Amino acid dipepetide frequency for Changjiang picorna-like virus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.532AlaAla: 5.532 ± 2.773
1.277AlaCys: 1.277 ± 0.686
3.404AlaAsp: 3.404 ± 0.725
1.277AlaGlu: 1.277 ± 0.686
1.702AlaPhe: 1.702 ± 0.914
5.532AlaGly: 5.532 ± 2.135
1.702AlaHis: 1.702 ± 0.276
3.83AlaIle: 3.83 ± 0.496
1.702AlaLys: 1.702 ± 0.914
5.106AlaLeu: 5.106 ± 0.449
2.553AlaMet: 2.553 ± 0.095
3.404AlaAsn: 3.404 ± 1.363
3.404AlaPro: 3.404 ± 1.363
1.702AlaGln: 1.702 ± 0.362
2.979AlaArg: 2.979 ± 0.953
4.255AlaSer: 4.255 ± 1.544
5.106AlaThr: 5.106 ± 1.725
6.809AlaVal: 6.809 ± 0.173
1.277AlaTrp: 1.277 ± 0.591
3.83AlaTyr: 3.83 ± 0.142
0.0AlaXaa: 0.0 ± 0.0
Cys
1.277CysAla: 1.277 ± 0.686
0.851CysCys: 0.851 ± 0.181
1.277CysAsp: 1.277 ± 0.686
0.851CysGlu: 0.851 ± 0.457
1.702CysPhe: 1.702 ± 0.362
2.128CysGly: 2.128 ± 0.504
0.0CysHis: 0.0 ± 0.0
0.851CysIle: 0.851 ± 0.457
2.128CysLys: 2.128 ± 1.143
1.277CysLeu: 1.277 ± 0.047
0.0CysMet: 0.0 ± 0.0
0.426CysAsn: 0.426 ± 0.41
1.702CysPro: 1.702 ± 0.276
0.851CysGln: 0.851 ± 0.181
0.426CysArg: 0.426 ± 0.229
1.277CysSer: 1.277 ± 0.686
0.851CysThr: 0.851 ± 0.181
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.851CysTyr: 0.851 ± 0.457
0.0CysXaa: 0.0 ± 0.0
Asp
3.83AspAla: 3.83 ± 2.41
1.277AspCys: 1.277 ± 0.047
2.553AspAsp: 2.553 ± 0.095
5.532AspGlu: 5.532 ± 0.418
2.979AspPhe: 2.979 ± 0.961
2.979AspGly: 2.979 ± 1.591
1.277AspHis: 1.277 ± 0.047
5.532AspIle: 5.532 ± 0.22
3.404AspLys: 3.404 ± 0.552
2.979AspLeu: 2.979 ± 0.961
0.851AspMet: 0.851 ± 0.181
1.702AspAsn: 1.702 ± 1.0
2.128AspPro: 2.128 ± 0.772
0.851AspGln: 0.851 ± 0.457
2.979AspArg: 2.979 ± 0.323
4.255AspSer: 4.255 ± 1.009
1.277AspThr: 1.277 ± 0.591
3.404AspVal: 3.404 ± 0.725
0.851AspTrp: 0.851 ± 0.457
2.128AspTyr: 2.128 ± 1.41
0.0AspXaa: 0.0 ± 0.0
Glu
1.702GluAla: 1.702 ± 0.914
2.553GluCys: 2.553 ± 1.371
4.681GluAsp: 4.681 ± 0.599
4.255GluGlu: 4.255 ± 2.285
4.681GluPhe: 4.681 ± 1.237
2.553GluGly: 2.553 ± 0.095
0.851GluHis: 0.851 ± 0.457
6.383GluIle: 6.383 ± 0.875
5.957GluLys: 5.957 ± 3.199
2.553GluLeu: 2.553 ± 0.095
0.426GluMet: 0.426 ± 0.229
3.83GluAsn: 3.83 ± 0.496
2.553GluPro: 2.553 ± 0.095
1.277GluGln: 1.277 ± 0.686
3.404GluArg: 3.404 ± 1.828
2.979GluSer: 2.979 ± 0.323
1.277GluThr: 1.277 ± 0.047
4.681GluVal: 4.681 ± 1.237
0.851GluTrp: 0.851 ± 0.457
2.553GluTyr: 2.553 ± 0.733
0.0GluXaa: 0.0 ± 0.0
Phe
3.404PheAla: 3.404 ± 2.001
0.426PheCys: 0.426 ± 0.229
3.404PheAsp: 3.404 ± 1.19
2.553PheGlu: 2.553 ± 0.733
2.979PhePhe: 2.979 ± 0.315
5.532PheGly: 5.532 ± 0.858
1.702PheHis: 1.702 ± 0.276
3.404PheIle: 3.404 ± 0.725
2.553PheLys: 2.553 ± 0.733
9.362PheLeu: 9.362 ± 0.56
0.851PheMet: 0.851 ± 0.457
2.553PheAsn: 2.553 ± 0.543
1.277PhePro: 1.277 ± 0.047
1.702PheGln: 1.702 ± 0.362
1.702PheArg: 1.702 ± 0.914
2.553PheSer: 2.553 ± 0.095
2.979PheThr: 2.979 ± 0.315
1.702PheVal: 1.702 ± 0.276
1.702PheTrp: 1.702 ± 0.914
3.404PheTyr: 3.404 ± 0.552
0.0PheXaa: 0.0 ± 0.0
Gly
5.957GlyAla: 5.957 ± 1.268
0.426GlyCys: 0.426 ± 0.229
4.255GlyAsp: 4.255 ± 0.267
4.255GlyGlu: 4.255 ± 0.267
4.255GlyPhe: 4.255 ± 0.371
3.404GlyGly: 3.404 ± 0.725
1.277GlyHis: 1.277 ± 0.686
5.106GlyIle: 5.106 ± 1.466
2.553GlyLys: 2.553 ± 0.543
3.83GlyLeu: 3.83 ± 0.78
0.426GlyMet: 0.426 ± 0.41
4.255GlyAsn: 4.255 ± 1.544
0.851GlyPro: 0.851 ± 0.819
0.851GlyGln: 0.851 ± 0.181
4.255GlyArg: 4.255 ± 1.009
2.979GlySer: 2.979 ± 1.591
5.957GlyThr: 5.957 ± 1.906
5.106GlyVal: 5.106 ± 0.828
1.702GlyTrp: 1.702 ± 1.0
2.553GlyTyr: 2.553 ± 1.182
0.0GlyXaa: 0.0 ± 0.0
His
0.851HisAla: 0.851 ± 0.457
0.426HisCys: 0.426 ± 0.229
0.851HisAsp: 0.851 ± 0.181
0.426HisGlu: 0.426 ± 0.229
1.277HisPhe: 1.277 ± 0.686
2.553HisGly: 2.553 ± 0.095
0.426HisHis: 0.426 ± 0.229
1.277HisIle: 1.277 ± 0.591
0.851HisLys: 0.851 ± 0.181
2.979HisLeu: 2.979 ± 0.961
1.702HisMet: 1.702 ± 0.914
0.426HisAsn: 0.426 ± 0.229
1.277HisPro: 1.277 ± 0.047
0.851HisGln: 0.851 ± 0.819
0.426HisArg: 0.426 ± 0.41
0.851HisSer: 0.851 ± 0.181
0.851HisThr: 0.851 ± 0.457
1.277HisVal: 1.277 ± 0.591
0.426HisTrp: 0.426 ± 0.229
0.851HisTyr: 0.851 ± 0.457
0.0HisXaa: 0.0 ± 0.0
Ile
5.532IleAla: 5.532 ± 0.22
0.0IleCys: 0.0 ± 0.0
2.128IleAsp: 2.128 ± 0.772
3.83IleGlu: 3.83 ± 0.142
4.255IlePhe: 4.255 ± 0.371
5.106IleGly: 5.106 ± 1.087
1.702IleHis: 1.702 ± 0.276
4.255IleIle: 4.255 ± 2.285
5.532IleLys: 5.532 ± 1.496
3.83IleLeu: 3.83 ± 2.057
1.277IleMet: 1.277 ± 0.686
4.255IleAsn: 4.255 ± 0.267
2.128IlePro: 2.128 ± 0.772
2.553IleGln: 2.553 ± 0.733
2.553IleArg: 2.553 ± 1.182
5.957IleSer: 5.957 ± 0.63
3.404IleThr: 3.404 ± 0.552
5.957IleVal: 5.957 ± 1.268
0.426IleTrp: 0.426 ± 0.229
2.128IleTyr: 2.128 ± 0.134
0.0IleXaa: 0.0 ± 0.0
Lys
4.255LysAla: 4.255 ± 1.647
1.277LysCys: 1.277 ± 0.686
5.106LysAsp: 5.106 ± 0.19
3.404LysGlu: 3.404 ± 1.19
2.979LysPhe: 2.979 ± 0.961
4.255LysGly: 4.255 ± 1.009
2.128LysHis: 2.128 ± 1.143
2.979LysIle: 2.979 ± 0.953
4.255LysLys: 4.255 ± 1.009
2.553LysLeu: 2.553 ± 0.543
1.702LysMet: 1.702 ± 0.914
2.553LysAsn: 2.553 ± 0.733
3.404LysPro: 3.404 ± 0.552
2.128LysGln: 2.128 ± 0.134
2.553LysArg: 2.553 ± 1.371
5.106LysSer: 5.106 ± 1.466
2.979LysThr: 2.979 ± 0.961
3.83LysVal: 3.83 ± 1.134
1.277LysTrp: 1.277 ± 0.686
1.277LysTyr: 1.277 ± 0.686
0.0LysXaa: 0.0 ± 0.0
Leu
5.532LeuAla: 5.532 ± 0.858
2.128LeuCys: 2.128 ± 0.504
4.255LeuAsp: 4.255 ± 0.267
5.106LeuGlu: 5.106 ± 2.742
3.83LeuPhe: 3.83 ± 0.78
2.128LeuGly: 2.128 ± 0.504
1.277LeuHis: 1.277 ± 0.591
4.255LeuIle: 4.255 ± 0.267
6.383LeuLys: 6.383 ± 0.401
4.255LeuLeu: 4.255 ± 0.371
1.702LeuMet: 1.702 ± 0.362
3.83LeuAsn: 3.83 ± 0.496
3.83LeuPro: 3.83 ± 0.78
2.553LeuGln: 2.553 ± 1.182
2.128LeuArg: 2.128 ± 0.504
6.809LeuSer: 6.809 ± 0.173
5.106LeuThr: 5.106 ± 1.087
6.383LeuVal: 6.383 ± 2.151
0.426LeuTrp: 0.426 ± 0.229
2.553LeuTyr: 2.553 ± 0.543
0.0LeuXaa: 0.0 ± 0.0
Met
1.277MetAla: 1.277 ± 0.047
1.702MetCys: 1.702 ± 0.914
0.851MetAsp: 0.851 ± 0.181
1.277MetGlu: 1.277 ± 0.047
0.0MetPhe: 0.0 ± 0.0
2.979MetGly: 2.979 ± 0.961
0.851MetHis: 0.851 ± 0.181
1.277MetIle: 1.277 ± 0.047
0.851MetLys: 0.851 ± 0.457
3.404MetLeu: 3.404 ± 0.086
0.0MetMet: 0.0 ± 0.0
2.128MetAsn: 2.128 ± 0.134
1.277MetPro: 1.277 ± 0.591
1.277MetGln: 1.277 ± 0.047
1.277MetArg: 1.277 ± 0.591
1.702MetSer: 1.702 ± 0.914
1.277MetThr: 1.277 ± 0.591
1.277MetVal: 1.277 ± 0.686
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.128AsnAla: 2.128 ± 1.41
0.0AsnCys: 0.0 ± 0.0
2.128AsnAsp: 2.128 ± 0.504
0.851AsnGlu: 0.851 ± 0.457
3.83AsnPhe: 3.83 ± 3.049
2.979AsnGly: 2.979 ± 0.315
0.426AsnHis: 0.426 ± 0.41
2.979AsnIle: 2.979 ± 0.323
2.128AsnLys: 2.128 ± 1.143
4.681AsnLeu: 4.681 ± 0.599
1.277AsnMet: 1.277 ± 0.172
3.404AsnAsn: 3.404 ± 1.363
3.404AsnPro: 3.404 ± 0.725
0.851AsnGln: 0.851 ± 0.819
2.128AsnArg: 2.128 ± 0.134
5.106AsnSer: 5.106 ± 0.449
7.234AsnThr: 7.234 ± 1.221
5.106AsnVal: 5.106 ± 0.828
1.702AsnTrp: 1.702 ± 0.362
2.553AsnTyr: 2.553 ± 1.82
0.0AsnXaa: 0.0 ± 0.0
Pro
2.553ProAla: 2.553 ± 1.82
0.0ProCys: 0.0 ± 0.0
2.979ProAsp: 2.979 ± 1.591
2.979ProGlu: 2.979 ± 1.6
3.83ProPhe: 3.83 ± 1.134
2.128ProGly: 2.128 ± 0.504
1.702ProHis: 1.702 ± 0.362
1.702ProIle: 1.702 ± 0.276
3.404ProLys: 3.404 ± 1.19
3.83ProLeu: 3.83 ± 0.496
2.128ProMet: 2.128 ± 0.772
2.553ProAsn: 2.553 ± 1.182
0.851ProPro: 0.851 ± 0.457
1.702ProGln: 1.702 ± 0.914
1.702ProArg: 1.702 ± 1.0
3.83ProSer: 3.83 ± 0.78
2.979ProThr: 2.979 ± 1.591
2.979ProVal: 2.979 ± 1.591
1.277ProTrp: 1.277 ± 0.047
0.851ProTyr: 0.851 ± 0.181
0.0ProXaa: 0.0 ± 0.0
Gln
3.404GlnAla: 3.404 ± 0.086
0.426GlnCys: 0.426 ± 0.229
1.277GlnAsp: 1.277 ± 0.047
2.128GlnGlu: 2.128 ± 0.134
2.979GlnPhe: 2.979 ± 0.315
2.553GlnGly: 2.553 ± 0.543
1.277GlnHis: 1.277 ± 0.047
2.553GlnIle: 2.553 ± 1.182
0.851GlnLys: 0.851 ± 0.181
1.277GlnLeu: 1.277 ± 0.047
0.851GlnMet: 0.851 ± 0.457
0.851GlnAsn: 0.851 ± 0.457
1.702GlnPro: 1.702 ± 1.0
0.426GlnGln: 0.426 ± 0.229
0.426GlnArg: 0.426 ± 0.229
1.702GlnSer: 1.702 ± 0.276
1.702GlnThr: 1.702 ± 1.0
1.277GlnVal: 1.277 ± 0.047
0.851GlnTrp: 0.851 ± 0.457
0.851GlnTyr: 0.851 ± 0.181
0.0GlnXaa: 0.0 ± 0.0
Arg
3.404ArgAla: 3.404 ± 1.19
1.277ArgCys: 1.277 ± 0.591
0.426ArgAsp: 0.426 ± 0.229
3.83ArgGlu: 3.83 ± 1.418
1.277ArgPhe: 1.277 ± 0.591
2.979ArgGly: 2.979 ± 0.953
0.426ArgHis: 0.426 ± 0.41
2.979ArgIle: 2.979 ± 0.961
2.979ArgLys: 2.979 ± 1.6
2.553ArgLeu: 2.553 ± 0.095
1.702ArgMet: 1.702 ± 0.362
2.979ArgAsn: 2.979 ± 0.315
1.277ArgPro: 1.277 ± 0.047
1.702ArgGln: 1.702 ± 0.276
2.128ArgArg: 2.128 ± 1.143
2.979ArgSer: 2.979 ± 0.961
3.83ArgThr: 3.83 ± 1.134
3.83ArgVal: 3.83 ± 1.418
0.0ArgTrp: 0.0 ± 0.0
2.979ArgTyr: 2.979 ± 0.961
0.0ArgXaa: 0.0 ± 0.0
Ser
4.255SerAla: 4.255 ± 0.906
0.426SerCys: 0.426 ± 0.229
3.83SerAsp: 3.83 ± 0.496
4.255SerGlu: 4.255 ± 1.009
3.83SerPhe: 3.83 ± 0.142
3.404SerGly: 3.404 ± 0.086
0.426SerHis: 0.426 ± 0.229
4.255SerIle: 4.255 ± 0.906
5.532SerLys: 5.532 ± 1.694
8.085SerLeu: 8.085 ± 0.125
2.128SerMet: 2.128 ± 0.504
3.404SerAsn: 3.404 ± 1.19
2.553SerPro: 2.553 ± 0.543
2.553SerGln: 2.553 ± 0.095
2.128SerArg: 2.128 ± 0.504
5.957SerSer: 5.957 ± 1.285
5.106SerThr: 5.106 ± 2.363
4.681SerVal: 4.681 ± 0.039
0.426SerTrp: 0.426 ± 0.229
2.979SerTyr: 2.979 ± 0.953
0.0SerXaa: 0.0 ± 0.0
Thr
1.277ThrAla: 1.277 ± 0.591
1.277ThrCys: 1.277 ± 0.591
2.979ThrAsp: 2.979 ± 1.591
2.979ThrGlu: 2.979 ± 0.323
3.404ThrPhe: 3.404 ± 0.086
2.979ThrGly: 2.979 ± 0.961
0.0ThrHis: 0.0 ± 0.0
4.681ThrIle: 4.681 ± 2.592
2.553ThrLys: 2.553 ± 0.095
5.106ThrLeu: 5.106 ± 1.725
2.128ThrMet: 2.128 ± 0.504
4.681ThrAsn: 4.681 ± 2.592
6.383ThrPro: 6.383 ± 1.678
1.702ThrGln: 1.702 ± 1.0
3.404ThrArg: 3.404 ± 1.19
5.106ThrSer: 5.106 ± 3.001
3.83ThrThr: 3.83 ± 0.142
5.532ThrVal: 5.532 ± 0.22
0.851ThrTrp: 0.851 ± 0.819
2.979ThrTyr: 2.979 ± 0.315
0.0ThrXaa: 0.0 ± 0.0
Val
7.234ValAla: 7.234 ± 1.221
1.702ValCys: 1.702 ± 0.362
2.979ValAsp: 2.979 ± 0.323
6.383ValGlu: 6.383 ± 2.151
2.979ValPhe: 2.979 ± 0.961
3.83ValGly: 3.83 ± 1.772
1.702ValHis: 1.702 ± 0.276
3.83ValIle: 3.83 ± 0.496
5.532ValLys: 5.532 ± 1.056
2.979ValLeu: 2.979 ± 0.315
1.277ValMet: 1.277 ± 0.225
3.404ValAsn: 3.404 ± 1.19
3.83ValPro: 3.83 ± 0.142
2.553ValGln: 2.553 ± 0.095
5.532ValArg: 5.532 ± 1.056
2.979ValSer: 2.979 ± 0.323
3.404ValThr: 3.404 ± 1.363
3.83ValVal: 3.83 ± 0.142
0.851ValTrp: 0.851 ± 0.457
2.553ValTyr: 2.553 ± 0.733
0.0ValXaa: 0.0 ± 0.0
Trp
1.277TrpAla: 1.277 ± 0.047
0.851TrpCys: 0.851 ± 0.457
0.426TrpAsp: 0.426 ± 0.229
1.702TrpGlu: 1.702 ± 0.914
1.277TrpPhe: 1.277 ± 0.047
1.277TrpGly: 1.277 ± 0.047
0.851TrpHis: 0.851 ± 0.457
0.851TrpIle: 0.851 ± 0.457
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.851TrpMet: 0.851 ± 0.819
1.277TrpAsn: 1.277 ± 0.686
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.426TrpArg: 0.426 ± 0.41
1.277TrpSer: 1.277 ± 0.047
0.851TrpThr: 0.851 ± 0.819
0.851TrpVal: 0.851 ± 0.457
0.426TrpTrp: 0.426 ± 0.229
0.851TrpTyr: 0.851 ± 0.181
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.702TyrAla: 1.702 ± 0.362
0.426TyrCys: 0.426 ± 0.229
2.979TyrAsp: 2.979 ± 1.591
2.128TyrGlu: 2.128 ± 0.134
1.702TyrPhe: 1.702 ± 0.276
2.979TyrGly: 2.979 ± 0.953
0.851TyrHis: 0.851 ± 0.181
3.83TyrIle: 3.83 ± 0.78
0.851TyrLys: 0.851 ± 0.457
3.83TyrLeu: 3.83 ± 0.496
0.426TyrMet: 0.426 ± 0.229
2.979TyrAsn: 2.979 ± 0.953
2.128TyrPro: 2.128 ± 0.134
1.277TyrGln: 1.277 ± 0.591
2.979TyrArg: 2.979 ± 0.323
2.553TyrSer: 2.553 ± 0.095
3.83TyrThr: 3.83 ± 0.142
1.277TyrVal: 1.277 ± 0.686
0.0TyrTrp: 0.0 ± 0.0
2.128TyrTyr: 2.128 ± 0.504
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2351 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski