Amino acid dipepetide frequency for Streptococcus phage Javan278

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.997AlaAla: 4.997 ± 1.243
0.588AlaCys: 0.588 ± 0.279
4.507AlaAsp: 4.507 ± 0.619
4.899AlaGlu: 4.899 ± 0.557
1.861AlaPhe: 1.861 ± 0.381
4.801AlaGly: 4.801 ± 0.725
0.784AlaHis: 0.784 ± 0.27
6.172AlaIle: 6.172 ± 1.108
5.193AlaLys: 5.193 ± 0.559
5.78AlaLeu: 5.78 ± 0.683
1.274AlaMet: 1.274 ± 0.346
4.311AlaAsn: 4.311 ± 0.665
1.274AlaPro: 1.274 ± 0.264
2.155AlaGln: 2.155 ± 0.47
3.625AlaArg: 3.625 ± 0.722
4.409AlaSer: 4.409 ± 0.64
3.331AlaThr: 3.331 ± 0.575
5.78AlaVal: 5.78 ± 0.885
1.861AlaTrp: 1.861 ± 0.74
1.861AlaTyr: 1.861 ± 0.508
0.0AlaXaa: 0.0 ± 0.0
Cys
0.392CysAla: 0.392 ± 0.248
0.196CysCys: 0.196 ± 0.127
0.784CysAsp: 0.784 ± 0.252
0.588CysGlu: 0.588 ± 0.236
0.196CysPhe: 0.196 ± 0.127
0.686CysGly: 0.686 ± 0.274
0.196CysHis: 0.196 ± 0.11
0.392CysIle: 0.392 ± 0.202
0.49CysLys: 0.49 ± 0.221
0.784CysLeu: 0.784 ± 0.211
0.098CysMet: 0.098 ± 0.114
0.49CysAsn: 0.49 ± 0.26
0.098CysPro: 0.098 ± 0.098
0.588CysGln: 0.588 ± 0.234
0.098CysArg: 0.098 ± 0.087
0.686CysSer: 0.686 ± 0.273
0.392CysThr: 0.392 ± 0.152
0.392CysVal: 0.392 ± 0.191
0.0CysTrp: 0.0 ± 0.0
0.098CysTyr: 0.098 ± 0.098
0.0CysXaa: 0.0 ± 0.0
Asp
3.625AspAla: 3.625 ± 0.598
0.49AspCys: 0.49 ± 0.189
3.233AspAsp: 3.233 ± 0.619
3.723AspGlu: 3.723 ± 0.752
4.213AspPhe: 4.213 ± 0.489
6.662AspGly: 6.662 ± 0.772
0.882AspHis: 0.882 ± 0.285
4.115AspIle: 4.115 ± 0.61
6.564AspLys: 6.564 ± 0.8
4.507AspLeu: 4.507 ± 0.617
1.763AspMet: 1.763 ± 0.301
3.135AspAsn: 3.135 ± 0.439
1.568AspPro: 1.568 ± 0.444
1.47AspGln: 1.47 ± 0.313
2.841AspArg: 2.841 ± 0.355
3.037AspSer: 3.037 ± 0.423
2.351AspThr: 2.351 ± 0.583
4.017AspVal: 4.017 ± 0.608
1.274AspTrp: 1.274 ± 0.336
2.841AspTyr: 2.841 ± 0.508
0.0AspXaa: 0.0 ± 0.0
Glu
4.899GluAla: 4.899 ± 0.907
0.392GluCys: 0.392 ± 0.21
3.821GluAsp: 3.821 ± 0.522
3.625GluGlu: 3.625 ± 0.627
3.625GluPhe: 3.625 ± 0.506
3.429GluGly: 3.429 ± 0.427
1.176GluHis: 1.176 ± 0.393
6.172GluIle: 6.172 ± 0.772
5.976GluLys: 5.976 ± 0.889
7.25GluLeu: 7.25 ± 0.707
1.666GluMet: 1.666 ± 0.373
4.997GluAsn: 4.997 ± 0.815
2.057GluPro: 2.057 ± 0.488
3.135GluGln: 3.135 ± 0.571
4.115GluArg: 4.115 ± 0.683
2.449GluSer: 2.449 ± 0.38
3.331GluThr: 3.331 ± 0.591
4.507GluVal: 4.507 ± 0.803
1.176GluTrp: 1.176 ± 0.349
2.057GluTyr: 2.057 ± 0.407
0.0GluXaa: 0.0 ± 0.0
Phe
2.155PheAla: 2.155 ± 0.425
0.392PheCys: 0.392 ± 0.283
2.645PheAsp: 2.645 ± 0.461
4.017PheGlu: 4.017 ± 0.393
1.861PhePhe: 1.861 ± 0.455
3.429PheGly: 3.429 ± 0.454
0.784PheHis: 0.784 ± 0.214
2.547PheIle: 2.547 ± 0.527
3.135PheLys: 3.135 ± 0.5
2.645PheLeu: 2.645 ± 0.58
0.882PheMet: 0.882 ± 0.352
2.841PheAsn: 2.841 ± 0.555
1.078PhePro: 1.078 ± 0.314
1.568PheGln: 1.568 ± 0.442
1.274PheArg: 1.274 ± 0.303
2.841PheSer: 2.841 ± 0.581
2.743PheThr: 2.743 ± 0.432
3.331PheVal: 3.331 ± 0.581
0.392PheTrp: 0.392 ± 0.174
1.568PheTyr: 1.568 ± 0.397
0.0PheXaa: 0.0 ± 0.0
Gly
5.29GlyAla: 5.29 ± 0.843
0.294GlyCys: 0.294 ± 0.181
4.409GlyAsp: 4.409 ± 0.714
4.017GlyGlu: 4.017 ± 0.581
4.017GlyPhe: 4.017 ± 0.667
3.233GlyGly: 3.233 ± 0.602
0.784GlyHis: 0.784 ± 0.294
6.564GlyIle: 6.564 ± 1.617
4.605GlyLys: 4.605 ± 0.739
6.466GlyLeu: 6.466 ± 0.958
2.351GlyMet: 2.351 ± 0.595
3.429GlyAsn: 3.429 ± 0.53
0.49GlyPro: 0.49 ± 0.192
3.527GlyGln: 3.527 ± 0.682
2.253GlyArg: 2.253 ± 0.382
3.429GlySer: 3.429 ± 0.715
3.429GlyThr: 3.429 ± 0.505
3.135GlyVal: 3.135 ± 0.655
0.98GlyTrp: 0.98 ± 0.313
3.233GlyTyr: 3.233 ± 0.495
0.0GlyXaa: 0.0 ± 0.0
His
0.588HisAla: 0.588 ± 0.199
0.588HisCys: 0.588 ± 0.255
0.98HisAsp: 0.98 ± 0.336
0.588HisGlu: 0.588 ± 0.312
0.784HisPhe: 0.784 ± 0.33
0.686HisGly: 0.686 ± 0.233
0.49HisHis: 0.49 ± 0.211
1.078HisIle: 1.078 ± 0.446
0.98HisLys: 0.98 ± 0.276
1.372HisLeu: 1.372 ± 0.47
0.294HisMet: 0.294 ± 0.156
0.882HisAsn: 0.882 ± 0.299
0.392HisPro: 0.392 ± 0.233
0.686HisGln: 0.686 ± 0.238
0.392HisArg: 0.392 ± 0.177
1.47HisSer: 1.47 ± 0.399
0.784HisThr: 0.784 ± 0.308
0.784HisVal: 0.784 ± 0.248
0.49HisTrp: 0.49 ± 0.249
0.98HisTyr: 0.98 ± 0.331
0.0HisXaa: 0.0 ± 0.0
Ile
4.213IleAla: 4.213 ± 0.74
0.588IleCys: 0.588 ± 0.275
4.703IleAsp: 4.703 ± 0.721
5.682IleGlu: 5.682 ± 0.821
3.233IlePhe: 3.233 ± 0.39
4.213IleGly: 4.213 ± 0.914
0.882IleHis: 0.882 ± 0.283
4.213IleIle: 4.213 ± 0.766
7.544IleLys: 7.544 ± 0.969
4.409IleLeu: 4.409 ± 0.662
1.959IleMet: 1.959 ± 0.474
4.213IleAsn: 4.213 ± 0.57
3.233IlePro: 3.233 ± 0.503
1.568IleGln: 1.568 ± 0.598
2.547IleArg: 2.547 ± 0.529
4.409IleSer: 4.409 ± 0.612
4.507IleThr: 4.507 ± 0.64
4.409IleVal: 4.409 ± 0.737
1.47IleTrp: 1.47 ± 0.522
2.155IleTyr: 2.155 ± 0.379
0.0IleXaa: 0.0 ± 0.0
Lys
6.074LysAla: 6.074 ± 0.84
0.49LysCys: 0.49 ± 0.218
5.584LysAsp: 5.584 ± 0.73
6.662LysGlu: 6.662 ± 0.888
2.253LysPhe: 2.253 ± 0.554
4.605LysGly: 4.605 ± 0.614
1.078LysHis: 1.078 ± 0.251
5.388LysIle: 5.388 ± 0.694
7.152LysLys: 7.152 ± 0.993
6.858LysLeu: 6.858 ± 0.721
2.449LysMet: 2.449 ± 0.364
5.486LysAsn: 5.486 ± 0.695
1.568LysPro: 1.568 ± 0.342
4.507LysGln: 4.507 ± 0.903
4.605LysArg: 4.605 ± 0.776
6.466LysSer: 6.466 ± 0.751
5.29LysThr: 5.29 ± 0.825
5.584LysVal: 5.584 ± 0.912
1.372LysTrp: 1.372 ± 0.288
2.841LysTyr: 2.841 ± 0.644
0.0LysXaa: 0.0 ± 0.0
Leu
6.368LeuAla: 6.368 ± 0.594
0.294LeuCys: 0.294 ± 0.184
4.899LeuAsp: 4.899 ± 0.76
5.486LeuGlu: 5.486 ± 0.744
2.547LeuPhe: 2.547 ± 0.508
6.074LeuGly: 6.074 ± 0.97
0.784LeuHis: 0.784 ± 0.235
4.311LeuIle: 4.311 ± 0.535
9.013LeuLys: 9.013 ± 0.814
6.27LeuLeu: 6.27 ± 0.741
1.274LeuMet: 1.274 ± 0.352
5.682LeuAsn: 5.682 ± 0.72
3.135LeuPro: 3.135 ± 0.448
2.939LeuGln: 2.939 ± 0.497
4.115LeuArg: 4.115 ± 0.798
4.605LeuSer: 4.605 ± 0.744
4.213LeuThr: 4.213 ± 0.575
4.703LeuVal: 4.703 ± 0.78
1.078LeuTrp: 1.078 ± 0.376
2.449LeuTyr: 2.449 ± 0.687
0.0LeuXaa: 0.0 ± 0.0
Met
1.372MetAla: 1.372 ± 0.416
0.098MetCys: 0.098 ± 0.099
1.568MetAsp: 1.568 ± 0.419
1.568MetGlu: 1.568 ± 0.418
0.784MetPhe: 0.784 ± 0.25
1.078MetGly: 1.078 ± 0.257
0.196MetHis: 0.196 ± 0.142
1.763MetIle: 1.763 ± 0.411
2.547MetLys: 2.547 ± 0.532
1.47MetLeu: 1.47 ± 0.34
0.196MetMet: 0.196 ± 0.151
1.176MetAsn: 1.176 ± 0.306
0.882MetPro: 0.882 ± 0.249
0.784MetGln: 0.784 ± 0.301
1.078MetArg: 1.078 ± 0.418
1.861MetSer: 1.861 ± 0.514
1.763MetThr: 1.763 ± 0.301
1.078MetVal: 1.078 ± 0.334
0.098MetTrp: 0.098 ± 0.082
0.588MetTyr: 0.588 ± 0.294
0.0MetXaa: 0.0 ± 0.0
Asn
3.233AsnAla: 3.233 ± 1.052
0.392AsnCys: 0.392 ± 0.172
3.821AsnAsp: 3.821 ± 0.662
3.135AsnGlu: 3.135 ± 0.406
2.351AsnPhe: 2.351 ± 0.579
5.29AsnGly: 5.29 ± 0.821
1.078AsnHis: 1.078 ± 0.327
4.213AsnIle: 4.213 ± 0.788
5.878AsnLys: 5.878 ± 0.776
4.703AsnLeu: 4.703 ± 0.563
1.372AsnMet: 1.372 ± 0.323
3.037AsnAsn: 3.037 ± 0.594
2.743AsnPro: 2.743 ± 0.66
3.821AsnGln: 3.821 ± 0.67
2.253AsnArg: 2.253 ± 0.527
2.939AsnSer: 2.939 ± 0.548
1.959AsnThr: 1.959 ± 0.387
4.801AsnVal: 4.801 ± 0.549
1.274AsnTrp: 1.274 ± 0.335
3.037AsnTyr: 3.037 ± 0.508
0.0AsnXaa: 0.0 ± 0.0
Pro
1.372ProAla: 1.372 ± 0.295
0.392ProCys: 0.392 ± 0.263
1.763ProAsp: 1.763 ± 0.475
2.449ProGlu: 2.449 ± 0.504
1.372ProPhe: 1.372 ± 0.396
0.49ProGly: 0.49 ± 0.18
0.686ProHis: 0.686 ± 0.286
1.763ProIle: 1.763 ± 0.379
2.841ProLys: 2.841 ± 0.608
2.645ProLeu: 2.645 ± 0.528
0.49ProMet: 0.49 ± 0.167
1.274ProAsn: 1.274 ± 0.301
0.588ProPro: 0.588 ± 0.249
1.372ProGln: 1.372 ± 0.292
1.274ProArg: 1.274 ± 0.419
1.666ProSer: 1.666 ± 0.364
2.253ProThr: 2.253 ± 0.511
2.449ProVal: 2.449 ± 0.544
0.196ProTrp: 0.196 ± 0.129
1.372ProTyr: 1.372 ± 0.413
0.0ProXaa: 0.0 ± 0.0
Gln
4.703GlnAla: 4.703 ± 0.674
0.294GlnCys: 0.294 ± 0.159
1.959GlnAsp: 1.959 ± 0.498
2.743GlnGlu: 2.743 ± 0.514
1.861GlnPhe: 1.861 ± 0.323
2.547GlnGly: 2.547 ± 0.639
0.784GlnHis: 0.784 ± 0.223
2.547GlnIle: 2.547 ± 0.613
3.919GlnLys: 3.919 ± 0.768
2.253GlnLeu: 2.253 ± 0.513
0.882GlnMet: 0.882 ± 0.351
2.841GlnAsn: 2.841 ± 0.375
1.078GlnPro: 1.078 ± 0.343
1.568GlnGln: 1.568 ± 0.469
1.568GlnArg: 1.568 ± 0.439
2.645GlnSer: 2.645 ± 0.456
2.449GlnThr: 2.449 ± 0.631
2.155GlnVal: 2.155 ± 0.486
0.49GlnTrp: 0.49 ± 0.229
0.98GlnTyr: 0.98 ± 0.346
0.0GlnXaa: 0.0 ± 0.0
Arg
3.331ArgAla: 3.331 ± 0.395
0.784ArgCys: 0.784 ± 0.359
3.037ArgAsp: 3.037 ± 0.5
3.527ArgGlu: 3.527 ± 0.666
1.274ArgPhe: 1.274 ± 0.378
1.861ArgGly: 1.861 ± 0.309
0.588ArgHis: 0.588 ± 0.234
3.527ArgIle: 3.527 ± 0.471
4.605ArgLys: 4.605 ± 0.735
3.625ArgLeu: 3.625 ± 0.557
0.784ArgMet: 0.784 ± 0.304
3.429ArgAsn: 3.429 ± 0.491
0.882ArgPro: 0.882 ± 0.22
1.372ArgGln: 1.372 ± 0.459
1.861ArgArg: 1.861 ± 0.543
1.666ArgSer: 1.666 ± 0.459
3.135ArgThr: 3.135 ± 0.606
3.037ArgVal: 3.037 ± 0.616
0.392ArgTrp: 0.392 ± 0.153
2.743ArgTyr: 2.743 ± 0.565
0.0ArgXaa: 0.0 ± 0.0
Ser
4.017SerAla: 4.017 ± 0.923
0.49SerCys: 0.49 ± 0.198
3.821SerAsp: 3.821 ± 0.526
5.095SerGlu: 5.095 ± 0.712
2.743SerPhe: 2.743 ± 0.616
4.311SerGly: 4.311 ± 0.812
0.882SerHis: 0.882 ± 0.315
4.311SerIle: 4.311 ± 0.566
3.429SerLys: 3.429 ± 0.653
5.193SerLeu: 5.193 ± 0.674
1.666SerMet: 1.666 ± 0.345
3.821SerAsn: 3.821 ± 0.564
1.372SerPro: 1.372 ± 0.407
2.351SerGln: 2.351 ± 0.365
2.351SerArg: 2.351 ± 0.399
3.527SerSer: 3.527 ± 0.681
2.547SerThr: 2.547 ± 0.482
4.311SerVal: 4.311 ± 0.65
0.588SerTrp: 0.588 ± 0.257
2.743SerTyr: 2.743 ± 0.405
0.0SerXaa: 0.0 ± 0.0
Thr
4.409ThrAla: 4.409 ± 0.897
0.098ThrCys: 0.098 ± 0.099
3.233ThrAsp: 3.233 ± 0.548
3.821ThrGlu: 3.821 ± 0.6
2.547ThrPhe: 2.547 ± 0.347
5.388ThrGly: 5.388 ± 0.695
0.98ThrHis: 0.98 ± 0.301
3.821ThrIle: 3.821 ± 0.618
3.135ThrLys: 3.135 ± 0.55
4.801ThrLeu: 4.801 ± 0.622
0.588ThrMet: 0.588 ± 0.239
3.037ThrAsn: 3.037 ± 0.634
1.763ThrPro: 1.763 ± 0.421
1.959ThrGln: 1.959 ± 0.391
2.253ThrArg: 2.253 ± 0.449
2.841ThrSer: 2.841 ± 0.499
3.331ThrThr: 3.331 ± 0.606
3.527ThrVal: 3.527 ± 0.492
0.882ThrTrp: 0.882 ± 0.257
1.666ThrTyr: 1.666 ± 0.443
0.0ThrXaa: 0.0 ± 0.0
Val
5.486ValAla: 5.486 ± 0.612
0.392ValCys: 0.392 ± 0.184
4.017ValAsp: 4.017 ± 0.599
4.703ValGlu: 4.703 ± 0.633
2.547ValPhe: 2.547 ± 0.445
3.233ValGly: 3.233 ± 0.602
0.882ValHis: 0.882 ± 0.28
3.625ValIle: 3.625 ± 0.672
5.193ValLys: 5.193 ± 0.722
5.976ValLeu: 5.976 ± 0.729
0.588ValMet: 0.588 ± 0.286
4.213ValAsn: 4.213 ± 0.632
2.449ValPro: 2.449 ± 0.534
2.253ValGln: 2.253 ± 0.466
3.625ValArg: 3.625 ± 0.628
4.801ValSer: 4.801 ± 0.81
3.429ValThr: 3.429 ± 0.684
5.095ValVal: 5.095 ± 0.805
1.078ValTrp: 1.078 ± 0.339
2.057ValTyr: 2.057 ± 0.387
0.0ValXaa: 0.0 ± 0.0
Trp
0.882TrpAla: 0.882 ± 0.318
0.294TrpCys: 0.294 ± 0.164
0.784TrpAsp: 0.784 ± 0.29
1.274TrpGlu: 1.274 ± 0.35
0.49TrpPhe: 0.49 ± 0.183
0.588TrpGly: 0.588 ± 0.277
0.098TrpHis: 0.098 ± 0.098
1.372TrpIle: 1.372 ± 0.324
0.686TrpLys: 0.686 ± 0.291
1.078TrpLeu: 1.078 ± 0.328
0.196TrpMet: 0.196 ± 0.13
1.372TrpAsn: 1.372 ± 0.659
0.098TrpPro: 0.098 ± 0.099
1.176TrpGln: 1.176 ± 0.371
1.078TrpArg: 1.078 ± 0.348
1.568TrpSer: 1.568 ± 0.364
0.882TrpThr: 0.882 ± 0.253
0.882TrpVal: 0.882 ± 0.251
0.098TrpTrp: 0.098 ± 0.115
0.784TrpTyr: 0.784 ± 0.238
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.057TyrAla: 2.057 ± 0.412
0.098TyrCys: 0.098 ± 0.1
2.743TyrAsp: 2.743 ± 0.558
2.253TyrGlu: 2.253 ± 0.442
1.568TyrPhe: 1.568 ± 0.401
3.331TyrGly: 3.331 ± 0.677
1.274TyrHis: 1.274 ± 0.357
2.351TyrIle: 2.351 ± 0.513
3.429TyrLys: 3.429 ± 0.652
2.155TyrLeu: 2.155 ± 0.352
1.078TyrMet: 1.078 ± 0.312
1.666TyrAsn: 1.666 ± 0.396
1.959TyrPro: 1.959 ± 0.461
1.47TyrGln: 1.47 ± 0.367
2.253TyrArg: 2.253 ± 0.44
2.253TyrSer: 2.253 ± 0.548
1.959TyrThr: 1.959 ± 0.508
1.666TyrVal: 1.666 ± 0.401
0.49TyrTrp: 0.49 ± 0.245
1.959TyrTyr: 1.959 ± 0.537
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (10208 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski