Amino acid dipepetide frequency for Marinisporobacter balticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.096AlaAla: 4.096 ± 0.081	0.807AlaCys: 0.807 ± 0.028	2.786AlaAsp: 2.786 ± 0.056	3.546AlaGlu: 3.546 ± 0.074	2.87AlaPhe: 2.87 ± 0.057	4.12AlaGly: 4.12 ± 0.081	1.05AlaHis: 1.05 ± 0.03	6.154AlaIle: 6.154 ± 0.089	5.08AlaLys: 5.08 ± 0.066	6.178AlaLeu: 6.178 ± 0.085	1.981AlaMet: 1.981 ± 0.042	2.732AlaAsn: 2.732 ± 0.052	1.553AlaPro: 1.553 ± 0.042	1.888AlaGln: 1.888 ± 0.046	2.114AlaArg: 2.114 ± 0.047	3.478AlaSer: 3.478 ± 0.062	3.21AlaThr: 3.21 ± 0.064	4.363AlaVal: 4.363 ± 0.071	0.411AlaTrp: 0.411 ± 0.022	2.421AlaTyr: 2.421 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.649CysAla: 0.649 ± 0.029	0.176CysCys: 0.176 ± 0.014	0.588CysAsp: 0.588 ± 0.022	0.717CysGlu: 0.717 ± 0.026	0.453CysPhe: 0.453 ± 0.02	1.031CysGly: 1.031 ± 0.034	0.215CysHis: 0.215 ± 0.013	1.172CysIle: 1.172 ± 0.033	0.883CysLys: 0.883 ± 0.032	0.808CysLeu: 0.808 ± 0.031	0.362CysMet: 0.362 ± 0.017	0.578CysAsn: 0.578 ± 0.027	0.498CysPro: 0.498 ± 0.025	0.247CysGln: 0.247 ± 0.015	0.386CysArg: 0.386 ± 0.019	0.746CysSer: 0.746 ± 0.029	0.587CysThr: 0.587 ± 0.022	0.687CysVal: 0.687 ± 0.026	0.076CysTrp: 0.076 ± 0.008	0.353CysTyr: 0.353 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.368AspAla: 3.368 ± 0.065	0.554AspCys: 0.554 ± 0.024	2.446AspAsp: 2.446 ± 0.053	4.468AspGlu: 4.468 ± 0.077	2.587AspPhe: 2.587 ± 0.044	3.399AspGly: 3.399 ± 0.06	1.092AspHis: 1.092 ± 0.036	5.656AspIle: 5.656 ± 0.082	4.464AspLys: 4.464 ± 0.078	5.121AspLeu: 5.121 ± 0.074	1.647AspMet: 1.647 ± 0.041	2.102AspAsn: 2.102 ± 0.053	1.57AspPro: 1.57 ± 0.041	1.643AspGln: 1.643 ± 0.039	2.076AspArg: 2.076 ± 0.05	2.27AspSer: 2.27 ± 0.041	2.754AspThr: 2.754 ± 0.05	3.66AspVal: 3.66 ± 0.056	0.421AspTrp: 0.421 ± 0.02	2.464AspTyr: 2.464 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.434GluAla: 4.434 ± 0.075	0.594GluCys: 0.594 ± 0.022	4.176GluAsp: 4.176 ± 0.077	7.024GluGlu: 7.024 ± 0.114	2.42GluPhe: 2.42 ± 0.055	4.303GluGly: 4.303 ± 0.073	1.17GluHis: 1.17 ± 0.034	7.809GluIle: 7.809 ± 0.097	8.847GluLys: 8.847 ± 0.111	5.967GluLeu: 5.967 ± 0.085	2.462GluMet: 2.462 ± 0.043	5.33GluAsn: 5.33 ± 0.069	1.424GluPro: 1.424 ± 0.031	2.206GluGln: 2.206 ± 0.05	2.795GluArg: 2.795 ± 0.05	3.312GluSer: 3.312 ± 0.048	3.2GluThr: 3.2 ± 0.06	4.86GluVal: 4.86 ± 0.07	0.482GluTrp: 0.482 ± 0.022	2.638GluTyr: 2.638 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	2.357PheAla: 2.357 ± 0.053	0.529PheCys: 0.529 ± 0.023	2.485PheAsp: 2.485 ± 0.053	2.967PheGlu: 2.967 ± 0.052	1.988PhePhe: 1.988 ± 0.053	2.876PheGly: 2.876 ± 0.057	0.819PheHis: 0.819 ± 0.027	4.315PheIle: 4.315 ± 0.08	3.348PheLys: 3.348 ± 0.064	3.74PheLeu: 3.74 ± 0.063	1.286PheMet: 1.286 ± 0.036	2.042PheAsn: 2.042 ± 0.047	1.242PhePro: 1.242 ± 0.034	1.143PheGln: 1.143 ± 0.03	1.326PheArg: 1.326 ± 0.038	2.969PheSer: 2.969 ± 0.056	2.269PheThr: 2.269 ± 0.051	3.005PheVal: 3.005 ± 0.061	0.289PheTrp: 0.289 ± 0.02	1.634PheTyr: 1.634 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.426GlyAla: 4.426 ± 0.086	0.929GlyCys: 0.929 ± 0.033	3.015GlyAsp: 3.015 ± 0.055	4.38GlyGlu: 4.38 ± 0.068	3.124GlyPhe: 3.124 ± 0.06	4.439GlyGly: 4.439 ± 0.088	1.1GlyHis: 1.1 ± 0.032	7.002GlyIle: 7.002 ± 0.097	5.906GlyLys: 5.906 ± 0.082	5.912GlyLeu: 5.912 ± 0.077	2.19GlyMet: 2.19 ± 0.05	3.224GlyAsn: 3.224 ± 0.066	1.264GlyPro: 1.264 ± 0.034	1.728GlyGln: 1.728 ± 0.041	2.348GlyArg: 2.348 ± 0.046	3.515GlySer: 3.515 ± 0.068	3.518GlyThr: 3.518 ± 0.059	4.803GlyVal: 4.803 ± 0.074	0.548GlyTrp: 0.548 ± 0.022	2.969GlyTyr: 2.969 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.071HisAla: 1.071 ± 0.038	0.228HisCys: 0.228 ± 0.015	0.775HisAsp: 0.775 ± 0.03	1.219HisGlu: 1.219 ± 0.036	0.791HisPhe: 0.791 ± 0.027	1.11HisGly: 1.11 ± 0.033	0.428HisHis: 0.428 ± 0.022	1.809HisIle: 1.809 ± 0.041	1.4HisLys: 1.4 ± 0.034	1.556HisLeu: 1.556 ± 0.036	0.505HisMet: 0.505 ± 0.022	0.815HisAsn: 0.815 ± 0.03	0.787HisPro: 0.787 ± 0.026	0.525HisGln: 0.525 ± 0.023	0.648HisArg: 0.648 ± 0.024	0.942HisSer: 0.942 ± 0.033	0.964HisThr: 0.964 ± 0.031	1.151HisVal: 1.151 ± 0.035	0.138HisTrp: 0.138 ± 0.011	0.701HisTyr: 0.701 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.412IleAla: 6.412 ± 0.084	1.188IleCys: 1.188 ± 0.033	5.997IleAsp: 5.997 ± 0.088	7.738IleGlu: 7.738 ± 0.089	4.133IlePhe: 4.133 ± 0.074	6.741IleGly: 6.741 ± 0.094	1.885IleHis: 1.885 ± 0.043	8.685IleIle: 8.685 ± 0.109	8.414IleLys: 8.414 ± 0.101	8.973IleLeu: 8.973 ± 0.114	2.478IleMet: 2.478 ± 0.051	5.0IleAsn: 5.0 ± 0.07	3.556IlePro: 3.556 ± 0.063	2.854IleGln: 2.854 ± 0.049	3.297IleArg: 3.297 ± 0.058	5.895IleSer: 5.895 ± 0.084	4.95IleThr: 4.95 ± 0.07	6.236IleVal: 6.236 ± 0.076	0.57IleTrp: 0.57 ± 0.026	3.35IleTyr: 3.35 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	4.94LysAla: 4.94 ± 0.074	0.769LysCys: 0.769 ± 0.03	5.631LysAsp: 5.631 ± 0.087	9.015LysGlu: 9.015 ± 0.104	2.799LysPhe: 2.799 ± 0.051	5.293LysGly: 5.293 ± 0.075	1.415LysHis: 1.415 ± 0.039	8.91LysIle: 8.91 ± 0.106	8.924LysLys: 8.924 ± 0.115	7.073LysLeu: 7.073 ± 0.082	2.772LysMet: 2.772 ± 0.048	6.123LysAsn: 6.123 ± 0.083	2.218LysPro: 2.218 ± 0.052	2.588LysGln: 2.588 ± 0.047	3.339LysArg: 3.339 ± 0.056	4.399LysSer: 4.399 ± 0.067	4.158LysThr: 4.158 ± 0.062	5.542LysVal: 5.542 ± 0.068	0.681LysTrp: 0.681 ± 0.026	3.719LysTyr: 3.719 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	5.305LeuAla: 5.305 ± 0.077	1.049LeuCys: 1.049 ± 0.034	4.977LeuAsp: 4.977 ± 0.071	6.589LeuGlu: 6.589 ± 0.084	3.915LeuPhe: 3.915 ± 0.071	6.205LeuGly: 6.205 ± 0.079	1.287LeuHis: 1.287 ± 0.041	7.386LeuIle: 7.386 ± 0.097	8.403LeuLys: 8.403 ± 0.094	8.17LeuLeu: 8.17 ± 0.106	2.543LeuMet: 2.543 ± 0.05	4.993LeuAsn: 4.993 ± 0.073	2.915LeuPro: 2.915 ± 0.057	2.371LeuGln: 2.371 ± 0.045	3.137LeuArg: 3.137 ± 0.061	6.0LeuSer: 6.0 ± 0.082	4.313LeuThr: 4.313 ± 0.066	5.401LeuVal: 5.401 ± 0.07	0.615LeuTrp: 0.615 ± 0.025	3.072LeuTyr: 3.072 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.041MetAla: 2.041 ± 0.043	0.266MetCys: 0.266 ± 0.015	1.832MetAsp: 1.832 ± 0.041	2.069MetGlu: 2.069 ± 0.048	1.004MetPhe: 1.004 ± 0.03	2.207MetGly: 2.207 ± 0.053	0.562MetHis: 0.562 ± 0.024	3.049MetIle: 3.049 ± 0.049	3.101MetLys: 3.101 ± 0.049	2.342MetLeu: 2.342 ± 0.042	0.981MetMet: 0.981 ± 0.033	1.875MetAsn: 1.875 ± 0.045	1.032MetPro: 1.032 ± 0.033	0.866MetGln: 0.866 ± 0.028	1.044MetArg: 1.044 ± 0.031	1.546MetSer: 1.546 ± 0.038	1.425MetThr: 1.425 ± 0.036	1.932MetVal: 1.932 ± 0.044	0.167MetTrp: 0.167 ± 0.013	0.875MetTyr: 0.875 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.001AsnAla: 3.001 ± 0.052	0.569AsnCys: 0.569 ± 0.029	2.51AsnAsp: 2.51 ± 0.047	3.822AsnGlu: 3.822 ± 0.07	2.162AsnPhe: 2.162 ± 0.052	3.327AsnGly: 3.327 ± 0.057	1.15AsnHis: 1.15 ± 0.032	6.186AsnIle: 6.186 ± 0.095	4.863AsnLys: 4.863 ± 0.077	4.79AsnLeu: 4.79 ± 0.066	1.82AsnMet: 1.82 ± 0.034	3.012AsnAsn: 3.012 ± 0.072	2.12AsnPro: 2.12 ± 0.041	1.741AsnGln: 1.741 ± 0.043	2.068AsnArg: 2.068 ± 0.046	2.445AsnSer: 2.445 ± 0.059	2.858AsnThr: 2.858 ± 0.053	3.32AsnVal: 3.32 ± 0.059	0.438AsnTrp: 0.438 ± 0.018	2.039AsnTyr: 2.039 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	1.627ProAla: 1.627 ± 0.043	0.343ProCys: 0.343 ± 0.022	1.497ProAsp: 1.497 ± 0.041	2.172ProGlu: 2.172 ± 0.055	1.453ProPhe: 1.453 ± 0.04	1.744ProGly: 1.744 ± 0.045	0.561ProHis: 0.561 ± 0.021	3.083ProIle: 3.083 ± 0.058	2.448ProLys: 2.448 ± 0.049	2.548ProLeu: 2.548 ± 0.051	0.87ProMet: 0.87 ± 0.027	1.54ProAsn: 1.54 ± 0.041	0.78ProPro: 0.78 ± 0.028	0.912ProGln: 0.912 ± 0.03	0.946ProArg: 0.946 ± 0.03	1.731ProSer: 1.731 ± 0.043	1.712ProThr: 1.712 ± 0.042	2.198ProVal: 2.198 ± 0.044	0.265ProTrp: 0.265 ± 0.013	1.355ProTyr: 1.355 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	1.717GlnAla: 1.717 ± 0.04	0.32GlnCys: 0.32 ± 0.018	1.332GlnAsp: 1.332 ± 0.034	2.192GlnGlu: 2.192 ± 0.049	1.153GlnPhe: 1.153 ± 0.029	1.747GlnGly: 1.747 ± 0.037	0.434GlnHis: 0.434 ± 0.021	2.672GlnIle: 2.672 ± 0.056	2.704GlnLys: 2.704 ± 0.06	2.644GlnLeu: 2.644 ± 0.056	0.957GlnMet: 0.957 ± 0.031	1.739GlnAsn: 1.739 ± 0.043	0.721GlnPro: 0.721 ± 0.028	0.957GlnGln: 0.957 ± 0.039	1.091GlnArg: 1.091 ± 0.036	1.625GlnSer: 1.625 ± 0.038	1.345GlnThr: 1.345 ± 0.033	1.807GlnVal: 1.807 ± 0.039	0.271GlnTrp: 0.271 ± 0.016	1.225GlnTyr: 1.225 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.037ArgAla: 2.037 ± 0.046	0.427ArgCys: 0.427 ± 0.019	1.839ArgAsp: 1.839 ± 0.041	2.91ArgGlu: 2.91 ± 0.057	1.544ArgPhe: 1.544 ± 0.035	2.222ArgGly: 2.222 ± 0.049	0.5ArgHis: 0.5 ± 0.021	3.546ArgIle: 3.546 ± 0.053	3.572ArgLys: 3.572 ± 0.055	3.018ArgLeu: 3.018 ± 0.056	1.183ArgMet: 1.183 ± 0.036	2.015ArgAsn: 2.015 ± 0.042	0.99ArgPro: 0.99 ± 0.033	1.052ArgGln: 1.052 ± 0.038	1.437ArgArg: 1.437 ± 0.045	1.674ArgSer: 1.674 ± 0.039	1.63ArgThr: 1.63 ± 0.042	2.28ArgVal: 2.28 ± 0.042	0.297ArgTrp: 0.297 ± 0.016	1.414ArgTyr: 1.414 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	3.054SerAla: 3.054 ± 0.057	0.587SerCys: 0.587 ± 0.023	2.644SerAsp: 2.644 ± 0.048	3.508SerGlu: 3.508 ± 0.052	2.835SerPhe: 2.835 ± 0.052	3.883SerGly: 3.883 ± 0.059	0.977SerHis: 0.977 ± 0.035	5.791SerIle: 5.791 ± 0.09	4.901SerLys: 4.901 ± 0.072	5.05SerLeu: 5.05 ± 0.071	1.701SerMet: 1.701 ± 0.039	2.97SerAsn: 2.97 ± 0.055	1.623SerPro: 1.623 ± 0.038	1.607SerGln: 1.607 ± 0.041	1.954SerArg: 1.954 ± 0.037	3.251SerSer: 3.251 ± 0.063	2.814SerThr: 2.814 ± 0.056	3.532SerVal: 3.532 ± 0.065	0.397SerTrp: 0.397 ± 0.021	2.025SerTyr: 2.025 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	3.207ThrAla: 3.207 ± 0.067	0.532ThrCys: 0.532 ± 0.022	2.506ThrAsp: 2.506 ± 0.049	3.011ThrGlu: 3.011 ± 0.047	2.283ThrPhe: 2.283 ± 0.054	3.846ThrGly: 3.846 ± 0.071	0.919ThrHis: 0.919 ± 0.028	4.959ThrIle: 4.959 ± 0.073	3.824ThrLys: 3.824 ± 0.064	4.723ThrLeu: 4.723 ± 0.077	1.293ThrMet: 1.293 ± 0.033	2.554ThrAsn: 2.554 ± 0.051	1.925ThrPro: 1.925 ± 0.047	1.429ThrGln: 1.429 ± 0.035	1.659ThrArg: 1.659 ± 0.035	2.917ThrSer: 2.917 ± 0.046	2.687ThrThr: 2.687 ± 0.059	3.44ThrVal: 3.44 ± 0.058	0.368ThrTrp: 0.368 ± 0.019	1.933ThrTyr: 1.933 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	4.475ValAla: 4.475 ± 0.071	0.809ValCys: 0.809 ± 0.027	3.946ValAsp: 3.946 ± 0.062	4.772ValGlu: 4.772 ± 0.073	2.92ValPhe: 2.92 ± 0.058	4.644ValGly: 4.644 ± 0.079	1.093ValHis: 1.093 ± 0.03	5.905ValIle: 5.905 ± 0.079	5.381ValLys: 5.381 ± 0.07	6.093ValLeu: 6.093 ± 0.076	1.838ValMet: 1.838 ± 0.039	3.162ValAsn: 3.162 ± 0.053	2.061ValPro: 2.061 ± 0.044	1.638ValGln: 1.638 ± 0.036	2.139ValArg: 2.139 ± 0.045	4.013ValSer: 4.013 ± 0.065	3.261ValThr: 3.261 ± 0.061	4.77ValVal: 4.77 ± 0.083	0.428ValTrp: 0.428 ± 0.022	2.338ValTyr: 2.338 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.427TrpAla: 0.427 ± 0.022	0.089TrpCys: 0.089 ± 0.009	0.434TrpAsp: 0.434 ± 0.022	0.532TrpGlu: 0.532 ± 0.021	0.306TrpPhe: 0.306 ± 0.018	0.549TrpGly: 0.549 ± 0.025	0.135TrpHis: 0.135 ± 0.011	0.73TrpIle: 0.73 ± 0.029	0.588TrpLys: 0.588 ± 0.023	0.602TrpLeu: 0.602 ± 0.024	0.268TrpMet: 0.268 ± 0.017	0.437TrpAsn: 0.437 ± 0.021	0.172TrpPro: 0.172 ± 0.012	0.202TrpGln: 0.202 ± 0.014	0.288TrpArg: 0.288 ± 0.015	0.32TrpSer: 0.32 ± 0.016	0.332TrpThr: 0.332 ± 0.018	0.469TrpVal: 0.469 ± 0.023	0.079TrpTrp: 0.079 ± 0.009	0.285TrpTyr: 0.285 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.196TyrAla: 2.196 ± 0.047	0.444TyrCys: 0.444 ± 0.02	2.345TyrAsp: 2.345 ± 0.058	2.804TyrGlu: 2.804 ± 0.059	1.889TyrPhe: 1.889 ± 0.049	2.651TyrGly: 2.651 ± 0.054	0.773TyrHis: 0.773 ± 0.03	3.534TyrIle: 3.534 ± 0.057	3.258TyrLys: 3.258 ± 0.054	3.337TyrLeu: 3.337 ± 0.057	1.078TyrMet: 1.078 ± 0.034	1.999TyrAsn: 1.999 ± 0.046	1.336TyrPro: 1.336 ± 0.034	1.055TyrGln: 1.055 ± 0.031	1.495TyrArg: 1.495 ± 0.034	2.058TyrSer: 2.058 ± 0.041	2.029TyrThr: 2.029 ± 0.046	2.23TyrVal: 2.23 ± 0.046	0.3TyrTrp: 0.3 ± 0.018	1.564TyrTyr: 1.564 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3681 proteins (1099301 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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