Amino acid dipepetide frequency for Tranquillimonas sp. M0103

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.072AlaAla: 20.072 ± 0.213	1.13AlaCys: 1.13 ± 0.036	7.686AlaAsp: 7.686 ± 0.11	8.551AlaGlu: 8.551 ± 0.102	4.207AlaPhe: 4.207 ± 0.066	12.404AlaGly: 12.404 ± 0.122	2.325AlaHis: 2.325 ± 0.058	5.688AlaIle: 5.688 ± 0.087	2.743AlaLys: 2.743 ± 0.067	14.385AlaLeu: 14.385 ± 0.141	3.826AlaMet: 3.826 ± 0.061	2.336AlaAsn: 2.336 ± 0.051	7.427AlaPro: 7.427 ± 0.109	4.696AlaGln: 4.696 ± 0.077	10.739AlaArg: 10.739 ± 0.121	5.355AlaSer: 5.355 ± 0.073	6.762AlaThr: 6.762 ± 0.081	8.85AlaVal: 8.85 ± 0.086	1.659AlaTrp: 1.659 ± 0.044	2.45AlaTyr: 2.45 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.029CysAla: 1.029 ± 0.03	0.113CysCys: 0.113 ± 0.01	0.596CysAsp: 0.596 ± 0.025	0.381CysGlu: 0.381 ± 0.016	0.297CysPhe: 0.297 ± 0.018	0.966CysGly: 0.966 ± 0.029	0.25CysHis: 0.25 ± 0.014	0.341CysIle: 0.341 ± 0.019	0.129CysLys: 0.129 ± 0.012	0.89CysLeu: 0.89 ± 0.028	0.141CysMet: 0.141 ± 0.013	0.165CysAsn: 0.165 ± 0.011	0.484CysPro: 0.484 ± 0.023	0.197CysGln: 0.197 ± 0.012	0.621CysArg: 0.621 ± 0.025	0.381CysSer: 0.381 ± 0.02	0.378CysThr: 0.378 ± 0.02	0.604CysVal: 0.604 ± 0.024	0.12CysTrp: 0.12 ± 0.01	0.162CysTyr: 0.162 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.303AspAla: 8.303 ± 0.11	0.502AspCys: 0.502 ± 0.025	3.79AspAsp: 3.79 ± 0.076	3.787AspGlu: 3.787 ± 0.07	2.165AspPhe: 2.165 ± 0.043	5.93AspGly: 5.93 ± 0.094	1.408AspHis: 1.408 ± 0.039	2.97AspIle: 2.97 ± 0.051	1.281AspLys: 1.281 ± 0.04	6.949AspLeu: 6.949 ± 0.103	1.665AspMet: 1.665 ± 0.045	1.039AspAsn: 1.039 ± 0.034	4.417AspPro: 4.417 ± 0.061	1.637AspGln: 1.637 ± 0.04	5.633AspArg: 5.633 ± 0.086	2.238AspSer: 2.238 ± 0.052	3.467AspThr: 3.467 ± 0.071	4.027AspVal: 4.027 ± 0.058	1.336AspTrp: 1.336 ± 0.037	1.534AspTyr: 1.534 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.471GluAla: 8.471 ± 0.119	0.298GluCys: 0.298 ± 0.017	3.545GluAsp: 3.545 ± 0.065	3.548GluGlu: 3.548 ± 0.071	1.571GluPhe: 1.571 ± 0.039	5.308GluGly: 5.308 ± 0.076	0.961GluHis: 0.961 ± 0.028	3.549GluIle: 3.549 ± 0.053	1.644GluLys: 1.644 ± 0.045	4.98GluLeu: 4.98 ± 0.072	1.753GluMet: 1.753 ± 0.05	1.354GluAsn: 1.354 ± 0.041	2.6GluPro: 2.6 ± 0.05	1.627GluGln: 1.627 ± 0.042	4.365GluArg: 4.365 ± 0.07	2.109GluSer: 2.109 ± 0.047	4.107GluThr: 4.107 ± 0.066	4.486GluVal: 4.486 ± 0.066	0.623GluTrp: 0.623 ± 0.026	0.86GluTyr: 0.86 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.501PheAla: 4.501 ± 0.067	0.381PheCys: 0.381 ± 0.018	2.884PheAsp: 2.884 ± 0.044	2.055PheGlu: 2.055 ± 0.042	1.276PhePhe: 1.276 ± 0.042	3.504PheGly: 3.504 ± 0.066	0.701PheHis: 0.701 ± 0.029	1.304PheIle: 1.304 ± 0.038	0.593PheLys: 0.593 ± 0.022	3.303PheLeu: 3.303 ± 0.065	0.674PheMet: 0.674 ± 0.022	0.817PheAsn: 0.817 ± 0.027	1.581PhePro: 1.581 ± 0.034	0.856PheGln: 0.856 ± 0.03	2.278PheArg: 2.278 ± 0.047	1.895PheSer: 1.895 ± 0.04	1.815PheThr: 1.815 ± 0.043	2.709PheVal: 2.709 ± 0.044	0.559PheTrp: 0.559 ± 0.027	0.833PheTyr: 0.833 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	11.539GlyAla: 11.539 ± 0.11	0.823GlyCys: 0.823 ± 0.027	5.275GlyAsp: 5.275 ± 0.078	4.807GlyGlu: 4.807 ± 0.068	3.521GlyPhe: 3.521 ± 0.06	8.365GlyGly: 8.365 ± 0.11	1.965GlyHis: 1.965 ± 0.046	4.333GlyIle: 4.333 ± 0.075	2.339GlyLys: 2.339 ± 0.055	9.657GlyLeu: 9.657 ± 0.111	2.582GlyMet: 2.582 ± 0.05	1.871GlyAsn: 1.871 ± 0.059	4.658GlyPro: 4.658 ± 0.07	3.144GlyGln: 3.144 ± 0.054	7.376GlyArg: 7.376 ± 0.092	4.206GlySer: 4.206 ± 0.069	5.128GlyThr: 5.128 ± 0.073	6.559GlyVal: 6.559 ± 0.08	1.541GlyTrp: 1.541 ± 0.036	2.25GlyTyr: 2.25 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.502HisAla: 2.502 ± 0.051	0.232HisCys: 0.232 ± 0.015	1.423HisAsp: 1.423 ± 0.044	1.005HisGlu: 1.005 ± 0.028	0.729HisPhe: 0.729 ± 0.025	2.046HisGly: 2.046 ± 0.052	0.567HisHis: 0.567 ± 0.029	0.813HisIle: 0.813 ± 0.027	0.375HisLys: 0.375 ± 0.018	2.03HisLeu: 2.03 ± 0.048	0.482HisMet: 0.482 ± 0.023	0.341HisAsn: 0.341 ± 0.017	1.455HisPro: 1.455 ± 0.042	0.505HisGln: 0.505 ± 0.022	1.504HisArg: 1.504 ± 0.034	0.778HisSer: 0.778 ± 0.028	0.763HisThr: 0.763 ± 0.025	1.534HisVal: 1.534 ± 0.036	0.354HisTrp: 0.354 ± 0.018	0.525HisTyr: 0.525 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.944IleAla: 6.944 ± 0.088	0.52IleCys: 0.52 ± 0.02	3.574IleAsp: 3.574 ± 0.059	3.348IleGlu: 3.348 ± 0.061	1.611IlePhe: 1.611 ± 0.043	4.434IleGly: 4.434 ± 0.077	0.807IleHis: 0.807 ± 0.029	1.714IleIle: 1.714 ± 0.043	0.947IleLys: 0.947 ± 0.034	4.707IleLeu: 4.707 ± 0.079	0.867IleMet: 0.867 ± 0.036	1.001IleAsn: 1.001 ± 0.036	2.2IlePro: 2.2 ± 0.04	0.972IleGln: 0.972 ± 0.031	3.183IleArg: 3.183 ± 0.058	2.491IleSer: 2.491 ± 0.05	2.393IleThr: 2.393 ± 0.047	3.587IleVal: 3.587 ± 0.063	0.639IleTrp: 0.639 ± 0.024	1.069IleTyr: 1.069 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	2.818LysAla: 2.818 ± 0.061	0.114LysCys: 0.114 ± 0.01	1.219LysAsp: 1.219 ± 0.037	1.159LysGlu: 1.159 ± 0.035	0.689LysPhe: 0.689 ± 0.026	1.969LysGly: 1.969 ± 0.044	0.405LysHis: 0.405 ± 0.021	1.247LysIle: 1.247 ± 0.037	0.821LysLys: 0.821 ± 0.032	2.288LysLeu: 2.288 ± 0.059	0.616LysMet: 0.616 ± 0.024	0.509LysAsn: 0.509 ± 0.024	1.266LysPro: 1.266 ± 0.035	0.643LysGln: 0.643 ± 0.027	1.737LysArg: 1.737 ± 0.045	1.411LysSer: 1.411 ± 0.041	1.437LysThr: 1.437 ± 0.041	1.817LysVal: 1.817 ± 0.043	0.28LysTrp: 0.28 ± 0.018	0.458LysTyr: 0.458 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.895LeuAla: 13.895 ± 0.135	0.955LeuCys: 0.955 ± 0.03	6.563LeuAsp: 6.563 ± 0.088	4.844LeuGlu: 4.844 ± 0.065	3.402LeuPhe: 3.402 ± 0.068	9.169LeuGly: 9.169 ± 0.101	1.884LeuHis: 1.884 ± 0.043	4.817LeuIle: 4.817 ± 0.074	2.405LeuLys: 2.405 ± 0.05	8.948LeuLeu: 8.948 ± 0.129	2.521LeuMet: 2.521 ± 0.051	2.226LeuAsn: 2.226 ± 0.047	5.985LeuPro: 5.985 ± 0.08	2.504LeuGln: 2.504 ± 0.045	7.868LeuArg: 7.868 ± 0.103	6.738LeuSer: 6.738 ± 0.088	6.21LeuThr: 6.21 ± 0.086	6.897LeuVal: 6.897 ± 0.087	1.381LeuTrp: 1.381 ± 0.041	1.937LeuTyr: 1.937 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.342MetAla: 3.342 ± 0.064	0.158MetCys: 0.158 ± 0.01	1.314MetAsp: 1.314 ± 0.04	1.228MetGlu: 1.228 ± 0.035	0.713MetPhe: 0.713 ± 0.028	2.097MetGly: 2.097 ± 0.047	0.48MetHis: 0.48 ± 0.024	1.375MetIle: 1.375 ± 0.035	0.811MetLys: 0.811 ± 0.03	2.434MetLeu: 2.434 ± 0.05	0.632MetMet: 0.632 ± 0.02	0.663MetAsn: 0.663 ± 0.023	1.559MetPro: 1.559 ± 0.038	0.967MetGln: 0.967 ± 0.03	1.908MetArg: 1.908 ± 0.041	1.739MetSer: 1.739 ± 0.041	2.105MetThr: 2.105 ± 0.041	1.803MetVal: 1.803 ± 0.042	0.213MetTrp: 0.213 ± 0.014	0.294MetTyr: 0.294 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.716AsnAla: 2.716 ± 0.056	0.175AsnCys: 0.175 ± 0.012	1.251AsnAsp: 1.251 ± 0.043	0.976AsnGlu: 0.976 ± 0.032	0.806AsnPhe: 0.806 ± 0.027	1.828AsnGly: 1.828 ± 0.047	0.421AsnHis: 0.421 ± 0.021	1.013AsnIle: 1.013 ± 0.035	0.423AsnLys: 0.423 ± 0.021	2.197AsnLeu: 2.197 ± 0.043	0.537AsnMet: 0.537 ± 0.021	0.466AsnAsn: 0.466 ± 0.024	1.525AsnPro: 1.525 ± 0.035	0.553AsnGln: 0.553 ± 0.021	1.532AsnArg: 1.532 ± 0.04	0.902AsnSer: 0.902 ± 0.03	1.041AsnThr: 1.041 ± 0.036	1.537AsnVal: 1.537 ± 0.037	0.337AsnTrp: 0.337 ± 0.016	0.529AsnTyr: 0.529 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.352ProAla: 7.352 ± 0.103	0.343ProCys: 0.343 ± 0.018	4.553ProAsp: 4.553 ± 0.08	4.526ProGlu: 4.526 ± 0.069	1.869ProPhe: 1.869 ± 0.039	5.768ProGly: 5.768 ± 0.081	1.154ProHis: 1.154 ± 0.036	2.013ProIle: 2.013 ± 0.043	1.285ProLys: 1.285 ± 0.041	5.036ProLeu: 5.036 ± 0.082	1.336ProMet: 1.336 ± 0.034	1.044ProAsn: 1.044 ± 0.026	2.815ProPro: 2.815 ± 0.068	1.871ProGln: 1.871 ± 0.044	3.735ProArg: 3.735 ± 0.075	2.458ProSer: 2.458 ± 0.052	2.507ProThr: 2.507 ± 0.053	4.536ProVal: 4.536 ± 0.067	0.722ProTrp: 0.722 ± 0.026	1.099ProTyr: 1.099 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.126GlnAla: 4.126 ± 0.066	0.181GlnCys: 0.181 ± 0.013	1.728GlnAsp: 1.728 ± 0.042	1.483GlnGlu: 1.483 ± 0.036	0.908GlnPhe: 0.908 ± 0.029	2.727GlnGly: 2.727 ± 0.053	0.515GlnHis: 0.515 ± 0.02	1.784GlnIle: 1.784 ± 0.045	0.815GlnLys: 0.815 ± 0.028	2.524GlnLeu: 2.524 ± 0.048	0.914GlnMet: 0.914 ± 0.032	0.728GlnAsn: 0.728 ± 0.028	1.662GlnPro: 1.662 ± 0.041	0.952GlnGln: 0.952 ± 0.029	2.201GlnArg: 2.201 ± 0.046	1.706GlnSer: 1.706 ± 0.04	1.696GlnThr: 1.696 ± 0.04	2.281GlnVal: 2.281 ± 0.042	0.358GlnTrp: 0.358 ± 0.02	0.473GlnTyr: 0.473 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.72ArgAla: 9.72 ± 0.113	0.52ArgCys: 0.52 ± 0.026	5.36ArgAsp: 5.36 ± 0.085	3.882ArgGlu: 3.882 ± 0.064	2.768ArgPhe: 2.768 ± 0.058	5.837ArgGly: 5.837 ± 0.075	1.841ArgHis: 1.841 ± 0.041	4.154ArgIle: 4.154 ± 0.059	1.804ArgLys: 1.804 ± 0.052	8.509ArgLeu: 8.509 ± 0.117	2.095ArgMet: 2.095 ± 0.045	1.633ArgAsn: 1.633 ± 0.039	4.255ArgPro: 4.255 ± 0.074	2.457ArgGln: 2.457 ± 0.048	6.555ArgArg: 6.555 ± 0.1	3.441ArgSer: 3.441 ± 0.056	3.47ArgThr: 3.47 ± 0.055	5.31ArgVal: 5.31 ± 0.073	0.998ArgTrp: 0.998 ± 0.035	1.564ArgTyr: 1.564 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.601SerAla: 5.601 ± 0.077	0.389SerCys: 0.389 ± 0.021	3.46SerAsp: 3.46 ± 0.062	2.795SerGlu: 2.795 ± 0.056	2.056SerPhe: 2.056 ± 0.045	5.318SerGly: 5.318 ± 0.063	1.002SerHis: 1.002 ± 0.029	2.124SerIle: 2.124 ± 0.046	1.12SerLys: 1.12 ± 0.037	4.802SerLeu: 4.802 ± 0.073	1.214SerMet: 1.214 ± 0.033	1.082SerAsn: 1.082 ± 0.034	2.611SerPro: 2.611 ± 0.045	1.49SerGln: 1.49 ± 0.036	3.424SerArg: 3.424 ± 0.071	2.388SerSer: 2.388 ± 0.058	2.397SerThr: 2.397 ± 0.043	3.569SerVal: 3.569 ± 0.06	0.627SerTrp: 0.627 ± 0.023	1.24SerTyr: 1.24 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.899ThrAla: 6.899 ± 0.088	0.464ThrCys: 0.464 ± 0.022	3.427ThrAsp: 3.427 ± 0.066	3.074ThrGlu: 3.074 ± 0.056	1.841ThrPhe: 1.841 ± 0.042	5.822ThrGly: 5.822 ± 0.075	1.129ThrHis: 1.129 ± 0.034	2.402ThrIle: 2.402 ± 0.052	1.049ThrLys: 1.049 ± 0.03	6.327ThrLeu: 6.327 ± 0.082	1.237ThrMet: 1.237 ± 0.033	1.012ThrAsn: 1.012 ± 0.033	3.792ThrPro: 3.792 ± 0.055	1.543ThrGln: 1.543 ± 0.033	3.926ThrArg: 3.926 ± 0.059	2.596ThrSer: 2.596 ± 0.054	2.827ThrThr: 2.827 ± 0.053	4.06ThrVal: 4.06 ± 0.063	0.714ThrTrp: 0.714 ± 0.026	1.118ThrTyr: 1.118 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.566ValAla: 9.566 ± 0.103	0.597ValCys: 0.597 ± 0.023	3.981ValAsp: 3.981 ± 0.061	4.473ValGlu: 4.473 ± 0.072	2.784ValPhe: 2.784 ± 0.051	5.467ValGly: 5.467 ± 0.07	1.3ValHis: 1.3 ± 0.032	3.849ValIle: 3.849 ± 0.062	1.591ValLys: 1.591 ± 0.041	7.358ValLeu: 7.358 ± 0.103	1.959ValMet: 1.959 ± 0.045	1.637ValAsn: 1.637 ± 0.041	3.928ValPro: 3.928 ± 0.062	1.918ValGln: 1.918 ± 0.037	4.718ValArg: 4.718 ± 0.066	4.035ValSer: 4.035 ± 0.06	4.885ValThr: 4.885 ± 0.072	5.557ValVal: 5.557 ± 0.093	0.952ValTrp: 0.952 ± 0.03	1.466ValTyr: 1.466 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.391TrpAla: 1.391 ± 0.038	0.141TrpCys: 0.141 ± 0.011	0.805TrpAsp: 0.805 ± 0.029	0.647TrpGlu: 0.647 ± 0.025	0.519TrpPhe: 0.519 ± 0.02	1.004TrpGly: 1.004 ± 0.032	0.388TrpHis: 0.388 ± 0.02	0.712TrpIle: 0.712 ± 0.029	0.34TrpLys: 0.34 ± 0.017	1.69TrpLeu: 1.69 ± 0.046	0.38TrpMet: 0.38 ± 0.018	0.347TrpAsn: 0.347 ± 0.021	0.735TrpPro: 0.735 ± 0.026	0.605TrpGln: 0.605 ± 0.023	1.28TrpArg: 1.28 ± 0.037	0.824TrpSer: 0.824 ± 0.031	0.818TrpThr: 0.818 ± 0.027	0.861TrpVal: 0.861 ± 0.028	0.229TrpTrp: 0.229 ± 0.013	0.25TrpTyr: 0.25 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.508TyrAla: 2.508 ± 0.042	0.209TyrCys: 0.209 ± 0.012	1.645TyrAsp: 1.645 ± 0.04	1.19TyrGlu: 1.19 ± 0.039	0.787TyrPhe: 0.787 ± 0.026	1.975TyrGly: 1.975 ± 0.04	0.462TyrHis: 0.462 ± 0.02	0.807TyrIle: 0.807 ± 0.028	0.389TyrLys: 0.389 ± 0.019	2.135TyrLeu: 2.135 ± 0.048	0.403TyrMet: 0.403 ± 0.02	0.495TyrAsn: 0.495 ± 0.023	1.069TyrPro: 1.069 ± 0.031	0.625TyrGln: 0.625 ± 0.024	1.587TyrArg: 1.587 ± 0.037	1.016TyrSer: 1.016 ± 0.032	1.054TyrThr: 1.054 ± 0.033	1.434TyrVal: 1.434 ± 0.039	0.321TyrTrp: 0.321 ± 0.016	0.522TyrTyr: 0.522 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3564 proteins (1129772 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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