Amino acid dipepetide frequency for Lactococcus phage 98202

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.706AlaAla: 3.706 ± 0.69
0.814AlaCys: 0.814 ± 0.226
3.435AlaAsp: 3.435 ± 0.686
4.158AlaGlu: 4.158 ± 0.83
2.893AlaPhe: 2.893 ± 0.489
3.797AlaGly: 3.797 ± 0.6
1.085AlaHis: 1.085 ± 0.306
3.887AlaIle: 3.887 ± 0.774
6.328AlaLys: 6.328 ± 1.002
6.961AlaLeu: 6.961 ± 0.828
1.537AlaMet: 1.537 ± 0.28
4.249AlaAsn: 4.249 ± 0.587
1.627AlaPro: 1.627 ± 0.368
2.17AlaGln: 2.17 ± 0.357
1.898AlaArg: 1.898 ± 0.486
3.526AlaSer: 3.526 ± 0.476
3.797AlaThr: 3.797 ± 0.646
3.254AlaVal: 3.254 ± 0.555
1.446AlaTrp: 1.446 ± 0.285
1.808AlaTyr: 1.808 ± 0.398
0.0AlaXaa: 0.0 ± 0.0
Cys
0.09CysAla: 0.09 ± 0.098
0.0CysCys: 0.0 ± 0.0
0.994CysAsp: 0.994 ± 0.373
0.633CysGlu: 0.633 ± 0.194
0.271CysPhe: 0.271 ± 0.148
0.542CysGly: 0.542 ± 0.238
0.271CysHis: 0.271 ± 0.161
0.452CysIle: 0.452 ± 0.156
0.362CysLys: 0.362 ± 0.235
0.0CysLeu: 0.0 ± 0.0
0.09CysMet: 0.09 ± 0.091
0.362CysAsn: 0.362 ± 0.223
0.271CysPro: 0.271 ± 0.152
0.0CysGln: 0.0 ± 0.0
0.271CysArg: 0.271 ± 0.13
0.542CysSer: 0.542 ± 0.236
0.271CysThr: 0.271 ± 0.154
0.271CysVal: 0.271 ± 0.131
0.09CysTrp: 0.09 ± 0.077
0.181CysTyr: 0.181 ± 0.098
0.0CysXaa: 0.0 ± 0.0
Asp
3.526AspAla: 3.526 ± 0.588
0.723AspCys: 0.723 ± 0.353
4.249AspAsp: 4.249 ± 0.671
4.701AspGlu: 4.701 ± 0.751
3.435AspPhe: 3.435 ± 0.638
4.339AspGly: 4.339 ± 0.663
0.814AspHis: 0.814 ± 0.315
4.882AspIle: 4.882 ± 0.707
4.52AspLys: 4.52 ± 0.703
4.701AspLeu: 4.701 ± 0.552
0.814AspMet: 0.814 ± 0.352
3.435AspAsn: 3.435 ± 0.527
1.085AspPro: 1.085 ± 0.397
1.085AspGln: 1.085 ± 0.33
1.898AspArg: 1.898 ± 0.322
4.61AspSer: 4.61 ± 0.788
4.158AspThr: 4.158 ± 0.536
4.068AspVal: 4.068 ± 0.517
0.994AspTrp: 0.994 ± 0.312
3.074AspTyr: 3.074 ± 0.404
0.0AspXaa: 0.0 ± 0.0
Glu
3.706GluAla: 3.706 ± 0.656
0.362GluCys: 0.362 ± 0.152
1.808GluAsp: 1.808 ± 0.399
6.328GluGlu: 6.328 ± 1.15
3.887GluPhe: 3.887 ± 0.648
2.802GluGly: 2.802 ± 0.506
0.904GluHis: 0.904 ± 0.259
5.153GluIle: 5.153 ± 0.716
7.594GluLys: 7.594 ± 1.223
7.142GluLeu: 7.142 ± 0.752
2.622GluMet: 2.622 ± 0.436
3.706GluAsn: 3.706 ± 0.657
1.898GluPro: 1.898 ± 0.468
3.074GluGln: 3.074 ± 0.532
2.712GluArg: 2.712 ± 0.413
3.435GluSer: 3.435 ± 0.531
3.887GluThr: 3.887 ± 0.706
4.882GluVal: 4.882 ± 0.6
0.994GluTrp: 0.994 ± 0.35
3.526GluTyr: 3.526 ± 0.64
0.0GluXaa: 0.0 ± 0.0
Phe
3.074PheAla: 3.074 ± 0.55
0.271PheCys: 0.271 ± 0.151
4.249PheAsp: 4.249 ± 0.533
3.706PheGlu: 3.706 ± 0.58
1.718PhePhe: 1.718 ± 0.411
2.441PheGly: 2.441 ± 0.423
0.271PheHis: 0.271 ± 0.135
3.074PheIle: 3.074 ± 0.484
3.978PheLys: 3.978 ± 0.56
2.893PheLeu: 2.893 ± 0.47
1.266PheMet: 1.266 ± 0.392
2.622PheAsn: 2.622 ± 0.431
1.085PhePro: 1.085 ± 0.33
2.079PheGln: 2.079 ± 0.337
1.446PheArg: 1.446 ± 0.367
3.706PheSer: 3.706 ± 0.496
3.706PheThr: 3.706 ± 0.707
2.079PheVal: 2.079 ± 0.469
0.181PheTrp: 0.181 ± 0.111
2.079PheTyr: 2.079 ± 0.379
0.0PheXaa: 0.0 ± 0.0
Gly
3.435GlyAla: 3.435 ± 0.68
0.362GlyCys: 0.362 ± 0.14
3.164GlyAsp: 3.164 ± 0.552
2.712GlyGlu: 2.712 ± 0.522
3.254GlyPhe: 3.254 ± 0.648
4.43GlyGly: 4.43 ± 0.963
0.633GlyHis: 0.633 ± 0.203
5.786GlyIle: 5.786 ± 0.882
6.78GlyLys: 6.78 ± 0.883
4.52GlyLeu: 4.52 ± 0.569
1.627GlyMet: 1.627 ± 0.435
3.616GlyAsn: 3.616 ± 0.627
0.723GlyPro: 0.723 ± 0.299
2.531GlyGln: 2.531 ± 0.546
3.254GlyArg: 3.254 ± 0.524
3.797GlySer: 3.797 ± 0.819
4.249GlyThr: 4.249 ± 0.739
3.616GlyVal: 3.616 ± 0.732
1.085GlyTrp: 1.085 ± 0.346
3.526GlyTyr: 3.526 ± 0.417
0.0GlyXaa: 0.0 ± 0.0
His
1.175HisAla: 1.175 ± 0.301
0.181HisCys: 0.181 ± 0.137
0.814HisAsp: 0.814 ± 0.271
1.356HisGlu: 1.356 ± 0.422
0.542HisPhe: 0.542 ± 0.222
0.904HisGly: 0.904 ± 0.329
0.452HisHis: 0.452 ± 0.231
0.814HisIle: 0.814 ± 0.296
0.904HisLys: 0.904 ± 0.242
0.904HisLeu: 0.904 ± 0.288
0.09HisMet: 0.09 ± 0.085
0.994HisAsn: 0.994 ± 0.269
0.542HisPro: 0.542 ± 0.167
0.633HisGln: 0.633 ± 0.185
0.362HisArg: 0.362 ± 0.163
1.085HisSer: 1.085 ± 0.38
0.542HisThr: 0.542 ± 0.212
0.994HisVal: 0.994 ± 0.279
0.181HisTrp: 0.181 ± 0.129
0.814HisTyr: 0.814 ± 0.242
0.0HisXaa: 0.0 ± 0.0
Ile
4.882IleAla: 4.882 ± 0.528
0.271IleCys: 0.271 ± 0.158
5.876IleAsp: 5.876 ± 0.639
5.605IleGlu: 5.605 ± 0.675
2.802IlePhe: 2.802 ± 0.444
3.164IleGly: 3.164 ± 0.615
1.085IleHis: 1.085 ± 0.263
4.249IleIle: 4.249 ± 0.912
7.503IleLys: 7.503 ± 0.654
4.339IleLeu: 4.339 ± 0.447
1.446IleMet: 1.446 ± 0.301
4.791IleAsn: 4.791 ± 0.771
2.26IlePro: 2.26 ± 0.632
3.345IleGln: 3.345 ± 0.575
2.531IleArg: 2.531 ± 0.501
5.334IleSer: 5.334 ± 0.807
4.882IleThr: 4.882 ± 0.553
2.893IleVal: 2.893 ± 0.413
0.904IleTrp: 0.904 ± 0.21
2.893IleTyr: 2.893 ± 0.625
0.0IleXaa: 0.0 ± 0.0
Lys
7.322LysAla: 7.322 ± 1.144
0.181LysCys: 0.181 ± 0.181
4.52LysAsp: 4.52 ± 0.583
6.509LysGlu: 6.509 ± 1.027
3.435LysPhe: 3.435 ± 0.571
6.147LysGly: 6.147 ± 0.8
1.537LysHis: 1.537 ± 0.482
6.147LysIle: 6.147 ± 0.828
9.04LysLys: 9.04 ± 1.074
7.955LysLeu: 7.955 ± 1.009
2.531LysMet: 2.531 ± 0.43
7.865LysAsn: 7.865 ± 0.788
2.441LysPro: 2.441 ± 0.4
4.339LysGln: 4.339 ± 0.653
4.339LysArg: 4.339 ± 0.794
3.978LysSer: 3.978 ± 0.649
5.695LysThr: 5.695 ± 0.696
5.695LysVal: 5.695 ± 0.606
0.542LysTrp: 0.542 ± 0.242
3.616LysTyr: 3.616 ± 0.537
0.0LysXaa: 0.0 ± 0.0
Leu
4.339LeuAla: 4.339 ± 0.534
0.994LeuCys: 0.994 ± 0.394
5.243LeuAsp: 5.243 ± 0.613
4.43LeuGlu: 4.43 ± 0.711
3.345LeuPhe: 3.345 ± 0.468
4.339LeuGly: 4.339 ± 0.584
0.633LeuHis: 0.633 ± 0.2
5.424LeuIle: 5.424 ± 0.736
7.684LeuLys: 7.684 ± 0.87
5.966LeuLeu: 5.966 ± 0.842
2.441LeuMet: 2.441 ± 0.372
5.062LeuAsn: 5.062 ± 0.643
3.345LeuPro: 3.345 ± 0.507
4.249LeuGln: 4.249 ± 0.601
2.441LeuArg: 2.441 ± 0.497
6.961LeuSer: 6.961 ± 0.499
5.243LeuThr: 5.243 ± 0.75
3.345LeuVal: 3.345 ± 0.516
0.904LeuTrp: 0.904 ± 0.232
2.35LeuTyr: 2.35 ± 0.331
0.0LeuXaa: 0.0 ± 0.0
Met
1.446MetAla: 1.446 ± 0.303
0.181MetCys: 0.181 ± 0.113
1.446MetAsp: 1.446 ± 0.32
1.989MetGlu: 1.989 ± 0.463
0.633MetPhe: 0.633 ± 0.228
1.898MetGly: 1.898 ± 0.48
0.181MetHis: 0.181 ± 0.125
1.718MetIle: 1.718 ± 0.356
2.622MetLys: 2.622 ± 0.626
1.446MetLeu: 1.446 ± 0.355
0.362MetMet: 0.362 ± 0.19
1.356MetAsn: 1.356 ± 0.335
0.542MetPro: 0.542 ± 0.265
1.175MetGln: 1.175 ± 0.301
1.266MetArg: 1.266 ± 0.373
2.17MetSer: 2.17 ± 0.491
2.26MetThr: 2.26 ± 0.527
0.723MetVal: 0.723 ± 0.239
0.181MetTrp: 0.181 ± 0.108
0.904MetTyr: 0.904 ± 0.282
0.0MetXaa: 0.0 ± 0.0
Asn
4.158AsnAla: 4.158 ± 0.624
0.362AsnCys: 0.362 ± 0.159
3.435AsnAsp: 3.435 ± 0.391
3.887AsnGlu: 3.887 ± 0.615
2.893AsnPhe: 2.893 ± 0.496
6.147AsnGly: 6.147 ± 0.773
0.994AsnHis: 0.994 ± 0.291
3.706AsnIle: 3.706 ± 0.614
5.695AsnLys: 5.695 ± 0.568
5.153AsnLeu: 5.153 ± 0.628
1.808AsnMet: 1.808 ± 0.468
3.254AsnAsn: 3.254 ± 0.543
2.26AsnPro: 2.26 ± 0.403
2.893AsnGln: 2.893 ± 0.402
1.989AsnArg: 1.989 ± 0.372
2.622AsnSer: 2.622 ± 0.405
3.254AsnThr: 3.254 ± 0.578
3.616AsnVal: 3.616 ± 0.502
1.175AsnTrp: 1.175 ± 0.265
2.531AsnTyr: 2.531 ± 0.755
0.0AsnXaa: 0.0 ± 0.0
Pro
0.904ProAla: 0.904 ± 0.258
0.09ProCys: 0.09 ± 0.095
1.808ProAsp: 1.808 ± 0.467
2.079ProGlu: 2.079 ± 0.399
1.446ProPhe: 1.446 ± 0.33
1.446ProGly: 1.446 ± 0.396
0.814ProHis: 0.814 ± 0.233
2.622ProIle: 2.622 ± 0.473
3.074ProLys: 3.074 ± 0.497
2.17ProLeu: 2.17 ± 0.346
0.271ProMet: 0.271 ± 0.171
1.718ProAsn: 1.718 ± 0.431
0.814ProPro: 0.814 ± 0.221
0.994ProGln: 0.994 ± 0.303
0.814ProArg: 0.814 ± 0.273
1.898ProSer: 1.898 ± 0.421
1.537ProThr: 1.537 ± 0.326
1.808ProVal: 1.808 ± 0.335
0.271ProTrp: 0.271 ± 0.135
0.904ProTyr: 0.904 ± 0.275
0.0ProXaa: 0.0 ± 0.0
Gln
4.158GlnAla: 4.158 ± 0.673
0.181GlnCys: 0.181 ± 0.108
1.718GlnAsp: 1.718 ± 0.422
3.706GlnGlu: 3.706 ± 0.644
2.079GlnPhe: 2.079 ± 0.398
2.622GlnGly: 2.622 ± 0.503
0.542GlnHis: 0.542 ± 0.242
2.983GlnIle: 2.983 ± 0.368
2.531GlnLys: 2.531 ± 0.632
3.526GlnLeu: 3.526 ± 0.479
1.175GlnMet: 1.175 ± 0.335
1.989GlnAsn: 1.989 ± 0.406
0.814GlnPro: 0.814 ± 0.26
1.989GlnGln: 1.989 ± 0.422
1.537GlnArg: 1.537 ± 0.366
2.712GlnSer: 2.712 ± 0.554
2.712GlnThr: 2.712 ± 0.409
3.435GlnVal: 3.435 ± 0.502
0.633GlnTrp: 0.633 ± 0.26
1.356GlnTyr: 1.356 ± 0.314
0.0GlnXaa: 0.0 ± 0.0
Arg
2.26ArgAla: 2.26 ± 0.381
0.181ArgCys: 0.181 ± 0.135
2.079ArgAsp: 2.079 ± 0.413
2.441ArgGlu: 2.441 ± 0.532
2.17ArgPhe: 2.17 ± 0.339
1.356ArgGly: 1.356 ± 0.321
0.362ArgHis: 0.362 ± 0.223
2.441ArgIle: 2.441 ± 0.501
5.243ArgLys: 5.243 ± 0.764
4.249ArgLeu: 4.249 ± 0.671
0.994ArgMet: 0.994 ± 0.291
2.079ArgAsn: 2.079 ± 0.478
0.994ArgPro: 0.994 ± 0.359
0.994ArgGln: 0.994 ± 0.254
1.446ArgArg: 1.446 ± 0.394
1.627ArgSer: 1.627 ± 0.449
2.17ArgThr: 2.17 ± 0.428
1.989ArgVal: 1.989 ± 0.4
0.271ArgTrp: 0.271 ± 0.159
1.446ArgTyr: 1.446 ± 0.429
0.0ArgXaa: 0.0 ± 0.0
Ser
3.074SerAla: 3.074 ± 0.471
0.0SerCys: 0.0 ± 0.0
4.972SerAsp: 4.972 ± 0.499
4.791SerGlu: 4.791 ± 0.639
3.345SerPhe: 3.345 ± 0.374
4.52SerGly: 4.52 ± 0.86
0.542SerHis: 0.542 ± 0.175
4.701SerIle: 4.701 ± 0.628
4.43SerLys: 4.43 ± 0.646
4.52SerLeu: 4.52 ± 0.559
1.718SerMet: 1.718 ± 0.377
4.701SerAsn: 4.701 ± 0.595
0.904SerPro: 0.904 ± 0.275
3.435SerGln: 3.435 ± 0.567
2.17SerArg: 2.17 ± 0.401
4.791SerSer: 4.791 ± 1.076
2.893SerThr: 2.893 ± 0.494
5.243SerVal: 5.243 ± 0.701
0.994SerTrp: 0.994 ± 0.257
2.893SerTyr: 2.893 ± 0.408
0.0SerXaa: 0.0 ± 0.0
Thr
4.972ThrAla: 4.972 ± 0.576
0.271ThrCys: 0.271 ± 0.228
3.435ThrAsp: 3.435 ± 0.47
4.249ThrGlu: 4.249 ± 0.673
3.164ThrPhe: 3.164 ± 0.512
5.786ThrGly: 5.786 ± 0.708
1.266ThrHis: 1.266 ± 0.385
4.249ThrIle: 4.249 ± 0.58
5.334ThrLys: 5.334 ± 0.679
4.158ThrLeu: 4.158 ± 0.627
1.266ThrMet: 1.266 ± 0.409
3.074ThrAsn: 3.074 ± 0.457
2.26ThrPro: 2.26 ± 0.356
1.537ThrGln: 1.537 ± 0.295
2.17ThrArg: 2.17 ± 0.493
4.158ThrSer: 4.158 ± 0.54
4.43ThrThr: 4.43 ± 0.666
4.249ThrVal: 4.249 ± 0.732
0.723ThrTrp: 0.723 ± 0.312
2.17ThrTyr: 2.17 ± 0.414
0.0ThrXaa: 0.0 ± 0.0
Val
3.345ValAla: 3.345 ± 0.666
0.09ValCys: 0.09 ± 0.071
3.978ValAsp: 3.978 ± 0.634
3.978ValGlu: 3.978 ± 0.637
2.17ValPhe: 2.17 ± 0.387
2.983ValGly: 2.983 ± 0.564
0.994ValHis: 0.994 ± 0.351
5.062ValIle: 5.062 ± 0.633
5.514ValLys: 5.514 ± 0.702
4.791ValLeu: 4.791 ± 0.716
1.266ValMet: 1.266 ± 0.281
3.978ValAsn: 3.978 ± 0.588
1.537ValPro: 1.537 ± 0.37
2.17ValGln: 2.17 ± 0.504
1.537ValArg: 1.537 ± 0.484
3.797ValSer: 3.797 ± 0.524
4.158ValThr: 4.158 ± 0.826
3.074ValVal: 3.074 ± 0.501
0.814ValTrp: 0.814 ± 0.28
2.622ValTyr: 2.622 ± 0.474
0.0ValXaa: 0.0 ± 0.0
Trp
1.085TrpAla: 1.085 ± 0.228
0.181TrpCys: 0.181 ± 0.106
1.175TrpAsp: 1.175 ± 0.253
0.723TrpGlu: 0.723 ± 0.232
0.542TrpPhe: 0.542 ± 0.218
0.723TrpGly: 0.723 ± 0.245
0.362TrpHis: 0.362 ± 0.154
1.085TrpIle: 1.085 ± 0.303
1.266TrpLys: 1.266 ± 0.314
1.085TrpLeu: 1.085 ± 0.347
0.181TrpMet: 0.181 ± 0.129
0.814TrpAsn: 0.814 ± 0.296
0.181TrpPro: 0.181 ± 0.108
0.814TrpGln: 0.814 ± 0.302
0.814TrpArg: 0.814 ± 0.208
0.542TrpSer: 0.542 ± 0.209
0.633TrpThr: 0.633 ± 0.336
0.362TrpVal: 0.362 ± 0.163
0.181TrpTrp: 0.181 ± 0.134
0.633TrpTyr: 0.633 ± 0.258
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.718TyrAla: 1.718 ± 0.392
0.271TyrCys: 0.271 ± 0.155
2.712TyrAsp: 2.712 ± 0.402
2.441TyrGlu: 2.441 ± 0.426
1.989TyrPhe: 1.989 ± 0.436
2.712TyrGly: 2.712 ± 0.606
0.542TyrHis: 0.542 ± 0.195
2.622TyrIle: 2.622 ± 0.551
3.435TyrLys: 3.435 ± 0.709
2.26TyrLeu: 2.26 ± 0.522
0.904TyrMet: 0.904 ± 0.296
2.17TyrAsn: 2.17 ± 0.477
1.898TyrPro: 1.898 ± 0.496
2.893TyrGln: 2.893 ± 0.536
1.898TyrArg: 1.898 ± 0.436
3.345TyrSer: 3.345 ± 0.406
2.441TyrThr: 2.441 ± 0.371
2.26TyrVal: 2.26 ± 0.492
0.814TyrTrp: 0.814 ± 0.213
2.079TyrTyr: 2.079 ± 0.396
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 53 proteins (11063 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski