Amino acid dipepetide frequency for Mycobacterium avium subsp. avium 2285 (R)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.481AlaAla: 21.481 ± 0.193	1.108AlaCys: 1.108 ± 0.026	8.342AlaAsp: 8.342 ± 0.071	7.718AlaGlu: 7.718 ± 0.084	3.36AlaPhe: 3.36 ± 0.047	12.707AlaGly: 12.707 ± 0.11	2.681AlaHis: 2.681 ± 0.049	4.962AlaIle: 4.962 ± 0.06	2.985AlaLys: 2.985 ± 0.049	12.693AlaLeu: 12.693 ± 0.113	2.868AlaMet: 2.868 ± 0.044	2.622AlaAsn: 2.622 ± 0.043	6.662AlaPro: 6.662 ± 0.082	4.234AlaGln: 4.234 ± 0.056	9.783AlaArg: 9.783 ± 0.083	6.038AlaSer: 6.038 ± 0.067	7.142AlaThr: 7.142 ± 0.074	11.396AlaVal: 11.396 ± 0.126	1.677AlaTrp: 1.677 ± 0.034	2.246AlaTyr: 2.246 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.382CysAla: 1.382 ± 0.034	0.235CysCys: 0.235 ± 0.014	0.568CysAsp: 0.568 ± 0.022	0.421CysGlu: 0.421 ± 0.018	0.24CysPhe: 0.24 ± 0.012	1.091CysGly: 1.091 ± 0.029	0.214CysHis: 0.214 ± 0.012	0.262CysIle: 0.262 ± 0.013	0.158CysLys: 0.158 ± 0.01	0.653CysLeu: 0.653 ± 0.019	0.183CysMet: 0.183 ± 0.011	0.178CysAsn: 0.178 ± 0.011	0.669CysPro: 0.669 ± 0.022	0.211CysGln: 0.211 ± 0.011	0.891CysArg: 0.891 ± 0.029	0.713CysSer: 0.713 ± 0.024	0.582CysThr: 0.582 ± 0.022	0.652CysVal: 0.652 ± 0.02	0.278CysTrp: 0.278 ± 0.016	0.216CysTyr: 0.216 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.7AspAla: 7.7 ± 0.08	0.461AspCys: 0.461 ± 0.017	4.202AspAsp: 4.202 ± 0.059	3.966AspGlu: 3.966 ± 0.059	1.76AspPhe: 1.76 ± 0.032	5.74AspGly: 5.74 ± 0.061	1.418AspHis: 1.418 ± 0.032	2.56AspIle: 2.56 ± 0.044	1.303AspLys: 1.303 ± 0.029	5.724AspLeu: 5.724 ± 0.063	0.981AspMet: 0.981 ± 0.027	1.204AspAsn: 1.204 ± 0.031	4.42AspPro: 4.42 ± 0.056	1.758AspGln: 1.758 ± 0.037	4.624AspArg: 4.624 ± 0.057	2.58AspSer: 2.58 ± 0.044	3.012AspThr: 3.012 ± 0.046	5.093AspVal: 5.093 ± 0.064	0.983AspTrp: 0.983 ± 0.023	1.485AspTyr: 1.485 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	5.874GluAla: 5.874 ± 0.072	0.375GluCys: 0.375 ± 0.016	2.268GluAsp: 2.268 ± 0.041	2.387GluGlu: 2.387 ± 0.05	1.791GluPhe: 1.791 ± 0.036	3.018GluGly: 3.018 ± 0.049	1.596GluHis: 1.596 ± 0.036	2.5GluIle: 2.5 ± 0.042	1.236GluLys: 1.236 ± 0.033	6.577GluLeu: 6.577 ± 0.074	1.016GluMet: 1.016 ± 0.025	1.047GluAsn: 1.047 ± 0.028	2.83GluPro: 2.83 ± 0.041	2.244GluGln: 2.244 ± 0.043	4.453GluArg: 4.453 ± 0.066	2.522GluSer: 2.522 ± 0.042	2.509GluThr: 2.509 ± 0.038	4.084GluVal: 4.084 ± 0.053	0.743GluTrp: 0.743 ± 0.022	1.076GluTyr: 1.076 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.906PheAla: 3.906 ± 0.058	0.339PheCys: 0.339 ± 0.014	2.36PheAsp: 2.36 ± 0.045	1.515PheGlu: 1.515 ± 0.03	0.982PhePhe: 0.982 ± 0.027	3.291PheGly: 3.291 ± 0.047	0.648PheHis: 0.648 ± 0.02	1.026PheIle: 1.026 ± 0.025	0.543PheLys: 0.543 ± 0.019	2.422PheLeu: 2.422 ± 0.039	0.505PheMet: 0.505 ± 0.019	0.709PheAsn: 0.709 ± 0.02	1.523PhePro: 1.523 ± 0.035	0.679PheGln: 0.679 ± 0.021	1.727PheArg: 1.727 ± 0.036	1.667PheSer: 1.667 ± 0.03	1.934PheThr: 1.934 ± 0.035	2.407PheVal: 2.407 ± 0.043	0.442PheTrp: 0.442 ± 0.019	0.704PheTyr: 0.704 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.408GlyAla: 10.408 ± 0.083	1.041GlyCys: 1.041 ± 0.028	4.857GlyAsp: 4.857 ± 0.059	4.19GlyGlu: 4.19 ± 0.053	2.909GlyPhe: 2.909 ± 0.047	7.68GlyGly: 7.68 ± 0.085	2.118GlyHis: 2.118 ± 0.04	3.852GlyIle: 3.852 ± 0.054	2.343GlyLys: 2.343 ± 0.041	8.24GlyLeu: 8.24 ± 0.088	2.289GlyMet: 2.289 ± 0.038	1.826GlyAsn: 1.826 ± 0.035	5.017GlyPro: 5.017 ± 0.073	2.868GlyGln: 2.868 ± 0.042	7.152GlyArg: 7.152 ± 0.077	5.238GlySer: 5.238 ± 0.064	4.968GlyThr: 4.968 ± 0.054	7.299GlyVal: 7.299 ± 0.078	1.878GlyTrp: 1.878 ± 0.038	2.384GlyTyr: 2.384 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.577HisAla: 2.577 ± 0.049	0.246HisCys: 0.246 ± 0.014	1.429HisAsp: 1.429 ± 0.03	1.053HisGlu: 1.053 ± 0.031	0.66HisPhe: 0.66 ± 0.018	2.241HisGly: 2.241 ± 0.034	0.757HisHis: 0.757 ± 0.023	0.805HisIle: 0.805 ± 0.024	0.374HisLys: 0.374 ± 0.016	2.092HisLeu: 2.092 ± 0.04	0.348HisMet: 0.348 ± 0.018	0.525HisAsn: 0.525 ± 0.018	1.801HisPro: 1.801 ± 0.036	0.726HisGln: 0.726 ± 0.023	2.286HisArg: 2.286 ± 0.048	1.073HisSer: 1.073 ± 0.029	1.265HisThr: 1.265 ± 0.031	1.664HisVal: 1.664 ± 0.033	0.426HisTrp: 0.426 ± 0.018	0.562HisTyr: 0.562 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.022IleAla: 6.022 ± 0.069	0.414IleCys: 0.414 ± 0.017	3.284IleAsp: 3.284 ± 0.046	2.525IleGlu: 2.525 ± 0.047	0.988IlePhe: 0.988 ± 0.026	4.237IleGly: 4.237 ± 0.057	0.777IleHis: 0.777 ± 0.023	1.345IleIle: 1.345 ± 0.032	0.885IleLys: 0.885 ± 0.026	2.774IleLeu: 2.774 ± 0.044	0.584IleMet: 0.584 ± 0.017	1.141IleAsn: 1.141 ± 0.026	2.371IlePro: 2.371 ± 0.039	0.947IleGln: 0.947 ± 0.03	2.698IleArg: 2.698 ± 0.043	2.226IleSer: 2.226 ± 0.042	2.745IleThr: 2.745 ± 0.039	3.38IleVal: 3.38 ± 0.052	0.483IleTrp: 0.483 ± 0.019	0.797IleTyr: 0.797 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.674LysAla: 2.674 ± 0.052	0.122LysCys: 0.122 ± 0.008	1.11LysAsp: 1.11 ± 0.03	0.951LysGlu: 0.951 ± 0.03	0.613LysPhe: 0.613 ± 0.02	1.482LysGly: 1.482 ± 0.035	0.529LysHis: 0.529 ± 0.021	1.036LysIle: 1.036 ± 0.027	0.638LysLys: 0.638 ± 0.025	2.192LysLeu: 2.192 ± 0.04	0.485LysMet: 0.485 ± 0.022	0.519LysAsn: 0.519 ± 0.018	1.515LysPro: 1.515 ± 0.027	0.724LysGln: 0.724 ± 0.026	1.621LysArg: 1.621 ± 0.033	1.229LysSer: 1.229 ± 0.029	1.342LysThr: 1.342 ± 0.031	1.903LysVal: 1.903 ± 0.037	0.31LysTrp: 0.31 ± 0.013	0.475LysTyr: 0.475 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	13.916LeuAla: 13.916 ± 0.109	0.828LeuCys: 0.828 ± 0.025	6.521LeuAsp: 6.521 ± 0.067	4.079LeuGlu: 4.079 ± 0.059	2.589LeuPhe: 2.589 ± 0.051	8.493LeuGly: 8.493 ± 0.085	2.145LeuHis: 2.145 ± 0.037	3.923LeuIle: 3.923 ± 0.057	1.78LeuLys: 1.78 ± 0.038	9.324LeuLeu: 9.324 ± 0.107	1.702LeuMet: 1.702 ± 0.035	2.093LeuAsn: 2.093 ± 0.038	5.83LeuPro: 5.83 ± 0.069	2.604LeuGln: 2.604 ± 0.044	7.953LeuArg: 7.953 ± 0.07	5.515LeuSer: 5.515 ± 0.062	5.915LeuThr: 5.915 ± 0.068	7.847LeuVal: 7.847 ± 0.079	1.201LeuTrp: 1.201 ± 0.033	1.661LeuTyr: 1.661 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.65MetAla: 2.65 ± 0.043	0.204MetCys: 0.204 ± 0.011	0.926MetAsp: 0.926 ± 0.024	0.697MetGlu: 0.697 ± 0.022	0.648MetPhe: 0.648 ± 0.019	1.472MetGly: 1.472 ± 0.031	0.477MetHis: 0.477 ± 0.018	0.947MetIle: 0.947 ± 0.025	0.449MetLys: 0.449 ± 0.018	2.23MetLeu: 2.23 ± 0.034	0.441MetMet: 0.441 ± 0.018	0.504MetAsn: 0.504 ± 0.02	1.281MetPro: 1.281 ± 0.029	0.543MetGln: 0.543 ± 0.019	1.662MetArg: 1.662 ± 0.033	1.372MetSer: 1.372 ± 0.025	1.73MetThr: 1.73 ± 0.033	1.66MetVal: 1.66 ± 0.032	0.286MetTrp: 0.286 ± 0.012	0.372MetTyr: 0.372 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.69AsnAla: 2.69 ± 0.043	0.192AsnCys: 0.192 ± 0.011	1.193AsnAsp: 1.193 ± 0.029	0.98AsnGlu: 0.98 ± 0.026	0.689AsnPhe: 0.689 ± 0.02	2.028AsnGly: 2.028 ± 0.04	0.473AsnHis: 0.473 ± 0.018	0.931AsnIle: 0.931 ± 0.023	0.495AsnLys: 0.495 ± 0.02	2.057AsnLeu: 2.057 ± 0.036	0.424AsnMet: 0.424 ± 0.015	0.575AsnAsn: 0.575 ± 0.022	1.778AsnPro: 1.778 ± 0.038	0.702AsnGln: 0.702 ± 0.022	1.661AsnArg: 1.661 ± 0.036	1.173AsnSer: 1.173 ± 0.025	1.277AsnThr: 1.277 ± 0.029	1.706AsnVal: 1.706 ± 0.037	0.418AsnTrp: 0.418 ± 0.016	0.573AsnTyr: 0.573 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	8.32ProAla: 8.32 ± 0.105	0.433ProCys: 0.433 ± 0.017	4.371ProAsp: 4.371 ± 0.056	3.498ProGlu: 3.498 ± 0.048	1.623ProPhe: 1.623 ± 0.031	6.263ProGly: 6.263 ± 0.07	1.316ProHis: 1.316 ± 0.025	2.189ProIle: 2.189 ± 0.038	1.356ProLys: 1.356 ± 0.032	4.92ProLeu: 4.92 ± 0.054	1.219ProMet: 1.219 ± 0.028	1.367ProAsn: 1.367 ± 0.031	4.401ProPro: 4.401 ± 0.087	1.932ProGln: 1.932 ± 0.036	4.482ProArg: 4.482 ± 0.066	3.435ProSer: 3.435 ± 0.051	3.682ProThr: 3.682 ± 0.056	4.955ProVal: 4.955 ± 0.058	0.913ProTrp: 0.913 ± 0.026	1.221ProTyr: 1.221 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.75GlnAla: 3.75 ± 0.057	0.238GlnCys: 0.238 ± 0.012	1.199GlnAsp: 1.199 ± 0.029	1.055GlnGlu: 1.055 ± 0.031	0.965GlnPhe: 0.965 ± 0.028	1.978GlnGly: 1.978 ± 0.037	0.861GlnHis: 0.861 ± 0.027	1.404GlnIle: 1.404 ± 0.033	0.617GlnLys: 0.617 ± 0.019	3.773GlnLeu: 3.773 ± 0.047	0.678GlnMet: 0.678 ± 0.021	0.638GlnAsn: 0.638 ± 0.021	2.026GlnPro: 2.026 ± 0.042	1.378GlnGln: 1.378 ± 0.035	3.132GlnArg: 3.132 ± 0.049	1.475GlnSer: 1.475 ± 0.028	1.585GlnThr: 1.585 ± 0.033	2.502GlnVal: 2.502 ± 0.046	0.534GlnTrp: 0.534 ± 0.019	0.639GlnTyr: 0.639 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.297ArgAla: 9.297 ± 0.103	1.152ArgCys: 1.152 ± 0.035	4.44ArgAsp: 4.44 ± 0.058	3.817ArgGlu: 3.817 ± 0.047	2.449ArgPhe: 2.449 ± 0.039	5.819ArgGly: 5.819 ± 0.064	2.025ArgHis: 2.025 ± 0.042	3.519ArgIle: 3.519 ± 0.052	1.595ArgLys: 1.595 ± 0.037	7.872ArgLeu: 7.872 ± 0.078	2.073ArgMet: 2.073 ± 0.036	1.763ArgAsn: 1.763 ± 0.035	5.176ArgPro: 5.176 ± 0.072	2.429ArgGln: 2.429 ± 0.039	8.696ArgArg: 8.696 ± 0.11	4.604ArgSer: 4.604 ± 0.06	4.368ArgThr: 4.368 ± 0.052	5.704ArgVal: 5.704 ± 0.068	1.761ArgTrp: 1.761 ± 0.039	1.994ArgTyr: 1.994 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	7.131SerAla: 7.131 ± 0.071	0.556SerCys: 0.556 ± 0.02	2.984SerAsp: 2.984 ± 0.045	2.363SerGlu: 2.363 ± 0.047	1.605SerPhe: 1.605 ± 0.034	5.581SerGly: 5.581 ± 0.064	1.023SerHis: 1.023 ± 0.023	2.04SerIle: 2.04 ± 0.035	1.119SerLys: 1.119 ± 0.025	4.536SerLeu: 4.536 ± 0.055	1.294SerMet: 1.294 ± 0.028	1.14SerAsn: 1.14 ± 0.029	3.608SerPro: 3.608 ± 0.046	1.403SerGln: 1.403 ± 0.034	4.235SerArg: 4.235 ± 0.053	3.335SerSer: 3.335 ± 0.046	3.579SerThr: 3.579 ± 0.051	4.195SerVal: 4.195 ± 0.057	1.043SerTrp: 1.043 ± 0.025	1.222SerTyr: 1.222 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	7.821ThrAla: 7.821 ± 0.07	0.543ThrCys: 0.543 ± 0.019	3.416ThrAsp: 3.416 ± 0.046	2.994ThrGlu: 2.994 ± 0.045	1.666ThrPhe: 1.666 ± 0.037	5.712ThrGly: 5.712 ± 0.068	1.127ThrHis: 1.127 ± 0.027	2.297ThrIle: 2.297 ± 0.045	1.235ThrLys: 1.235 ± 0.028	5.278ThrLeu: 5.278 ± 0.066	1.26ThrMet: 1.26 ± 0.03	1.229ThrAsn: 1.229 ± 0.03	4.045ThrPro: 4.045 ± 0.062	1.46ThrGln: 1.46 ± 0.032	4.068ThrArg: 4.068 ± 0.059	3.207ThrSer: 3.207 ± 0.056	3.75ThrThr: 3.75 ± 0.057	5.388ThrVal: 5.388 ± 0.064	0.903ThrTrp: 0.903 ± 0.025	1.189ThrTyr: 1.189 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	10.932ValAla: 10.932 ± 0.102	0.788ValCys: 0.788 ± 0.023	5.373ValAsp: 5.373 ± 0.06	4.261ValGlu: 4.261 ± 0.052	2.531ValPhe: 2.531 ± 0.041	6.671ValGly: 6.671 ± 0.07	1.833ValHis: 1.833 ± 0.036	3.753ValIle: 3.753 ± 0.052	1.666ValLys: 1.666 ± 0.044	8.45ValLeu: 8.45 ± 0.088	1.539ValMet: 1.539 ± 0.031	2.063ValAsn: 2.063 ± 0.037	4.552ValPro: 4.552 ± 0.056	2.173ValGln: 2.173 ± 0.039	5.95ValArg: 5.95 ± 0.063	4.44ValSer: 4.44 ± 0.052	5.081ValThr: 5.081 ± 0.06	7.867ValVal: 7.867 ± 0.074	0.975ValTrp: 0.975 ± 0.024	1.486ValTyr: 1.486 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.713TrpAla: 1.713 ± 0.034	0.279TrpCys: 0.279 ± 0.015	0.79TrpAsp: 0.79 ± 0.023	0.672TrpGlu: 0.672 ± 0.02	0.493TrpPhe: 0.493 ± 0.018	1.026TrpGly: 1.026 ± 0.026	0.373TrpHis: 0.373 ± 0.016	0.599TrpIle: 0.599 ± 0.019	0.342TrpLys: 0.342 ± 0.017	1.723TrpLeu: 1.723 ± 0.035	0.384TrpMet: 0.384 ± 0.014	0.405TrpAsn: 0.405 ± 0.014	1.127TrpPro: 1.127 ± 0.029	0.648TrpGln: 0.648 ± 0.022	1.528TrpArg: 1.528 ± 0.04	1.082TrpSer: 1.082 ± 0.024	0.994TrpThr: 0.994 ± 0.025	1.108TrpVal: 1.108 ± 0.029	0.407TrpTrp: 0.407 ± 0.019	0.329TrpTyr: 0.329 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.461TyrAla: 2.461 ± 0.039	0.24TyrCys: 0.24 ± 0.011	1.342TyrAsp: 1.342 ± 0.031	1.004TyrGlu: 1.004 ± 0.023	0.772TyrPhe: 0.772 ± 0.02	2.027TyrGly: 2.027 ± 0.046	0.518TyrHis: 0.518 ± 0.018	0.675TyrIle: 0.675 ± 0.021	0.352TyrLys: 0.352 ± 0.016	2.387TyrLeu: 2.387 ± 0.042	0.275TyrMet: 0.275 ± 0.013	0.467TyrAsn: 0.467 ± 0.019	1.263TyrPro: 1.263 ± 0.038	0.763TyrGln: 0.763 ± 0.021	1.948TyrArg: 1.948 ± 0.033	1.069TyrSer: 1.069 ± 0.025	1.132TyrThr: 1.132 ± 0.025	1.576TyrVal: 1.576 ± 0.031	0.359TyrTrp: 0.359 ± 0.016	0.511TyrTyr: 0.511 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6021 proteins (1547435 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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