Amino acid dipepetide frequency for Corynebacterium doosanense CAU 212 = DSM 45436

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.437AlaAla: 16.437 ± 0.213
0.799AlaCys: 0.799 ± 0.032
7.598AlaAsp: 7.598 ± 0.109
8.58AlaGlu: 8.58 ± 0.123
3.444AlaPhe: 3.444 ± 0.069
11.091AlaGly: 11.091 ± 0.15
2.292AlaHis: 2.292 ± 0.057
4.865AlaIle: 4.865 ± 0.082
2.874AlaLys: 2.874 ± 0.073
11.796AlaLeu: 11.796 ± 0.163
2.683AlaMet: 2.683 ± 0.057
2.552AlaAsn: 2.552 ± 0.066
5.45AlaPro: 5.45 ± 0.105
4.054AlaGln: 4.054 ± 0.083
7.893AlaArg: 7.893 ± 0.131
6.156AlaSer: 6.156 ± 0.097
7.006AlaThr: 7.006 ± 0.095
10.169AlaVal: 10.169 ± 0.134
1.57AlaTrp: 1.57 ± 0.047
2.27AlaTyr: 2.27 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.716CysAla: 0.716 ± 0.032
0.056CysCys: 0.056 ± 0.01
0.368CysAsp: 0.368 ± 0.024
0.335CysGlu: 0.335 ± 0.023
0.182CysPhe: 0.182 ± 0.015
0.65CysGly: 0.65 ± 0.036
0.172CysHis: 0.172 ± 0.015
0.242CysIle: 0.242 ± 0.018
0.095CysLys: 0.095 ± 0.013
0.495CysLeu: 0.495 ± 0.028
0.092CysMet: 0.092 ± 0.011
0.141CysAsn: 0.141 ± 0.014
0.349CysPro: 0.349 ± 0.024
0.179CysGln: 0.179 ± 0.016
0.397CysArg: 0.397 ± 0.025
0.472CysSer: 0.472 ± 0.026
0.35CysThr: 0.35 ± 0.02
0.496CysVal: 0.496 ± 0.032
0.087CysTrp: 0.087 ± 0.011
0.132CysTyr: 0.132 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.37AspAla: 7.37 ± 0.099
0.327AspCys: 0.327 ± 0.02
4.141AspAsp: 4.141 ± 0.087
4.677AspGlu: 4.677 ± 0.076
2.08AspPhe: 2.08 ± 0.053
5.613AspGly: 5.613 ± 0.106
1.352AspHis: 1.352 ± 0.044
2.87AspIle: 2.87 ± 0.055
1.67AspLys: 1.67 ± 0.061
6.095AspLeu: 6.095 ± 0.103
1.241AspMet: 1.241 ± 0.04
1.7AspAsn: 1.7 ± 0.053
3.993AspPro: 3.993 ± 0.073
1.828AspGln: 1.828 ± 0.048
4.053AspArg: 4.053 ± 0.082
3.3AspSer: 3.3 ± 0.064
3.718AspThr: 3.718 ± 0.074
5.235AspVal: 5.235 ± 0.079
0.863AspTrp: 0.863 ± 0.034
1.509AspTyr: 1.509 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
6.977GluAla: 6.977 ± 0.111
0.292GluCys: 0.292 ± 0.02
3.695GluAsp: 3.695 ± 0.072
4.107GluGlu: 4.107 ± 0.085
2.144GluPhe: 2.144 ± 0.046
4.532GluGly: 4.532 ± 0.089
1.566GluHis: 1.566 ± 0.044
3.443GluIle: 3.443 ± 0.07
2.312GluLys: 2.312 ± 0.064
7.256GluLeu: 7.256 ± 0.115
1.313GluMet: 1.313 ± 0.044
1.911GluAsn: 1.911 ± 0.057
3.042GluPro: 3.042 ± 0.066
2.744GluGln: 2.744 ± 0.065
4.631GluArg: 4.631 ± 0.095
3.449GluSer: 3.449 ± 0.078
3.482GluThr: 3.482 ± 0.069
5.124GluVal: 5.124 ± 0.087
0.818GluTrp: 0.818 ± 0.031
1.251GluTyr: 1.251 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.689PheAla: 3.689 ± 0.073
0.214PheCys: 0.214 ± 0.018
2.493PheAsp: 2.493 ± 0.059
1.75PheGlu: 1.75 ± 0.05
1.123PhePhe: 1.123 ± 0.05
3.321PheGly: 3.321 ± 0.076
0.693PheHis: 0.693 ± 0.033
1.405PheIle: 1.405 ± 0.042
0.591PheLys: 0.591 ± 0.028
2.921PheLeu: 2.921 ± 0.075
0.558PheMet: 0.558 ± 0.029
0.829PheAsn: 0.829 ± 0.034
1.524PhePro: 1.524 ± 0.048
0.847PheGln: 0.847 ± 0.034
1.796PheArg: 1.796 ± 0.053
2.041PheSer: 2.041 ± 0.051
2.298PheThr: 2.298 ± 0.054
2.458PheVal: 2.458 ± 0.06
0.435PheTrp: 0.435 ± 0.023
0.736PheTyr: 0.736 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
9.05GlyAla: 9.05 ± 0.13
0.567GlyCys: 0.567 ± 0.03
4.956GlyAsp: 4.956 ± 0.083
5.837GlyGlu: 5.837 ± 0.104
3.04GlyPhe: 3.04 ± 0.065
7.185GlyGly: 7.185 ± 0.14
1.985GlyHis: 1.985 ± 0.051
4.517GlyIle: 4.517 ± 0.082
2.619GlyLys: 2.619 ± 0.07
8.453GlyLeu: 8.453 ± 0.121
2.294GlyMet: 2.294 ± 0.053
2.256GlyAsn: 2.256 ± 0.063
3.529GlyPro: 3.529 ± 0.077
3.013GlyGln: 3.013 ± 0.059
5.688GlyArg: 5.688 ± 0.09
5.388GlySer: 5.388 ± 0.087
5.46GlyThr: 5.46 ± 0.083
7.342GlyVal: 7.342 ± 0.114
1.488GlyTrp: 1.488 ± 0.04
2.206GlyTyr: 2.206 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.18HisAla: 2.18 ± 0.049
0.17HisCys: 0.17 ± 0.013
1.279HisAsp: 1.279 ± 0.043
1.257HisGlu: 1.257 ± 0.039
0.654HisPhe: 0.654 ± 0.031
1.923HisGly: 1.923 ± 0.057
0.614HisHis: 0.614 ± 0.037
0.827HisIle: 0.827 ± 0.035
0.392HisLys: 0.392 ± 0.023
2.205HisLeu: 2.205 ± 0.058
0.427HisMet: 0.427 ± 0.023
0.501HisAsn: 0.501 ± 0.026
1.506HisPro: 1.506 ± 0.044
0.619HisGln: 0.619 ± 0.028
1.602HisArg: 1.602 ± 0.045
1.187HisSer: 1.187 ± 0.04
1.173HisThr: 1.173 ± 0.039
1.664HisVal: 1.664 ± 0.043
0.297HisTrp: 0.297 ± 0.02
0.533HisTyr: 0.533 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.0IleAla: 6.0 ± 0.079
0.287IleCys: 0.287 ± 0.018
3.936IleAsp: 3.936 ± 0.072
2.843IleGlu: 2.843 ± 0.063
1.438IlePhe: 1.438 ± 0.049
4.2IleGly: 4.2 ± 0.072
0.959IleHis: 0.959 ± 0.039
2.328IleIle: 2.328 ± 0.062
0.998IleLys: 0.998 ± 0.04
4.039IleLeu: 4.039 ± 0.078
0.891IleMet: 0.891 ± 0.034
1.4IleAsn: 1.4 ± 0.05
2.499IlePro: 2.499 ± 0.064
1.155IleGln: 1.155 ± 0.043
2.772IleArg: 2.772 ± 0.058
2.747IleSer: 2.747 ± 0.064
3.104IleThr: 3.104 ± 0.066
3.913IleVal: 3.913 ± 0.072
0.484IleTrp: 0.484 ± 0.025
0.927IleTyr: 0.927 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
2.881LysAla: 2.881 ± 0.083
0.097LysCys: 0.097 ± 0.011
1.482LysAsp: 1.482 ± 0.052
1.452LysGlu: 1.452 ± 0.055
0.742LysPhe: 0.742 ± 0.037
1.782LysGly: 1.782 ± 0.061
0.496LysHis: 0.496 ± 0.022
1.289LysIle: 1.289 ± 0.038
1.273LysLys: 1.273 ± 0.053
2.485LysLeu: 2.485 ± 0.069
0.633LysMet: 0.633 ± 0.029
0.875LysAsn: 0.875 ± 0.036
1.274LysPro: 1.274 ± 0.049
0.896LysGln: 0.896 ± 0.036
1.753LysArg: 1.753 ± 0.058
1.496LysSer: 1.496 ± 0.044
1.506LysThr: 1.506 ± 0.049
2.051LysVal: 2.051 ± 0.064
0.331LysTrp: 0.331 ± 0.02
0.631LysTyr: 0.631 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
13.007LeuAla: 13.007 ± 0.162
0.614LeuCys: 0.614 ± 0.028
6.307LeuAsp: 6.307 ± 0.096
5.072LeuGlu: 5.072 ± 0.093
2.821LeuPhe: 2.821 ± 0.067
8.953LeuGly: 8.953 ± 0.131
1.976LeuHis: 1.976 ± 0.05
4.83LeuIle: 4.83 ± 0.073
2.205LeuLys: 2.205 ± 0.061
9.437LeuLeu: 9.437 ± 0.142
1.874LeuMet: 1.874 ± 0.055
2.337LeuAsn: 2.337 ± 0.053
5.287LeuPro: 5.287 ± 0.083
2.433LeuGln: 2.433 ± 0.054
6.868LeuArg: 6.868 ± 0.109
6.261LeuSer: 6.261 ± 0.096
6.483LeuThr: 6.483 ± 0.094
8.04LeuVal: 8.04 ± 0.117
1.216LeuTrp: 1.216 ± 0.046
1.646LeuTyr: 1.646 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.592MetAla: 2.592 ± 0.061
0.136MetCys: 0.136 ± 0.014
1.096MetAsp: 1.096 ± 0.04
1.013MetGlu: 1.013 ± 0.037
0.633MetPhe: 0.633 ± 0.027
1.655MetGly: 1.655 ± 0.055
0.383MetHis: 0.383 ± 0.025
1.142MetIle: 1.142 ± 0.034
0.609MetLys: 0.609 ± 0.032
2.052MetLeu: 2.052 ± 0.053
0.474MetMet: 0.474 ± 0.025
0.687MetAsn: 0.687 ± 0.03
1.118MetPro: 1.118 ± 0.038
0.592MetGln: 0.592 ± 0.027
1.364MetArg: 1.364 ± 0.046
1.844MetSer: 1.844 ± 0.051
1.811MetThr: 1.811 ± 0.041
1.525MetVal: 1.525 ± 0.041
0.258MetTrp: 0.258 ± 0.018
0.363MetTyr: 0.363 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
2.776AsnAla: 2.776 ± 0.07
0.142AsnCys: 0.142 ± 0.015
1.395AsnAsp: 1.395 ± 0.047
1.441AsnGlu: 1.441 ± 0.045
0.891AsnPhe: 0.891 ± 0.034
2.024AsnGly: 2.024 ± 0.063
0.559AsnHis: 0.559 ± 0.029
1.232AsnIle: 1.232 ± 0.05
0.681AsnLys: 0.681 ± 0.033
2.492AsnLeu: 2.492 ± 0.055
0.561AsnMet: 0.561 ± 0.025
0.761AsnAsn: 0.761 ± 0.037
1.948AsnPro: 1.948 ± 0.058
0.872AsnGln: 0.872 ± 0.035
1.592AsnArg: 1.592 ± 0.048
1.469AsnSer: 1.469 ± 0.045
1.453AsnThr: 1.453 ± 0.05
1.985AsnVal: 1.985 ± 0.055
0.365AsnTrp: 0.365 ± 0.02
0.713AsnTyr: 0.713 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
6.593ProAla: 6.593 ± 0.12
0.22ProCys: 0.22 ± 0.019
3.702ProAsp: 3.702 ± 0.059
4.562ProGlu: 4.562 ± 0.084
1.553ProPhe: 1.553 ± 0.044
5.231ProGly: 5.231 ± 0.087
0.991ProHis: 0.991 ± 0.036
1.724ProIle: 1.724 ± 0.051
1.243ProLys: 1.243 ± 0.041
4.363ProLeu: 4.363 ± 0.079
1.011ProMet: 1.011 ± 0.032
1.081ProAsn: 1.081 ± 0.041
1.865ProPro: 1.865 ± 0.055
1.565ProGln: 1.565 ± 0.048
3.04ProArg: 3.04 ± 0.062
2.902ProSer: 2.902 ± 0.063
3.179ProThr: 3.179 ± 0.069
4.822ProVal: 4.822 ± 0.079
0.742ProTrp: 0.742 ± 0.029
0.988ProTyr: 0.988 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
3.691GlnAla: 3.691 ± 0.085
0.149GlnCys: 0.149 ± 0.016
1.496GlnAsp: 1.496 ± 0.045
1.738GlnGlu: 1.738 ± 0.061
0.984GlnPhe: 0.984 ± 0.032
2.242GlnGly: 2.242 ± 0.057
0.67GlnHis: 0.67 ± 0.028
1.716GlnIle: 1.716 ± 0.047
0.779GlnLys: 0.779 ± 0.031
3.485GlnLeu: 3.485 ± 0.07
0.773GlnMet: 0.773 ± 0.032
0.813GlnAsn: 0.813 ± 0.036
1.719GlnPro: 1.719 ± 0.049
1.359GlnGln: 1.359 ± 0.043
2.392GlnArg: 2.392 ± 0.067
1.67GlnSer: 1.67 ± 0.048
1.606GlnThr: 1.606 ± 0.044
2.606GlnVal: 2.606 ± 0.061
0.563GlnTrp: 0.563 ± 0.029
0.637GlnTyr: 0.637 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
7.278ArgAla: 7.278 ± 0.121
0.342ArgCys: 0.342 ± 0.02
4.081ArgAsp: 4.081 ± 0.075
4.972ArgGlu: 4.972 ± 0.082
2.211ArgPhe: 2.211 ± 0.054
5.201ArgGly: 5.201 ± 0.091
1.446ArgHis: 1.446 ± 0.046
3.44ArgIle: 3.44 ± 0.059
1.842ArgLys: 1.842 ± 0.053
6.382ArgLeu: 6.382 ± 0.105
1.655ArgMet: 1.655 ± 0.048
1.571ArgAsn: 1.571 ± 0.051
3.343ArgPro: 3.343 ± 0.071
2.29ArgGln: 2.29 ± 0.067
5.722ArgArg: 5.722 ± 0.098
3.864ArgSer: 3.864 ± 0.081
3.88ArgThr: 3.88 ± 0.071
5.089ArgVal: 5.089 ± 0.079
1.065ArgTrp: 1.065 ± 0.037
1.586ArgTyr: 1.586 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
7.133SerAla: 7.133 ± 0.098
0.349SerCys: 0.349 ± 0.023
3.444SerAsp: 3.444 ± 0.065
3.499SerGlu: 3.499 ± 0.07
1.938SerPhe: 1.938 ± 0.048
5.773SerGly: 5.773 ± 0.091
1.207SerHis: 1.207 ± 0.039
2.487SerIle: 2.487 ± 0.056
1.324SerLys: 1.324 ± 0.051
5.605SerLeu: 5.605 ± 0.088
1.442SerMet: 1.442 ± 0.045
1.357SerAsn: 1.357 ± 0.042
3.199SerPro: 3.199 ± 0.071
1.746SerGln: 1.746 ± 0.043
3.989SerArg: 3.989 ± 0.07
3.809SerSer: 3.809 ± 0.095
3.921SerThr: 3.921 ± 0.077
4.895SerVal: 4.895 ± 0.084
0.983SerTrp: 0.983 ± 0.038
1.378SerTyr: 1.378 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
7.165ThrAla: 7.165 ± 0.098
0.401ThrCys: 0.401 ± 0.026
3.916ThrAsp: 3.916 ± 0.071
3.768ThrGlu: 3.768 ± 0.071
1.958ThrPhe: 1.958 ± 0.055
5.949ThrGly: 5.949 ± 0.09
1.291ThrHis: 1.291 ± 0.038
2.744ThrIle: 2.744 ± 0.062
1.32ThrLys: 1.32 ± 0.046
5.767ThrLeu: 5.767 ± 0.085
1.186ThrMet: 1.186 ± 0.037
1.442ThrAsn: 1.442 ± 0.052
3.881ThrPro: 3.881 ± 0.072
1.624ThrGln: 1.624 ± 0.044
3.886ThrArg: 3.886 ± 0.072
3.793ThrSer: 3.793 ± 0.075
3.966ThrThr: 3.966 ± 0.075
5.776ThrVal: 5.776 ± 0.083
0.899ThrTrp: 0.899 ± 0.039
1.456ThrTyr: 1.456 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
10.241ValAla: 10.241 ± 0.129
0.547ValCys: 0.547 ± 0.023
6.136ValAsp: 6.136 ± 0.098
5.182ValGlu: 5.182 ± 0.083
2.581ValPhe: 2.581 ± 0.062
6.598ValGly: 6.598 ± 0.106
1.615ValHis: 1.615 ± 0.044
4.357ValIle: 4.357 ± 0.076
1.843ValLys: 1.843 ± 0.054
8.349ValLeu: 8.349 ± 0.134
1.579ValMet: 1.579 ± 0.044
2.161ValAsn: 2.161 ± 0.057
4.02ValPro: 4.02 ± 0.082
2.0ValGln: 2.0 ± 0.05
5.123ValArg: 5.123 ± 0.093
5.312ValSer: 5.312 ± 0.086
5.799ValThr: 5.799 ± 0.094
7.699ValVal: 7.699 ± 0.124
0.99ValTrp: 0.99 ± 0.037
1.528ValTyr: 1.528 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.556TrpAla: 1.556 ± 0.041
0.106TrpCys: 0.106 ± 0.013
0.713TrpAsp: 0.713 ± 0.035
0.79TrpGlu: 0.79 ± 0.034
0.515TrpPhe: 0.515 ± 0.031
0.933TrpGly: 0.933 ± 0.038
0.322TrpHis: 0.322 ± 0.022
0.713TrpIle: 0.713 ± 0.033
0.345TrpLys: 0.345 ± 0.022
1.652TrpLeu: 1.652 ± 0.055
0.34TrpMet: 0.34 ± 0.02
0.424TrpAsn: 0.424 ± 0.025
0.687TrpPro: 0.687 ± 0.025
0.55TrpGln: 0.55 ± 0.028
1.022TrpArg: 1.022 ± 0.039
0.845TrpSer: 0.845 ± 0.032
0.797TrpThr: 0.797 ± 0.032
1.159TrpVal: 1.159 ± 0.039
0.324TrpTrp: 0.324 ± 0.024
0.286TrpTyr: 0.286 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.246TyrAla: 2.246 ± 0.052
0.19TyrCys: 0.19 ± 0.019
1.4TyrAsp: 1.4 ± 0.042
1.216TyrGlu: 1.216 ± 0.037
0.786TyrPhe: 0.786 ± 0.032
2.02TyrGly: 2.02 ± 0.051
0.42TyrHis: 0.42 ± 0.025
0.751TyrIle: 0.751 ± 0.036
0.411TyrLys: 0.411 ± 0.026
2.34TyrLeu: 2.34 ± 0.054
0.319TyrMet: 0.319 ± 0.021
0.552TyrAsn: 0.552 ± 0.029
1.146TyrPro: 1.146 ± 0.037
0.722TyrGln: 0.722 ± 0.03
1.677TyrArg: 1.677 ± 0.051
1.473TyrSer: 1.473 ± 0.043
1.193TyrThr: 1.193 ± 0.044
1.611TyrVal: 1.611 ± 0.049
0.3TyrTrp: 0.3 ± 0.022
0.477TyrTyr: 0.477 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2476 proteins (780190 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski