Amino acid dipepetide frequency for Candidatus Pantoea carbekii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.128AlaAla: 5.128 ± 0.151
1.096AlaCys: 1.096 ± 0.067
2.859AlaAsp: 2.859 ± 0.115
3.645AlaGlu: 3.645 ± 0.122
2.453AlaPhe: 2.453 ± 0.101
4.247AlaGly: 4.247 ± 0.144
1.464AlaHis: 1.464 ± 0.081
6.489AlaIle: 6.489 ± 0.168
4.044AlaLys: 4.044 ± 0.13
7.742AlaLeu: 7.742 ± 0.175
1.985AlaMet: 1.985 ± 0.077
3.128AlaAsn: 3.128 ± 0.11
1.794AlaPro: 1.794 ± 0.08
2.595AlaGln: 2.595 ± 0.114
3.472AlaArg: 3.472 ± 0.119
3.576AlaSer: 3.576 ± 0.119
3.269AlaThr: 3.269 ± 0.118
4.185AlaVal: 4.185 ± 0.149
0.782AlaTrp: 0.782 ± 0.051
1.982AlaTyr: 1.982 ± 0.094
0.0AlaXaa: 0.0 ± 0.0
Cys
0.901CysAla: 0.901 ± 0.059
0.264CysCys: 0.264 ± 0.033
0.655CysAsp: 0.655 ± 0.049
0.736CysGlu: 0.736 ± 0.058
0.617CysPhe: 0.617 ± 0.05
1.085CysGly: 1.085 ± 0.063
0.387CysHis: 0.387 ± 0.035
1.441CysIle: 1.441 ± 0.084
0.889CysLys: 0.889 ± 0.059
1.353CysLeu: 1.353 ± 0.078
0.345CysMet: 0.345 ± 0.038
0.924CysAsn: 0.924 ± 0.067
0.517CysPro: 0.517 ± 0.045
0.548CysGln: 0.548 ± 0.051
0.659CysArg: 0.659 ± 0.052
1.023CysSer: 1.023 ± 0.056
0.675CysThr: 0.675 ± 0.047
0.744CysVal: 0.744 ± 0.047
0.207CysTrp: 0.207 ± 0.024
0.579CysTyr: 0.579 ± 0.05
0.0CysXaa: 0.0 ± 0.0
Asp
2.848AspAla: 2.848 ± 0.096
0.59AspCys: 0.59 ± 0.051
1.859AspAsp: 1.859 ± 0.084
2.587AspGlu: 2.587 ± 0.103
2.1AspPhe: 2.1 ± 0.087
2.472AspGly: 2.472 ± 0.104
1.089AspHis: 1.089 ± 0.058
5.006AspIle: 5.006 ± 0.156
2.664AspLys: 2.664 ± 0.113
4.684AspLeu: 4.684 ± 0.153
1.184AspMet: 1.184 ± 0.062
2.384AspAsn: 2.384 ± 0.083
1.64AspPro: 1.64 ± 0.072
1.752AspGln: 1.752 ± 0.084
2.403AspArg: 2.403 ± 0.111
2.675AspSer: 2.675 ± 0.105
2.357AspThr: 2.357 ± 0.107
2.878AspVal: 2.878 ± 0.112
0.571AspTrp: 0.571 ± 0.047
1.732AspTyr: 1.732 ± 0.088
0.0AspXaa: 0.0 ± 0.0
Glu
3.541GluAla: 3.541 ± 0.113
0.636GluCys: 0.636 ± 0.057
2.039GluAsp: 2.039 ± 0.1
3.062GluGlu: 3.062 ± 0.119
2.008GluPhe: 2.008 ± 0.082
2.779GluGly: 2.779 ± 0.124
1.476GluHis: 1.476 ± 0.075
5.232GluIle: 5.232 ± 0.15
4.162GluLys: 4.162 ± 0.139
5.741GluLeu: 5.741 ± 0.152
1.571GluMet: 1.571 ± 0.081
3.036GluAsn: 3.036 ± 0.117
1.43GluPro: 1.43 ± 0.073
2.461GluGln: 2.461 ± 0.105
2.993GluArg: 2.993 ± 0.118
2.71GluSer: 2.71 ± 0.099
2.595GluThr: 2.595 ± 0.109
3.518GluVal: 3.518 ± 0.123
0.491GluTrp: 0.491 ± 0.039
1.725GluTyr: 1.725 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
2.143PheAla: 2.143 ± 0.093
0.751PheCys: 0.751 ± 0.063
2.254PheAsp: 2.254 ± 0.082
2.054PheGlu: 2.054 ± 0.094
2.043PhePhe: 2.043 ± 0.121
2.886PheGly: 2.886 ± 0.111
0.878PheHis: 0.878 ± 0.065
3.944PheIle: 3.944 ± 0.143
2.43PheLys: 2.43 ± 0.102
3.917PheLeu: 3.917 ± 0.129
0.989PheMet: 0.989 ± 0.061
2.775PheAsn: 2.775 ± 0.112
1.495PhePro: 1.495 ± 0.075
1.491PheGln: 1.491 ± 0.074
1.863PheArg: 1.863 ± 0.098
3.637PheSer: 3.637 ± 0.122
2.108PheThr: 2.108 ± 0.098
1.982PheVal: 1.982 ± 0.088
0.529PheTrp: 0.529 ± 0.049
1.633PheTyr: 1.633 ± 0.083
0.0PheXaa: 0.0 ± 0.0
Gly
3.867GlyAla: 3.867 ± 0.145
1.031GlyCys: 1.031 ± 0.056
2.717GlyAsp: 2.717 ± 0.111
3.181GlyGlu: 3.181 ± 0.119
2.729GlyPhe: 2.729 ± 0.123
3.909GlyGly: 3.909 ± 0.148
1.587GlyHis: 1.587 ± 0.081
6.497GlyIle: 6.497 ± 0.168
4.262GlyLys: 4.262 ± 0.131
6.037GlyLeu: 6.037 ± 0.132
1.844GlyMet: 1.844 ± 0.082
2.855GlyAsn: 2.855 ± 0.119
1.652GlyPro: 1.652 ± 0.074
2.376GlyGln: 2.376 ± 0.088
3.158GlyArg: 3.158 ± 0.133
3.699GlySer: 3.699 ± 0.13
3.185GlyThr: 3.185 ± 0.12
3.84GlyVal: 3.84 ± 0.103
0.698GlyTrp: 0.698 ± 0.051
2.399GlyTyr: 2.399 ± 0.097
0.0GlyXaa: 0.0 ± 0.0
His
1.748HisAla: 1.748 ± 0.08
0.445HisCys: 0.445 ± 0.039
1.115HisAsp: 1.115 ± 0.067
1.062HisGlu: 1.062 ± 0.073
1.192HisPhe: 1.192 ± 0.065
1.667HisGly: 1.667 ± 0.075
0.763HisHis: 0.763 ± 0.054
2.43HisIle: 2.43 ± 0.085
1.169HisLys: 1.169 ± 0.076
2.656HisLeu: 2.656 ± 0.09
0.678HisMet: 0.678 ± 0.047
1.326HisAsn: 1.326 ± 0.073
1.226HisPro: 1.226 ± 0.071
1.004HisGln: 1.004 ± 0.059
1.188HisArg: 1.188 ± 0.074
1.556HisSer: 1.556 ± 0.075
1.246HisThr: 1.246 ± 0.064
1.384HisVal: 1.384 ± 0.075
0.36HisTrp: 0.36 ± 0.04
1.062HisTyr: 1.062 ± 0.077
0.0HisXaa: 0.0 ± 0.0
Ile
7.194IleAla: 7.194 ± 0.167
1.253IleCys: 1.253 ± 0.063
5.351IleAsp: 5.351 ± 0.138
5.623IleGlu: 5.623 ± 0.149
3.702IlePhe: 3.702 ± 0.124
6.474IleGly: 6.474 ± 0.182
2.12IleHis: 2.12 ± 0.112
8.279IleIle: 8.279 ± 0.226
5.841IleLys: 5.841 ± 0.156
8.873IleLeu: 8.873 ± 0.199
2.169IleMet: 2.169 ± 0.104
5.757IleAsn: 5.757 ± 0.153
3.384IlePro: 3.384 ± 0.119
3.645IleGln: 3.645 ± 0.109
4.224IleArg: 4.224 ± 0.136
6.719IleSer: 6.719 ± 0.179
5.389IleThr: 5.389 ± 0.149
5.492IleVal: 5.492 ± 0.165
0.882IleTrp: 0.882 ± 0.059
2.806IleTyr: 2.806 ± 0.11
0.0IleXaa: 0.0 ± 0.0
Lys
3.871LysAla: 3.871 ± 0.123
0.767LysCys: 0.767 ± 0.057
2.556LysAsp: 2.556 ± 0.115
3.499LysGlu: 3.499 ± 0.122
2.223LysPhe: 2.223 ± 0.102
3.626LysGly: 3.626 ± 0.121
1.545LysHis: 1.545 ± 0.073
6.543LysIle: 6.543 ± 0.182
5.791LysLys: 5.791 ± 0.184
6.68LysLeu: 6.68 ± 0.174
1.775LysMet: 1.775 ± 0.096
4.507LysAsn: 4.507 ± 0.129
2.008LysPro: 2.008 ± 0.088
2.771LysGln: 2.771 ± 0.107
3.354LysArg: 3.354 ± 0.118
3.446LysSer: 3.446 ± 0.125
3.193LysThr: 3.193 ± 0.103
3.626LysVal: 3.626 ± 0.114
0.64LysTrp: 0.64 ± 0.044
2.227LysTyr: 2.227 ± 0.115
0.0LysXaa: 0.0 ± 0.0
Leu
7.52LeuAla: 7.52 ± 0.197
1.568LeuCys: 1.568 ± 0.074
4.944LeuAsp: 4.944 ± 0.148
5.699LeuGlu: 5.699 ± 0.143
4.224LeuPhe: 4.224 ± 0.153
5.991LeuGly: 5.991 ± 0.165
2.737LeuHis: 2.737 ± 0.107
8.861LeuIle: 8.861 ± 0.227
7.114LeuLys: 7.114 ± 0.154
11.05LeuLeu: 11.05 ± 0.265
2.767LeuMet: 2.767 ± 0.107
5.741LeuAsn: 5.741 ± 0.164
4.569LeuPro: 4.569 ± 0.146
4.228LeuGln: 4.228 ± 0.119
5.603LeuArg: 5.603 ± 0.153
7.34LeuSer: 7.34 ± 0.185
5.573LeuThr: 5.573 ± 0.138
6.129LeuVal: 6.129 ± 0.163
1.039LeuTrp: 1.039 ± 0.07
3.277LeuTyr: 3.277 ± 0.118
0.0LeuXaa: 0.0 ± 0.0
Met
1.755MetAla: 1.755 ± 0.08
0.287MetCys: 0.287 ± 0.031
1.035MetAsp: 1.035 ± 0.07
1.207MetGlu: 1.207 ± 0.073
0.928MetPhe: 0.928 ± 0.063
1.51MetGly: 1.51 ± 0.083
0.755MetHis: 0.755 ± 0.051
2.449MetIle: 2.449 ± 0.104
1.625MetLys: 1.625 ± 0.079
3.342MetLeu: 3.342 ± 0.104
0.736MetMet: 0.736 ± 0.053
1.525MetAsn: 1.525 ± 0.081
1.154MetPro: 1.154 ± 0.07
1.15MetGln: 1.15 ± 0.065
1.426MetArg: 1.426 ± 0.081
1.61MetSer: 1.61 ± 0.08
1.288MetThr: 1.288 ± 0.07
1.575MetVal: 1.575 ± 0.078
0.188MetTrp: 0.188 ± 0.025
0.686MetTyr: 0.686 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
3.43AsnAla: 3.43 ± 0.124
0.694AsnCys: 0.694 ± 0.048
2.388AsnAsp: 2.388 ± 0.118
2.691AsnGlu: 2.691 ± 0.084
2.79AsnPhe: 2.79 ± 0.113
3.12AsnGly: 3.12 ± 0.128
1.433AsnHis: 1.433 ± 0.083
5.987AsnIle: 5.987 ± 0.167
3.798AsnLys: 3.798 ± 0.133
5.408AsnLeu: 5.408 ± 0.143
1.525AsnMet: 1.525 ± 0.086
3.676AsnAsn: 3.676 ± 0.158
2.104AsnPro: 2.104 ± 0.093
2.242AsnGln: 2.242 ± 0.103
2.694AsnArg: 2.694 ± 0.104
3.384AsnSer: 3.384 ± 0.127
3.043AsnThr: 3.043 ± 0.106
3.193AsnVal: 3.193 ± 0.131
0.805AsnTrp: 0.805 ± 0.058
1.997AsnTyr: 1.997 ± 0.077
0.0AsnXaa: 0.0 ± 0.0
Pro
1.882ProAla: 1.882 ± 0.085
0.498ProCys: 0.498 ± 0.051
1.571ProAsp: 1.571 ± 0.082
2.154ProGlu: 2.154 ± 0.085
1.759ProPhe: 1.759 ± 0.083
2.166ProGly: 2.166 ± 0.101
0.866ProHis: 0.866 ± 0.055
3.522ProIle: 3.522 ± 0.124
2.012ProLys: 2.012 ± 0.082
3.722ProLeu: 3.722 ± 0.117
0.951ProMet: 0.951 ± 0.064
1.936ProAsn: 1.936 ± 0.079
0.928ProPro: 0.928 ± 0.062
1.192ProGln: 1.192 ± 0.069
1.307ProArg: 1.307 ± 0.066
2.143ProSer: 2.143 ± 0.096
1.974ProThr: 1.974 ± 0.089
2.365ProVal: 2.365 ± 0.082
0.418ProTrp: 0.418 ± 0.034
1.437ProTyr: 1.437 ± 0.077
0.0ProXaa: 0.0 ± 0.0
Gln
2.717GlnAla: 2.717 ± 0.111
0.552GlnCys: 0.552 ± 0.048
1.541GlnAsp: 1.541 ± 0.082
2.261GlnGlu: 2.261 ± 0.104
1.495GlnPhe: 1.495 ± 0.071
2.395GlnGly: 2.395 ± 0.09
1.173GlnHis: 1.173 ± 0.069
3.576GlnIle: 3.576 ± 0.128
3.055GlnLys: 3.055 ± 0.1
4.5GlnLeu: 4.5 ± 0.145
0.924GlnMet: 0.924 ± 0.066
1.936GlnAsn: 1.936 ± 0.082
1.464GlnPro: 1.464 ± 0.077
2.062GlnGln: 2.062 ± 0.101
2.208GlnArg: 2.208 ± 0.093
2.2GlnSer: 2.2 ± 0.077
1.859GlnThr: 1.859 ± 0.071
2.545GlnVal: 2.545 ± 0.108
0.383GlnTrp: 0.383 ± 0.039
1.51GlnTyr: 1.51 ± 0.077
0.0GlnXaa: 0.0 ± 0.0
Arg
3.17ArgAla: 3.17 ± 0.104
0.671ArgCys: 0.671 ± 0.053
2.307ArgAsp: 2.307 ± 0.1
2.951ArgGlu: 2.951 ± 0.105
2.522ArgPhe: 2.522 ± 0.097
2.771ArgGly: 2.771 ± 0.105
1.326ArgHis: 1.326 ± 0.066
4.634ArgIle: 4.634 ± 0.129
2.936ArgLys: 2.936 ± 0.112
5.496ArgLeu: 5.496 ± 0.155
1.242ArgMet: 1.242 ± 0.079
2.694ArgAsn: 2.694 ± 0.095
1.717ArgPro: 1.717 ± 0.077
2.269ArgGln: 2.269 ± 0.092
2.89ArgArg: 2.89 ± 0.101
2.875ArgSer: 2.875 ± 0.107
2.407ArgThr: 2.407 ± 0.104
2.94ArgVal: 2.94 ± 0.127
0.598ArgTrp: 0.598 ± 0.052
2.005ArgTyr: 2.005 ± 0.091
0.0ArgXaa: 0.0 ± 0.0
Ser
4.116SerAla: 4.116 ± 0.135
0.924SerCys: 0.924 ± 0.065
2.752SerAsp: 2.752 ± 0.1
3.009SerGlu: 3.009 ± 0.106
2.683SerPhe: 2.683 ± 0.097
4.442SerGly: 4.442 ± 0.149
1.464SerHis: 1.464 ± 0.075
5.876SerIle: 5.876 ± 0.155
3.699SerLys: 3.699 ± 0.13
6.807SerLeu: 6.807 ± 0.184
1.69SerMet: 1.69 ± 0.085
3.718SerAsn: 3.718 ± 0.117
1.759SerPro: 1.759 ± 0.073
2.334SerGln: 2.334 ± 0.103
2.955SerArg: 2.955 ± 0.124
4.074SerSer: 4.074 ± 0.143
3.304SerThr: 3.304 ± 0.115
3.729SerVal: 3.729 ± 0.128
0.767SerTrp: 0.767 ± 0.053
2.058SerTyr: 2.058 ± 0.091
0.0SerXaa: 0.0 ± 0.0
Thr
3.346ThrAla: 3.346 ± 0.112
0.751ThrCys: 0.751 ± 0.055
2.415ThrAsp: 2.415 ± 0.09
2.599ThrGlu: 2.599 ± 0.103
2.154ThrPhe: 2.154 ± 0.098
3.653ThrGly: 3.653 ± 0.127
1.257ThrHis: 1.257 ± 0.071
4.346ThrIle: 4.346 ± 0.144
2.633ThrLys: 2.633 ± 0.087
6.443ThrLeu: 6.443 ± 0.148
1.134ThrMet: 1.134 ± 0.066
2.576ThrAsn: 2.576 ± 0.084
2.085ThrPro: 2.085 ± 0.094
1.955ThrGln: 1.955 ± 0.093
2.503ThrArg: 2.503 ± 0.104
2.955ThrSer: 2.955 ± 0.101
2.694ThrThr: 2.694 ± 0.092
3.499ThrVal: 3.499 ± 0.112
0.648ThrTrp: 0.648 ± 0.055
1.491ThrTyr: 1.491 ± 0.084
0.0ThrXaa: 0.0 ± 0.0
Val
4.051ValAla: 4.051 ± 0.138
0.882ValCys: 0.882 ± 0.054
2.974ValAsp: 2.974 ± 0.103
3.285ValGlu: 3.285 ± 0.122
2.223ValPhe: 2.223 ± 0.104
3.672ValGly: 3.672 ± 0.117
1.583ValHis: 1.583 ± 0.075
6.033ValIle: 6.033 ± 0.166
3.86ValLys: 3.86 ± 0.142
6.274ValLeu: 6.274 ± 0.175
1.594ValMet: 1.594 ± 0.076
3.227ValAsn: 3.227 ± 0.109
2.211ValPro: 2.211 ± 0.095
1.943ValGln: 1.943 ± 0.08
3.089ValArg: 3.089 ± 0.115
3.833ValSer: 3.833 ± 0.122
3.066ValThr: 3.066 ± 0.112
3.879ValVal: 3.879 ± 0.129
0.487ValTrp: 0.487 ± 0.04
1.648ValTyr: 1.648 ± 0.082
0.0ValXaa: 0.0 ± 0.0
Trp
0.56TrpAla: 0.56 ± 0.048
0.188TrpCys: 0.188 ± 0.028
0.341TrpAsp: 0.341 ± 0.04
0.406TrpGlu: 0.406 ± 0.04
0.517TrpPhe: 0.517 ± 0.048
0.51TrpGly: 0.51 ± 0.045
0.41TrpHis: 0.41 ± 0.039
1.062TrpIle: 1.062 ± 0.076
0.832TrpLys: 0.832 ± 0.061
1.568TrpLeu: 1.568 ± 0.092
0.326TrpMet: 0.326 ± 0.035
0.579TrpAsn: 0.579 ± 0.046
0.41TrpPro: 0.41 ± 0.033
0.617TrpGln: 0.617 ± 0.048
0.59TrpArg: 0.59 ± 0.048
0.579TrpSer: 0.579 ± 0.052
0.425TrpThr: 0.425 ± 0.036
0.583TrpVal: 0.583 ± 0.051
0.13TrpTrp: 0.13 ± 0.024
0.441TrpTyr: 0.441 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.146TyrAla: 2.146 ± 0.081
0.701TyrCys: 0.701 ± 0.057
1.801TyrAsp: 1.801 ± 0.073
1.495TyrGlu: 1.495 ± 0.07
1.437TyrPhe: 1.437 ± 0.076
2.15TyrGly: 2.15 ± 0.093
0.966TyrHis: 0.966 ± 0.063
2.97TyrIle: 2.97 ± 0.102
1.832TyrLys: 1.832 ± 0.083
3.683TyrLeu: 3.683 ± 0.122
0.797TyrMet: 0.797 ± 0.053
2.104TyrAsn: 2.104 ± 0.095
1.253TyrPro: 1.253 ± 0.073
1.721TyrGln: 1.721 ± 0.086
1.84TyrArg: 1.84 ± 0.097
2.127TyrSer: 2.127 ± 0.093
1.487TyrThr: 1.487 ± 0.073
1.729TyrVal: 1.729 ± 0.074
0.452TyrTrp: 0.452 ± 0.046
1.353TyrTyr: 1.353 ± 0.079
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 825 proteins (260910 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski