Amino acid dipepetide frequency for Gammapapillomavirus 6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.75AlaAla: 4.75 ± 0.85
1.295AlaCys: 1.295 ± 0.627
4.75AlaAsp: 4.75 ± 1.611
4.75AlaGlu: 4.75 ± 1.382
4.75AlaPhe: 4.75 ± 0.852
2.591AlaGly: 2.591 ± 0.593
0.432AlaHis: 0.432 ± 0.352
2.159AlaIle: 2.159 ± 0.854
4.318AlaLys: 4.318 ± 1.28
5.613AlaLeu: 5.613 ± 1.667
1.727AlaMet: 1.727 ± 0.678
1.727AlaAsn: 1.727 ± 1.089
3.886AlaPro: 3.886 ± 1.715
2.159AlaGln: 2.159 ± 0.706
3.454AlaArg: 3.454 ± 1.774
1.727AlaSer: 1.727 ± 0.212
6.477AlaThr: 6.477 ± 1.333
5.613AlaVal: 5.613 ± 1.539
0.432AlaTrp: 0.432 ± 0.327
1.295AlaTyr: 1.295 ± 0.98
0.0AlaXaa: 0.0 ± 0.0
Cys
2.159CysAla: 2.159 ± 0.812
0.864CysCys: 0.864 ± 0.653
1.295CysAsp: 1.295 ± 0.464
0.864CysGlu: 0.864 ± 0.653
0.432CysPhe: 0.432 ± 0.327
1.727CysGly: 1.727 ± 1.839
0.0CysHis: 0.0 ± 0.0
0.864CysIle: 0.864 ± 0.467
2.591CysLys: 2.591 ± 1.098
1.727CysLeu: 1.727 ± 0.709
0.432CysMet: 0.432 ± 0.327
2.159CysAsn: 2.159 ± 1.231
1.727CysPro: 1.727 ± 0.829
0.0CysGln: 0.0 ± 0.0
0.432CysArg: 0.432 ± 0.327
1.295CysSer: 1.295 ± 0.658
0.864CysThr: 0.864 ± 0.54
2.159CysVal: 2.159 ± 1.0
0.864CysTrp: 0.864 ± 0.54
0.432CysTyr: 0.432 ± 0.327
0.0CysXaa: 0.0 ± 0.0
Asp
2.159AspAla: 2.159 ± 1.28
1.295AspCys: 1.295 ± 0.627
3.886AspAsp: 3.886 ± 0.888
3.022AspGlu: 3.022 ± 1.442
2.591AspPhe: 2.591 ± 0.83
4.75AspGly: 4.75 ± 1.289
0.432AspHis: 0.432 ± 0.352
6.477AspIle: 6.477 ± 1.637
2.159AspLys: 2.159 ± 0.693
6.908AspLeu: 6.908 ± 1.815
1.295AspMet: 1.295 ± 0.464
3.886AspAsn: 3.886 ± 0.869
6.045AspPro: 6.045 ± 1.455
1.295AspGln: 1.295 ± 0.56
2.591AspArg: 2.591 ± 0.69
3.454AspSer: 3.454 ± 0.864
7.772AspThr: 7.772 ± 2.574
5.181AspVal: 5.181 ± 1.338
1.295AspTrp: 1.295 ± 0.627
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
4.318GluAla: 4.318 ± 0.799
0.432GluCys: 0.432 ± 0.327
6.477GluAsp: 6.477 ± 1.445
6.045GluGlu: 6.045 ± 3.682
0.864GluPhe: 0.864 ± 0.389
4.318GluGly: 4.318 ± 2.133
0.864GluHis: 0.864 ± 0.685
0.432GluIle: 0.432 ± 0.327
1.727GluLys: 1.727 ± 0.778
3.886GluLeu: 3.886 ± 1.406
0.864GluMet: 0.864 ± 0.444
3.454GluAsn: 3.454 ± 1.103
3.454GluPro: 3.454 ± 2.148
3.886GluGln: 3.886 ± 1.254
1.727GluArg: 1.727 ± 1.387
3.454GluSer: 3.454 ± 0.902
6.908GluThr: 6.908 ± 1.863
3.454GluVal: 3.454 ± 1.262
0.864GluTrp: 0.864 ± 0.653
0.432GluTyr: 0.432 ± 0.352
0.0GluXaa: 0.0 ± 0.0
Phe
1.727PheAla: 1.727 ± 0.804
1.295PheCys: 1.295 ± 0.627
1.295PheAsp: 1.295 ± 0.659
4.318PheGlu: 4.318 ± 1.314
2.159PhePhe: 2.159 ± 1.331
3.454PheGly: 3.454 ± 0.769
0.432PheHis: 0.432 ± 0.352
2.591PheIle: 2.591 ± 0.439
2.591PheLys: 2.591 ± 0.964
3.454PheLeu: 3.454 ± 0.877
0.864PheMet: 0.864 ± 0.467
1.295PheAsn: 1.295 ± 0.659
0.432PhePro: 0.432 ± 0.327
2.159PheGln: 2.159 ± 1.035
1.295PheArg: 1.295 ± 0.666
1.727PheSer: 1.727 ± 0.657
0.432PheThr: 0.432 ± 0.327
2.591PheVal: 2.591 ± 0.746
0.864PheTrp: 0.864 ± 0.389
2.159PheTyr: 2.159 ± 0.72
0.0PheXaa: 0.0 ± 0.0
Gly
2.159GlyAla: 2.159 ± 0.899
2.159GlyCys: 2.159 ± 1.28
5.181GlyAsp: 5.181 ± 0.966
3.454GlyGlu: 3.454 ± 0.814
2.159GlyPhe: 2.159 ± 0.45
5.181GlyGly: 5.181 ± 2.134
2.591GlyHis: 2.591 ± 0.883
3.886GlyIle: 3.886 ± 0.544
3.454GlyLys: 3.454 ± 1.146
4.318GlyLeu: 4.318 ± 0.565
0.864GlyMet: 0.864 ± 0.54
4.75GlyAsn: 4.75 ± 1.912
3.022GlyPro: 3.022 ± 1.016
3.454GlyGln: 3.454 ± 1.289
5.181GlyArg: 5.181 ± 0.64
5.181GlySer: 5.181 ± 2.301
4.75GlyThr: 4.75 ± 3.431
2.159GlyVal: 2.159 ± 0.897
0.432GlyTrp: 0.432 ± 0.465
1.295GlyTyr: 1.295 ± 0.882
0.0GlyXaa: 0.0 ± 0.0
His
1.295HisAla: 1.295 ± 0.627
1.295HisCys: 1.295 ± 0.682
0.432HisAsp: 0.432 ± 0.405
0.0HisGlu: 0.0 ± 0.0
1.295HisPhe: 1.295 ± 0.442
1.295HisGly: 1.295 ± 0.764
0.0HisHis: 0.0 ± 0.0
0.432HisIle: 0.432 ± 0.352
0.864HisLys: 0.864 ± 0.481
0.432HisLeu: 0.432 ± 0.405
0.432HisMet: 0.432 ± 0.465
0.0HisAsn: 0.0 ± 0.0
2.159HisPro: 2.159 ± 1.047
0.432HisGln: 0.432 ± 0.327
2.159HisArg: 2.159 ± 1.175
1.727HisSer: 1.727 ± 0.678
0.864HisThr: 0.864 ± 0.419
1.295HisVal: 1.295 ± 0.684
0.864HisTrp: 0.864 ± 0.54
0.864HisTyr: 0.864 ± 0.54
0.0HisXaa: 0.0 ± 0.0
Ile
3.886IleAla: 3.886 ± 1.549
0.0IleCys: 0.0 ± 0.0
5.613IleAsp: 5.613 ± 1.761
3.022IleGlu: 3.022 ± 0.847
0.864IlePhe: 0.864 ± 0.685
4.318IleGly: 4.318 ± 1.421
1.295IleHis: 1.295 ± 0.659
2.159IleIle: 2.159 ± 0.823
1.295IleLys: 1.295 ± 0.827
3.022IleLeu: 3.022 ± 0.699
0.432IleMet: 0.432 ± 0.327
3.454IleAsn: 3.454 ± 0.944
3.886IlePro: 3.886 ± 1.695
3.886IleGln: 3.886 ± 0.578
1.295IleArg: 1.295 ± 0.967
3.454IleSer: 3.454 ± 1.419
3.886IleThr: 3.886 ± 1.549
3.886IleVal: 3.886 ± 2.191
0.432IleTrp: 0.432 ± 0.327
2.159IleTyr: 2.159 ± 0.9
0.0IleXaa: 0.0 ± 0.0
Lys
2.159LysAla: 2.159 ± 0.824
2.159LysCys: 2.159 ± 1.227
3.454LysAsp: 3.454 ± 1.12
1.727LysGlu: 1.727 ± 0.992
0.864LysPhe: 0.864 ± 0.389
3.454LysGly: 3.454 ± 1.691
2.591LysHis: 2.591 ± 0.621
0.864LysIle: 0.864 ± 0.653
3.022LysLys: 3.022 ± 1.549
3.886LysLeu: 3.886 ± 1.643
1.295LysMet: 1.295 ± 0.627
1.295LysAsn: 1.295 ± 0.785
1.295LysPro: 1.295 ± 0.56
3.886LysGln: 3.886 ± 1.187
3.886LysArg: 3.886 ± 1.07
3.022LysSer: 3.022 ± 1.128
2.591LysThr: 2.591 ± 2.299
4.318LysVal: 4.318 ± 1.59
0.864LysTrp: 0.864 ± 0.419
3.022LysTyr: 3.022 ± 1.429
0.0LysXaa: 0.0 ± 0.0
Leu
6.908LeuAla: 6.908 ± 1.769
3.886LeuCys: 3.886 ± 1.94
5.181LeuAsp: 5.181 ± 1.374
3.454LeuGlu: 3.454 ± 1.405
4.318LeuPhe: 4.318 ± 1.724
3.886LeuGly: 3.886 ± 1.682
1.727LeuHis: 1.727 ± 0.746
1.727LeuIle: 1.727 ± 0.714
4.318LeuLys: 4.318 ± 1.494
9.067LeuLeu: 9.067 ± 2.813
0.864LeuMet: 0.864 ± 0.457
1.295LeuAsn: 1.295 ± 0.627
3.454LeuPro: 3.454 ± 1.255
6.045LeuGln: 6.045 ± 1.154
5.181LeuArg: 5.181 ± 1.139
6.045LeuSer: 6.045 ± 1.581
3.454LeuThr: 3.454 ± 1.236
7.34LeuVal: 7.34 ± 2.673
1.295LeuTrp: 1.295 ± 0.659
2.591LeuTyr: 2.591 ± 1.105
0.0LeuXaa: 0.0 ± 0.0
Met
1.727MetAla: 1.727 ± 0.92
0.864MetCys: 0.864 ± 0.704
1.727MetAsp: 1.727 ± 0.212
0.432MetGlu: 0.432 ± 0.465
1.295MetPhe: 1.295 ± 0.666
1.295MetGly: 1.295 ± 0.784
0.0MetHis: 0.0 ± 0.0
0.432MetIle: 0.432 ± 0.327
0.432MetLys: 0.432 ± 0.327
0.432MetLeu: 0.432 ± 0.327
0.864MetMet: 0.864 ± 0.389
0.432MetAsn: 0.432 ± 0.352
1.727MetPro: 1.727 ± 0.929
1.295MetGln: 1.295 ± 0.401
1.295MetArg: 1.295 ± 0.827
0.864MetSer: 0.864 ± 0.389
0.864MetThr: 0.864 ± 0.676
1.295MetVal: 1.295 ± 0.98
0.432MetTrp: 0.432 ± 0.465
0.432MetTyr: 0.432 ± 0.327
0.0MetXaa: 0.0 ± 0.0
Asn
3.886AsnAla: 3.886 ± 1.751
0.864AsnCys: 0.864 ± 0.653
2.159AsnAsp: 2.159 ± 0.796
1.727AsnGlu: 1.727 ± 1.318
1.727AsnPhe: 1.727 ± 0.992
2.591AsnGly: 2.591 ± 1.045
0.432AsnHis: 0.432 ± 0.327
5.181AsnIle: 5.181 ± 0.553
3.022AsnLys: 3.022 ± 0.679
1.295AsnLeu: 1.295 ± 0.956
0.432AsnMet: 0.432 ± 0.327
3.454AsnAsn: 3.454 ± 1.694
1.727AsnPro: 1.727 ± 0.556
0.864AsnGln: 0.864 ± 0.389
1.727AsnArg: 1.727 ± 0.888
1.727AsnSer: 1.727 ± 0.778
3.886AsnThr: 3.886 ± 1.201
4.318AsnVal: 4.318 ± 1.245
0.0AsnTrp: 0.0 ± 0.0
0.432AsnTyr: 0.432 ± 0.352
0.0AsnXaa: 0.0 ± 0.0
Pro
2.591ProAla: 2.591 ± 1.369
1.727ProCys: 1.727 ± 0.778
4.75ProAsp: 4.75 ± 1.817
4.318ProGlu: 4.318 ± 1.295
0.432ProPhe: 0.432 ± 0.327
2.159ProGly: 2.159 ± 1.562
0.432ProHis: 0.432 ± 0.327
4.75ProIle: 4.75 ± 2.17
3.022ProLys: 3.022 ± 0.481
5.613ProLeu: 5.613 ± 1.034
0.0ProMet: 0.0 ± 0.0
3.022ProAsn: 3.022 ± 0.481
6.908ProPro: 6.908 ± 1.911
2.159ProGln: 2.159 ± 0.763
5.181ProArg: 5.181 ± 1.15
5.613ProSer: 5.613 ± 0.631
4.318ProThr: 4.318 ± 1.695
3.454ProVal: 3.454 ± 0.743
0.0ProTrp: 0.0 ± 0.0
3.454ProTyr: 3.454 ± 1.498
0.0ProXaa: 0.0 ± 0.0
Gln
3.454GlnAla: 3.454 ± 1.262
0.432GlnCys: 0.432 ± 0.621
2.591GlnAsp: 2.591 ± 0.939
3.022GlnGlu: 3.022 ± 1.087
3.022GlnPhe: 3.022 ± 0.89
1.295GlnGly: 1.295 ± 1.394
0.432GlnHis: 0.432 ± 0.621
2.159GlnIle: 2.159 ± 0.812
2.591GlnLys: 2.591 ± 0.471
6.045GlnLeu: 6.045 ± 2.052
1.727GlnMet: 1.727 ± 0.82
2.159GlnAsn: 2.159 ± 0.955
2.591GlnPro: 2.591 ± 0.827
2.159GlnGln: 2.159 ± 1.126
3.454GlnArg: 3.454 ± 1.296
2.159GlnSer: 2.159 ± 0.679
3.454GlnThr: 3.454 ± 1.139
2.591GlnVal: 2.591 ± 0.883
0.864GlnTrp: 0.864 ± 0.676
0.864GlnTyr: 0.864 ± 0.653
0.0GlnXaa: 0.0 ± 0.0
Arg
2.591ArgAla: 2.591 ± 0.837
0.432ArgCys: 0.432 ± 0.327
1.295ArgAsp: 1.295 ± 0.759
1.295ArgGlu: 1.295 ± 0.464
1.727ArgPhe: 1.727 ± 1.08
4.318ArgGly: 4.318 ± 0.593
3.454ArgHis: 3.454 ± 0.74
2.591ArgIle: 2.591 ± 1.263
3.022ArgLys: 3.022 ± 0.629
5.181ArgLeu: 5.181 ± 1.607
0.432ArgMet: 0.432 ± 0.327
1.295ArgAsn: 1.295 ± 0.36
4.75ArgPro: 4.75 ± 1.595
4.75ArgGln: 4.75 ± 1.194
8.636ArgArg: 8.636 ± 3.134
4.318ArgSer: 4.318 ± 0.888
2.159ArgThr: 2.159 ± 0.844
4.318ArgVal: 4.318 ± 1.845
0.864ArgTrp: 0.864 ± 0.481
1.727ArgTyr: 1.727 ± 0.212
0.0ArgXaa: 0.0 ± 0.0
Ser
3.454SerAla: 3.454 ± 0.902
0.864SerCys: 0.864 ± 0.653
3.886SerAsp: 3.886 ± 1.009
4.75SerGlu: 4.75 ± 1.613
2.591SerPhe: 2.591 ± 0.915
3.022SerGly: 3.022 ± 0.93
0.0SerHis: 0.0 ± 0.0
4.318SerIle: 4.318 ± 1.019
2.591SerLys: 2.591 ± 1.196
6.477SerLeu: 6.477 ± 1.423
1.727SerMet: 1.727 ± 0.92
3.022SerAsn: 3.022 ± 0.629
5.181SerPro: 5.181 ± 0.987
2.159SerGln: 2.159 ± 0.626
3.886SerArg: 3.886 ± 1.741
8.636SerSer: 8.636 ± 2.235
6.477SerThr: 6.477 ± 1.127
3.886SerVal: 3.886 ± 1.403
1.295SerTrp: 1.295 ± 0.873
1.295SerTyr: 1.295 ± 0.36
0.0SerXaa: 0.0 ± 0.0
Thr
6.045ThrAla: 6.045 ± 2.212
1.295ThrCys: 1.295 ± 0.684
4.75ThrAsp: 4.75 ± 1.233
5.613ThrGlu: 5.613 ± 0.4
3.454ThrPhe: 3.454 ± 1.287
6.908ThrGly: 6.908 ± 1.356
1.295ThrHis: 1.295 ± 0.65
4.318ThrIle: 4.318 ± 1.767
2.159ThrLys: 2.159 ± 0.626
5.181ThrLeu: 5.181 ± 1.46
0.432ThrMet: 0.432 ± 0.352
1.727ThrAsn: 1.727 ± 0.92
5.613ThrPro: 5.613 ± 3.125
1.727ThrGln: 1.727 ± 1.13
3.022ThrArg: 3.022 ± 0.772
5.181ThrSer: 5.181 ± 1.734
4.75ThrThr: 4.75 ± 2.111
5.181ThrVal: 5.181 ± 1.017
0.0ThrTrp: 0.0 ± 0.0
1.727ThrTyr: 1.727 ± 0.843
0.0ThrXaa: 0.0 ± 0.0
Val
5.613ValAla: 5.613 ± 1.378
1.727ValCys: 1.727 ± 0.828
3.886ValAsp: 3.886 ± 1.369
4.75ValGlu: 4.75 ± 1.516
1.295ValPhe: 1.295 ± 0.659
6.477ValGly: 6.477 ± 1.207
1.295ValHis: 1.295 ± 0.785
4.318ValIle: 4.318 ± 2.626
3.886ValLys: 3.886 ± 1.429
5.181ValLeu: 5.181 ± 2.133
1.295ValMet: 1.295 ± 0.367
1.727ValAsn: 1.727 ± 0.593
3.886ValPro: 3.886 ± 1.526
3.022ValGln: 3.022 ± 0.874
1.727ValArg: 1.727 ± 0.212
7.772ValSer: 7.772 ± 2.125
4.75ValThr: 4.75 ± 1.846
5.613ValVal: 5.613 ± 1.529
0.432ValTrp: 0.432 ± 0.352
3.454ValTyr: 3.454 ± 0.868
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
2.159TrpAsp: 2.159 ± 0.419
0.0TrpGlu: 0.0 ± 0.0
0.432TrpPhe: 0.432 ± 0.327
1.295TrpGly: 1.295 ± 0.464
0.432TrpHis: 0.432 ± 0.465
1.295TrpIle: 1.295 ± 0.36
1.295TrpLys: 1.295 ± 0.627
1.295TrpLeu: 1.295 ± 0.627
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.432TrpPro: 0.432 ± 0.352
1.295TrpGln: 1.295 ± 0.944
0.432TrpArg: 0.432 ± 0.465
0.0TrpSer: 0.0 ± 0.0
0.864TrpThr: 0.864 ± 0.93
1.295TrpVal: 1.295 ± 0.659
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.022TyrAla: 3.022 ± 0.679
0.0TyrCys: 0.0 ± 0.0
1.727TyrAsp: 1.727 ± 0.212
1.295TyrGlu: 1.295 ± 0.873
0.864TyrPhe: 0.864 ± 0.419
1.295TyrGly: 1.295 ± 0.442
0.0TyrHis: 0.0 ± 0.0
1.295TyrIle: 1.295 ± 0.745
1.295TyrLys: 1.295 ± 0.737
3.022TyrLeu: 3.022 ± 0.984
1.727TyrMet: 1.727 ± 0.745
1.295TyrAsn: 1.295 ± 0.36
1.727TyrPro: 1.727 ± 0.678
0.864TyrGln: 0.864 ± 0.467
2.591TyrArg: 2.591 ± 0.54
2.159TyrSer: 2.159 ± 0.329
0.864TyrThr: 0.864 ± 0.467
2.159TyrVal: 2.159 ± 0.849
0.432TyrTrp: 0.432 ± 0.352
2.159TyrTyr: 2.159 ± 0.9
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2317 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski