673 ± 0.039
4.709LeuAsn: 4.709 ± 0.054
4.696LeuPro: 4.696 ± 0.048
3.292LeuGln: 3.292 ± 0.054
4.137LeuArg: 4.137 ± 0.058
8.256LeuSer: 8.256 ± 0.078
5.937LeuThr: 5.937 ± 0.06
7.105LeuVal: 7.105 ± 0.064
1.048LeuTrp: 1.048 ± 0.029
2.63LeuTyr: 2.63 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
2.384MetAla: 2.384 ± 0.04
0.227MetCys: 0.227 ± 0.01
1.28MetAsp: 1.28 ± 0.027
1.45MetGlu: 1.45 ± 0.032
0.937MetPhe: 0.937 ± 0.026
1.742MetGly: 1.742 ± 0.033
0.451MetHis: 0.451 ± 0.015
1.517MetIle: 1.517 ± 0.031
1.648MetLys: 1.648 ± 0.031
2.665MetLeu: 2.665 ± 0.039
0.819MetMet: 0.819 ± 0.022
1.155MetAsn: 1.155 ± 0.025
1.221MetPro: 1.221 ± 0.027
0.975MetGln: 0.975 ± 0.025
1.106MetArg: 1.106 ± 0.025
2.063MetSer: 2.063 ± 0.034
1.626MetThr: 1.626 ± 0.03
1.852MetVal: 1.852 ± 0.035
0.227MetTrp: 0.227 ± 0.011
0.59MetTyr: 0.59 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.599AsnAla: 3.599 ± 0.043
0.406AsnCys: 0.406 ± 0.016
2.227AsnAsp: 2.227 ± 0.045
2.54AsnGlu: 2.54 ± 0.039
1.568AsnPhe: 1.568 ± 0.03
3.138AsnGly: 3.138 ± 0.051
1.041AsnHis: 1.041 ± 0.026
2.716AsnIle: 2.716 ± 0.042
2.156AsnLys: 2.156 ± 0.041
4.102AsnLeu: 4.102 ± 0.047
1.023AsnMet: 1.023 ± 0.025
1.786AsnAsn: 1.786 ± 0.038
2.164AsnPro: 2.164 ± 0.041
2.293AsnGln: 2.293 ± 0.043
2.078AsnArg: 2.078 ± 0.034
2.622AsnSer: 2.622 ± 0.044
2.269AsnThr: 2.269 ± 0.036
2.808AsnVal: 2.808 ± 0.04
0.649AsnTrp: 0.649 ± 0.021
1.343AsnTyr: 1.343 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
2.946ProAla: 2.946 ± 0.041
0.339ProCys: 0.339 ± 0.014
2.607ProAsp: 2.607 ± 0.047
3.397ProGlu: 3.397 ± 0.059
1.871ProPhe: 1.871 ± 0.03
2.273ProGly: 2.273 ± 0.039
0.867ProHis: 0.867 ± 0.022
2.454ProIle: 2.454 ± 0.039
2.062ProLys: 2.062 ± 0.036
3.947ProLeu: 3.947 ± 0.044
0.981ProMet: 0.981 ± 0.021
1.828ProAsn: 1.828 ± 0.031
1.2ProPro: 1.2 ± 0.031
1.45ProGln: 1.45 ± 0.029
1.3ProArg: 1.3 ± 0.03
2.659ProSer: 2.659 ± 0.037
2.27ProThr: 2.27 ± 0.034
3.268ProVal: 3.268 ± 0.046
0.516ProTrp: 0.516 ± 0.017
1.262ProTyr: 1.262 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.832GlnAla: 3.832 ± 0.057
0.387GlnCys: 0.387 ± 0.015
2.004GlnAsp: 2.004 ± 0.032
2.496GlnGlu: 2.496 ± 0.039
1.73GlnPhe: 1.73 ± 0.029
2.778GlnGly: 2.778 ± 0.042
1.035GlnHis: 1.035 ± 0.024
2.606GlnIle: 2.606 ± 0.043
2.211GlnLys: 2.211 ± 0.036
4.555GlnLeu: 4.555 ± 0.054
1.09GlnMet: 1.09 ± 0.024
1.725GlnAsn: 1.725 ± 0.033
1.766GlnPro: 1.766 ± 0.033
2.326GlnGln: 2.326 ± 0.05
2.142GlnArg: 2.142 ± 0.035
3.091GlnSer: 3.091 ± 0.047
2.241GlnThr: 2.241 ± 0.042
3.08GlnVal: 3.08 ± 0.048
0.582GlnTrp: 0.582 ± 0.02
1.392GlnTyr: 1.392 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
3.307ArgAla: 3.307 ± 0.045
0.475ArgCys: 0.475 ± 0.017
2.42ArgAsp: 2.42 ± 0.038
2.995ArgGlu: 2.995 ± 0.046
2.191ArgPhe: 2.191 ± 0.034
2.456ArgGly: 2.456 ± 0.039
1.11ArgHis: 1.11 ± 0.025
2.978ArgIle: 2.978 ± 0.042
2.463ArgLys: 2.463 ± 0.041
4.635ArgLeu: 4.635 ± 0.056
1.139ArgMet: 1.139 ± 0.026
1.912ArgAsn: 1.912 ± 0.034
1.516ArgPro: 1.516 ± 0.027
2.073ArgGln: 2.073 ± 0.045
2.163ArgArg: 2.163 ± 0.037
2.72ArgSer: 2.72 ± 0.038
2.179ArgThr: 2.179 ± 0.037
3.184ArgVal: 3.184 ± 0.041
0.671ArgTrp: 0.671 ± 0.022
1.652ArgTyr: 1.652 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
5.531SerAla: 5.531 ± 0.068
0.604SerCys: 0.604 ± 0.019
4.038SerAsp: 4.038 ± 0.062
4.757SerGlu: 4.757 ± 0.056
2.954SerPhe: 2.954 ± 0.045
5.429SerGly: 5.429 ± 0.063
1.689SerHis: 1.689 ± 0.034
4.358SerIle: 4.358 ± 0.05
3.574SerLys: 3.574 ± 0.044
7.327SerLeu: 7.327 ± 0.067
1.817SerMet: 1.817 ± 0.034
2.928SerAsn: 2.928 ± 0.038
2.706SerPro: 2.706 ± 0.037
3.123SerGln: 3.123 ± 0.045
2.934SerArg: 2.934 ± 0.041
4.842SerSer: 4.842 ± 0.061
3.503SerThr: 3.503 ± 0.049
5.091SerVal: 5.091 ± 0.062
0.917SerTrp: 0.917 ± 0.025
2.106SerTyr: 2.106 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
4.235ThrAla: 4.235 ± 0.047
0.503ThrCys: 0.503 ± 0.018
2.83ThrAsp: 2.83 ± 0.053
3.294ThrGlu: 3.294 ± 0.046
2.26ThrPhe: 2.26 ± 0.04
4.016ThrGly: 4.016 ± 0.058
1.329ThrHis: 1.329 ± 0.027
3.303ThrIle: 3.303 ± 0.04
2.438ThrLys: 2.438 ± 0.035
6.21ThrLeu: 6.21 ± 0.059
1.161ThrMet: 1.161 ± 0.026
2.046ThrAsn: 2.046 ± 0.036
2.739ThrPro: 2.739 ± 0.044
2.405ThrGln: 2.405 ± 0.038
2.189ThrArg: 2.189 ± 0.038
3.614ThrSer: 3.614 ± 0.047
2.839ThrThr: 2.839 ± 0.05
3.792ThrVal: 3.792 ± 0.055
0.645ThrTrp: 0.645 ± 0.019
1.567ThrTyr: 1.567 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
6.229ValAla: 6.229 ± 0.062
0.803ValCys: 0.803 ± 0.024
4.023ValAsp: 4.023 ± 0.048
4.827ValGlu: 4.827 ± 0.051
2.954ValPhe: 2.954 ± 0.047
4.852ValGly: 4.852 ± 0.056
1.333ValHis: 1.333 ± 0.025
4.659ValIle: 4.659 ± 0.057
3.664ValLys: 3.664 ± 0.054
7.086ValLeu: 7.086 ± 0.077
1.956ValMet: 1.956 ± 0.036
3.004ValAsn: 3.004 ± 0.043
2.727ValPro: 2.727 ± 0.035
2.294ValGln: 2.294 ± 0.032
2.941ValArg: 2.941 ± 0.041
5.448ValSer: 5.448 ± 0.058
4.286ValThr: 4.286 ± 0.056
5.58ValVal: 5.58 ± 0.071
0.824ValTrp: 0.824 ± 0.023
1.971ValTyr: 1.971 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
0.868TrpAla: 0.868 ± 0.023
0.137TrpCys: 0.137 ± 0.009
0.662TrpAsp: 0.662 ± 0.019
0.668TrpGlu: 0.668 ± 0.02
0.616TrpPhe: 0.616 ± 0.021
0.808TrpGly: 0.808 ± 0.022
0.373TrpHis: 0.373 ± 0.012
0.709TrpIle: 0.709 ± 0.021
0.65TrpLys: 0.65 ± 0.018
1.722TrpLeu: 1.722 ± 0.037
0.353TrpMet: 0.353 ± 0.011
0.552TrpAsn: 0.552 ± 0.016
0.368TrpPro: 0.368 ± 0.013
0.827TrpGln: 0.827 ± 0.02
0.665TrpArg: 0.665 ± 0.02
0.825TrpSer: 0.825 ± 0.023
0.553TrpThr: 0.553 ± 0.022
0.944TrpVal: 0.944 ± 0.022
0.211TrpTrp: 0.211 ± 0.012
0.362TrpTyr: 0.362 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.26TyrAla: 2.26 ± 0.039
0.367TyrCys: 0.367 ± 0.016
1.718TyrAsp: 1.718 ± 0.033
1.622TyrGlu: 1.622 ± 0.03
1.434TyrPhe: 1.434 ± 0.028
2.159TyrGly: 2.159 ± 0.038
0.777TyrHis: 0.777 ± 0.018
1.67TyrIle: 1.67 ± 0.032
1.347TyrLys: 1.347 ± 0.03
3.334TyrLeu: 3.334 ± 0.046
0.647TyrMet: 0.647 ± 0.02
1.129TyrAsn: 1.129 ± 0.027
1.337TyrPro: 1.337 ± 0.024
1.849TyrGln: 1.849 ± 0.032
1.668TyrArg: 1.668 ± 0.033
2.156TyrSer: 2.156 ± 0.036
1.469TyrThr: 1.469 ± 0.028
1.966TyrVal: 1.966 ± 0.031
0.489TyrTrp: 0.489 ± 0.017
0.991TyrTyr: 0.991 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5540 proteins (1827484 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski