Amino acid dipepetide frequency for Phaeobacter inhibens (strain ATCC 700781 / DSM 17395 / CIP 105210 / JCM 21319 / NBRC 16654 / NCIMB 13546 / BS107)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.446AlaAla: 16.446 ± 0.181
1.074AlaCys: 1.074 ± 0.034
7.098AlaAsp: 7.098 ± 0.083
8.425AlaGlu: 8.425 ± 0.097
3.945AlaPhe: 3.945 ± 0.054
10.178AlaGly: 10.178 ± 0.098
2.35AlaHis: 2.35 ± 0.048
5.599AlaIle: 5.599 ± 0.073
4.024AlaLys: 4.024 ± 0.06
13.504AlaLeu: 13.504 ± 0.13
3.592AlaMet: 3.592 ± 0.052
2.848AlaAsn: 2.848 ± 0.054
5.684AlaPro: 5.684 ± 0.081
4.736AlaGln: 4.736 ± 0.074
8.095AlaArg: 8.095 ± 0.095
5.707AlaSer: 5.707 ± 0.078
5.943AlaThr: 5.943 ± 0.073
8.157AlaVal: 8.157 ± 0.091
1.257AlaTrp: 1.257 ± 0.038
2.584AlaTyr: 2.584 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
1.181CysAla: 1.181 ± 0.03
0.137CysCys: 0.137 ± 0.011
0.673CysAsp: 0.673 ± 0.021
0.485CysGlu: 0.485 ± 0.022
0.339CysPhe: 0.339 ± 0.017
0.959CysGly: 0.959 ± 0.028
0.276CysHis: 0.276 ± 0.016
0.449CysIle: 0.449 ± 0.021
0.232CysLys: 0.232 ± 0.015
0.918CysLeu: 0.918 ± 0.03
0.184CysMet: 0.184 ± 0.011
0.275CysAsn: 0.275 ± 0.016
0.502CysPro: 0.502 ± 0.023
0.29CysGln: 0.29 ± 0.014
0.545CysArg: 0.545 ± 0.022
0.495CysSer: 0.495 ± 0.022
0.473CysThr: 0.473 ± 0.022
0.606CysVal: 0.606 ± 0.021
0.118CysTrp: 0.118 ± 0.01
0.247CysTyr: 0.247 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
6.98AspAla: 6.98 ± 0.078
0.6AspCys: 0.6 ± 0.022
3.36AspAsp: 3.36 ± 0.062
3.279AspGlu: 3.279 ± 0.06
2.256AspPhe: 2.256 ± 0.043
5.547AspGly: 5.547 ± 0.075
1.583AspHis: 1.583 ± 0.041
3.222AspIle: 3.222 ± 0.052
1.679AspLys: 1.679 ± 0.045
6.917AspLeu: 6.917 ± 0.079
1.703AspMet: 1.703 ± 0.041
1.408AspAsn: 1.408 ± 0.031
3.558AspPro: 3.558 ± 0.055
2.396AspGln: 2.396 ± 0.044
4.242AspArg: 4.242 ± 0.066
2.598AspSer: 2.598 ± 0.051
3.108AspThr: 3.108 ± 0.065
4.316AspVal: 4.316 ± 0.066
1.212AspTrp: 1.212 ± 0.037
1.592AspTyr: 1.592 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
7.822GluAla: 7.822 ± 0.09
0.37GluCys: 0.37 ± 0.018
3.555GluAsp: 3.555 ± 0.058
3.484GluGlu: 3.484 ± 0.065
1.801GluPhe: 1.801 ± 0.036
4.523GluGly: 4.523 ± 0.067
1.129GluHis: 1.129 ± 0.031
3.647GluIle: 3.647 ± 0.055
2.023GluLys: 2.023 ± 0.054
5.419GluLeu: 5.419 ± 0.071
1.814GluMet: 1.814 ± 0.036
1.738GluAsn: 1.738 ± 0.035
2.33GluPro: 2.33 ± 0.054
2.363GluGln: 2.363 ± 0.048
3.931GluArg: 3.931 ± 0.063
2.113GluSer: 2.113 ± 0.046
3.955GluThr: 3.955 ± 0.061
4.353GluVal: 4.353 ± 0.07
0.682GluTrp: 0.682 ± 0.025
1.036GluTyr: 1.036 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.412PheAla: 4.412 ± 0.06
0.455PheCys: 0.455 ± 0.02
2.933PheAsp: 2.933 ± 0.047
2.151PheGlu: 2.151 ± 0.05
1.324PhePhe: 1.324 ± 0.045
3.53PheGly: 3.53 ± 0.061
0.743PheHis: 0.743 ± 0.023
1.525PheIle: 1.525 ± 0.034
0.939PheLys: 0.939 ± 0.028
3.328PheLeu: 3.328 ± 0.063
0.874PheMet: 0.874 ± 0.026
1.083PheAsn: 1.083 ± 0.035
1.432PhePro: 1.432 ± 0.039
1.152PheGln: 1.152 ± 0.033
1.93PheArg: 1.93 ± 0.04
2.159PheSer: 2.159 ± 0.043
1.965PheThr: 1.965 ± 0.047
2.479PheVal: 2.479 ± 0.049
0.569PheTrp: 0.569 ± 0.023
0.928PheTyr: 0.928 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
9.542GlyAla: 9.542 ± 0.097
0.89GlyCys: 0.89 ± 0.027
4.946GlyAsp: 4.946 ± 0.075
4.573GlyGlu: 4.573 ± 0.058
3.64GlyPhe: 3.64 ± 0.061
7.281GlyGly: 7.281 ± 0.104
1.954GlyHis: 1.954 ± 0.042
4.209GlyIle: 4.209 ± 0.06
3.133GlyLys: 3.133 ± 0.063
8.956GlyLeu: 8.956 ± 0.101
2.468GlyMet: 2.468 ± 0.044
2.254GlyAsn: 2.254 ± 0.054
3.403GlyPro: 3.403 ± 0.049
3.41GlyGln: 3.41 ± 0.053
5.368GlyArg: 5.368 ± 0.07
4.381GlySer: 4.381 ± 0.062
4.504GlyThr: 4.504 ± 0.076
6.176GlyVal: 6.176 ± 0.075
1.452GlyTrp: 1.452 ± 0.033
2.36GlyTyr: 2.36 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.271HisAla: 2.271 ± 0.041
0.272HisCys: 0.272 ± 0.015
1.339HisAsp: 1.339 ± 0.031
1.029HisGlu: 1.029 ± 0.028
0.839HisPhe: 0.839 ± 0.024
1.909HisGly: 1.909 ± 0.039
0.592HisHis: 0.592 ± 0.023
1.067HisIle: 1.067 ± 0.034
0.597HisLys: 0.597 ± 0.023
2.242HisLeu: 2.242 ± 0.045
0.592HisMet: 0.592 ± 0.025
0.53HisAsn: 0.53 ± 0.022
1.444HisPro: 1.444 ± 0.035
0.798HisGln: 0.798 ± 0.025
1.386HisArg: 1.386 ± 0.036
1.047HisSer: 1.047 ± 0.033
0.886HisThr: 0.886 ± 0.028
1.519HisVal: 1.519 ± 0.032
0.38HisTrp: 0.38 ± 0.019
0.587HisTyr: 0.587 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.82IleAla: 6.82 ± 0.072
0.665IleCys: 0.665 ± 0.022
3.326IleAsp: 3.326 ± 0.057
3.36IleGlu: 3.36 ± 0.053
1.66IlePhe: 1.66 ± 0.042
4.727IleGly: 4.727 ± 0.071
0.948IleHis: 0.948 ± 0.029
2.127IleIle: 2.127 ± 0.051
1.531IleLys: 1.531 ± 0.038
4.809IleLeu: 4.809 ± 0.066
1.083IleMet: 1.083 ± 0.031
1.519IleAsn: 1.519 ± 0.034
2.222IlePro: 2.222 ± 0.048
1.306IleGln: 1.306 ± 0.034
3.206IleArg: 3.206 ± 0.05
3.157IleSer: 3.157 ± 0.055
3.074IleThr: 3.074 ± 0.057
3.266IleVal: 3.266 ± 0.055
0.755IleTrp: 0.755 ± 0.026
1.28IleTyr: 1.28 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
3.807LysAla: 3.807 ± 0.065
0.181LysCys: 0.181 ± 0.013
1.951LysAsp: 1.951 ± 0.038
1.591LysGlu: 1.591 ± 0.043
0.945LysPhe: 0.945 ± 0.031
2.655LysGly: 2.655 ± 0.057
0.641LysHis: 0.641 ± 0.024
1.737LysIle: 1.737 ± 0.041
1.173LysLys: 1.173 ± 0.041
2.975LysLeu: 2.975 ± 0.045
0.908LysMet: 0.908 ± 0.029
0.839LysAsn: 0.839 ± 0.027
1.839LysPro: 1.839 ± 0.044
1.02LysGln: 1.02 ± 0.028
2.242LysArg: 2.242 ± 0.046
1.972LysSer: 1.972 ± 0.039
2.134LysThr: 2.134 ± 0.038
2.214LysVal: 2.214 ± 0.047
0.374LysTrp: 0.374 ± 0.019
0.649LysTyr: 0.649 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
12.799LeuAla: 12.799 ± 0.137
1.049LeuCys: 1.049 ± 0.03
5.957LeuAsp: 5.957 ± 0.078
5.448LeuGlu: 5.448 ± 0.062
3.458LeuPhe: 3.458 ± 0.058
8.245LeuGly: 8.245 ± 0.097
2.035LeuHis: 2.035 ± 0.044
5.347LeuIle: 5.347 ± 0.075
3.234LeuLys: 3.234 ± 0.057
9.191LeuLeu: 9.191 ± 0.118
2.83LeuMet: 2.83 ± 0.048
2.86LeuAsn: 2.86 ± 0.049
5.658LeuPro: 5.658 ± 0.07
3.194LeuGln: 3.194 ± 0.051
7.501LeuArg: 7.501 ± 0.076
7.097LeuSer: 7.097 ± 0.091
6.172LeuThr: 6.172 ± 0.071
6.651LeuVal: 6.651 ± 0.08
1.314LeuTrp: 1.314 ± 0.033
1.961LeuTyr: 1.961 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
3.48MetAla: 3.48 ± 0.053
0.199MetCys: 0.199 ± 0.012
1.453MetAsp: 1.453 ± 0.035
1.337MetGlu: 1.337 ± 0.031
0.81MetPhe: 0.81 ± 0.026
2.248MetGly: 2.248 ± 0.046
0.457MetHis: 0.457 ± 0.02
1.549MetIle: 1.549 ± 0.035
1.012MetLys: 1.012 ± 0.028
2.691MetLeu: 2.691 ± 0.044
0.849MetMet: 0.849 ± 0.029
0.815MetAsn: 0.815 ± 0.025
1.521MetPro: 1.521 ± 0.036
1.176MetGln: 1.176 ± 0.033
1.878MetArg: 1.878 ± 0.043
1.793MetSer: 1.793 ± 0.04
2.141MetThr: 2.141 ± 0.037
1.913MetVal: 1.913 ± 0.04
0.244MetTrp: 0.244 ± 0.014
0.338MetTyr: 0.338 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.229AsnAla: 3.229 ± 0.05
0.271AsnCys: 0.271 ± 0.015
1.537AsnAsp: 1.537 ± 0.047
1.223AsnGlu: 1.223 ± 0.031
0.974AsnPhe: 0.974 ± 0.027
2.522AsnGly: 2.522 ± 0.052
0.564AsnHis: 0.564 ± 0.025
1.449AsnIle: 1.449 ± 0.037
0.707AsnLys: 0.707 ± 0.026
2.608AsnLeu: 2.608 ± 0.047
0.749AsnMet: 0.749 ± 0.024
0.716AsnAsn: 0.716 ± 0.027
1.882AsnPro: 1.882 ± 0.036
0.843AsnGln: 0.843 ± 0.031
1.905AsnArg: 1.905 ± 0.036
1.3AsnSer: 1.3 ± 0.034
1.44AsnThr: 1.44 ± 0.041
1.831AsnVal: 1.831 ± 0.044
0.476AsnTrp: 0.476 ± 0.02
0.63AsnTyr: 0.63 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
5.611ProAla: 5.611 ± 0.078
0.377ProCys: 0.377 ± 0.019
3.806ProAsp: 3.806 ± 0.062
3.933ProGlu: 3.933 ± 0.068
1.844ProPhe: 1.844 ± 0.042
4.18ProGly: 4.18 ± 0.057
1.045ProHis: 1.045 ± 0.026
2.138ProIle: 2.138 ± 0.044
1.716ProLys: 1.716 ± 0.04
4.763ProLeu: 4.763 ± 0.068
1.376ProMet: 1.376 ± 0.037
1.339ProAsn: 1.339 ± 0.035
2.143ProPro: 2.143 ± 0.048
2.027ProGln: 2.027 ± 0.042
2.671ProArg: 2.671 ± 0.05
2.557ProSer: 2.557 ± 0.045
2.501ProThr: 2.501 ± 0.046
4.128ProVal: 4.128 ± 0.058
0.643ProTrp: 0.643 ± 0.028
1.186ProTyr: 1.186 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.291GlnAla: 4.291 ± 0.065
0.224GlnCys: 0.224 ± 0.013
2.099GlnAsp: 2.099 ± 0.042
1.793GlnGlu: 1.793 ± 0.04
1.234GlnPhe: 1.234 ± 0.032
2.807GlnGly: 2.807 ± 0.036
0.727GlnHis: 0.727 ± 0.025
2.279GlnIle: 2.279 ± 0.044
1.203GlnLys: 1.203 ± 0.034
3.68GlnLeu: 3.68 ± 0.061
1.22GlnMet: 1.22 ± 0.032
0.995GlnAsn: 0.995 ± 0.028
1.875GlnPro: 1.875 ± 0.041
1.47GlnGln: 1.47 ± 0.039
2.532GlnArg: 2.532 ± 0.047
2.147GlnSer: 2.147 ± 0.046
2.121GlnThr: 2.121 ± 0.042
2.515GlnVal: 2.515 ± 0.053
0.45GlnTrp: 0.45 ± 0.018
0.66GlnTyr: 0.66 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
7.578ArgAla: 7.578 ± 0.084
0.549ArgCys: 0.549 ± 0.021
4.243ArgAsp: 4.243 ± 0.054
3.574ArgGlu: 3.574 ± 0.058
2.579ArgPhe: 2.579 ± 0.045
4.439ArgGly: 4.439 ± 0.064
1.58ArgHis: 1.58 ± 0.035
3.622ArgIle: 3.622 ± 0.059
2.265ArgLys: 2.265 ± 0.046
7.246ArgLeu: 7.246 ± 0.097
1.933ArgMet: 1.933 ± 0.041
1.926ArgAsn: 1.926 ± 0.041
3.162ArgPro: 3.162 ± 0.055
2.589ArgGln: 2.589 ± 0.046
4.831ArgArg: 4.831 ± 0.084
3.57ArgSer: 3.57 ± 0.062
2.844ArgThr: 2.844 ± 0.048
4.432ArgVal: 4.432 ± 0.065
0.934ArgTrp: 0.934 ± 0.029
1.573ArgTyr: 1.573 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.235SerAla: 6.235 ± 0.079
0.487SerCys: 0.487 ± 0.021
3.678SerAsp: 3.678 ± 0.064
3.074SerGlu: 3.074 ± 0.057
2.219SerPhe: 2.219 ± 0.049
5.573SerGly: 5.573 ± 0.077
1.274SerHis: 1.274 ± 0.034
2.499SerIle: 2.499 ± 0.045
1.648SerLys: 1.648 ± 0.038
5.235SerLeu: 5.235 ± 0.071
1.448SerMet: 1.448 ± 0.033
1.493SerAsn: 1.493 ± 0.037
2.611SerPro: 2.611 ± 0.044
1.88SerGln: 1.88 ± 0.042
3.319SerArg: 3.319 ± 0.056
2.745SerSer: 2.745 ± 0.053
2.669SerThr: 2.669 ± 0.05
3.841SerVal: 3.841 ± 0.051
0.814SerTrp: 0.814 ± 0.027
1.482SerTyr: 1.482 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
6.536ThrAla: 6.536 ± 0.086
0.535ThrCys: 0.535 ± 0.021
3.107ThrAsp: 3.107 ± 0.05
2.92ThrGlu: 2.92 ± 0.051
1.766ThrPhe: 1.766 ± 0.04
5.252ThrGly: 5.252 ± 0.061
1.214ThrHis: 1.214 ± 0.031
2.625ThrIle: 2.625 ± 0.057
1.563ThrLys: 1.563 ± 0.037
6.252ThrLeu: 6.252 ± 0.082
1.264ThrMet: 1.264 ± 0.028
1.299ThrAsn: 1.299 ± 0.038
3.596ThrPro: 3.596 ± 0.058
1.741ThrGln: 1.741 ± 0.036
3.464ThrArg: 3.464 ± 0.061
2.997ThrSer: 2.997 ± 0.056
2.95ThrThr: 2.95 ± 0.064
4.118ThrVal: 4.118 ± 0.065
0.669ThrTrp: 0.669 ± 0.026
1.314ThrTyr: 1.314 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.384ValAla: 8.384 ± 0.095
0.623ValCys: 0.623 ± 0.023
4.087ValAsp: 4.087 ± 0.067
4.444ValGlu: 4.444 ± 0.067
2.796ValPhe: 2.796 ± 0.047
5.146ValGly: 5.146 ± 0.064
1.272ValHis: 1.272 ± 0.031
4.116ValIle: 4.116 ± 0.066
2.14ValLys: 2.14 ± 0.05
7.348ValLeu: 7.348 ± 0.083
2.121ValMet: 2.121 ± 0.043
1.912ValAsn: 1.912 ± 0.039
3.376ValPro: 3.376 ± 0.05
2.335ValGln: 2.335 ± 0.044
3.791ValArg: 3.791 ± 0.063
4.291ValSer: 4.291 ± 0.056
4.492ValThr: 4.492 ± 0.061
5.527ValVal: 5.527 ± 0.079
0.86ValTrp: 0.86 ± 0.024
1.408ValTyr: 1.408 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.331TrpAla: 1.331 ± 0.034
0.16TrpCys: 0.16 ± 0.01
0.767TrpAsp: 0.767 ± 0.027
0.681TrpGlu: 0.681 ± 0.024
0.576TrpPhe: 0.576 ± 0.023
1.028TrpGly: 1.028 ± 0.033
0.346TrpHis: 0.346 ± 0.017
0.711TrpIle: 0.711 ± 0.026
0.412TrpLys: 0.412 ± 0.018
1.604TrpLeu: 1.604 ± 0.041
0.388TrpMet: 0.388 ± 0.021
0.409TrpAsn: 0.409 ± 0.021
0.677TrpPro: 0.677 ± 0.023
0.739TrpGln: 0.739 ± 0.022
1.042TrpArg: 1.042 ± 0.031
0.84TrpSer: 0.84 ± 0.028
0.73TrpThr: 0.73 ± 0.024
0.874TrpVal: 0.874 ± 0.028
0.224TrpTrp: 0.224 ± 0.013
0.26TrpTyr: 0.26 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.489TyrAla: 2.489 ± 0.046
0.266TyrCys: 0.266 ± 0.014
1.642TyrAsp: 1.642 ± 0.036
1.284TyrGlu: 1.284 ± 0.032
0.908TyrPhe: 0.908 ± 0.024
2.153TyrGly: 2.153 ± 0.043
0.597TyrHis: 0.597 ± 0.023
0.925TyrIle: 0.925 ± 0.027
0.614TyrLys: 0.614 ± 0.023
2.315TyrLeu: 2.315 ± 0.043
0.503TyrMet: 0.503 ± 0.02
0.595TyrAsn: 0.595 ± 0.023
1.07TyrPro: 1.07 ± 0.031
0.859TyrGln: 0.859 ± 0.026
1.591TyrArg: 1.591 ± 0.04
1.255TyrSer: 1.255 ± 0.033
1.079TyrThr: 1.079 ± 0.026
1.554TyrVal: 1.554 ± 0.034
0.376TyrTrp: 0.376 ± 0.017
0.606TyrTyr: 0.606 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3853 proteins (1234078 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski