Amino acid dipepetide frequency for Pedobacter yulinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.178AlaAla: 10.178 ± 0.143
0.905AlaCys: 0.905 ± 0.029
5.217AlaAsp: 5.217 ± 0.065
5.376AlaGlu: 5.376 ± 0.076
4.105AlaPhe: 4.105 ± 0.06
7.977AlaGly: 7.977 ± 0.101
1.491AlaHis: 1.491 ± 0.034
5.038AlaIle: 5.038 ± 0.074
3.918AlaLys: 3.918 ± 0.061
8.508AlaLeu: 8.508 ± 0.092
1.953AlaMet: 1.953 ± 0.04
3.538AlaAsn: 3.538 ± 0.058
2.944AlaPro: 2.944 ± 0.056
3.379AlaGln: 3.379 ± 0.053
4.444AlaArg: 4.444 ± 0.067
5.116AlaSer: 5.116 ± 0.066
4.309AlaThr: 4.309 ± 0.064
5.976AlaVal: 5.976 ± 0.083
1.023AlaTrp: 1.023 ± 0.032
3.26AlaTyr: 3.26 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.611CysAla: 0.611 ± 0.024
0.151CysCys: 0.151 ± 0.012
0.356CysAsp: 0.356 ± 0.016
0.329CysGlu: 0.329 ± 0.015
0.387CysPhe: 0.387 ± 0.017
0.672CysGly: 0.672 ± 0.026
0.177CysHis: 0.177 ± 0.014
0.535CysIle: 0.535 ± 0.021
0.433CysLys: 0.433 ± 0.019
0.887CysLeu: 0.887 ± 0.031
0.185CysMet: 0.185 ± 0.013
0.33CysAsn: 0.33 ± 0.017
0.333CysPro: 0.333 ± 0.016
0.24CysGln: 0.24 ± 0.014
0.471CysArg: 0.471 ± 0.022
0.571CysSer: 0.571 ± 0.02
0.432CysThr: 0.432 ± 0.018
0.46CysVal: 0.46 ± 0.02
0.094CysTrp: 0.094 ± 0.008
0.286CysTyr: 0.286 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.329AspAla: 4.329 ± 0.058
0.355AspCys: 0.355 ± 0.016
2.337AspAsp: 2.337 ± 0.052
3.183AspGlu: 3.183 ± 0.055
2.942AspPhe: 2.942 ± 0.048
3.755AspGly: 3.755 ± 0.069
1.093AspHis: 1.093 ± 0.027
3.376AspIle: 3.376 ± 0.049
2.931AspLys: 2.931 ± 0.046
5.256AspLeu: 5.256 ± 0.071
1.242AspMet: 1.242 ± 0.033
2.083AspAsn: 2.083 ± 0.041
2.408AspPro: 2.408 ± 0.044
2.025AspGln: 2.025 ± 0.045
2.956AspArg: 2.956 ± 0.051
2.648AspSer: 2.648 ± 0.052
2.434AspThr: 2.434 ± 0.05
3.289AspVal: 3.289 ± 0.058
0.77AspTrp: 0.77 ± 0.025
2.26AspTyr: 2.26 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
4.949GluAla: 4.949 ± 0.075
0.28GluCys: 0.28 ± 0.015
2.482GluAsp: 2.482 ± 0.052
3.495GluGlu: 3.495 ± 0.065
2.149GluPhe: 2.149 ± 0.046
3.466GluGly: 3.466 ± 0.054
1.197GluHis: 1.197 ± 0.03
3.693GluIle: 3.693 ± 0.055
4.196GluLys: 4.196 ± 0.066
5.933GluLeu: 5.933 ± 0.078
1.362GluMet: 1.362 ± 0.033
2.944GluAsn: 2.944 ± 0.054
1.986GluPro: 1.986 ± 0.045
2.787GluGln: 2.787 ± 0.047
3.222GluArg: 3.222 ± 0.056
2.743GluSer: 2.743 ± 0.036
3.215GluThr: 3.215 ± 0.055
3.714GluVal: 3.714 ± 0.057
0.605GluTrp: 0.605 ± 0.027
1.644GluTyr: 1.644 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.86PheAla: 3.86 ± 0.059
0.494PheCys: 0.494 ± 0.018
2.987PheAsp: 2.987 ± 0.049
2.719PheGlu: 2.719 ± 0.042
2.558PhePhe: 2.558 ± 0.057
3.662PheGly: 3.662 ± 0.062
0.787PheHis: 0.787 ± 0.026
2.871PheIle: 2.871 ± 0.051
2.496PheLys: 2.496 ± 0.044
4.411PheLeu: 4.411 ± 0.067
1.101PheMet: 1.101 ± 0.029
2.579PheAsn: 2.579 ± 0.051
1.819PhePro: 1.819 ± 0.04
1.417PheGln: 1.417 ± 0.034
2.624PheArg: 2.624 ± 0.041
3.977PheSer: 3.977 ± 0.062
2.857PheThr: 2.857 ± 0.047
2.925PheVal: 2.925 ± 0.047
0.617PheTrp: 0.617 ± 0.022
1.973PheTyr: 1.973 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.714GlyAla: 5.714 ± 0.076
0.618GlyCys: 0.618 ± 0.024
3.343GlyAsp: 3.343 ± 0.054
3.498GlyGlu: 3.498 ± 0.049
3.878GlyPhe: 3.878 ± 0.057
5.438GlyGly: 5.438 ± 0.079
1.358GlyHis: 1.358 ± 0.035
4.966GlyIle: 4.966 ± 0.065
5.087GlyLys: 5.087 ± 0.06
7.304GlyLeu: 7.304 ± 0.075
1.943GlyMet: 1.943 ± 0.043
3.66GlyAsn: 3.66 ± 0.06
2.06GlyPro: 2.06 ± 0.046
2.832GlyGln: 2.832 ± 0.047
3.946GlyArg: 3.946 ± 0.063
5.065GlySer: 5.065 ± 0.064
4.545GlyThr: 4.545 ± 0.065
4.492GlyVal: 4.492 ± 0.065
1.057GlyTrp: 1.057 ± 0.028
3.226GlyTyr: 3.226 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.582HisAla: 1.582 ± 0.04
0.212HisCys: 0.212 ± 0.013
0.905HisAsp: 0.905 ± 0.029
1.07HisGlu: 1.07 ± 0.028
1.203HisPhe: 1.203 ± 0.034
1.246HisGly: 1.246 ± 0.036
0.501HisHis: 0.501 ± 0.021
1.227HisIle: 1.227 ± 0.031
0.84HisLys: 0.84 ± 0.027
1.967HisLeu: 1.967 ± 0.042
0.408HisMet: 0.408 ± 0.019
0.814HisAsn: 0.814 ± 0.026
1.048HisPro: 1.048 ± 0.031
0.757HisGln: 0.757 ± 0.023
1.019HisArg: 1.019 ± 0.027
1.031HisSer: 1.031 ± 0.029
1.013HisThr: 1.013 ± 0.03
1.086HisVal: 1.086 ± 0.025
0.258HisTrp: 0.258 ± 0.017
0.806HisTyr: 0.806 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.376IleAla: 5.376 ± 0.059
0.617IleCys: 0.617 ± 0.023
3.81IleAsp: 3.81 ± 0.048
3.501IleGlu: 3.501 ± 0.054
2.706IlePhe: 2.706 ± 0.048
4.475IleGly: 4.475 ± 0.072
1.087IleHis: 1.087 ± 0.035
3.471IleIle: 3.471 ± 0.057
3.109IleLys: 3.109 ± 0.057
5.32IleLeu: 5.32 ± 0.075
1.188IleMet: 1.188 ± 0.032
3.042IleAsn: 3.042 ± 0.05
2.745IlePro: 2.745 ± 0.046
1.946IleGln: 1.946 ± 0.041
3.766IleArg: 3.766 ± 0.059
4.381IleSer: 4.381 ± 0.067
3.578IleThr: 3.578 ± 0.061
3.665IleVal: 3.665 ± 0.051
0.672IleTrp: 0.672 ± 0.024
2.157IleTyr: 2.157 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.653LysAla: 4.653 ± 0.068
0.265LysCys: 0.265 ± 0.014
3.151LysAsp: 3.151 ± 0.054
3.406LysGlu: 3.406 ± 0.062
2.125LysPhe: 2.125 ± 0.044
3.867LysGly: 3.867 ± 0.053
1.101LysHis: 1.101 ± 0.029
3.709LysIle: 3.709 ± 0.059
4.37LysLys: 4.37 ± 0.066
5.285LysLeu: 5.285 ± 0.061
1.599LysMet: 1.599 ± 0.035
3.197LysAsn: 3.197 ± 0.053
2.574LysPro: 2.574 ± 0.05
2.286LysGln: 2.286 ± 0.044
2.766LysArg: 2.766 ± 0.045
3.127LysSer: 3.127 ± 0.047
3.699LysThr: 3.699 ± 0.051
3.531LysVal: 3.531 ± 0.059
0.666LysTrp: 0.666 ± 0.024
2.098LysTyr: 2.098 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
8.759LeuAla: 8.759 ± 0.099
0.844LeuCys: 0.844 ± 0.025
4.96LeuAsp: 4.96 ± 0.055
5.212LeuGlu: 5.212 ± 0.079
4.747LeuPhe: 4.747 ± 0.066
6.453LeuGly: 6.453 ± 0.08
1.916LeuHis: 1.916 ± 0.037
5.748LeuIle: 5.748 ± 0.086
6.082LeuLys: 6.082 ± 0.074
10.336LeuLeu: 10.336 ± 0.126
2.013LeuMet: 2.013 ± 0.037
5.125LeuAsn: 5.125 ± 0.065
4.635LeuPro: 4.635 ± 0.068
4.188LeuGln: 4.188 ± 0.053
5.275LeuArg: 5.275 ± 0.071
7.077LeuSer: 7.077 ± 0.074
5.341LeuThr: 5.341 ± 0.071
6.311LeuVal: 6.311 ± 0.076
0.94LeuTrp: 0.94 ± 0.03
3.14LeuTyr: 3.14 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
1.998MetAla: 1.998 ± 0.04
0.151MetCys: 0.151 ± 0.01
1.061MetAsp: 1.061 ± 0.028
1.342MetGlu: 1.342 ± 0.034
0.813MetPhe: 0.813 ± 0.029
1.533MetGly: 1.533 ± 0.039
0.443MetHis: 0.443 ± 0.019
1.299MetIle: 1.299 ± 0.037
1.838MetLys: 1.838 ± 0.034
2.256MetLeu: 2.256 ± 0.044
0.587MetMet: 0.587 ± 0.022
1.239MetAsn: 1.239 ± 0.032
1.087MetPro: 1.087 ± 0.032
1.074MetGln: 1.074 ± 0.029
1.256MetArg: 1.256 ± 0.027
1.346MetSer: 1.346 ± 0.033
1.211MetThr: 1.211 ± 0.032
1.365MetVal: 1.365 ± 0.036
0.181MetTrp: 0.181 ± 0.01
0.668MetTyr: 0.668 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.952AsnAla: 3.952 ± 0.065
0.384AsnCys: 0.384 ± 0.019
2.289AsnAsp: 2.289 ± 0.041
2.567AsnGlu: 2.567 ± 0.046
2.398AsnPhe: 2.398 ± 0.049
3.819AsnGly: 3.819 ± 0.057
0.813AsnHis: 0.813 ± 0.025
3.105AsnIle: 3.105 ± 0.052
2.634AsnLys: 2.634 ± 0.046
4.666AsnLeu: 4.666 ± 0.073
1.114AsnMet: 1.114 ± 0.031
2.434AsnAsn: 2.434 ± 0.053
2.469AsnPro: 2.469 ± 0.046
1.687AsnGln: 1.687 ± 0.036
2.754AsnArg: 2.754 ± 0.05
2.688AsnSer: 2.688 ± 0.053
2.773AsnThr: 2.773 ± 0.06
2.846AsnVal: 2.846 ± 0.056
0.716AsnTrp: 0.716 ± 0.026
2.151AsnTyr: 2.151 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
4.936ProAla: 4.936 ± 0.076
0.231ProCys: 0.231 ± 0.014
2.704ProAsp: 2.704 ± 0.045
3.277ProGlu: 3.277 ± 0.053
2.076ProPhe: 2.076 ± 0.041
3.946ProGly: 3.946 ± 0.06
0.751ProHis: 0.751 ± 0.026
1.885ProIle: 1.885 ± 0.032
1.836ProLys: 1.836 ± 0.038
3.686ProLeu: 3.686 ± 0.05
0.819ProMet: 0.819 ± 0.027
1.7ProAsn: 1.7 ± 0.037
1.232ProPro: 1.232 ± 0.041
1.528ProGln: 1.528 ± 0.037
1.579ProArg: 1.579 ± 0.041
2.055ProSer: 2.055 ± 0.046
1.68ProThr: 1.68 ± 0.04
3.733ProVal: 3.733 ± 0.059
0.443ProTrp: 0.443 ± 0.018
1.491ProTyr: 1.491 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
3.699GlnAla: 3.699 ± 0.055
0.181GlnCys: 0.181 ± 0.012
1.763GlnAsp: 1.763 ± 0.036
2.216GlnGlu: 2.216 ± 0.046
1.632GlnPhe: 1.632 ± 0.033
2.455GlnGly: 2.455 ± 0.043
0.853GlnHis: 0.853 ± 0.027
2.245GlnIle: 2.245 ± 0.042
2.328GlnLys: 2.328 ± 0.048
4.163GlnLeu: 4.163 ± 0.055
0.869GlnMet: 0.869 ± 0.026
1.798GlnAsn: 1.798 ± 0.04
1.893GlnPro: 1.893 ± 0.044
2.236GlnGln: 2.236 ± 0.051
1.988GlnArg: 1.988 ± 0.043
2.084GlnSer: 2.084 ± 0.041
2.241GlnThr: 2.241 ± 0.04
2.845GlnVal: 2.845 ± 0.044
0.43GlnTrp: 0.43 ± 0.017
1.283GlnTyr: 1.283 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.955ArgAla: 3.955 ± 0.065
0.324ArgCys: 0.324 ± 0.018
2.435ArgAsp: 2.435 ± 0.044
3.191ArgGlu: 3.191 ± 0.055
2.942ArgPhe: 2.942 ± 0.052
2.88ArgGly: 2.88 ± 0.056
1.104ArgHis: 1.104 ± 0.028
3.555ArgIle: 3.555 ± 0.051
3.322ArgLys: 3.322 ± 0.056
5.563ArgLeu: 5.563 ± 0.071
1.419ArgMet: 1.419 ± 0.031
2.778ArgAsn: 2.778 ± 0.05
2.173ArgPro: 2.173 ± 0.048
2.488ArgGln: 2.488 ± 0.046
2.782ArgArg: 2.782 ± 0.051
3.308ArgSer: 3.308 ± 0.053
2.664ArgThr: 2.664 ± 0.046
3.269ArgVal: 3.269 ± 0.053
0.686ArgTrp: 0.686 ± 0.025
2.421ArgTyr: 2.421 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
5.508SerAla: 5.508 ± 0.065
0.534SerCys: 0.534 ± 0.025
2.894SerAsp: 2.894 ± 0.046
2.992SerGlu: 2.992 ± 0.049
3.398SerPhe: 3.398 ± 0.054
5.625SerGly: 5.625 ± 0.085
1.109SerHis: 1.109 ± 0.029
3.717SerIle: 3.717 ± 0.047
3.175SerLys: 3.175 ± 0.056
6.301SerLeu: 6.301 ± 0.068
1.388SerMet: 1.388 ± 0.032
2.664SerAsn: 2.664 ± 0.05
2.506SerPro: 2.506 ± 0.047
1.994SerGln: 1.994 ± 0.039
3.325SerArg: 3.325 ± 0.057
3.774SerSer: 3.774 ± 0.056
3.143SerThr: 3.143 ± 0.052
4.195SerVal: 4.195 ± 0.06
0.844SerTrp: 0.844 ± 0.028
2.526SerTyr: 2.526 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
5.337ThrAla: 5.337 ± 0.068
0.382ThrCys: 0.382 ± 0.018
3.216ThrAsp: 3.216 ± 0.052
2.965ThrGlu: 2.965 ± 0.052
2.637ThrPhe: 2.637 ± 0.051
5.31ThrGly: 5.31 ± 0.073
0.936ThrHis: 0.936 ± 0.03
3.315ThrIle: 3.315 ± 0.052
2.412ThrLys: 2.412 ± 0.045
5.418ThrLeu: 5.418 ± 0.065
0.999ThrMet: 0.999 ± 0.027
2.33ThrAsn: 2.33 ± 0.049
2.621ThrPro: 2.621 ± 0.052
1.766ThrGln: 1.766 ± 0.037
2.651ThrArg: 2.651 ± 0.042
3.005ThrSer: 3.005 ± 0.048
3.025ThrThr: 3.025 ± 0.067
3.874ThrVal: 3.874 ± 0.056
0.698ThrTrp: 0.698 ± 0.026
2.173ThrTyr: 2.173 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
5.347ValAla: 5.347 ± 0.058
0.608ValCys: 0.608 ± 0.023
3.055ValAsp: 3.055 ± 0.057
3.208ValGlu: 3.208 ± 0.049
3.384ValPhe: 3.384 ± 0.052
3.831ValGly: 3.831 ± 0.063
1.178ValHis: 1.178 ± 0.032
4.247ValIle: 4.247 ± 0.061
3.623ValLys: 3.623 ± 0.061
6.666ValLeu: 6.666 ± 0.068
1.493ValMet: 1.493 ± 0.036
3.286ValAsn: 3.286 ± 0.055
2.917ValPro: 2.917 ± 0.058
2.388ValGln: 2.388 ± 0.04
3.456ValArg: 3.456 ± 0.052
4.594ValSer: 4.594 ± 0.061
3.887ValThr: 3.887 ± 0.056
4.517ValVal: 4.517 ± 0.065
0.74ValTrp: 0.74 ± 0.024
2.412ValTyr: 2.412 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.837TrpAla: 0.837 ± 0.028
0.11TrpCys: 0.11 ± 0.009
0.595TrpAsp: 0.595 ± 0.025
0.63TrpGlu: 0.63 ± 0.021
0.61TrpPhe: 0.61 ± 0.023
0.83TrpGly: 0.83 ± 0.023
0.255TrpHis: 0.255 ± 0.013
0.689TrpIle: 0.689 ± 0.027
0.829TrpLys: 0.829 ± 0.026
1.296TrpLeu: 1.296 ± 0.038
0.36TrpMet: 0.36 ± 0.017
0.664TrpAsn: 0.664 ± 0.024
0.43TrpPro: 0.43 ± 0.02
0.625TrpGln: 0.625 ± 0.027
0.601TrpArg: 0.601 ± 0.023
0.733TrpSer: 0.733 ± 0.026
0.676TrpThr: 0.676 ± 0.024
0.685TrpVal: 0.685 ± 0.024
0.194TrpTrp: 0.194 ± 0.013
0.488TrpTyr: 0.488 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.076TyrAla: 3.076 ± 0.052
0.295TyrCys: 0.295 ± 0.015
2.112TyrAsp: 2.112 ± 0.043
1.884TyrGlu: 1.884 ± 0.038
2.043TyrPhe: 2.043 ± 0.046
2.789TyrGly: 2.789 ± 0.05
0.843TyrHis: 0.843 ± 0.026
1.92TyrIle: 1.92 ± 0.045
2.016TyrLys: 2.016 ± 0.045
3.881TyrLeu: 3.881 ± 0.059
0.703TyrMet: 0.703 ± 0.022
2.054TyrAsn: 2.054 ± 0.049
1.709TyrPro: 1.709 ± 0.035
1.559TyrGln: 1.559 ± 0.037
2.381TyrArg: 2.381 ± 0.043
2.287TyrSer: 2.287 ± 0.047
2.349TyrThr: 2.349 ± 0.041
2.061TyrVal: 2.061 ± 0.041
0.501TyrTrp: 0.501 ± 0.023
1.548TyrTyr: 1.548 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3772 proteins (1296689 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski