Amino acid dipepetide frequency for Mesorhizobium sp. YR577

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.824AlaAla: 15.824 ± 0.148	0.947AlaCys: 0.947 ± 0.024	6.722AlaAsp: 6.722 ± 0.064	7.298AlaGlu: 7.298 ± 0.081	4.661AlaPhe: 4.661 ± 0.052	10.605AlaGly: 10.605 ± 0.083	2.005AlaHis: 2.005 ± 0.034	6.948AlaIle: 6.948 ± 0.075	4.583AlaLys: 4.583 ± 0.071	12.522AlaLeu: 12.522 ± 0.097	3.461AlaMet: 3.461 ± 0.04	3.152AlaAsn: 3.152 ± 0.058	4.985AlaPro: 4.985 ± 0.063	3.42AlaGln: 3.42 ± 0.04	7.658AlaArg: 7.658 ± 0.079	6.6AlaSer: 6.6 ± 0.07	6.02AlaThr: 6.02 ± 0.077	8.597AlaVal: 8.597 ± 0.073	1.394AlaTrp: 1.394 ± 0.025	2.645AlaTyr: 2.645 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.859CysAla: 0.859 ± 0.022	0.113CysCys: 0.113 ± 0.008	0.475CysAsp: 0.475 ± 0.016	0.434CysGlu: 0.434 ± 0.015	0.346CysPhe: 0.346 ± 0.013	0.862CysGly: 0.862 ± 0.022	0.21CysHis: 0.21 ± 0.01	0.383CysIle: 0.383 ± 0.014	0.196CysLys: 0.196 ± 0.009	0.738CysLeu: 0.738 ± 0.022	0.17CysMet: 0.17 ± 0.009	0.197CysAsn: 0.197 ± 0.009	0.391CysPro: 0.391 ± 0.016	0.22CysGln: 0.22 ± 0.012	0.572CysArg: 0.572 ± 0.018	0.455CysSer: 0.455 ± 0.016	0.383CysThr: 0.383 ± 0.015	0.568CysVal: 0.568 ± 0.017	0.1CysTrp: 0.1 ± 0.007	0.185CysTyr: 0.185 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.474AspAla: 6.474 ± 0.067	0.452AspCys: 0.452 ± 0.015	3.066AspAsp: 3.066 ± 0.049	3.447AspGlu: 3.447 ± 0.045	2.316AspPhe: 2.316 ± 0.037	5.251AspGly: 5.251 ± 0.08	1.255AspHis: 1.255 ± 0.024	3.341AspIle: 3.341 ± 0.039	1.926AspLys: 1.926 ± 0.037	5.542AspLeu: 5.542 ± 0.054	1.42AspMet: 1.42 ± 0.029	1.44AspAsn: 1.44 ± 0.026	3.28AspPro: 3.28 ± 0.045	1.657AspGln: 1.657 ± 0.03	4.118AspArg: 4.118 ± 0.044	2.182AspSer: 2.182 ± 0.04	2.641AspThr: 2.641 ± 0.068	4.113AspVal: 4.113 ± 0.051	0.929AspTrp: 0.929 ± 0.024	1.48AspTyr: 1.48 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.365GluAla: 7.365 ± 0.075	0.352GluCys: 0.352 ± 0.013	2.719GluAsp: 2.719 ± 0.044	3.153GluGlu: 3.153 ± 0.05	1.949GluPhe: 1.949 ± 0.033	4.158GluGly: 4.158 ± 0.047	1.168GluHis: 1.168 ± 0.023	3.75GluIle: 3.75 ± 0.044	2.809GluLys: 2.809 ± 0.044	5.312GluLeu: 5.312 ± 0.061	1.538GluMet: 1.538 ± 0.028	1.903GluAsn: 1.903 ± 0.028	2.761GluPro: 2.761 ± 0.046	1.977GluGln: 1.977 ± 0.034	4.642GluArg: 4.642 ± 0.054	2.401GluSer: 2.401 ± 0.039	3.618GluThr: 3.618 ± 0.042	3.688GluVal: 3.688 ± 0.05	0.742GluTrp: 0.742 ± 0.018	1.047GluTyr: 1.047 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.692PheAla: 4.692 ± 0.056	0.388PheCys: 0.388 ± 0.015	2.751PheAsp: 2.751 ± 0.038	2.271PheGlu: 2.271 ± 0.033	1.588PhePhe: 1.588 ± 0.032	3.9PheGly: 3.9 ± 0.052	0.78PheHis: 0.78 ± 0.021	1.965PheIle: 1.965 ± 0.033	1.119PheLys: 1.119 ± 0.027	3.633PheLeu: 3.633 ± 0.049	0.882PheMet: 0.882 ± 0.021	1.172PheAsn: 1.172 ± 0.032	1.645PhePro: 1.645 ± 0.032	1.169PheGln: 1.169 ± 0.026	2.312PheArg: 2.312 ± 0.034	2.605PheSer: 2.605 ± 0.039	2.007PheThr: 2.007 ± 0.042	3.077PheVal: 3.077 ± 0.044	0.606PheTrp: 0.606 ± 0.018	0.949PheTyr: 0.949 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	8.788GlyAla: 8.788 ± 0.074	0.786GlyCys: 0.786 ± 0.024	4.413GlyAsp: 4.413 ± 0.076	4.817GlyGlu: 4.817 ± 0.053	3.777GlyPhe: 3.777 ± 0.051	7.478GlyGly: 7.478 ± 0.115	1.771GlyHis: 1.771 ± 0.032	5.128GlyIle: 5.128 ± 0.054	3.911GlyLys: 3.911 ± 0.05	8.814GlyLeu: 8.814 ± 0.08	2.42GlyMet: 2.42 ± 0.035	2.44GlyAsn: 2.44 ± 0.049	3.315GlyPro: 3.315 ± 0.043	2.751GlyGln: 2.751 ± 0.044	5.582GlyArg: 5.582 ± 0.065	4.992GlySer: 4.992 ± 0.066	4.828GlyThr: 4.828 ± 0.108	6.222GlyVal: 6.222 ± 0.064	1.337GlyTrp: 1.337 ± 0.03	2.353GlyTyr: 2.353 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.16HisAla: 2.16 ± 0.036	0.217HisCys: 0.217 ± 0.01	1.236HisAsp: 1.236 ± 0.023	1.048HisGlu: 1.048 ± 0.02	0.874HisPhe: 0.874 ± 0.024	1.851HisGly: 1.851 ± 0.033	0.553HisHis: 0.553 ± 0.021	1.055HisIle: 1.055 ± 0.024	0.515HisLys: 0.515 ± 0.018	1.9HisLeu: 1.9 ± 0.033	0.522HisMet: 0.522 ± 0.016	0.477HisAsn: 0.477 ± 0.013	1.215HisPro: 1.215 ± 0.027	0.582HisGln: 0.582 ± 0.018	1.283HisArg: 1.283 ± 0.027	0.964HisSer: 0.964 ± 0.023	0.791HisThr: 0.791 ± 0.021	1.428HisVal: 1.428 ± 0.027	0.318HisTrp: 0.318 ± 0.012	0.539HisTyr: 0.539 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	7.831IleAla: 7.831 ± 0.068	0.547IleCys: 0.547 ± 0.017	3.792IleAsp: 3.792 ± 0.047	3.735IleGlu: 3.735 ± 0.043	2.027IlePhe: 2.027 ± 0.034	5.356IleGly: 5.356 ± 0.077	0.965IleHis: 0.965 ± 0.024	2.719IleIle: 2.719 ± 0.042	1.656IleLys: 1.656 ± 0.032	4.84IleLeu: 4.84 ± 0.055	1.141IleMet: 1.141 ± 0.027	1.569IleAsn: 1.569 ± 0.029	2.481IlePro: 2.481 ± 0.035	1.278IleGln: 1.278 ± 0.025	3.354IleArg: 3.354 ± 0.043	3.405IleSer: 3.405 ± 0.04	2.882IleThr: 2.882 ± 0.052	4.872IleVal: 4.872 ± 0.06	0.651IleTrp: 0.651 ± 0.017	1.23IleTyr: 1.23 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.816LysAla: 4.816 ± 0.065	0.162LysCys: 0.162 ± 0.009	1.955LysAsp: 1.955 ± 0.037	1.84LysGlu: 1.84 ± 0.037	1.091LysPhe: 1.091 ± 0.026	2.846LysGly: 2.846 ± 0.046	0.646LysHis: 0.646 ± 0.018	2.152LysIle: 2.152 ± 0.04	1.641LysLys: 1.641 ± 0.04	3.793LysLeu: 3.793 ± 0.053	0.91LysMet: 0.91 ± 0.02	1.11LysAsn: 1.11 ± 0.026	2.39LysPro: 2.39 ± 0.049	1.165LysGln: 1.165 ± 0.027	2.524LysArg: 2.524 ± 0.044	2.18LysSer: 2.18 ± 0.035	2.348LysThr: 2.348 ± 0.034	2.716LysVal: 2.716 ± 0.043	0.438LysTrp: 0.438 ± 0.014	0.698LysTyr: 0.698 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	12.662LeuAla: 12.662 ± 0.112	0.844LeuCys: 0.844 ± 0.021	5.816LeuAsp: 5.816 ± 0.059	5.195LeuGlu: 5.195 ± 0.056	3.779LeuPhe: 3.779 ± 0.053	8.263LeuGly: 8.263 ± 0.073	1.751LeuHis: 1.751 ± 0.035	5.305LeuIle: 5.305 ± 0.059	3.956LeuLys: 3.956 ± 0.053	9.329LeuLeu: 9.329 ± 0.103	2.296LeuMet: 2.296 ± 0.033	2.647LeuAsn: 2.647 ± 0.041	5.316LeuPro: 5.316 ± 0.049	2.602LeuGln: 2.602 ± 0.04	6.111LeuArg: 6.111 ± 0.067	6.717LeuSer: 6.717 ± 0.058	5.474LeuThr: 5.474 ± 0.062	7.405LeuVal: 7.405 ± 0.061	1.112LeuTrp: 1.112 ± 0.027	2.097LeuTyr: 2.097 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	3.11MetAla: 3.11 ± 0.046	0.142MetCys: 0.142 ± 0.009	1.088MetAsp: 1.088 ± 0.023	1.179MetGlu: 1.179 ± 0.026	0.777MetPhe: 0.777 ± 0.019	1.791MetGly: 1.791 ± 0.032	0.444MetHis: 0.444 ± 0.015	1.514MetIle: 1.514 ± 0.029	1.178MetLys: 1.178 ± 0.027	2.62MetLeu: 2.62 ± 0.042	0.712MetMet: 0.712 ± 0.02	0.895MetAsn: 0.895 ± 0.022	1.482MetPro: 1.482 ± 0.028	0.857MetGln: 0.857 ± 0.021	1.805MetArg: 1.805 ± 0.031	1.772MetSer: 1.772 ± 0.03	1.889MetThr: 1.889 ± 0.031	1.787MetVal: 1.787 ± 0.031	0.225MetTrp: 0.225 ± 0.01	0.329MetTyr: 0.329 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.423AsnAla: 3.423 ± 0.041	0.233AsnCys: 0.233 ± 0.012	1.595AsnAsp: 1.595 ± 0.051	1.396AsnGlu: 1.396 ± 0.028	1.08AsnPhe: 1.08 ± 0.022	2.755AsnGly: 2.755 ± 0.071	0.542AsnHis: 0.542 ± 0.018	1.553AsnIle: 1.553 ± 0.025	0.809AsnLys: 0.809 ± 0.022	2.723AsnLeu: 2.723 ± 0.036	0.688AsnMet: 0.688 ± 0.018	0.779AsnAsn: 0.779 ± 0.025	1.977AsnPro: 1.977 ± 0.036	0.784AsnGln: 0.784 ± 0.023	1.876AsnArg: 1.876 ± 0.03	1.469AsnSer: 1.469 ± 0.03	1.371AsnThr: 1.371 ± 0.028	2.072AsnVal: 2.072 ± 0.035	0.459AsnTrp: 0.459 ± 0.018	0.762AsnTyr: 0.762 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	5.957ProAla: 5.957 ± 0.072	0.282ProCys: 0.282 ± 0.011	3.416ProAsp: 3.416 ± 0.049	3.626ProGlu: 3.626 ± 0.044	2.052ProPhe: 2.052 ± 0.037	4.201ProGly: 4.201 ± 0.046	1.017ProHis: 1.017 ± 0.02	2.447ProIle: 2.447 ± 0.04	1.904ProLys: 1.904 ± 0.036	4.608ProLeu: 4.608 ± 0.051	1.17ProMet: 1.17 ± 0.026	1.442ProAsn: 1.442 ± 0.029	2.109ProPro: 2.109 ± 0.041	1.552ProGln: 1.552 ± 0.031	2.6ProArg: 2.6 ± 0.04	2.809ProSer: 2.809 ± 0.04	2.46ProThr: 2.46 ± 0.036	4.243ProVal: 4.243 ± 0.055	0.622ProTrp: 0.622 ± 0.017	1.246ProTyr: 1.246 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.728GlnAla: 3.728 ± 0.04	0.193GlnCys: 0.193 ± 0.009	1.396GlnAsp: 1.396 ± 0.026	1.492GlnGlu: 1.492 ± 0.03	1.091GlnPhe: 1.091 ± 0.025	2.229GlnGly: 2.229 ± 0.035	0.589GlnHis: 0.589 ± 0.018	1.841GlnIle: 1.841 ± 0.029	1.234GlnLys: 1.234 ± 0.025	2.73GlnLeu: 2.73 ± 0.04	0.877GlnMet: 0.877 ± 0.019	0.917GlnAsn: 0.917 ± 0.02	1.73GlnPro: 1.73 ± 0.038	1.122GlnGln: 1.122 ± 0.026	2.236GlnArg: 2.236 ± 0.034	1.809GlnSer: 1.809 ± 0.036	1.687GlnThr: 1.687 ± 0.03	1.987GlnVal: 1.987 ± 0.034	0.392GlnTrp: 0.392 ± 0.015	0.601GlnTyr: 0.601 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	6.876ArgAla: 6.876 ± 0.065	0.454ArgCys: 0.454 ± 0.016	3.801ArgAsp: 3.801 ± 0.049	3.954ArgGlu: 3.954 ± 0.059	2.823ArgPhe: 2.823 ± 0.044	4.405ArgGly: 4.405 ± 0.059	1.602ArgHis: 1.602 ± 0.031	3.938ArgIle: 3.938 ± 0.043	2.567ArgLys: 2.567 ± 0.039	7.038ArgLeu: 7.038 ± 0.069	1.816ArgMet: 1.816 ± 0.029	2.005ArgAsn: 2.005 ± 0.031	3.197ArgPro: 3.197 ± 0.043	2.401ArgGln: 2.401 ± 0.033	4.886ArgArg: 4.886 ± 0.062	3.659ArgSer: 3.659 ± 0.049	3.279ArgThr: 3.279 ± 0.044	4.36ArgVal: 4.36 ± 0.048	0.901ArgTrp: 0.901 ± 0.022	1.646ArgTyr: 1.646 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.418SerAla: 6.418 ± 0.06	0.411SerCys: 0.411 ± 0.015	3.131SerAsp: 3.131 ± 0.048	3.033SerGlu: 3.033 ± 0.038	2.523SerPhe: 2.523 ± 0.043	5.987SerGly: 5.987 ± 0.075	1.157SerHis: 1.157 ± 0.025	3.166SerIle: 3.166 ± 0.036	1.855SerLys: 1.855 ± 0.036	5.675SerLeu: 5.675 ± 0.06	1.437SerMet: 1.437 ± 0.03	1.553SerAsn: 1.553 ± 0.028	2.877SerPro: 2.877 ± 0.039	1.65SerGln: 1.65 ± 0.029	3.665SerArg: 3.665 ± 0.047	3.273SerSer: 3.273 ± 0.046	2.899SerThr: 2.899 ± 0.042	4.331SerVal: 4.331 ± 0.052	0.803SerTrp: 0.803 ± 0.022	1.399SerTyr: 1.399 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.337ThrAla: 6.337 ± 0.082	0.361ThrCys: 0.361 ± 0.015	2.808ThrAsp: 2.808 ± 0.043	2.73ThrGlu: 2.73 ± 0.04	2.191ThrPhe: 2.191 ± 0.036	5.175ThrGly: 5.175 ± 0.069	1.017ThrHis: 1.017 ± 0.022	3.284ThrIle: 3.284 ± 0.052	1.715ThrLys: 1.715 ± 0.034	5.698ThrLeu: 5.698 ± 0.066	1.324ThrMet: 1.324 ± 0.025	1.4ThrAsn: 1.4 ± 0.036	3.121ThrPro: 3.121 ± 0.049	1.429ThrGln: 1.429 ± 0.028	3.059ThrArg: 3.059 ± 0.039	2.923ThrSer: 2.923 ± 0.039	3.062ThrThr: 3.062 ± 0.059	4.671ThrVal: 4.671 ± 0.088	0.657ThrTrp: 0.657 ± 0.019	1.25ThrTyr: 1.25 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.007ValAla: 9.007 ± 0.076	0.598ValCys: 0.598 ± 0.022	4.088ValAsp: 4.088 ± 0.05	4.577ValGlu: 4.577 ± 0.051	3.02ValPhe: 3.02 ± 0.041	5.709ValGly: 5.709 ± 0.065	1.27ValHis: 1.27 ± 0.026	4.199ValIle: 4.199 ± 0.045	2.614ValLys: 2.614 ± 0.042	7.322ValLeu: 7.322 ± 0.072	1.994ValMet: 1.994 ± 0.032	2.116ValAsn: 2.116 ± 0.056	3.686ValPro: 3.686 ± 0.044	1.964ValGln: 1.964 ± 0.035	4.558ValArg: 4.558 ± 0.054	4.84ValSer: 4.84 ± 0.057	4.629ValThr: 4.629 ± 0.085	6.043ValVal: 6.043 ± 0.065	0.892ValTrp: 0.892 ± 0.024	1.529ValTyr: 1.529 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.218TrpAla: 1.218 ± 0.026	0.137TrpCys: 0.137 ± 0.009	0.59TrpAsp: 0.59 ± 0.018	0.548TrpGlu: 0.548 ± 0.016	0.552TrpPhe: 0.552 ± 0.016	0.896TrpGly: 0.896 ± 0.022	0.314TrpHis: 0.314 ± 0.012	0.687TrpIle: 0.687 ± 0.02	0.522TrpLys: 0.522 ± 0.016	1.595TrpLeu: 1.595 ± 0.028	0.36TrpMet: 0.36 ± 0.014	0.506TrpAsn: 0.506 ± 0.018	0.671TrpPro: 0.671 ± 0.02	0.563TrpGln: 0.563 ± 0.017	1.043TrpArg: 1.043 ± 0.024	0.869TrpSer: 0.869 ± 0.025	0.775TrpThr: 0.775 ± 0.021	0.779TrpVal: 0.779 ± 0.019	0.218TrpTrp: 0.218 ± 0.009	0.3TrpTyr: 0.3 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.501TyrAla: 2.501 ± 0.036	0.238TyrCys: 0.238 ± 0.01	1.47TyrAsp: 1.47 ± 0.029	1.28TyrGlu: 1.28 ± 0.024	0.994TyrPhe: 0.994 ± 0.022	2.204TyrGly: 2.204 ± 0.036	0.472TyrHis: 0.472 ± 0.015	0.959TyrIle: 0.959 ± 0.024	0.713TyrLys: 0.713 ± 0.022	2.244TyrLeu: 2.244 ± 0.04	0.458TyrMet: 0.458 ± 0.016	0.627TyrAsn: 0.627 ± 0.019	1.135TyrPro: 1.135 ± 0.022	0.737TyrGln: 0.737 ± 0.02	1.722TyrArg: 1.722 ± 0.033	1.319TyrSer: 1.319 ± 0.024	1.17TyrThr: 1.17 ± 0.04	1.697TyrVal: 1.697 ± 0.027	0.345TyrTrp: 0.345 ± 0.015	0.579TyrTyr: 0.579 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6444 proteins (2014053 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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