Amino acid dipepetide frequency for Leptolyngbya boryana NIES-2135

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.35AlaAla: 8.35 ± 0.097	0.863AlaCys: 0.863 ± 0.02	4.292AlaAsp: 4.292 ± 0.059	5.911AlaGlu: 5.911 ± 0.055	3.283AlaPhe: 3.283 ± 0.043	5.76AlaGly: 5.76 ± 0.07	1.533AlaHis: 1.533 ± 0.026	8.172AlaIle: 8.172 ± 0.072	3.941AlaLys: 3.941 ± 0.051	9.66AlaLeu: 9.66 ± 0.082	1.997AlaMet: 1.997 ± 0.033	3.225AlaAsn: 3.225 ± 0.049	3.624AlaPro: 3.624 ± 0.058	5.154AlaGln: 5.154 ± 0.058	4.337AlaArg: 4.337 ± 0.045	5.146AlaSer: 5.146 ± 0.057	5.154AlaThr: 5.154 ± 0.068	5.779AlaVal: 5.779 ± 0.064	1.19AlaTrp: 1.19 ± 0.025	2.383AlaTyr: 2.383 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.724CysAla: 0.724 ± 0.021	0.16CysCys: 0.16 ± 0.008	0.611CysAsp: 0.611 ± 0.017	0.523CysGlu: 0.523 ± 0.017	0.431CysPhe: 0.431 ± 0.015	0.742CysGly: 0.742 ± 0.021	0.264CysHis: 0.264 ± 0.011	0.496CysIle: 0.496 ± 0.015	0.306CysLys: 0.306 ± 0.014	1.055CysLeu: 1.055 ± 0.028	0.16CysMet: 0.16 ± 0.009	0.351CysAsn: 0.351 ± 0.015	0.551CysPro: 0.551 ± 0.017	0.533CysGln: 0.533 ± 0.016	0.587CysArg: 0.587 ± 0.021	0.615CysSer: 0.615 ± 0.018	0.471CysThr: 0.471 ± 0.016	0.576CysVal: 0.576 ± 0.016	0.142CysTrp: 0.142 ± 0.009	0.32CysTyr: 0.32 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.397AspAla: 4.397 ± 0.063	0.561AspCys: 0.561 ± 0.016	2.315AspAsp: 2.315 ± 0.044	2.999AspGlu: 2.999 ± 0.04	2.21AspPhe: 2.21 ± 0.036	3.262AspGly: 3.262 ± 0.05	0.988AspHis: 0.988 ± 0.024	2.634AspIle: 2.634 ± 0.036	1.494AspLys: 1.494 ± 0.03	6.197AspLeu: 6.197 ± 0.061	0.8AspMet: 0.8 ± 0.018	1.341AspAsn: 1.341 ± 0.029	2.846AspPro: 2.846 ± 0.044	2.664AspGln: 2.664 ± 0.042	5.125AspArg: 5.125 ± 0.056	2.915AspSer: 2.915 ± 0.046	2.217AspThr: 2.217 ± 0.046	3.139AspVal: 3.139 ± 0.046	0.964AspTrp: 0.964 ± 0.023	1.653AspTyr: 1.653 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	6.052GluAla: 6.052 ± 0.065	0.491GluCys: 0.491 ± 0.018	2.661GluAsp: 2.661 ± 0.042	3.545GluGlu: 3.545 ± 0.054	2.548GluPhe: 2.548 ± 0.035	3.117GluGly: 3.117 ± 0.041	1.109GluHis: 1.109 ± 0.027	4.521GluIle: 4.521 ± 0.047	2.869GluLys: 2.869 ± 0.047	6.834GluLeu: 6.834 ± 0.063	1.418GluMet: 1.418 ± 0.03	2.17GluAsn: 2.17 ± 0.035	2.653GluPro: 2.653 ± 0.043	3.851GluGln: 3.851 ± 0.047	3.701GluArg: 3.701 ± 0.051	3.621GluSer: 3.621 ± 0.044	3.744GluThr: 3.744 ± 0.047	4.231GluVal: 4.231 ± 0.052	0.829GluTrp: 0.829 ± 0.022	1.525GluTyr: 1.525 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.389PheAla: 3.389 ± 0.043	0.514PheCys: 0.514 ± 0.017	2.415PheAsp: 2.415 ± 0.04	2.42PheGlu: 2.42 ± 0.039	1.622PhePhe: 1.622 ± 0.031	2.98PheGly: 2.98 ± 0.047	0.769PheHis: 0.769 ± 0.019	1.974PheIle: 1.974 ± 0.032	1.391PheLys: 1.391 ± 0.029	4.028PheLeu: 4.028 ± 0.047	0.675PheMet: 0.675 ± 0.02	1.56PheAsn: 1.56 ± 0.03	1.84PhePro: 1.84 ± 0.034	1.938PheGln: 1.938 ± 0.035	2.121PheArg: 2.121 ± 0.036	2.995PheSer: 2.995 ± 0.039	2.266PheThr: 2.266 ± 0.036	2.603PheVal: 2.603 ± 0.035	0.697PheTrp: 0.697 ± 0.026	1.246PheTyr: 1.246 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	5.313GlyAla: 5.313 ± 0.065	0.753GlyCys: 0.753 ± 0.019	3.265GlyAsp: 3.265 ± 0.058	3.853GlyGlu: 3.853 ± 0.044	3.065GlyPhe: 3.065 ± 0.046	4.623GlyGly: 4.623 ± 0.078	1.219GlyHis: 1.219 ± 0.031	4.837GlyIle: 4.837 ± 0.052	3.4GlyLys: 3.4 ± 0.048	6.938GlyLeu: 6.938 ± 0.059	1.585GlyMet: 1.585 ± 0.031	2.68GlyAsn: 2.68 ± 0.058	0.9GlyPro: 0.9 ± 0.024	3.288GlyGln: 3.288 ± 0.049	3.535GlyArg: 3.535 ± 0.043	4.282GlySer: 4.282 ± 0.069	4.128GlyThr: 4.128 ± 0.067	4.579GlyVal: 4.579 ± 0.054	1.154GlyTrp: 1.154 ± 0.028	2.216GlyTyr: 2.216 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	1.323HisAla: 1.323 ± 0.026	0.303HisCys: 0.303 ± 0.012	0.923HisAsp: 0.923 ± 0.022	0.998HisGlu: 0.998 ± 0.025	0.821HisPhe: 0.821 ± 0.02	1.104HisGly: 1.104 ± 0.023	0.677HisHis: 0.677 ± 0.023	0.951HisIle: 0.951 ± 0.021	0.54HisLys: 0.54 ± 0.018	2.408HisLeu: 2.408 ± 0.039	0.272HisMet: 0.272 ± 0.011	0.566HisAsn: 0.566 ± 0.019	1.434HisPro: 1.434 ± 0.031	1.262HisGln: 1.262 ± 0.032	1.279HisArg: 1.279 ± 0.027	1.25HisSer: 1.25 ± 0.026	0.902HisThr: 0.902 ± 0.024	0.937HisVal: 0.937 ± 0.025	0.384HisTrp: 0.384 ± 0.015	0.677HisTyr: 0.677 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	8.084IleAla: 8.084 ± 0.062	0.676IleCys: 0.676 ± 0.018	3.906IleAsp: 3.906 ± 0.051	4.803IleGlu: 4.803 ± 0.055	2.111IlePhe: 2.111 ± 0.038	4.508IleGly: 4.508 ± 0.057	1.225IleHis: 1.225 ± 0.024	2.458IleIle: 2.458 ± 0.034	1.991IleLys: 1.991 ± 0.034	6.222IleLeu: 6.222 ± 0.054	0.77IleMet: 0.77 ± 0.019	2.104IleAsn: 2.104 ± 0.035	3.36IlePro: 3.36 ± 0.039	3.45IleGln: 3.45 ± 0.045	3.54IleArg: 3.54 ± 0.043	3.999IleSer: 3.999 ± 0.056	3.282IleThr: 3.282 ± 0.061	4.807IleVal: 4.807 ± 0.05	0.838IleTrp: 0.838 ± 0.022	1.598IleTyr: 1.598 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.847LysAla: 3.847 ± 0.051	0.255LysCys: 0.255 ± 0.012	1.852LysAsp: 1.852 ± 0.035	2.095LysGlu: 2.095 ± 0.04	1.489LysPhe: 1.489 ± 0.026	2.337LysGly: 2.337 ± 0.041	0.759LysHis: 0.759 ± 0.018	2.583LysIle: 2.583 ± 0.034	1.656LysLys: 1.656 ± 0.035	4.602LysLeu: 4.602 ± 0.054	0.812LysMet: 0.812 ± 0.016	1.364LysAsn: 1.364 ± 0.024	2.366LysPro: 2.366 ± 0.038	2.404LysGln: 2.404 ± 0.037	2.423LysArg: 2.423 ± 0.042	2.686LysSer: 2.686 ± 0.04	2.69LysThr: 2.69 ± 0.035	2.743LysVal: 2.743 ± 0.039	0.432LysTrp: 0.432 ± 0.015	0.946LysTyr: 0.946 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	9.606LeuAla: 9.606 ± 0.075	1.048LeuCys: 1.048 ± 0.026	5.708LeuAsp: 5.708 ± 0.051	6.994LeuGlu: 6.994 ± 0.059	3.823LeuPhe: 3.823 ± 0.05	7.261LeuGly: 7.261 ± 0.064	1.984LeuHis: 1.984 ± 0.035	6.508LeuIle: 6.508 ± 0.066	5.468LeuLys: 5.468 ± 0.058	11.052LeuLeu: 11.052 ± 0.101	2.301LeuMet: 2.301 ± 0.034	4.548LeuAsn: 4.548 ± 0.059	5.638LeuPro: 5.638 ± 0.068	5.513LeuGln: 5.513 ± 0.063	6.111LeuArg: 6.111 ± 0.063	7.997LeuSer: 7.997 ± 0.067	6.405LeuThr: 6.405 ± 0.062	6.739LeuVal: 6.739 ± 0.071	1.437LeuTrp: 1.437 ± 0.035	2.671LeuTyr: 2.671 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	1.709MetAla: 1.709 ± 0.031	0.123MetCys: 0.123 ± 0.007	0.756MetAsp: 0.756 ± 0.021	0.889MetGlu: 0.889 ± 0.021	0.587MetPhe: 0.587 ± 0.018	1.286MetGly: 1.286 ± 0.027	0.316MetHis: 0.316 ± 0.013	1.232MetIle: 1.232 ± 0.03	0.953MetLys: 0.953 ± 0.023	2.117MetLeu: 2.117 ± 0.036	0.53MetMet: 0.53 ± 0.018	0.916MetAsn: 0.916 ± 0.024	1.121MetPro: 1.121 ± 0.024	1.186MetGln: 1.186 ± 0.025	1.203MetArg: 1.203 ± 0.027	1.547MetSer: 1.547 ± 0.028	1.468MetThr: 1.468 ± 0.028	1.267MetVal: 1.267 ± 0.023	0.158MetTrp: 0.158 ± 0.01	0.357MetTyr: 0.357 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.278AsnAla: 3.278 ± 0.048	0.382AsnCys: 0.382 ± 0.014	1.645AsnAsp: 1.645 ± 0.044	1.626AsnGlu: 1.626 ± 0.029	1.576AsnPhe: 1.576 ± 0.031	2.588AsnGly: 2.588 ± 0.054	0.731AsnHis: 0.731 ± 0.021	1.817AsnIle: 1.817 ± 0.034	0.924AsnLys: 0.924 ± 0.029	4.743AsnLeu: 4.743 ± 0.047	0.553AsnMet: 0.553 ± 0.017	1.178AsnAsn: 1.178 ± 0.032	2.705AsnPro: 2.705 ± 0.041	2.465AsnGln: 2.465 ± 0.037	2.443AsnArg: 2.443 ± 0.039	2.436AsnSer: 2.436 ± 0.046	1.894AsnThr: 1.894 ± 0.046	2.095AsnVal: 2.095 ± 0.037	0.676AsnTrp: 0.676 ± 0.019	1.125AsnTyr: 1.125 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	3.824ProAla: 3.824 ± 0.051	0.361ProCys: 0.361 ± 0.014	3.174ProAsp: 3.174 ± 0.044	3.96ProGlu: 3.96 ± 0.047	1.809ProPhe: 1.809 ± 0.033	3.014ProGly: 3.014 ± 0.045	0.888ProHis: 0.888 ± 0.023	3.282ProIle: 3.282 ± 0.041	2.176ProLys: 2.176 ± 0.04	4.421ProLeu: 4.421 ± 0.047	0.922ProMet: 0.922 ± 0.022	2.209ProAsn: 2.209 ± 0.039	2.281ProPro: 2.281 ± 0.051	2.369ProGln: 2.369 ± 0.039	2.003ProArg: 2.003 ± 0.037	3.085ProSer: 3.085 ± 0.042	3.234ProThr: 3.234 ± 0.049	3.271ProVal: 3.271 ± 0.044	0.636ProTrp: 0.636 ± 0.018	1.222ProTyr: 1.222 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	5.668GlnAla: 5.668 ± 0.061	0.408GlnCys: 0.408 ± 0.014	2.274GlnAsp: 2.274 ± 0.039	3.111GlnGlu: 3.111 ± 0.04	2.194GlnPhe: 2.194 ± 0.036	3.412GlnGly: 3.412 ± 0.042	1.091GlnHis: 1.091 ± 0.028	3.784GlnIle: 3.784 ± 0.044	2.311GlnLys: 2.311 ± 0.037	5.949GlnLeu: 5.949 ± 0.065	1.171GlnMet: 1.171 ± 0.024	1.965GlnAsn: 1.965 ± 0.034	2.832GlnPro: 2.832 ± 0.045	3.885GlnGln: 3.885 ± 0.065	3.314GlnArg: 3.314 ± 0.043	3.631GlnSer: 3.631 ± 0.045	3.408GlnThr: 3.408 ± 0.047	4.0GlnVal: 4.0 ± 0.049	0.746GlnTrp: 0.746 ± 0.021	1.358GlnTyr: 1.358 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	4.267ArgAla: 4.267 ± 0.052	0.523ArgCys: 0.523 ± 0.015	3.113ArgAsp: 3.113 ± 0.043	3.549ArgGlu: 3.549 ± 0.047	2.631ArgPhe: 2.631 ± 0.041	3.183ArgGly: 3.183 ± 0.045	1.112ArgHis: 1.112 ± 0.023	3.732ArgIle: 3.732 ± 0.043	2.381ArgLys: 2.381 ± 0.037	6.567ArgLeu: 6.567 ± 0.063	1.276ArgMet: 1.276 ± 0.027	2.185ArgAsn: 2.185 ± 0.031	2.366ArgPro: 2.366 ± 0.04	3.482ArgGln: 3.482 ± 0.045	3.49ArgArg: 3.49 ± 0.049	4.789ArgSer: 4.789 ± 0.052	3.019ArgThr: 3.019 ± 0.037	3.855ArgVal: 3.855 ± 0.043	0.946ArgTrp: 0.946 ± 0.025	1.99ArgTyr: 1.99 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.578SerAla: 5.578 ± 0.066	0.568SerCys: 0.568 ± 0.019	3.624SerAsp: 3.624 ± 0.046	4.075SerGlu: 4.075 ± 0.047	2.589SerPhe: 2.589 ± 0.037	4.879SerGly: 4.879 ± 0.065	1.284SerHis: 1.284 ± 0.028	4.21SerIle: 4.21 ± 0.055	2.286SerLys: 2.286 ± 0.037	7.161SerLeu: 7.161 ± 0.062	1.321SerMet: 1.321 ± 0.025	2.489SerAsn: 2.489 ± 0.044	3.521SerPro: 3.521 ± 0.052	3.51SerGln: 3.51 ± 0.043	3.644SerArg: 3.644 ± 0.045	4.625SerSer: 4.625 ± 0.065	3.918SerThr: 3.918 ± 0.064	4.171SerVal: 4.171 ± 0.047	0.883SerTrp: 0.883 ± 0.019	1.682SerTyr: 1.682 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.249ThrAla: 5.249 ± 0.065	0.495ThrCys: 0.495 ± 0.016	2.659ThrAsp: 2.659 ± 0.043	3.33ThrGlu: 3.33 ± 0.043	2.192ThrPhe: 2.192 ± 0.04	4.269ThrGly: 4.269 ± 0.064	1.056ThrHis: 1.056 ± 0.023	4.146ThrIle: 4.146 ± 0.067	1.877ThrLys: 1.877 ± 0.031	6.605ThrLeu: 6.605 ± 0.06	0.88ThrMet: 0.88 ± 0.022	1.923ThrAsn: 1.923 ± 0.037	3.471ThrPro: 3.471 ± 0.054	3.173ThrGln: 3.173 ± 0.046	2.814ThrArg: 2.814 ± 0.039	3.409ThrSer: 3.409 ± 0.057	3.375ThrThr: 3.375 ± 0.063	4.283ThrVal: 4.283 ± 0.056	0.781ThrTrp: 0.781 ± 0.022	1.522ThrTyr: 1.522 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	5.856ValAla: 5.856 ± 0.06	0.636ValCys: 0.636 ± 0.017	3.442ValAsp: 3.442 ± 0.04	4.389ValGlu: 4.389 ± 0.052	2.588ValPhe: 2.588 ± 0.038	4.462ValGly: 4.462 ± 0.059	1.071ValHis: 1.071 ± 0.026	4.117ValIle: 4.117 ± 0.049	2.888ValLys: 2.888 ± 0.039	7.199ValLeu: 7.199 ± 0.068	1.512ValMet: 1.512 ± 0.03	2.503ValAsn: 2.503 ± 0.044	3.121ValPro: 3.121 ± 0.041	3.402ValGln: 3.402 ± 0.043	3.73ValArg: 3.73 ± 0.046	4.306ValSer: 4.306 ± 0.052	3.828ValThr: 3.828 ± 0.059	4.574ValVal: 4.574 ± 0.053	0.914ValTrp: 0.914 ± 0.026	1.654ValTyr: 1.654 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.063TrpAla: 1.063 ± 0.024	0.153TrpCys: 0.153 ± 0.008	0.616TrpAsp: 0.616 ± 0.017	0.807TrpGlu: 0.807 ± 0.023	0.677TrpPhe: 0.677 ± 0.02	0.872TrpGly: 0.872 ± 0.02	0.347TrpHis: 0.347 ± 0.013	1.032TrpIle: 1.032 ± 0.025	0.668TrpLys: 0.668 ± 0.02	1.834TrpLeu: 1.834 ± 0.036	0.391TrpMet: 0.391 ± 0.014	0.714TrpAsn: 0.714 ± 0.02	0.071TrpPro: 0.071 ± 0.006	1.186TrpGln: 1.186 ± 0.025	0.885TrpArg: 0.885 ± 0.023	0.942TrpSer: 0.942 ± 0.021	0.732TrpThr: 0.732 ± 0.02	0.936TrpVal: 0.936 ± 0.024	0.248TrpTrp: 0.248 ± 0.012	0.412TrpTyr: 0.412 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.178TyrAla: 2.178 ± 0.035	0.346TyrCys: 0.346 ± 0.015	1.473TyrAsp: 1.473 ± 0.041	1.612TyrGlu: 1.612 ± 0.029	1.199TyrPhe: 1.199 ± 0.028	1.954TyrGly: 1.954 ± 0.033	0.59TyrHis: 0.59 ± 0.017	1.244TyrIle: 1.244 ± 0.028	0.823TyrLys: 0.823 ± 0.022	3.216TyrLeu: 3.216 ± 0.04	0.375TyrMet: 0.375 ± 0.014	0.888TyrAsn: 0.888 ± 0.023	1.442TyrPro: 1.442 ± 0.029	1.797TyrGln: 1.797 ± 0.035	2.168TyrArg: 2.168 ± 0.035	1.742TyrSer: 1.742 ± 0.03	1.373TyrThr: 1.373 ± 0.027	1.61TyrVal: 1.61 ± 0.025	0.529TyrTrp: 0.529 ± 0.018	0.881TyrTyr: 0.881 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6678 proteins (2078917 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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