Amino acid dipepetide frequency for Salinivibrio phage SMHB1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.138AlaAla: 9.138 ± 1.159
0.688AlaCys: 0.688 ± 0.276
5.11AlaAsp: 5.11 ± 0.56
6.485AlaGlu: 6.485 ± 0.863
3.636AlaPhe: 3.636 ± 0.98
4.717AlaGly: 4.717 ± 0.743
2.162AlaHis: 2.162 ± 0.463
6.583AlaIle: 6.583 ± 0.89
4.717AlaLys: 4.717 ± 0.519
9.63AlaLeu: 9.63 ± 0.951
4.127AlaMet: 4.127 ± 0.552
3.144AlaAsn: 3.144 ± 0.566
3.734AlaPro: 3.734 ± 0.689
5.503AlaGln: 5.503 ± 0.803
3.734AlaArg: 3.734 ± 0.66
5.306AlaSer: 5.306 ± 0.674
5.994AlaThr: 5.994 ± 0.893
5.601AlaVal: 5.601 ± 0.909
1.474AlaTrp: 1.474 ± 0.364
2.555AlaTyr: 2.555 ± 0.552
0.0AlaXaa: 0.0 ± 0.0
Cys
1.376CysAla: 1.376 ± 0.342
0.295CysCys: 0.295 ± 0.177
0.688CysAsp: 0.688 ± 0.325
0.884CysGlu: 0.884 ± 0.314
0.295CysPhe: 0.295 ± 0.155
1.179CysGly: 1.179 ± 0.607
0.0CysHis: 0.0 ± 0.0
0.197CysIle: 0.197 ± 0.123
0.197CysLys: 0.197 ± 0.134
0.688CysLeu: 0.688 ± 0.228
0.197CysMet: 0.197 ± 0.146
0.098CysAsn: 0.098 ± 0.105
0.491CysPro: 0.491 ± 0.214
0.393CysGln: 0.393 ± 0.264
0.688CysArg: 0.688 ± 0.232
0.786CysSer: 0.786 ± 0.306
0.786CysThr: 0.786 ± 0.265
0.688CysVal: 0.688 ± 0.25
0.197CysTrp: 0.197 ± 0.155
0.295CysTyr: 0.295 ± 0.183
0.0CysXaa: 0.0 ± 0.0
Asp
6.19AspAla: 6.19 ± 0.649
0.983AspCys: 0.983 ± 0.365
5.011AspAsp: 5.011 ± 1.006
5.208AspGlu: 5.208 ± 0.777
2.358AspPhe: 2.358 ± 0.472
3.93AspGly: 3.93 ± 0.744
0.884AspHis: 0.884 ± 0.273
3.439AspIle: 3.439 ± 0.587
3.832AspLys: 3.832 ± 0.642
5.896AspLeu: 5.896 ± 0.674
1.965AspMet: 1.965 ± 0.336
1.867AspAsn: 1.867 ± 0.494
2.751AspPro: 2.751 ± 0.423
1.965AspGln: 1.965 ± 0.479
2.162AspArg: 2.162 ± 0.408
2.555AspSer: 2.555 ± 0.461
3.046AspThr: 3.046 ± 0.59
4.815AspVal: 4.815 ± 0.606
1.376AspTrp: 1.376 ± 0.351
2.358AspTyr: 2.358 ± 0.638
0.0AspXaa: 0.0 ± 0.0
Glu
5.503GluAla: 5.503 ± 0.771
0.393GluCys: 0.393 ± 0.191
3.832GluAsp: 3.832 ± 0.613
3.439GluGlu: 3.439 ± 0.627
2.555GluPhe: 2.555 ± 0.478
2.26GluGly: 2.26 ± 0.557
2.457GluHis: 2.457 ± 0.512
4.029GluIle: 4.029 ± 0.586
3.734GluLys: 3.734 ± 0.573
8.156GluLeu: 8.156 ± 0.766
2.653GluMet: 2.653 ± 0.64
3.636GluAsn: 3.636 ± 0.575
2.358GluPro: 2.358 ± 0.416
5.404GluGln: 5.404 ± 0.832
4.029GluArg: 4.029 ± 0.664
4.127GluSer: 4.127 ± 0.786
3.93GluThr: 3.93 ± 0.56
3.046GluVal: 3.046 ± 0.478
0.786GluTrp: 0.786 ± 0.27
2.358GluTyr: 2.358 ± 0.527
0.0GluXaa: 0.0 ± 0.0
Phe
3.439PheAla: 3.439 ± 0.518
0.491PheCys: 0.491 ± 0.218
3.439PheAsp: 3.439 ± 0.599
2.457PheGlu: 2.457 ± 0.556
0.983PhePhe: 0.983 ± 0.291
2.555PheGly: 2.555 ± 0.6
0.295PheHis: 0.295 ± 0.144
1.867PheIle: 1.867 ± 0.421
2.457PheLys: 2.457 ± 0.564
1.965PheLeu: 1.965 ± 0.392
0.491PheMet: 0.491 ± 0.216
1.867PheAsn: 1.867 ± 0.469
0.983PhePro: 0.983 ± 0.314
1.376PheGln: 1.376 ± 0.373
2.457PheArg: 2.457 ± 0.484
2.948PheSer: 2.948 ± 0.67
1.965PheThr: 1.965 ± 0.491
2.162PheVal: 2.162 ± 0.573
0.59PheTrp: 0.59 ± 0.275
0.884PheTyr: 0.884 ± 0.291
0.0PheXaa: 0.0 ± 0.0
Gly
4.422GlyAla: 4.422 ± 0.77
0.59GlyCys: 0.59 ± 0.251
4.029GlyAsp: 4.029 ± 0.525
5.699GlyGlu: 5.699 ± 0.609
1.867GlyPhe: 1.867 ± 0.377
5.699GlyGly: 5.699 ± 0.769
1.179GlyHis: 1.179 ± 0.313
4.029GlyIle: 4.029 ± 0.588
4.422GlyLys: 4.422 ± 0.752
4.323GlyLeu: 4.323 ± 0.582
1.67GlyMet: 1.67 ± 0.44
3.243GlyAsn: 3.243 ± 0.472
0.884GlyPro: 0.884 ± 0.355
2.85GlyGln: 2.85 ± 0.504
4.618GlyArg: 4.618 ± 0.797
2.555GlySer: 2.555 ± 0.383
3.243GlyThr: 3.243 ± 0.701
5.208GlyVal: 5.208 ± 0.79
1.081GlyTrp: 1.081 ± 0.301
2.85GlyTyr: 2.85 ± 0.502
0.0GlyXaa: 0.0 ± 0.0
His
2.063HisAla: 2.063 ± 0.412
0.688HisCys: 0.688 ± 0.283
1.474HisAsp: 1.474 ± 0.418
0.59HisGlu: 0.59 ± 0.232
0.393HisPhe: 0.393 ± 0.196
1.376HisGly: 1.376 ± 0.265
0.491HisHis: 0.491 ± 0.216
1.474HisIle: 1.474 ± 0.424
1.179HisLys: 1.179 ± 0.342
1.572HisLeu: 1.572 ± 0.423
0.295HisMet: 0.295 ± 0.154
1.572HisAsn: 1.572 ± 0.319
0.884HisPro: 0.884 ± 0.355
1.081HisGln: 1.081 ± 0.409
1.572HisArg: 1.572 ± 0.476
0.688HisSer: 0.688 ± 0.353
0.884HisThr: 0.884 ± 0.372
1.572HisVal: 1.572 ± 0.339
0.295HisTrp: 0.295 ± 0.139
0.983HisTyr: 0.983 ± 0.293
0.0HisXaa: 0.0 ± 0.0
Ile
6.682IleAla: 6.682 ± 0.718
0.295IleCys: 0.295 ± 0.156
4.717IleAsp: 4.717 ± 0.818
6.485IleGlu: 6.485 ± 1.043
1.277IlePhe: 1.277 ± 0.344
4.618IleGly: 4.618 ± 0.718
0.983IleHis: 0.983 ± 0.293
2.751IleIle: 2.751 ± 0.421
3.537IleLys: 3.537 ± 0.464
2.85IleLeu: 2.85 ± 0.447
0.983IleMet: 0.983 ± 0.32
2.26IleAsn: 2.26 ± 0.519
3.144IlePro: 3.144 ± 0.722
2.457IleGln: 2.457 ± 0.485
3.046IleArg: 3.046 ± 0.638
3.636IleSer: 3.636 ± 0.603
3.341IleThr: 3.341 ± 0.504
3.341IleVal: 3.341 ± 0.522
0.491IleTrp: 0.491 ± 0.219
1.474IleTyr: 1.474 ± 0.337
0.0IleXaa: 0.0 ± 0.0
Lys
6.092LysAla: 6.092 ± 0.688
0.393LysCys: 0.393 ± 0.24
3.537LysAsp: 3.537 ± 0.576
3.144LysGlu: 3.144 ± 0.589
1.965LysPhe: 1.965 ± 0.509
3.832LysGly: 3.832 ± 0.429
0.983LysHis: 0.983 ± 0.274
2.751LysIle: 2.751 ± 0.492
4.913LysLys: 4.913 ± 0.589
5.797LysLeu: 5.797 ± 0.529
1.965LysMet: 1.965 ± 0.411
3.537LysAsn: 3.537 ± 0.525
2.85LysPro: 2.85 ± 0.564
2.85LysGln: 2.85 ± 0.451
2.555LysArg: 2.555 ± 0.465
4.323LysSer: 4.323 ± 0.7
3.341LysThr: 3.341 ± 0.556
3.537LysVal: 3.537 ± 0.452
1.179LysTrp: 1.179 ± 0.256
1.572LysTyr: 1.572 ± 0.458
0.0LysXaa: 0.0 ± 0.0
Leu
6.682LeuAla: 6.682 ± 0.775
0.786LeuCys: 0.786 ± 0.224
5.994LeuAsp: 5.994 ± 0.622
5.306LeuGlu: 5.306 ± 0.707
4.029LeuPhe: 4.029 ± 0.556
5.601LeuGly: 5.601 ± 0.789
2.162LeuHis: 2.162 ± 0.472
5.11LeuIle: 5.11 ± 0.554
5.11LeuLys: 5.11 ± 0.927
6.878LeuLeu: 6.878 ± 0.713
2.358LeuMet: 2.358 ± 0.446
3.636LeuAsn: 3.636 ± 0.722
3.832LeuPro: 3.832 ± 0.806
3.046LeuGln: 3.046 ± 0.467
6.19LeuArg: 6.19 ± 0.657
5.306LeuSer: 5.306 ± 0.728
5.404LeuThr: 5.404 ± 0.523
4.717LeuVal: 4.717 ± 0.585
0.884LeuTrp: 0.884 ± 0.312
1.376LeuTyr: 1.376 ± 0.4
0.0LeuXaa: 0.0 ± 0.0
Met
3.341MetAla: 3.341 ± 0.476
0.491MetCys: 0.491 ± 0.232
0.983MetAsp: 0.983 ± 0.284
1.081MetGlu: 1.081 ± 0.28
0.786MetPhe: 0.786 ± 0.312
2.358MetGly: 2.358 ± 0.576
0.393MetHis: 0.393 ± 0.213
1.474MetIle: 1.474 ± 0.406
1.376MetLys: 1.376 ± 0.473
1.769MetLeu: 1.769 ± 0.478
0.688MetMet: 0.688 ± 0.267
1.867MetAsn: 1.867 ± 0.465
1.081MetPro: 1.081 ± 0.353
1.474MetGln: 1.474 ± 0.477
1.572MetArg: 1.572 ± 0.427
2.162MetSer: 2.162 ± 0.464
1.474MetThr: 1.474 ± 0.448
1.474MetVal: 1.474 ± 0.334
0.197MetTrp: 0.197 ± 0.139
0.393MetTyr: 0.393 ± 0.239
0.0MetXaa: 0.0 ± 0.0
Asn
4.422AsnAla: 4.422 ± 0.605
0.59AsnCys: 0.59 ± 0.246
1.769AsnAsp: 1.769 ± 0.361
3.341AsnGlu: 3.341 ± 0.552
1.867AsnPhe: 1.867 ± 0.423
4.618AsnGly: 4.618 ± 0.735
0.688AsnHis: 0.688 ± 0.208
2.653AsnIle: 2.653 ± 0.479
2.948AsnLys: 2.948 ± 0.536
3.636AsnLeu: 3.636 ± 0.584
0.884AsnMet: 0.884 ± 0.249
1.474AsnAsn: 1.474 ± 0.366
1.867AsnPro: 1.867 ± 0.362
2.162AsnGln: 2.162 ± 0.458
1.965AsnArg: 1.965 ± 0.478
2.555AsnSer: 2.555 ± 0.654
2.85AsnThr: 2.85 ± 0.658
2.653AsnVal: 2.653 ± 0.562
0.59AsnTrp: 0.59 ± 0.244
0.983AsnTyr: 0.983 ± 0.289
0.0AsnXaa: 0.0 ± 0.0
Pro
2.85ProAla: 2.85 ± 0.535
0.098ProCys: 0.098 ± 0.091
2.948ProAsp: 2.948 ± 0.647
4.422ProGlu: 4.422 ± 0.792
1.965ProPhe: 1.965 ± 0.392
2.26ProGly: 2.26 ± 0.431
1.67ProHis: 1.67 ± 0.378
1.376ProIle: 1.376 ± 0.281
2.358ProLys: 2.358 ± 0.523
2.948ProLeu: 2.948 ± 0.514
0.884ProMet: 0.884 ± 0.268
1.67ProAsn: 1.67 ± 0.412
0.983ProPro: 0.983 ± 0.337
1.572ProGln: 1.572 ± 0.444
2.26ProArg: 2.26 ± 0.547
2.751ProSer: 2.751 ± 0.5
2.85ProThr: 2.85 ± 0.575
3.243ProVal: 3.243 ± 0.518
0.098ProTrp: 0.098 ± 0.088
1.376ProTyr: 1.376 ± 0.434
0.0ProXaa: 0.0 ± 0.0
Gln
5.306GlnAla: 5.306 ± 0.622
0.491GlnCys: 0.491 ± 0.282
2.751GlnAsp: 2.751 ± 0.512
1.965GlnGlu: 1.965 ± 0.662
2.26GlnPhe: 2.26 ± 0.383
2.162GlnGly: 2.162 ± 0.641
1.081GlnHis: 1.081 ± 0.392
3.046GlnIle: 3.046 ± 0.6
2.26GlnLys: 2.26 ± 0.483
4.618GlnLeu: 4.618 ± 0.74
0.983GlnMet: 0.983 ± 0.302
2.26GlnAsn: 2.26 ± 0.582
2.751GlnPro: 2.751 ± 0.495
3.144GlnGln: 3.144 ± 0.577
3.537GlnArg: 3.537 ± 0.571
2.948GlnSer: 2.948 ± 0.515
2.26GlnThr: 2.26 ± 0.451
2.358GlnVal: 2.358 ± 0.498
1.179GlnTrp: 1.179 ± 0.291
1.67GlnTyr: 1.67 ± 0.362
0.0GlnXaa: 0.0 ± 0.0
Arg
4.717ArgAla: 4.717 ± 0.658
0.491ArgCys: 0.491 ± 0.206
3.832ArgAsp: 3.832 ± 0.76
4.717ArgGlu: 4.717 ± 0.696
1.867ArgPhe: 1.867 ± 0.34
2.555ArgGly: 2.555 ± 0.497
1.376ArgHis: 1.376 ± 0.352
4.52ArgIle: 4.52 ± 0.567
3.93ArgLys: 3.93 ± 0.812
4.717ArgLeu: 4.717 ± 0.882
1.081ArgMet: 1.081 ± 0.303
2.358ArgAsn: 2.358 ± 0.485
1.769ArgPro: 1.769 ± 0.451
2.948ArgGln: 2.948 ± 0.646
3.243ArgArg: 3.243 ± 0.762
2.948ArgSer: 2.948 ± 0.547
2.653ArgThr: 2.653 ± 0.451
2.948ArgVal: 2.948 ± 0.656
0.983ArgTrp: 0.983 ± 0.324
2.358ArgTyr: 2.358 ± 0.451
0.0ArgXaa: 0.0 ± 0.0
Ser
5.797SerAla: 5.797 ± 0.739
0.59SerCys: 0.59 ± 0.23
3.93SerAsp: 3.93 ± 0.504
3.734SerGlu: 3.734 ± 0.76
1.277SerPhe: 1.277 ± 0.242
4.029SerGly: 4.029 ± 0.637
1.081SerHis: 1.081 ± 0.266
3.144SerIle: 3.144 ± 0.507
4.323SerLys: 4.323 ± 0.734
4.52SerLeu: 4.52 ± 0.747
1.67SerMet: 1.67 ± 0.543
2.653SerAsn: 2.653 ± 0.526
2.653SerPro: 2.653 ± 0.589
3.243SerGln: 3.243 ± 0.562
2.457SerArg: 2.457 ± 0.596
3.636SerSer: 3.636 ± 0.927
2.85SerThr: 2.85 ± 0.424
4.029SerVal: 4.029 ± 0.544
0.688SerTrp: 0.688 ± 0.239
1.867SerTyr: 1.867 ± 0.498
0.0SerXaa: 0.0 ± 0.0
Thr
5.797ThrAla: 5.797 ± 0.735
0.59ThrCys: 0.59 ± 0.202
4.323ThrAsp: 4.323 ± 0.655
3.734ThrGlu: 3.734 ± 0.642
2.063ThrPhe: 2.063 ± 0.384
4.913ThrGly: 4.913 ± 0.563
1.179ThrHis: 1.179 ± 0.323
2.948ThrIle: 2.948 ± 0.566
3.832ThrLys: 3.832 ± 0.534
4.618ThrLeu: 4.618 ± 0.606
0.786ThrMet: 0.786 ± 0.304
2.26ThrAsn: 2.26 ± 0.605
3.537ThrPro: 3.537 ± 0.509
2.653ThrGln: 2.653 ± 0.632
2.653ThrArg: 2.653 ± 0.425
2.555ThrSer: 2.555 ± 0.46
3.144ThrThr: 3.144 ± 0.579
3.439ThrVal: 3.439 ± 0.428
1.474ThrTrp: 1.474 ± 0.324
1.277ThrTyr: 1.277 ± 0.389
0.0ThrXaa: 0.0 ± 0.0
Val
6.583ValAla: 6.583 ± 1.085
0.786ValCys: 0.786 ± 0.229
2.555ValAsp: 2.555 ± 0.393
4.127ValGlu: 4.127 ± 0.701
2.26ValPhe: 2.26 ± 0.498
3.537ValGly: 3.537 ± 0.633
0.393ValHis: 0.393 ± 0.182
3.93ValIle: 3.93 ± 0.853
3.537ValLys: 3.537 ± 0.621
5.208ValLeu: 5.208 ± 0.721
1.67ValMet: 1.67 ± 0.381
3.537ValAsn: 3.537 ± 0.645
2.653ValPro: 2.653 ± 0.612
1.572ValGln: 1.572 ± 0.362
3.243ValArg: 3.243 ± 0.747
3.537ValSer: 3.537 ± 0.647
5.306ValThr: 5.306 ± 0.787
3.93ValVal: 3.93 ± 0.702
0.786ValTrp: 0.786 ± 0.277
2.26ValTyr: 2.26 ± 0.419
0.0ValXaa: 0.0 ± 0.0
Trp
0.884TrpAla: 0.884 ± 0.283
0.295TrpCys: 0.295 ± 0.222
0.884TrpAsp: 0.884 ± 0.271
0.688TrpGlu: 0.688 ± 0.213
0.393TrpPhe: 0.393 ± 0.179
0.491TrpGly: 0.491 ± 0.236
0.393TrpHis: 0.393 ± 0.181
1.081TrpIle: 1.081 ± 0.306
0.688TrpLys: 0.688 ± 0.223
1.769TrpLeu: 1.769 ± 0.395
0.491TrpMet: 0.491 ± 0.171
0.688TrpAsn: 0.688 ± 0.22
0.688TrpPro: 0.688 ± 0.264
1.376TrpGln: 1.376 ± 0.356
1.376TrpArg: 1.376 ± 0.502
0.884TrpSer: 0.884 ± 0.296
1.081TrpThr: 1.081 ± 0.311
0.983TrpVal: 0.983 ± 0.288
0.098TrpTrp: 0.098 ± 0.088
0.098TrpTyr: 0.098 ± 0.105
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.751TyrAla: 2.751 ± 0.51
0.393TyrCys: 0.393 ± 0.282
0.786TyrAsp: 0.786 ± 0.251
1.179TyrGlu: 1.179 ± 0.277
1.572TyrPhe: 1.572 ± 0.344
1.769TyrGly: 1.769 ± 0.349
1.277TyrHis: 1.277 ± 0.328
1.965TyrIle: 1.965 ± 0.391
1.769TyrLys: 1.769 ± 0.328
2.85TyrLeu: 2.85 ± 0.478
0.59TyrMet: 0.59 ± 0.237
0.884TyrAsn: 0.884 ± 0.232
0.688TyrPro: 0.688 ± 0.272
1.965TyrGln: 1.965 ± 0.392
2.653TyrArg: 2.653 ± 0.511
1.965TyrSer: 1.965 ± 0.453
1.376TyrThr: 1.376 ± 0.374
1.67TyrVal: 1.67 ± 0.434
0.884TyrTrp: 0.884 ± 0.255
0.884TyrTyr: 0.884 ± 0.238
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (10178 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski