Amino acid dipepetide frequency for Tissierella sp. P1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.749AlaAla: 3.749 ± 0.083	0.531AlaCys: 0.531 ± 0.022	2.596AlaAsp: 2.596 ± 0.052	3.616AlaGlu: 3.616 ± 0.064	2.369AlaPhe: 2.369 ± 0.052	3.869AlaGly: 3.869 ± 0.069	0.812AlaHis: 0.812 ± 0.026	5.748AlaIle: 5.748 ± 0.082	4.267AlaLys: 4.267 ± 0.063	5.624AlaLeu: 5.624 ± 0.079	1.767AlaMet: 1.767 ± 0.045	2.598AlaAsn: 2.598 ± 0.05	1.383AlaPro: 1.383 ± 0.037	1.309AlaGln: 1.309 ± 0.035	1.976AlaArg: 1.976 ± 0.047	3.131AlaSer: 3.131 ± 0.061	2.822AlaThr: 2.822 ± 0.066	3.735AlaVal: 3.735 ± 0.063	0.351AlaTrp: 0.351 ± 0.017	2.029AlaTyr: 2.029 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.426CysAla: 0.426 ± 0.019	0.118CysCys: 0.118 ± 0.01	0.509CysAsp: 0.509 ± 0.021	0.544CysGlu: 0.544 ± 0.022	0.373CysPhe: 0.373 ± 0.019	0.867CysGly: 0.867 ± 0.032	0.201CysHis: 0.201 ± 0.014	0.895CysIle: 0.895 ± 0.031	0.709CysLys: 0.709 ± 0.025	0.66CysLeu: 0.66 ± 0.024	0.222CysMet: 0.222 ± 0.016	0.554CysAsn: 0.554 ± 0.023	0.439CysPro: 0.439 ± 0.023	0.201CysGln: 0.201 ± 0.014	0.359CysArg: 0.359 ± 0.018	0.626CysSer: 0.626 ± 0.024	0.452CysThr: 0.452 ± 0.021	0.475CysVal: 0.475 ± 0.021	0.064CysTrp: 0.064 ± 0.006	0.347CysTyr: 0.347 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	2.512AspAla: 2.512 ± 0.054	0.424AspCys: 0.424 ± 0.021	2.777AspAsp: 2.777 ± 0.059	4.808AspGlu: 4.808 ± 0.064	2.703AspPhe: 2.703 ± 0.059	3.538AspGly: 3.538 ± 0.069	0.634AspHis: 0.634 ± 0.025	7.03AspIle: 7.03 ± 0.09	5.321AspLys: 5.321 ± 0.067	5.218AspLeu: 5.218 ± 0.068	1.695AspMet: 1.695 ± 0.038	3.48AspAsn: 3.48 ± 0.057	1.49AspPro: 1.49 ± 0.041	0.797AspGln: 0.797 ± 0.027	2.125AspArg: 2.125 ± 0.046	3.022AspSer: 3.022 ± 0.051	2.554AspThr: 2.554 ± 0.048	3.241AspVal: 3.241 ± 0.056	0.485AspTrp: 0.485 ± 0.021	2.874AspTyr: 2.874 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	3.956GluAla: 3.956 ± 0.066	0.493GluCys: 0.493 ± 0.02	4.773GluAsp: 4.773 ± 0.07	7.72GluGlu: 7.72 ± 0.113	3.018GluPhe: 3.018 ± 0.052	4.461GluGly: 4.461 ± 0.067	0.942GluHis: 0.942 ± 0.031	8.156GluIle: 8.156 ± 0.1	7.455GluLys: 7.455 ± 0.09	7.348GluLeu: 7.348 ± 0.082	2.134GluMet: 2.134 ± 0.047	5.162GluAsn: 5.162 ± 0.08	1.683GluPro: 1.683 ± 0.037	1.842GluGln: 1.842 ± 0.046	2.938GluArg: 2.938 ± 0.055	3.742GluSer: 3.742 ± 0.06	3.194GluThr: 3.194 ± 0.055	4.812GluVal: 4.812 ± 0.073	0.584GluTrp: 0.584 ± 0.022	3.353GluTyr: 3.353 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	2.33PheAla: 2.33 ± 0.052	0.431PheCys: 0.431 ± 0.021	2.39PheAsp: 2.39 ± 0.041	2.778PheGlu: 2.778 ± 0.054	1.914PhePhe: 1.914 ± 0.052	2.911PheGly: 2.911 ± 0.058	0.679PheHis: 0.679 ± 0.026	4.77PheIle: 4.77 ± 0.08	3.145PheLys: 3.145 ± 0.049	4.035PheLeu: 4.035 ± 0.071	1.15PheMet: 1.15 ± 0.035	2.659PheAsn: 2.659 ± 0.05	1.341PhePro: 1.341 ± 0.035	1.12PheGln: 1.12 ± 0.03	1.401PheArg: 1.401 ± 0.033	3.148PheSer: 3.148 ± 0.058	2.437PheThr: 2.437 ± 0.051	2.483PheVal: 2.483 ± 0.049	0.325PheTrp: 0.325 ± 0.019	1.863PheTyr: 1.863 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	3.89GlyAla: 3.89 ± 0.064	0.794GlyCys: 0.794 ± 0.032	3.254GlyAsp: 3.254 ± 0.057	4.557GlyGlu: 4.557 ± 0.066	3.256GlyPhe: 3.256 ± 0.058	4.467GlyGly: 4.467 ± 0.074	1.044GlyHis: 1.044 ± 0.031	7.282GlyIle: 7.282 ± 0.102	5.398GlyLys: 5.398 ± 0.074	6.155GlyLeu: 6.155 ± 0.082	1.862GlyMet: 1.862 ± 0.043	3.452GlyAsn: 3.452 ± 0.059	1.334GlyPro: 1.334 ± 0.042	1.581GlyGln: 1.581 ± 0.041	2.424GlyArg: 2.424 ± 0.045	3.716GlySer: 3.716 ± 0.05	3.609GlyThr: 3.609 ± 0.063	4.352GlyVal: 4.352 ± 0.058	0.512GlyTrp: 0.512 ± 0.025	3.099GlyTyr: 3.099 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	0.684HisAla: 0.684 ± 0.023	0.186HisCys: 0.186 ± 0.013	0.738HisAsp: 0.738 ± 0.025	0.952HisGlu: 0.952 ± 0.031	0.652HisPhe: 0.652 ± 0.022	1.053HisGly: 1.053 ± 0.029	0.302HisHis: 0.302 ± 0.017	1.472HisIle: 1.472 ± 0.035	1.035HisLys: 1.035 ± 0.03	1.282HisLeu: 1.282 ± 0.034	0.39HisMet: 0.39 ± 0.018	0.813HisAsn: 0.813 ± 0.026	0.656HisPro: 0.656 ± 0.025	0.374HisGln: 0.374 ± 0.019	0.611HisArg: 0.611 ± 0.024	0.925HisSer: 0.925 ± 0.026	0.685HisThr: 0.685 ± 0.025	0.748HisVal: 0.748 ± 0.028	0.116HisTrp: 0.116 ± 0.01	0.665HisTyr: 0.665 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.976IleAla: 5.976 ± 0.084	1.01IleCys: 1.01 ± 0.031	6.639IleAsp: 6.639 ± 0.078	8.081IleGlu: 8.081 ± 0.096	4.532IlePhe: 4.532 ± 0.072	6.938IleGly: 6.938 ± 0.085	1.399IleHis: 1.399 ± 0.04	10.615IleIle: 10.615 ± 0.131	8.155IleLys: 8.155 ± 0.096	10.057IleLeu: 10.057 ± 0.109	2.593IleMet: 2.593 ± 0.048	6.096IleAsn: 6.096 ± 0.084	3.565IlePro: 3.565 ± 0.059	2.426IleGln: 2.426 ± 0.041	3.641IleArg: 3.641 ± 0.054	7.419IleSer: 7.419 ± 0.084	5.069IleThr: 5.069 ± 0.074	6.449IleVal: 6.449 ± 0.076	0.653IleTrp: 0.653 ± 0.024	3.763IleTyr: 3.763 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.301LysAla: 4.301 ± 0.069	0.607LysCys: 0.607 ± 0.028	5.751LysAsp: 5.751 ± 0.087	8.59LysGlu: 8.59 ± 0.103	2.744LysPhe: 2.744 ± 0.054	5.021LysGly: 5.021 ± 0.07	1.094LysHis: 1.094 ± 0.029	8.02LysIle: 8.02 ± 0.104	6.745LysLys: 6.745 ± 0.082	7.054LysLeu: 7.054 ± 0.081	2.251LysMet: 2.251 ± 0.049	5.121LysAsn: 5.121 ± 0.078	2.069LysPro: 2.069 ± 0.046	1.911LysGln: 1.911 ± 0.04	2.979LysArg: 2.979 ± 0.053	4.619LysSer: 4.619 ± 0.059	3.743LysThr: 3.743 ± 0.056	5.166LysVal: 5.166 ± 0.076	0.635LysTrp: 0.635 ± 0.023	3.698LysTyr: 3.698 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	5.283LeuAla: 5.283 ± 0.08	0.861LeuCys: 0.861 ± 0.033	5.615LeuAsp: 5.615 ± 0.08	7.02LeuGlu: 7.02 ± 0.099	3.964LeuPhe: 3.964 ± 0.069	6.49LeuGly: 6.49 ± 0.071	1.169LeuHis: 1.169 ± 0.032	8.875LeuIle: 8.875 ± 0.11	7.639LeuLys: 7.639 ± 0.085	8.449LeuLeu: 8.449 ± 0.098	2.423LeuMet: 2.423 ± 0.045	5.672LeuAsn: 5.672 ± 0.073	3.149LeuPro: 3.149 ± 0.053	2.245LeuGln: 2.245 ± 0.047	3.404LeuArg: 3.404 ± 0.058	6.923LeuSer: 6.923 ± 0.096	4.568LeuThr: 4.568 ± 0.066	5.47LeuVal: 5.47 ± 0.067	0.678LeuTrp: 0.678 ± 0.026	3.437LeuTyr: 3.437 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.84MetAla: 1.84 ± 0.04	0.188MetCys: 0.188 ± 0.013	1.775MetAsp: 1.775 ± 0.039	2.338MetGlu: 2.338 ± 0.047	0.986MetPhe: 0.986 ± 0.032	1.893MetGly: 1.893 ± 0.047	0.343MetHis: 0.343 ± 0.018	2.497MetIle: 2.497 ± 0.048	2.669MetLys: 2.669 ± 0.045	2.328MetLeu: 2.328 ± 0.048	0.702MetMet: 0.702 ± 0.025	1.629MetAsn: 1.629 ± 0.039	0.847MetPro: 0.847 ± 0.029	0.598MetGln: 0.598 ± 0.028	1.005MetArg: 1.005 ± 0.031	1.561MetSer: 1.561 ± 0.031	1.409MetThr: 1.409 ± 0.036	1.756MetVal: 1.756 ± 0.04	0.174MetTrp: 0.174 ± 0.012	0.828MetTyr: 0.828 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.628AsnAla: 2.628 ± 0.047	0.547AsnCys: 0.547 ± 0.02	2.685AsnAsp: 2.685 ± 0.055	4.132AsnGlu: 4.132 ± 0.062	2.297AsnPhe: 2.297 ± 0.047	3.487AsnGly: 3.487 ± 0.067	0.94AsnHis: 0.94 ± 0.03	7.246AsnIle: 7.246 ± 0.091	5.126AsnLys: 5.126 ± 0.075	5.555AsnLeu: 5.555 ± 0.08	1.713AsnMet: 1.713 ± 0.035	3.816AsnAsn: 3.816 ± 0.073	2.261AsnPro: 2.261 ± 0.045	1.588AsnGln: 1.588 ± 0.041	2.387AsnArg: 2.387 ± 0.046	3.593AsnSer: 3.593 ± 0.06	2.881AsnThr: 2.881 ± 0.051	3.117AsnVal: 3.117 ± 0.053	0.477AsnTrp: 0.477 ± 0.02	2.537AsnTyr: 2.537 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	1.547ProAla: 1.547 ± 0.046	0.255ProCys: 0.255 ± 0.016	1.621ProAsp: 1.621 ± 0.043	2.442ProGlu: 2.442 ± 0.057	1.451ProPhe: 1.451 ± 0.04	1.662ProGly: 1.662 ± 0.037	0.515ProHis: 0.515 ± 0.024	3.195ProIle: 3.195 ± 0.059	2.194ProLys: 2.194 ± 0.042	2.655ProLeu: 2.655 ± 0.049	0.825ProMet: 0.825 ± 0.029	1.668ProAsn: 1.668 ± 0.04	0.756ProPro: 0.756 ± 0.031	0.814ProGln: 0.814 ± 0.029	0.956ProArg: 0.956 ± 0.029	1.903ProSer: 1.903 ± 0.037	1.667ProThr: 1.667 ± 0.043	2.045ProVal: 2.045 ± 0.045	0.281ProTrp: 0.281 ± 0.015	1.393ProTyr: 1.393 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.398GlnAla: 1.398 ± 0.038	0.186GlnCys: 0.186 ± 0.014	1.262GlnAsp: 1.262 ± 0.032	1.902GlnGlu: 1.902 ± 0.042	0.961GlnPhe: 0.961 ± 0.028	1.649GlnGly: 1.649 ± 0.04	0.335GlnHis: 0.335 ± 0.019	2.408GlnIle: 2.408 ± 0.048	1.902GlnLys: 1.902 ± 0.04	2.18GlnLeu: 2.18 ± 0.052	0.723GlnMet: 0.723 ± 0.028	1.418GlnAsn: 1.418 ± 0.038	0.632GlnPro: 0.632 ± 0.022	0.668GlnGln: 0.668 ± 0.026	1.119GlnArg: 1.119 ± 0.031	1.36GlnSer: 1.36 ± 0.037	1.099GlnThr: 1.099 ± 0.031	1.472GlnVal: 1.472 ± 0.034	0.21GlnTrp: 0.21 ± 0.015	1.008GlnTyr: 1.008 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	1.955ArgAla: 1.955 ± 0.046	0.334ArgCys: 0.334 ± 0.019	2.17ArgAsp: 2.17 ± 0.044	3.286ArgGlu: 3.286 ± 0.062	1.657ArgPhe: 1.657 ± 0.041	2.234ArgGly: 2.234 ± 0.041	0.535ArgHis: 0.535 ± 0.021	3.729ArgIle: 3.729 ± 0.061	3.187ArgLys: 3.187 ± 0.052	3.388ArgLeu: 3.388 ± 0.052	1.059ArgMet: 1.059 ± 0.031	2.154ArgAsn: 2.154 ± 0.052	0.975ArgPro: 0.975 ± 0.028	1.03ArgGln: 1.03 ± 0.03	1.628ArgArg: 1.628 ± 0.045	1.676ArgSer: 1.676 ± 0.038	1.761ArgThr: 1.761 ± 0.04	2.29ArgVal: 2.29 ± 0.041	0.286ArgTrp: 0.286 ± 0.016	1.628ArgTyr: 1.628 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	2.881SerAla: 2.881 ± 0.059	0.541SerCys: 0.541 ± 0.024	3.007SerAsp: 3.007 ± 0.052	3.749SerGlu: 3.749 ± 0.059	3.148SerPhe: 3.148 ± 0.054	4.199SerGly: 4.199 ± 0.064	1.044SerHis: 1.044 ± 0.028	7.069SerIle: 7.069 ± 0.093	4.958SerLys: 4.958 ± 0.065	6.097SerLeu: 6.097 ± 0.085	1.815SerMet: 1.815 ± 0.04	3.545SerAsn: 3.545 ± 0.056	1.813SerPro: 1.813 ± 0.042	1.732SerGln: 1.732 ± 0.047	2.247SerArg: 2.247 ± 0.056	3.986SerSer: 3.986 ± 0.066	3.125SerThr: 3.125 ± 0.056	3.352SerVal: 3.352 ± 0.053	0.506SerTrp: 0.506 ± 0.024	2.72SerTyr: 2.72 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	2.937ThrAla: 2.937 ± 0.062	0.428ThrCys: 0.428 ± 0.021	2.507ThrAsp: 2.507 ± 0.044	3.096ThrGlu: 3.096 ± 0.063	2.104ThrPhe: 2.104 ± 0.042	3.734ThrGly: 3.734 ± 0.067	0.781ThrHis: 0.781 ± 0.027	5.362ThrIle: 5.362 ± 0.081	3.537ThrLys: 3.537 ± 0.054	4.708ThrLeu: 4.708 ± 0.061	1.259ThrMet: 1.259 ± 0.033	2.606ThrAsn: 2.606 ± 0.048	1.908ThrPro: 1.908 ± 0.046	1.109ThrGln: 1.109 ± 0.035	1.656ThrArg: 1.656 ± 0.038	3.052ThrSer: 3.052 ± 0.052	2.736ThrThr: 2.736 ± 0.065	3.432ThrVal: 3.432 ± 0.065	0.415ThrTrp: 0.415 ± 0.02	1.795ThrTyr: 1.795 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	3.696ValAla: 3.696 ± 0.06	0.572ValCys: 0.572 ± 0.027	3.777ValAsp: 3.777 ± 0.054	4.648ValGlu: 4.648 ± 0.073	2.826ValPhe: 2.826 ± 0.046	4.262ValGly: 4.262 ± 0.069	0.803ValHis: 0.803 ± 0.027	5.701ValIle: 5.701 ± 0.07	4.657ValLys: 4.657 ± 0.073	5.854ValLeu: 5.854 ± 0.072	1.574ValMet: 1.574 ± 0.037	3.383ValAsn: 3.383 ± 0.054	1.986ValPro: 1.986 ± 0.045	1.338ValGln: 1.338 ± 0.033	2.072ValArg: 2.072 ± 0.04	3.986ValSer: 3.986 ± 0.061	2.983ValThr: 2.983 ± 0.064	4.199ValVal: 4.199 ± 0.067	0.404ValTrp: 0.404 ± 0.019	2.285ValTyr: 2.285 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.412TrpAla: 0.412 ± 0.021	0.083TrpCys: 0.083 ± 0.009	0.464TrpAsp: 0.464 ± 0.023	0.552TrpGlu: 0.552 ± 0.023	0.356TrpPhe: 0.356 ± 0.018	0.595TrpGly: 0.595 ± 0.026	0.107TrpHis: 0.107 ± 0.01	0.785TrpIle: 0.785 ± 0.026	0.563TrpLys: 0.563 ± 0.024	0.673TrpLeu: 0.673 ± 0.028	0.224TrpMet: 0.224 ± 0.014	0.472TrpAsn: 0.472 ± 0.022	0.176TrpPro: 0.176 ± 0.013	0.221TrpGln: 0.221 ± 0.015	0.307TrpArg: 0.307 ± 0.016	0.405TrpSer: 0.405 ± 0.018	0.379TrpThr: 0.379 ± 0.017	0.398TrpVal: 0.398 ± 0.022	0.09TrpTrp: 0.09 ± 0.009	0.304TrpTyr: 0.304 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.879TyrAla: 1.879 ± 0.049	0.453TyrCys: 0.453 ± 0.02	2.418TyrAsp: 2.418 ± 0.046	2.955TyrGlu: 2.955 ± 0.052	1.998TyrPhe: 1.998 ± 0.046	2.709TyrGly: 2.709 ± 0.046	0.663TyrHis: 0.663 ± 0.027	4.224TyrIle: 4.224 ± 0.072	3.453TyrLys: 3.453 ± 0.06	4.015TyrLeu: 4.015 ± 0.073	0.987TyrMet: 0.987 ± 0.025	2.718TyrAsn: 2.718 ± 0.054	1.381TyrPro: 1.381 ± 0.038	0.986TyrGln: 0.986 ± 0.031	1.723TyrArg: 1.723 ± 0.039	2.742TyrSer: 2.742 ± 0.052	1.987TyrThr: 1.987 ± 0.042	2.016TyrVal: 2.016 ± 0.044	0.32TyrTrp: 0.32 ± 0.019	1.993TyrTyr: 1.993 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3981 proteins (1147079 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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