Amino acid dipepetide frequency for Ginsengibacter hankyongi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.643AlaAla: 5.643 ± 0.072	0.672AlaCys: 0.672 ± 0.022	3.829AlaAsp: 3.829 ± 0.051	3.669AlaGlu: 3.669 ± 0.052	3.415AlaPhe: 3.415 ± 0.049	5.381AlaGly: 5.381 ± 0.073	1.143AlaHis: 1.143 ± 0.032	5.363AlaIle: 5.363 ± 0.076	4.556AlaLys: 4.556 ± 0.058	6.175AlaLeu: 6.175 ± 0.072	1.616AlaMet: 1.616 ± 0.035	3.744AlaAsn: 3.744 ± 0.061	2.127AlaPro: 2.127 ± 0.043	2.394AlaGln: 2.394 ± 0.037	2.269AlaArg: 2.269 ± 0.039	4.43AlaSer: 4.43 ± 0.053	4.008AlaThr: 4.008 ± 0.06	4.321AlaVal: 4.321 ± 0.053	0.861AlaTrp: 0.861 ± 0.028	2.521AlaTyr: 2.521 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.523CysAla: 0.523 ± 0.019	0.159CysCys: 0.159 ± 0.011	0.456CysAsp: 0.456 ± 0.016	0.459CysGlu: 0.459 ± 0.019	0.53CysPhe: 0.53 ± 0.019	0.7CysGly: 0.7 ± 0.025	0.223CysHis: 0.223 ± 0.014	0.76CysIle: 0.76 ± 0.021	0.592CysLys: 0.592 ± 0.021	0.773CysLeu: 0.773 ± 0.023	0.217CysMet: 0.217 ± 0.012	0.544CysAsn: 0.544 ± 0.017	0.394CysPro: 0.394 ± 0.019	0.218CysGln: 0.218 ± 0.014	0.311CysArg: 0.311 ± 0.015	0.654CysSer: 0.654 ± 0.021	0.524CysThr: 0.524 ± 0.019	0.508CysVal: 0.508 ± 0.018	0.118CysTrp: 0.118 ± 0.008	0.384CysTyr: 0.384 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.882AspAla: 3.882 ± 0.045	0.428AspCys: 0.428 ± 0.018	2.666AspAsp: 2.666 ± 0.048	3.445AspGlu: 3.445 ± 0.043	3.003AspPhe: 3.003 ± 0.044	3.793AspGly: 3.793 ± 0.061	0.97AspHis: 0.97 ± 0.027	4.186AspIle: 4.186 ± 0.046	4.012AspLys: 4.012 ± 0.056	4.415AspLeu: 4.415 ± 0.046	1.102AspMet: 1.102 ± 0.029	3.001AspAsn: 3.001 ± 0.05	2.009AspPro: 2.009 ± 0.036	1.394AspGln: 1.394 ± 0.034	1.713AspArg: 1.713 ± 0.032	3.486AspSer: 3.486 ± 0.061	2.689AspThr: 2.689 ± 0.049	3.472AspVal: 3.472 ± 0.045	0.78AspTrp: 0.78 ± 0.027	2.572AspTyr: 2.572 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	3.565GluAla: 3.565 ± 0.056	0.414GluCys: 0.414 ± 0.018	2.558GluAsp: 2.558 ± 0.042	3.574GluGlu: 3.574 ± 0.069	2.465GluPhe: 2.465 ± 0.04	3.186GluGly: 3.186 ± 0.052	0.99GluHis: 0.99 ± 0.027	4.667GluIle: 4.667 ± 0.062	5.42GluLys: 5.42 ± 0.07	5.165GluLeu: 5.165 ± 0.065	1.601GluMet: 1.601 ± 0.035	3.69GluAsn: 3.69 ± 0.052	1.625GluPro: 1.625 ± 0.034	2.041GluGln: 2.041 ± 0.046	2.216GluArg: 2.216 ± 0.041	2.726GluSer: 2.726 ± 0.045	2.894GluThr: 2.894 ± 0.046	3.425GluVal: 3.425 ± 0.054	0.779GluTrp: 0.779 ± 0.024	2.06GluTyr: 2.06 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.282PheAla: 3.282 ± 0.053	0.566PheCys: 0.566 ± 0.02	2.841PheAsp: 2.841 ± 0.041	2.634PheGlu: 2.634 ± 0.042	2.844PhePhe: 2.844 ± 0.05	3.511PheGly: 3.511 ± 0.05	0.935PheHis: 0.935 ± 0.027	4.303PheIle: 4.303 ± 0.061	3.312PheLys: 3.312 ± 0.054	4.689PheLeu: 4.689 ± 0.071	1.114PheMet: 1.114 ± 0.027	3.224PheAsn: 3.224 ± 0.046	1.92PhePro: 1.92 ± 0.039	1.446PheGln: 1.446 ± 0.031	1.728PheArg: 1.728 ± 0.031	3.981PheSer: 3.981 ± 0.05	3.277PheThr: 3.277 ± 0.047	2.827PheVal: 2.827 ± 0.049	0.642PheTrp: 0.642 ± 0.022	2.249PheTyr: 2.249 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.31GlyAla: 4.31 ± 0.062	0.703GlyCys: 0.703 ± 0.024	3.478GlyAsp: 3.478 ± 0.05	3.376GlyGlu: 3.376 ± 0.047	3.58GlyPhe: 3.58 ± 0.046	5.018GlyGly: 5.018 ± 0.094	1.193GlyHis: 1.193 ± 0.033	5.776GlyIle: 5.776 ± 0.068	5.463GlyLys: 5.463 ± 0.062	5.793GlyLeu: 5.793 ± 0.072	1.716GlyMet: 1.716 ± 0.041	4.302GlyAsn: 4.302 ± 0.059	1.716GlyPro: 1.716 ± 0.04	1.919GlyGln: 1.919 ± 0.034	2.46GlyArg: 2.46 ± 0.038	4.403GlySer: 4.403 ± 0.074	4.266GlyThr: 4.266 ± 0.087	4.235GlyVal: 4.235 ± 0.06	1.079GlyTrp: 1.079 ± 0.031	3.106GlyTyr: 3.106 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.149HisAla: 1.149 ± 0.03	0.209HisCys: 0.209 ± 0.013	0.959HisAsp: 0.959 ± 0.02	1.071HisGlu: 1.071 ± 0.025	1.214HisPhe: 1.214 ± 0.031	1.19HisGly: 1.19 ± 0.028	0.596HisHis: 0.596 ± 0.021	1.411HisIle: 1.411 ± 0.027	1.175HisLys: 1.175 ± 0.027	1.954HisLeu: 1.954 ± 0.04	0.362HisMet: 0.362 ± 0.017	1.002HisAsn: 1.002 ± 0.026	1.051HisPro: 1.051 ± 0.026	0.647HisGln: 0.647 ± 0.022	0.734HisArg: 0.734 ± 0.022	1.191HisSer: 1.191 ± 0.026	1.003HisThr: 1.003 ± 0.026	1.046HisVal: 1.046 ± 0.027	0.292HisTrp: 0.292 ± 0.015	0.835HisTyr: 0.835 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.895IleAla: 5.895 ± 0.071	0.822IleCys: 0.822 ± 0.025	4.495IleAsp: 4.495 ± 0.055	4.487IleGlu: 4.487 ± 0.068	3.814IlePhe: 3.814 ± 0.056	4.859IleGly: 4.859 ± 0.069	1.502IleHis: 1.502 ± 0.035	6.379IleIle: 6.379 ± 0.082	5.882IleLys: 5.882 ± 0.067	6.713IleLeu: 6.713 ± 0.082	1.508IleMet: 1.508 ± 0.034	5.156IleAsn: 5.156 ± 0.065	3.427IlePro: 3.427 ± 0.049	2.386IleGln: 2.386 ± 0.041	2.771IleArg: 2.771 ± 0.041	5.568IleSer: 5.568 ± 0.059	5.032IleThr: 5.032 ± 0.06	4.584IleVal: 4.584 ± 0.069	0.77IleTrp: 0.77 ± 0.024	2.897IleTyr: 2.897 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.653LysAla: 4.653 ± 0.057	0.391LysCys: 0.391 ± 0.019	4.557LysAsp: 4.557 ± 0.056	5.343LysGlu: 5.343 ± 0.058	2.941LysPhe: 2.941 ± 0.048	4.516LysGly: 4.516 ± 0.054	1.204LysHis: 1.204 ± 0.03	6.386LysIle: 6.386 ± 0.06	6.833LysLys: 6.833 ± 0.085	6.108LysLeu: 6.108 ± 0.067	2.16LysMet: 2.16 ± 0.041	5.545LysAsn: 5.545 ± 0.062	2.735LysPro: 2.735 ± 0.044	2.733LysGln: 2.733 ± 0.046	2.794LysArg: 2.794 ± 0.04	4.21LysSer: 4.21 ± 0.053	4.153LysThr: 4.153 ± 0.053	4.314LysVal: 4.314 ± 0.056	0.972LysTrp: 0.972 ± 0.026	3.127LysTyr: 3.127 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	5.872LeuAla: 5.872 ± 0.072	0.82LeuCys: 0.82 ± 0.022	4.23LeuAsp: 4.23 ± 0.058	4.418LeuGlu: 4.418 ± 0.067	4.9LeuPhe: 4.9 ± 0.066	5.373LeuGly: 5.373 ± 0.072	1.923LeuHis: 1.923 ± 0.034	6.701LeuIle: 6.701 ± 0.078	7.091LeuLys: 7.091 ± 0.08	9.05LeuLeu: 9.05 ± 0.102	2.053LeuMet: 2.053 ± 0.039	5.429LeuAsn: 5.429 ± 0.053	4.1LeuPro: 4.1 ± 0.055	3.908LeuGln: 3.908 ± 0.063	3.347LeuArg: 3.347 ± 0.046	6.61LeuSer: 6.61 ± 0.075	5.005LeuThr: 5.005 ± 0.06	4.991LeuVal: 4.991 ± 0.06	1.024LeuTrp: 1.024 ± 0.026	3.301LeuTyr: 3.301 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.725MetAla: 1.725 ± 0.034	0.167MetCys: 0.167 ± 0.01	1.207MetAsp: 1.207 ± 0.029	1.335MetGlu: 1.335 ± 0.032	0.869MetPhe: 0.869 ± 0.029	1.454MetGly: 1.454 ± 0.035	0.51MetHis: 0.51 ± 0.017	1.649MetIle: 1.649 ± 0.036	2.3MetLys: 2.3 ± 0.042	2.076MetLeu: 2.076 ± 0.038	0.709MetMet: 0.709 ± 0.026	1.401MetAsn: 1.401 ± 0.033	1.123MetPro: 1.123 ± 0.026	1.019MetGln: 1.019 ± 0.027	0.923MetArg: 0.923 ± 0.022	1.268MetSer: 1.268 ± 0.026	1.03MetThr: 1.03 ± 0.025	1.399MetVal: 1.399 ± 0.033	0.22MetTrp: 0.22 ± 0.013	0.761MetTyr: 0.761 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	4.199AsnAla: 4.199 ± 0.066	0.542AsnCys: 0.542 ± 0.019	3.349AsnAsp: 3.349 ± 0.05	3.561AsnGlu: 3.561 ± 0.056	3.172AsnPhe: 3.172 ± 0.047	4.419AsnGly: 4.419 ± 0.067	1.109AsnHis: 1.109 ± 0.025	5.181AsnIle: 5.181 ± 0.065	4.586AsnLys: 4.586 ± 0.056	4.999AsnLeu: 4.999 ± 0.06	1.26AsnMet: 1.26 ± 0.027	4.293AsnAsn: 4.293 ± 0.064	2.816AsnPro: 2.816 ± 0.044	1.793AsnGln: 1.793 ± 0.033	2.168AsnArg: 2.168 ± 0.039	3.907AsnSer: 3.907 ± 0.06	3.417AsnThr: 3.417 ± 0.057	3.534AsnVal: 3.534 ± 0.053	0.798AsnTrp: 0.798 ± 0.024	2.946AsnTyr: 2.946 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	3.063ProAla: 3.063 ± 0.048	0.265ProCys: 0.265 ± 0.014	2.478ProAsp: 2.478 ± 0.043	2.537ProGlu: 2.537 ± 0.041	2.116ProPhe: 2.116 ± 0.035	3.281ProGly: 3.281 ± 0.045	0.757ProHis: 0.757 ± 0.022	2.195ProIle: 2.195 ± 0.037	2.258ProLys: 2.258 ± 0.039	3.488ProLeu: 3.488 ± 0.046	0.745ProMet: 0.745 ± 0.02	1.946ProAsn: 1.946 ± 0.037	1.293ProPro: 1.293 ± 0.036	1.365ProGln: 1.365 ± 0.031	1.032ProArg: 1.032 ± 0.027	2.498ProSer: 2.498 ± 0.048	1.934ProThr: 1.934 ± 0.047	3.463ProVal: 3.463 ± 0.053	0.488ProTrp: 0.488 ± 0.021	1.617ProTyr: 1.617 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.029GlnAla: 2.029 ± 0.034	0.235GlnCys: 0.235 ± 0.012	1.418GlnAsp: 1.418 ± 0.029	1.632GlnGlu: 1.632 ± 0.034	1.681GlnPhe: 1.681 ± 0.034	1.764GlnGly: 1.764 ± 0.034	0.772GlnHis: 0.772 ± 0.023	2.311GlnIle: 2.311 ± 0.035	2.934GlnLys: 2.934 ± 0.044	3.675GlnLeu: 3.675 ± 0.046	0.948GlnMet: 0.948 ± 0.026	2.154GlnAsn: 2.154 ± 0.042	1.413GlnPro: 1.413 ± 0.03	1.894GlnGln: 1.894 ± 0.039	1.284GlnArg: 1.284 ± 0.034	2.146GlnSer: 2.146 ± 0.035	1.909GlnThr: 1.909 ± 0.037	2.031GlnVal: 2.031 ± 0.037	0.487GlnTrp: 0.487 ± 0.022	1.493GlnTyr: 1.493 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.035ArgAla: 2.035 ± 0.042	0.268ArgCys: 0.268 ± 0.014	1.826ArgAsp: 1.826 ± 0.036	2.06ArgGlu: 2.06 ± 0.04	1.822ArgPhe: 1.822 ± 0.036	2.023ArgGly: 2.023 ± 0.04	0.679ArgHis: 0.679 ± 0.02	3.04ArgIle: 3.04 ± 0.043	2.969ArgLys: 2.969 ± 0.042	3.426ArgLeu: 3.426 ± 0.054	0.962ArgMet: 0.962 ± 0.026	2.345ArgAsn: 2.345 ± 0.04	1.298ArgPro: 1.298 ± 0.025	1.318ArgGln: 1.318 ± 0.031	1.467ArgArg: 1.467 ± 0.03	2.026ArgSer: 2.026 ± 0.039	1.795ArgThr: 1.795 ± 0.034	2.043ArgVal: 2.043 ± 0.036	0.534ArgTrp: 0.534 ± 0.021	1.603ArgTyr: 1.603 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.387SerAla: 4.387 ± 0.062	0.724SerCys: 0.724 ± 0.023	3.143SerAsp: 3.143 ± 0.043	2.983SerGlu: 2.983 ± 0.045	3.995SerPhe: 3.995 ± 0.051	5.212SerGly: 5.212 ± 0.085	1.155SerHis: 1.155 ± 0.027	5.318SerIle: 5.318 ± 0.061	4.324SerLys: 4.324 ± 0.06	6.365SerLeu: 6.365 ± 0.073	1.404SerMet: 1.404 ± 0.029	3.611SerAsn: 3.611 ± 0.055	2.509SerPro: 2.509 ± 0.039	2.0SerGln: 2.0 ± 0.037	2.226SerArg: 2.226 ± 0.037	4.583SerSer: 4.583 ± 0.062	3.647SerThr: 3.647 ± 0.056	4.273SerVal: 4.273 ± 0.057	0.883SerTrp: 0.883 ± 0.026	2.756SerTyr: 2.756 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.209ThrAla: 4.209 ± 0.066	0.482ThrCys: 0.482 ± 0.021	3.277ThrAsp: 3.277 ± 0.069	2.775ThrGlu: 2.775 ± 0.047	2.787ThrPhe: 2.787 ± 0.043	4.992ThrGly: 4.992 ± 0.068	1.051ThrHis: 1.051 ± 0.031	4.614ThrIle: 4.614 ± 0.068	3.481ThrLys: 3.481 ± 0.05	5.05ThrLeu: 5.05 ± 0.066	1.002ThrMet: 1.002 ± 0.023	3.245ThrAsn: 3.245 ± 0.059	2.554ThrPro: 2.554 ± 0.052	1.795ThrGln: 1.795 ± 0.036	1.795ThrArg: 1.795 ± 0.038	3.795ThrSer: 3.795 ± 0.068	3.509ThrThr: 3.509 ± 0.064	3.718ThrVal: 3.718 ± 0.065	0.761ThrTrp: 0.761 ± 0.026	2.2ThrTyr: 2.2 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	4.281ValAla: 4.281 ± 0.061	0.655ValCys: 0.655 ± 0.024	3.183ValAsp: 3.183 ± 0.047	3.07ValGlu: 3.07 ± 0.052	3.072ValPhe: 3.072 ± 0.048	3.522ValGly: 3.522 ± 0.057	1.141ValHis: 1.141 ± 0.028	5.025ValIle: 5.025 ± 0.058	4.428ValLys: 4.428 ± 0.051	5.392ValLeu: 5.392 ± 0.056	1.447ValMet: 1.447 ± 0.03	3.721ValAsn: 3.721 ± 0.068	2.54ValPro: 2.54 ± 0.036	1.953ValGln: 1.953 ± 0.037	2.052ValArg: 2.052 ± 0.036	4.345ValSer: 4.345 ± 0.052	3.971ValThr: 3.971 ± 0.084	3.786ValVal: 3.786 ± 0.058	0.75ValTrp: 0.75 ± 0.021	2.479ValTyr: 2.479 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.787TrpAla: 0.787 ± 0.024	0.122TrpCys: 0.122 ± 0.008	0.716TrpAsp: 0.716 ± 0.024	0.665TrpGlu: 0.665 ± 0.021	0.64TrpPhe: 0.64 ± 0.025	0.91TrpGly: 0.91 ± 0.024	0.301TrpHis: 0.301 ± 0.012	0.936TrpIle: 0.936 ± 0.025	1.086TrpLys: 1.086 ± 0.03	1.195TrpLeu: 1.195 ± 0.032	0.406TrpMet: 0.406 ± 0.016	0.899TrpAsn: 0.899 ± 0.026	0.403TrpPro: 0.403 ± 0.018	0.565TrpGln: 0.565 ± 0.021	0.53TrpArg: 0.53 ± 0.019	0.763TrpSer: 0.763 ± 0.021	0.669TrpThr: 0.669 ± 0.03	0.704TrpVal: 0.704 ± 0.021	0.278TrpTrp: 0.278 ± 0.016	0.531TrpTyr: 0.531 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.65TyrAla: 2.65 ± 0.049	0.402TyrCys: 0.402 ± 0.015	2.352TyrAsp: 2.352 ± 0.04	1.97TyrGlu: 1.97 ± 0.032	2.463TyrPhe: 2.463 ± 0.042	2.788TyrGly: 2.788 ± 0.046	0.936TyrHis: 0.936 ± 0.026	2.748TyrIle: 2.748 ± 0.049	2.974TyrLys: 2.974 ± 0.049	3.644TyrLeu: 3.644 ± 0.056	0.811TyrMet: 0.811 ± 0.027	2.799TyrAsn: 2.799 ± 0.045	1.765TyrPro: 1.765 ± 0.034	1.424TyrGln: 1.424 ± 0.033	1.719TyrArg: 1.719 ± 0.032	2.909TyrSer: 2.909 ± 0.046	2.357TyrThr: 2.357 ± 0.042	2.139TyrVal: 2.139 ± 0.039	0.588TyrTrp: 0.588 ± 0.021	1.953TyrTyr: 1.953 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4476 proteins (1583608 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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