Amino acid dipepetide frequency for Photobacterium ganghwense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.356AlaAla: 9.356 ± 0.114
1.084AlaCys: 1.084 ± 0.029
5.168AlaAsp: 5.168 ± 0.059
6.226AlaGlu: 6.226 ± 0.078
3.597AlaPhe: 3.597 ± 0.058
6.966AlaGly: 6.966 ± 0.074
1.742AlaHis: 1.742 ± 0.039
6.012AlaIle: 6.012 ± 0.066
4.499AlaLys: 4.499 ± 0.065
10.628AlaLeu: 10.628 ± 0.101
3.245AlaMet: 3.245 ± 0.046
3.411AlaAsn: 3.411 ± 0.051
3.205AlaPro: 3.205 ± 0.051
3.977AlaGln: 3.977 ± 0.053
4.506AlaArg: 4.506 ± 0.067
5.675AlaSer: 5.675 ± 0.066
4.856AlaThr: 4.856 ± 0.059
6.751AlaVal: 6.751 ± 0.073
1.028AlaTrp: 1.028 ± 0.028
2.488AlaTyr: 2.488 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.86CysAla: 0.86 ± 0.028
0.173CysCys: 0.173 ± 0.011
0.644CysAsp: 0.644 ± 0.022
0.642CysGlu: 0.642 ± 0.021
0.477CysPhe: 0.477 ± 0.019
0.98CysGly: 0.98 ± 0.028
0.416CysHis: 0.416 ± 0.019
0.559CysIle: 0.559 ± 0.018
0.406CysLys: 0.406 ± 0.019
1.103CysLeu: 1.103 ± 0.029
0.268CysMet: 0.268 ± 0.013
0.339CysAsn: 0.339 ± 0.015
0.468CysPro: 0.468 ± 0.02
0.582CysGln: 0.582 ± 0.02
0.636CysArg: 0.636 ± 0.023
0.714CysSer: 0.714 ± 0.022
0.504CysThr: 0.504 ± 0.021
0.705CysVal: 0.705 ± 0.021
0.158CysTrp: 0.158 ± 0.011
0.361CysTyr: 0.361 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.856AspAla: 4.856 ± 0.059
0.57AspCys: 0.57 ± 0.021
3.027AspAsp: 3.027 ± 0.051
3.697AspGlu: 3.697 ± 0.059
2.251AspPhe: 2.251 ± 0.042
3.853AspGly: 3.853 ± 0.058
1.24AspHis: 1.24 ± 0.028
3.769AspIle: 3.769 ± 0.047
2.88AspLys: 2.88 ± 0.05
5.025AspLeu: 5.025 ± 0.067
1.47AspMet: 1.47 ± 0.029
2.357AspAsn: 2.357 ± 0.046
2.232AspPro: 2.232 ± 0.044
1.99AspGln: 1.99 ± 0.037
2.468AspArg: 2.468 ± 0.045
3.17AspSer: 3.17 ± 0.049
2.825AspThr: 2.825 ± 0.041
3.897AspVal: 3.897 ± 0.054
0.856AspTrp: 0.856 ± 0.024
1.941AspTyr: 1.941 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
5.753GluAla: 5.753 ± 0.078
0.55GluCys: 0.55 ± 0.024
2.71GluAsp: 2.71 ± 0.042
3.552GluGlu: 3.552 ± 0.06
2.183GluPhe: 2.183 ± 0.04
3.613GluGly: 3.613 ± 0.05
1.626GluHis: 1.626 ± 0.035
3.347GluIle: 3.347 ± 0.049
3.427GluLys: 3.427 ± 0.057
6.749GluLeu: 6.749 ± 0.084
1.778GluMet: 1.778 ± 0.04
2.388GluAsn: 2.388 ± 0.043
2.298GluPro: 2.298 ± 0.043
4.037GluGln: 4.037 ± 0.055
3.615GluArg: 3.615 ± 0.06
3.373GluSer: 3.373 ± 0.052
3.144GluThr: 3.144 ± 0.048
4.127GluVal: 4.127 ± 0.059
0.833GluTrp: 0.833 ± 0.024
1.691GluTyr: 1.691 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.674PheAla: 3.674 ± 0.055
0.522PheCys: 0.522 ± 0.023
2.661PheAsp: 2.661 ± 0.041
2.329PheGlu: 2.329 ± 0.042
1.613PhePhe: 1.613 ± 0.039
3.108PheGly: 3.108 ± 0.053
0.835PheHis: 0.835 ± 0.024
2.458PheIle: 2.458 ± 0.041
1.589PheLys: 1.589 ± 0.036
3.377PheLeu: 3.377 ± 0.061
0.989PheMet: 0.989 ± 0.025
1.792PheAsn: 1.792 ± 0.038
1.485PhePro: 1.485 ± 0.035
1.202PheGln: 1.202 ± 0.025
1.77PheArg: 1.77 ± 0.033
3.094PheSer: 3.094 ± 0.056
2.41PheThr: 2.41 ± 0.042
2.726PheVal: 2.726 ± 0.052
0.544PheTrp: 0.544 ± 0.018
1.28PheTyr: 1.28 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
5.598GlyAla: 5.598 ± 0.067
1.01GlyCys: 1.01 ± 0.03
3.634GlyAsp: 3.634 ± 0.053
4.453GlyGlu: 4.453 ± 0.056
3.248GlyPhe: 3.248 ± 0.042
5.022GlyGly: 5.022 ± 0.091
1.724GlyHis: 1.724 ± 0.037
4.851GlyIle: 4.851 ± 0.059
3.84GlyLys: 3.84 ± 0.055
7.383GlyLeu: 7.383 ± 0.071
2.413GlyMet: 2.413 ± 0.04
2.635GlyAsn: 2.635 ± 0.047
1.78GlyPro: 1.78 ± 0.041
3.118GlyGln: 3.118 ± 0.051
3.396GlyArg: 3.396 ± 0.044
4.081GlySer: 4.081 ± 0.057
3.532GlyThr: 3.532 ± 0.052
5.259GlyVal: 5.259 ± 0.058
1.109GlyTrp: 1.109 ± 0.029
2.738GlyTyr: 2.738 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
1.836HisAla: 1.836 ± 0.036
0.37HisCys: 0.37 ± 0.017
1.196HisAsp: 1.196 ± 0.029
1.203HisGlu: 1.203 ± 0.029
1.12HisPhe: 1.12 ± 0.032
1.694HisGly: 1.694 ± 0.037
0.814HisHis: 0.814 ± 0.027
1.397HisIle: 1.397 ± 0.031
0.911HisLys: 0.911 ± 0.024
2.355HisLeu: 2.355 ± 0.045
0.525HisMet: 0.525 ± 0.018
0.839HisAsn: 0.839 ± 0.025
1.414HisPro: 1.414 ± 0.031
1.321HisGln: 1.321 ± 0.031
1.259HisArg: 1.259 ± 0.035
1.425HisSer: 1.425 ± 0.036
1.208HisThr: 1.208 ± 0.029
1.306HisVal: 1.306 ± 0.032
0.402HisTrp: 0.402 ± 0.019
0.911HisTyr: 0.911 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.266IleAla: 6.266 ± 0.071
0.677IleCys: 0.677 ± 0.022
3.733IleAsp: 3.733 ± 0.054
3.981IleGlu: 3.981 ± 0.062
2.021IlePhe: 2.021 ± 0.04
4.507IleGly: 4.507 ± 0.058
1.255IleHis: 1.255 ± 0.032
3.162IleIle: 3.162 ± 0.058
2.547IleLys: 2.547 ± 0.048
5.058IleLeu: 5.058 ± 0.072
1.328IleMet: 1.328 ± 0.033
2.528IleAsn: 2.528 ± 0.038
2.705IlePro: 2.705 ± 0.045
2.203IleGln: 2.203 ± 0.042
3.121IleArg: 3.121 ± 0.049
4.016IleSer: 4.016 ± 0.053
3.524IleThr: 3.524 ± 0.056
3.858IleVal: 3.858 ± 0.053
0.628IleTrp: 0.628 ± 0.022
1.529IleTyr: 1.529 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.837LysAla: 4.837 ± 0.061
0.297LysCys: 0.297 ± 0.014
2.296LysAsp: 2.296 ± 0.041
2.734LysGlu: 2.734 ± 0.046
1.298LysPhe: 1.298 ± 0.035
3.098LysGly: 3.098 ± 0.049
1.088LysHis: 1.088 ± 0.026
2.357LysIle: 2.357 ± 0.038
2.363LysLys: 2.363 ± 0.05
4.793LysLeu: 4.793 ± 0.062
1.303LysMet: 1.303 ± 0.031
1.705LysAsn: 1.705 ± 0.036
2.342LysPro: 2.342 ± 0.045
2.495LysGln: 2.495 ± 0.045
2.548LysArg: 2.548 ± 0.05
2.574LysSer: 2.574 ± 0.042
2.572LysThr: 2.572 ± 0.044
3.501LysVal: 3.501 ± 0.054
0.516LysTrp: 0.516 ± 0.02
1.235LysTyr: 1.235 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
11.287LeuAla: 11.287 ± 0.112
1.162LeuCys: 1.162 ± 0.032
5.764LeuAsp: 5.764 ± 0.075
5.958LeuGlu: 5.958 ± 0.071
4.183LeuPhe: 4.183 ± 0.06
7.308LeuGly: 7.308 ± 0.068
2.194LeuHis: 2.194 ± 0.039
5.943LeuIle: 5.943 ± 0.064
4.9LeuLys: 4.9 ± 0.059
11.013LeuLeu: 11.013 ± 0.14
2.946LeuMet: 2.946 ± 0.049
4.261LeuAsn: 4.261 ± 0.057
5.236LeuPro: 5.236 ± 0.064
3.678LeuGln: 3.678 ± 0.06
4.938LeuArg: 4.938 ± 0.069
7.592LeuSer: 7.592 ± 0.079
6.467LeuThr: 6.467 ± 0.066
7.065LeuVal: 7.065 ± 0.081
1.132LeuTrp: 1.132 ± 0.031
2.604LeuTyr: 2.604 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.104MetAla: 3.104 ± 0.048
0.225MetCys: 0.225 ± 0.013
1.347MetAsp: 1.347 ± 0.035
1.396MetGlu: 1.396 ± 0.034
0.964MetPhe: 0.964 ± 0.028
1.935MetGly: 1.935 ± 0.04
0.508MetHis: 0.508 ± 0.019
1.594MetIle: 1.594 ± 0.031
1.523MetLys: 1.523 ± 0.033
3.034MetLeu: 3.034 ± 0.054
0.921MetMet: 0.921 ± 0.026
1.09MetAsn: 1.09 ± 0.027
1.396MetPro: 1.396 ± 0.04
1.126MetGln: 1.126 ± 0.025
1.288MetArg: 1.288 ± 0.029
1.894MetSer: 1.894 ± 0.037
1.847MetThr: 1.847 ± 0.036
2.101MetVal: 2.101 ± 0.031
0.231MetTrp: 0.231 ± 0.013
0.59MetTyr: 0.59 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.292AsnAla: 3.292 ± 0.044
0.398AsnCys: 0.398 ± 0.017
2.048AsnAsp: 2.048 ± 0.037
2.144AsnGlu: 2.144 ± 0.041
1.386AsnPhe: 1.386 ± 0.03
2.975AsnGly: 2.975 ± 0.049
0.945AsnHis: 0.945 ± 0.027
2.329AsnIle: 2.329 ± 0.039
1.769AsnLys: 1.769 ± 0.033
3.651AsnLeu: 3.651 ± 0.054
0.966AsnMet: 0.966 ± 0.027
1.579AsnAsn: 1.579 ± 0.04
2.158AsnPro: 2.158 ± 0.039
2.0AsnGln: 2.0 ± 0.039
2.008AsnArg: 2.008 ± 0.035
2.006AsnSer: 2.006 ± 0.042
2.069AsnThr: 2.069 ± 0.036
2.48AsnVal: 2.48 ± 0.046
0.606AsnTrp: 0.606 ± 0.021
1.16AsnTyr: 1.16 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
4.137ProAla: 4.137 ± 0.061
0.367ProCys: 0.367 ± 0.016
2.792ProAsp: 2.792 ± 0.042
3.45ProGlu: 3.45 ± 0.051
1.778ProPhe: 1.778 ± 0.034
2.805ProGly: 2.805 ± 0.043
0.995ProHis: 0.995 ± 0.03
2.203ProIle: 2.203 ± 0.044
1.73ProLys: 1.73 ± 0.031
4.533ProLeu: 4.533 ± 0.06
1.185ProMet: 1.185 ± 0.029
1.466ProAsn: 1.466 ± 0.03
1.435ProPro: 1.435 ± 0.033
1.892ProGln: 1.892 ± 0.037
1.632ProArg: 1.632 ± 0.034
2.451ProSer: 2.451 ± 0.041
2.242ProThr: 2.242 ± 0.044
3.727ProVal: 3.727 ± 0.056
0.566ProTrp: 0.566 ± 0.02
1.35ProTyr: 1.35 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.872GlnAla: 4.872 ± 0.066
0.422GlnCys: 0.422 ± 0.017
2.076GlnAsp: 2.076 ± 0.034
2.351GlnGlu: 2.351 ± 0.041
1.7GlnPhe: 1.7 ± 0.036
3.036GlnGly: 3.036 ± 0.048
1.317GlnHis: 1.317 ± 0.028
2.402GlnIle: 2.402 ± 0.046
1.839GlnLys: 1.839 ± 0.038
5.453GlnLeu: 5.453 ± 0.066
1.211GlnMet: 1.211 ± 0.029
1.477GlnAsn: 1.477 ± 0.035
2.271GlnPro: 2.271 ± 0.046
3.14GlnGln: 3.14 ± 0.066
2.607GlnArg: 2.607 ± 0.045
2.661GlnSer: 2.661 ± 0.05
2.305GlnThr: 2.305 ± 0.038
3.208GlnVal: 3.208 ± 0.049
0.712GlnTrp: 0.712 ± 0.024
1.379GlnTyr: 1.379 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
3.922ArgAla: 3.922 ± 0.054
0.59ArgCys: 0.59 ± 0.02
2.778ArgAsp: 2.778 ± 0.044
3.398ArgGlu: 3.398 ± 0.054
2.403ArgPhe: 2.403 ± 0.043
2.901ArgGly: 2.901 ± 0.046
1.511ArgHis: 1.511 ± 0.036
3.122ArgIle: 3.122 ± 0.042
2.309ArgLys: 2.309 ± 0.044
5.614ArgLeu: 5.614 ± 0.088
1.329ArgMet: 1.329 ± 0.028
1.904ArgAsn: 1.904 ± 0.039
1.886ArgPro: 1.886 ± 0.038
2.982ArgGln: 2.982 ± 0.059
2.893ArgArg: 2.893 ± 0.052
2.682ArgSer: 2.682 ± 0.047
2.312ArgThr: 2.312 ± 0.04
3.363ArgVal: 3.363 ± 0.05
0.753ArgTrp: 0.753 ± 0.025
1.862ArgTyr: 1.862 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.504SerAla: 5.504 ± 0.059
0.646SerCys: 0.646 ± 0.021
3.414SerAsp: 3.414 ± 0.053
3.723SerGlu: 3.723 ± 0.053
2.462SerPhe: 2.462 ± 0.046
4.995SerGly: 4.995 ± 0.068
1.565SerHis: 1.565 ± 0.033
3.224SerIle: 3.224 ± 0.051
2.517SerLys: 2.517 ± 0.044
6.941SerLeu: 6.941 ± 0.071
1.74SerMet: 1.74 ± 0.037
2.069SerAsn: 2.069 ± 0.041
2.661SerPro: 2.661 ± 0.04
3.041SerGln: 3.041 ± 0.055
3.272SerArg: 3.272 ± 0.049
3.763SerSer: 3.763 ± 0.057
3.131SerThr: 3.131 ± 0.05
4.419SerVal: 4.419 ± 0.056
0.848SerTrp: 0.848 ± 0.025
1.902SerTyr: 1.902 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
5.021ThrAla: 5.021 ± 0.067
0.511ThrCys: 0.511 ± 0.019
2.896ThrAsp: 2.896 ± 0.042
3.145ThrGlu: 3.145 ± 0.051
2.135ThrPhe: 2.135 ± 0.041
4.256ThrGly: 4.256 ± 0.056
1.273ThrHis: 1.273 ± 0.027
3.112ThrIle: 3.112 ± 0.051
1.942ThrLys: 1.942 ± 0.042
6.579ThrLeu: 6.579 ± 0.073
1.251ThrMet: 1.251 ± 0.028
1.829ThrAsn: 1.829 ± 0.032
2.89ThrPro: 2.89 ± 0.045
2.407ThrGln: 2.407 ± 0.044
2.632ThrArg: 2.632 ± 0.04
3.162ThrSer: 3.162 ± 0.044
2.93ThrThr: 2.93 ± 0.046
4.17ThrVal: 4.17 ± 0.05
0.605ThrTrp: 0.605 ± 0.023
1.461ThrTyr: 1.461 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
6.96ValAla: 6.96 ± 0.082
0.829ValCys: 0.829 ± 0.026
3.931ValAsp: 3.931 ± 0.048
4.394ValGlu: 4.394 ± 0.061
2.738ValPhe: 2.738 ± 0.046
4.781ValGly: 4.781 ± 0.063
1.244ValHis: 1.244 ± 0.029
4.697ValIle: 4.697 ± 0.053
3.353ValLys: 3.353 ± 0.049
6.986ValLeu: 6.986 ± 0.08
2.231ValMet: 2.231 ± 0.04
2.834ValAsn: 2.834 ± 0.043
2.891ValPro: 2.891 ± 0.048
2.251ValGln: 2.251 ± 0.041
3.275ValArg: 3.275 ± 0.049
4.921ValSer: 4.921 ± 0.057
4.29ValThr: 4.29 ± 0.058
5.538ValVal: 5.538 ± 0.076
0.812ValTrp: 0.812 ± 0.025
1.86ValTyr: 1.86 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
0.916TrpAla: 0.916 ± 0.027
0.164TrpCys: 0.164 ± 0.012
0.613TrpAsp: 0.613 ± 0.021
0.595TrpGlu: 0.595 ± 0.023
0.602TrpPhe: 0.602 ± 0.022
0.845TrpGly: 0.845 ± 0.029
0.381TrpHis: 0.381 ± 0.016
0.658TrpIle: 0.658 ± 0.021
0.488TrpLys: 0.488 ± 0.019
1.953TrpLeu: 1.953 ± 0.05
0.381TrpMet: 0.381 ± 0.017
0.434TrpAsn: 0.434 ± 0.017
0.537TrpPro: 0.537 ± 0.02
1.043TrpGln: 1.043 ± 0.032
0.699TrpArg: 0.699 ± 0.023
0.712TrpSer: 0.712 ± 0.024
0.545TrpThr: 0.545 ± 0.021
0.871TrpVal: 0.871 ± 0.028
0.222TrpTrp: 0.222 ± 0.013
0.392TrpTyr: 0.392 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.368TyrAla: 2.368 ± 0.039
0.429TyrCys: 0.429 ± 0.017
1.644TyrAsp: 1.644 ± 0.036
1.421TyrGlu: 1.421 ± 0.033
1.299TyrPhe: 1.299 ± 0.031
2.144TyrGly: 2.144 ± 0.04
0.83TyrHis: 0.83 ± 0.024
1.453TyrIle: 1.453 ± 0.032
1.12TyrLys: 1.12 ± 0.031
3.403TyrLeu: 3.403 ± 0.056
0.636TyrMet: 0.636 ± 0.021
1.032TyrAsn: 1.032 ± 0.026
1.447TyrPro: 1.447 ± 0.032
1.954TyrGln: 1.954 ± 0.035
1.952TyrArg: 1.952 ± 0.035
1.875TyrSer: 1.875 ± 0.039
1.495TyrThr: 1.495 ± 0.03
1.745TyrVal: 1.745 ± 0.032
0.487TyrTrp: 0.487 ± 0.016
0.984TyrTyr: 0.984 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4693 proteins (1473747 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski