Amino acid dipepetide frequency for Filimonas lacunae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.555AlaAla: 8.555 ± 0.091
0.8AlaCys: 0.8 ± 0.02
4.495AlaAsp: 4.495 ± 0.058
4.093AlaGlu: 4.093 ± 0.055
3.651AlaPhe: 3.651 ± 0.043
6.951AlaGly: 6.951 ± 0.082
1.498AlaHis: 1.498 ± 0.031
5.434AlaIle: 5.434 ± 0.052
4.071AlaLys: 4.071 ± 0.05
7.614AlaLeu: 7.614 ± 0.076
1.819AlaMet: 1.819 ± 0.028
4.109AlaAsn: 4.109 ± 0.068
2.962AlaPro: 2.962 ± 0.049
3.377AlaGln: 3.377 ± 0.045
2.994AlaArg: 2.994 ± 0.038
5.359AlaSer: 5.359 ± 0.067
5.944AlaThr: 5.944 ± 0.104
5.787AlaVal: 5.787 ± 0.065
0.977AlaTrp: 0.977 ± 0.024
3.341AlaTyr: 3.341 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
0.619CysAla: 0.619 ± 0.022
0.165CysCys: 0.165 ± 0.009
0.398CysAsp: 0.398 ± 0.02
0.38CysGlu: 0.38 ± 0.014
0.463CysPhe: 0.463 ± 0.015
0.648CysGly: 0.648 ± 0.021
0.188CysHis: 0.188 ± 0.009
0.659CysIle: 0.659 ± 0.02
0.545CysLys: 0.545 ± 0.017
0.847CysLeu: 0.847 ± 0.021
0.257CysMet: 0.257 ± 0.011
0.479CysAsn: 0.479 ± 0.015
0.313CysPro: 0.313 ± 0.014
0.267CysGln: 0.267 ± 0.013
0.387CysArg: 0.387 ± 0.017
0.627CysSer: 0.627 ± 0.027
0.618CysThr: 0.618 ± 0.022
0.57CysVal: 0.57 ± 0.015
0.121CysTrp: 0.121 ± 0.008
0.406CysTyr: 0.406 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.413AspAla: 4.413 ± 0.048
0.37AspCys: 0.37 ± 0.013
2.156AspAsp: 2.156 ± 0.035
2.597AspGlu: 2.597 ± 0.035
2.463AspPhe: 2.463 ± 0.039
3.623AspGly: 3.623 ± 0.049
0.841AspHis: 0.841 ± 0.019
3.644AspIle: 3.644 ± 0.038
3.428AspLys: 3.428 ± 0.042
3.831AspLeu: 3.831 ± 0.044
1.223AspMet: 1.223 ± 0.023
2.782AspAsn: 2.782 ± 0.037
1.636AspPro: 1.636 ± 0.03
1.333AspGln: 1.333 ± 0.027
1.755AspArg: 1.755 ± 0.031
3.53AspSer: 3.53 ± 0.064
3.114AspThr: 3.114 ± 0.05
3.412AspVal: 3.412 ± 0.043
0.712AspTrp: 0.712 ± 0.019
2.427AspTyr: 2.427 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
4.299GluAla: 4.299 ± 0.052
0.36GluCys: 0.36 ± 0.012
2.401GluAsp: 2.401 ± 0.032
3.636GluGlu: 3.636 ± 0.081
1.855GluPhe: 1.855 ± 0.031
3.36GluGly: 3.36 ± 0.045
1.015GluHis: 1.015 ± 0.027
3.167GluIle: 3.167 ± 0.049
4.183GluLys: 4.183 ± 0.054
4.97GluLeu: 4.97 ± 0.065
1.359GluMet: 1.359 ± 0.026
2.683GluAsn: 2.683 ± 0.034
1.446GluPro: 1.446 ± 0.028
2.594GluGln: 2.594 ± 0.037
2.182GluArg: 2.182 ± 0.04
2.442GluSer: 2.442 ± 0.034
2.712GluThr: 2.712 ± 0.035
3.739GluVal: 3.739 ± 0.052
0.712GluTrp: 0.712 ± 0.018
1.999GluTyr: 1.999 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.311PheAla: 3.311 ± 0.048
0.475PheCys: 0.475 ± 0.016
2.425PheAsp: 2.425 ± 0.033
2.189PheGlu: 2.189 ± 0.033
2.131PhePhe: 2.131 ± 0.042
2.774PheGly: 2.774 ± 0.045
0.869PheHis: 0.869 ± 0.019
2.937PheIle: 2.937 ± 0.047
2.414PheLys: 2.414 ± 0.036
3.734PheLeu: 3.734 ± 0.053
1.013PheMet: 1.013 ± 0.022
2.672PheAsn: 2.672 ± 0.038
1.614PhePro: 1.614 ± 0.03
1.451PheGln: 1.451 ± 0.025
1.798PheArg: 1.798 ± 0.028
3.501PheSer: 3.501 ± 0.042
3.765PheThr: 3.765 ± 0.053
2.7PheVal: 2.7 ± 0.035
0.557PheTrp: 0.557 ± 0.015
1.998PheTyr: 1.998 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
5.283GlyAla: 5.283 ± 0.07
0.758GlyCys: 0.758 ± 0.026
3.212GlyAsp: 3.212 ± 0.045
3.127GlyGlu: 3.127 ± 0.041
3.328GlyPhe: 3.328 ± 0.043
5.275GlyGly: 5.275 ± 0.083
1.204GlyHis: 1.204 ± 0.025
5.004GlyIle: 5.004 ± 0.048
5.01GlyLys: 5.01 ± 0.062
5.841GlyLeu: 5.841 ± 0.062
1.746GlyMet: 1.746 ± 0.033
4.216GlyAsn: 4.216 ± 0.063
1.54GlyPro: 1.54 ± 0.029
2.304GlyGln: 2.304 ± 0.037
2.618GlyArg: 2.618 ± 0.037
4.82GlySer: 4.82 ± 0.068
4.878GlyThr: 4.878 ± 0.097
5.057GlyVal: 5.057 ± 0.055
1.073GlyTrp: 1.073 ± 0.024
3.393GlyTyr: 3.393 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
1.426HisAla: 1.426 ± 0.029
0.213HisCys: 0.213 ± 0.009
0.838HisAsp: 0.838 ± 0.019
0.897HisGlu: 0.897 ± 0.023
1.18HisPhe: 1.18 ± 0.024
1.124HisGly: 1.124 ± 0.025
0.582HisHis: 0.582 ± 0.018
1.478HisIle: 1.478 ± 0.026
1.055HisLys: 1.055 ± 0.024
2.026HisLeu: 2.026 ± 0.036
0.466HisMet: 0.466 ± 0.014
0.994HisAsn: 0.994 ± 0.021
1.047HisPro: 1.047 ± 0.026
0.843HisGln: 0.843 ± 0.021
0.779HisArg: 0.779 ± 0.02
1.139HisSer: 1.139 ± 0.025
1.297HisThr: 1.297 ± 0.032
1.143HisVal: 1.143 ± 0.026
0.29HisTrp: 0.29 ± 0.012
1.029HisTyr: 1.029 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.757IleAla: 5.757 ± 0.053
0.652IleCys: 0.652 ± 0.019
3.52IleAsp: 3.52 ± 0.042
3.424IleGlu: 3.424 ± 0.045
2.161IlePhe: 2.161 ± 0.039
4.057IleGly: 4.057 ± 0.048
1.453IleHis: 1.453 ± 0.03
4.058IleIle: 4.058 ± 0.054
3.668IleLys: 3.668 ± 0.047
4.958IleLeu: 4.958 ± 0.059
1.135IleMet: 1.135 ± 0.02
3.561IleAsn: 3.561 ± 0.041
2.855IlePro: 2.855 ± 0.035
2.651IleGln: 2.651 ± 0.038
2.738IleArg: 2.738 ± 0.037
4.44IleSer: 4.44 ± 0.05
5.178IleThr: 5.178 ± 0.062
3.923IleVal: 3.923 ± 0.051
0.673IleTrp: 0.673 ± 0.017
2.435IleTyr: 2.435 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
5.276LysAla: 5.276 ± 0.053
0.314LysCys: 0.314 ± 0.018
3.443LysAsp: 3.443 ± 0.04
4.28LysGlu: 4.28 ± 0.055
1.727LysPhe: 1.727 ± 0.031
4.437LysGly: 4.437 ± 0.051
1.178LysHis: 1.178 ± 0.026
3.456LysIle: 3.456 ± 0.047
4.569LysLys: 4.569 ± 0.06
5.07LysLeu: 5.07 ± 0.059
1.585LysMet: 1.585 ± 0.031
3.261LysAsn: 3.261 ± 0.043
2.522LysPro: 2.522 ± 0.035
2.958LysGln: 2.958 ± 0.042
2.524LysArg: 2.524 ± 0.036
3.086LysSer: 3.086 ± 0.045
3.584LysThr: 3.584 ± 0.043
4.096LysVal: 4.096 ± 0.049
0.807LysTrp: 0.807 ± 0.019
2.363LysTyr: 2.363 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
7.029LeuAla: 7.029 ± 0.066
0.924LeuCys: 0.924 ± 0.021
4.245LeuAsp: 4.245 ± 0.052
4.56LeuGlu: 4.56 ± 0.05
4.415LeuPhe: 4.415 ± 0.055
5.305LeuGly: 5.305 ± 0.054
2.176LeuHis: 2.176 ± 0.041
4.87LeuIle: 4.87 ± 0.059
5.522LeuLys: 5.522 ± 0.055
10.497LeuLeu: 10.497 ± 0.105
2.035LeuMet: 2.035 ± 0.029
4.762LeuAsn: 4.762 ± 0.054
4.617LeuPro: 4.617 ± 0.039
5.229LeuGln: 5.229 ± 0.062
3.68LeuArg: 3.68 ± 0.05
6.556LeuSer: 6.556 ± 0.066
5.78LeuThr: 5.78 ± 0.064
5.93LeuVal: 5.93 ± 0.052
1.013LeuTrp: 1.013 ± 0.021
3.763LeuTyr: 3.763 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
1.876MetAla: 1.876 ± 0.03
0.159MetCys: 0.159 ± 0.008
1.099MetAsp: 1.099 ± 0.023
1.307MetGlu: 1.307 ± 0.027
0.734MetPhe: 0.734 ± 0.018
1.506MetGly: 1.506 ± 0.027
0.508MetHis: 0.508 ± 0.015
1.267MetIle: 1.267 ± 0.025
1.808MetLys: 1.808 ± 0.029
2.239MetLeu: 2.239 ± 0.031
0.59MetMet: 0.59 ± 0.017
1.244MetAsn: 1.244 ± 0.025
1.163MetPro: 1.163 ± 0.021
1.309MetGln: 1.309 ± 0.024
1.065MetArg: 1.065 ± 0.02
1.29MetSer: 1.29 ± 0.027
1.016MetThr: 1.016 ± 0.022
1.463MetVal: 1.463 ± 0.029
0.182MetTrp: 0.182 ± 0.009
0.805MetTyr: 0.805 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
4.508AsnAla: 4.508 ± 0.066
0.457AsnCys: 0.457 ± 0.015
2.635AsnAsp: 2.635 ± 0.06
2.601AsnGlu: 2.601 ± 0.039
2.136AsnPhe: 2.136 ± 0.036
4.492AsnGly: 4.492 ± 0.078
0.904AsnHis: 0.904 ± 0.02
3.799AsnIle: 3.799 ± 0.048
3.258AsnLys: 3.258 ± 0.04
4.305AsnLeu: 4.305 ± 0.053
1.199AsnMet: 1.199 ± 0.025
3.668AsnAsn: 3.668 ± 0.058
2.498AsnPro: 2.498 ± 0.034
1.9AsnGln: 1.9 ± 0.031
2.398AsnArg: 2.398 ± 0.036
3.499AsnSer: 3.499 ± 0.049
3.923AsnThr: 3.923 ± 0.071
3.295AsnVal: 3.295 ± 0.047
0.79AsnTrp: 0.79 ± 0.019
2.605AsnTyr: 2.605 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
4.282ProAla: 4.282 ± 0.063
0.263ProCys: 0.263 ± 0.012
2.52ProAsp: 2.52 ± 0.034
2.494ProGlu: 2.494 ± 0.032
1.908ProPhe: 1.908 ± 0.034
3.149ProGly: 3.149 ± 0.038
0.776ProHis: 0.776 ± 0.021
1.862ProIle: 1.862 ± 0.031
1.643ProLys: 1.643 ± 0.032
3.606ProLeu: 3.606 ± 0.044
0.79ProMet: 0.79 ± 0.02
1.684ProAsn: 1.684 ± 0.027
1.239ProPro: 1.239 ± 0.029
1.53ProGln: 1.53 ± 0.025
1.134ProArg: 1.134 ± 0.024
2.195ProSer: 2.195 ± 0.035
2.019ProThr: 2.019 ± 0.034
4.045ProVal: 4.045 ± 0.058
0.419ProTrp: 0.419 ± 0.014
1.671ProTyr: 1.671 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.379GlnAla: 3.379 ± 0.047
0.263GlnCys: 0.263 ± 0.012
1.615GlnAsp: 1.615 ± 0.03
2.216GlnGlu: 2.216 ± 0.034
1.778GlnPhe: 1.778 ± 0.032
2.243GlnGly: 2.243 ± 0.039
1.073GlnHis: 1.073 ± 0.025
1.991GlnIle: 1.991 ± 0.029
2.567GlnLys: 2.567 ± 0.04
5.148GlnLeu: 5.148 ± 0.059
1.028GlnMet: 1.028 ± 0.022
1.96GlnAsn: 1.96 ± 0.035
2.034GlnPro: 2.034 ± 0.034
3.571GlnGln: 3.571 ± 0.059
1.772GlnArg: 1.772 ± 0.034
2.298GlnSer: 2.298 ± 0.034
2.305GlnThr: 2.305 ± 0.035
3.094GlnVal: 3.094 ± 0.038
0.723GlnTrp: 0.723 ± 0.019
1.98GlnTyr: 1.98 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
2.502ArgAla: 2.502 ± 0.035
0.304ArgCys: 0.304 ± 0.012
1.749ArgAsp: 1.749 ± 0.029
2.135ArgGlu: 2.135 ± 0.036
2.258ArgPhe: 2.258 ± 0.032
2.092ArgGly: 2.092 ± 0.035
0.754ArgHis: 0.754 ± 0.019
2.949ArgIle: 2.949 ± 0.037
2.75ArgLys: 2.75 ± 0.038
4.115ArgLeu: 4.115 ± 0.047
1.183ArgMet: 1.183 ± 0.022
2.433ArgAsn: 2.433 ± 0.034
1.325ArgPro: 1.325 ± 0.028
1.745ArgGln: 1.745 ± 0.032
1.664ArgArg: 1.664 ± 0.033
2.181ArgSer: 2.181 ± 0.029
2.147ArgThr: 2.147 ± 0.033
2.633ArgVal: 2.633 ± 0.039
0.661ArgTrp: 0.661 ± 0.016
2.023ArgTyr: 2.023 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
5.149SerAla: 5.149 ± 0.058
0.678SerCys: 0.678 ± 0.018
3.139SerAsp: 3.139 ± 0.041
2.615SerGlu: 2.615 ± 0.038
3.613SerPhe: 3.613 ± 0.048
5.226SerGly: 5.226 ± 0.076
1.128SerHis: 1.128 ± 0.024
4.268SerIle: 4.268 ± 0.047
3.306SerLys: 3.306 ± 0.04
6.225SerLeu: 6.225 ± 0.058
1.329SerMet: 1.329 ± 0.024
3.487SerAsn: 3.487 ± 0.056
2.285SerPro: 2.285 ± 0.035
2.038SerGln: 2.038 ± 0.029
2.598SerArg: 2.598 ± 0.033
4.441SerSer: 4.441 ± 0.072
4.076SerThr: 4.076 ± 0.065
4.598SerVal: 4.598 ± 0.058
0.902SerTrp: 0.902 ± 0.021
3.136SerTyr: 3.136 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
6.172ThrAla: 6.172 ± 0.109
0.518ThrCys: 0.518 ± 0.019
3.498ThrAsp: 3.498 ± 0.045
2.922ThrGlu: 2.922 ± 0.034
2.794ThrPhe: 2.794 ± 0.038
6.024ThrGly: 6.024 ± 0.086
1.171ThrHis: 1.171 ± 0.024
4.489ThrIle: 4.489 ± 0.064
2.677ThrLys: 2.677 ± 0.034
6.009ThrLeu: 6.009 ± 0.052
1.026ThrMet: 1.026 ± 0.024
3.139ThrAsn: 3.139 ± 0.052
3.206ThrPro: 3.206 ± 0.064
2.365ThrGln: 2.365 ± 0.035
2.405ThrArg: 2.405 ± 0.035
4.26ThrSer: 4.26 ± 0.068
4.854ThrThr: 4.854 ± 0.1
5.062ThrVal: 5.062 ± 0.097
0.807ThrTrp: 0.807 ± 0.021
3.093ThrTyr: 3.093 ± 0.077
0.0ThrXaa: 0.0 ± 0.0
Val
5.842ValAla: 5.842 ± 0.063
0.705ValCys: 0.705 ± 0.021
3.026ValAsp: 3.026 ± 0.042
3.054ValGlu: 3.054 ± 0.042
3.107ValPhe: 3.107 ± 0.037
3.57ValGly: 3.57 ± 0.049
1.265ValHis: 1.265 ± 0.025
4.687ValIle: 4.687 ± 0.05
4.599ValLys: 4.599 ± 0.053
6.579ValLeu: 6.579 ± 0.06
1.599ValMet: 1.599 ± 0.032
4.078ValAsn: 4.078 ± 0.065
2.762ValPro: 2.762 ± 0.042
2.786ValGln: 2.786 ± 0.043
2.534ValArg: 2.534 ± 0.038
4.809ValSer: 4.809 ± 0.054
5.174ValThr: 5.174 ± 0.09
4.913ValVal: 4.913 ± 0.05
0.808ValTrp: 0.808 ± 0.021
2.893ValTyr: 2.893 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.812TrpAla: 0.812 ± 0.023
0.141TrpCys: 0.141 ± 0.008
0.648TrpAsp: 0.648 ± 0.017
0.67TrpGlu: 0.67 ± 0.016
0.552TrpPhe: 0.552 ± 0.015
0.879TrpGly: 0.879 ± 0.023
0.315TrpHis: 0.315 ± 0.013
0.763TrpIle: 0.763 ± 0.022
0.918TrpLys: 0.918 ± 0.02
1.414TrpLeu: 1.414 ± 0.028
0.39TrpMet: 0.39 ± 0.013
0.784TrpAsn: 0.784 ± 0.02
0.389TrpPro: 0.389 ± 0.017
0.813TrpGln: 0.813 ± 0.019
0.539TrpArg: 0.539 ± 0.015
0.728TrpSer: 0.728 ± 0.022
0.698TrpThr: 0.698 ± 0.02
0.779TrpVal: 0.779 ± 0.017
0.243TrpTrp: 0.243 ± 0.011
0.606TrpTyr: 0.606 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.341TyrAla: 3.341 ± 0.047
0.439TyrCys: 0.439 ± 0.017
2.229TyrAsp: 2.229 ± 0.039
1.918TyrGlu: 1.918 ± 0.028
2.073TyrPhe: 2.073 ± 0.032
2.95TyrGly: 2.95 ± 0.044
0.947TyrHis: 0.947 ± 0.021
2.515TyrIle: 2.515 ± 0.033
2.543TyrLys: 2.543 ± 0.038
3.881TyrLeu: 3.881 ± 0.037
0.859TyrMet: 0.859 ± 0.022
2.876TyrAsn: 2.876 ± 0.046
1.775TyrPro: 1.775 ± 0.032
1.974TyrGln: 1.974 ± 0.032
2.042TyrArg: 2.042 ± 0.031
3.036TyrSer: 3.036 ± 0.054
3.409TyrThr: 3.409 ± 0.069
2.551TyrVal: 2.551 ± 0.034
0.608TyrTrp: 0.608 ± 0.017
2.269TyrTyr: 2.269 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6193 proteins (2362209 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski