Amino acid dipepetide frequency for Mucilaginibacter sp. 94

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.021AlaAla: 7.021 ± 0.09	0.722AlaCys: 0.722 ± 0.024	4.993AlaAsp: 4.993 ± 0.066	4.58AlaGlu: 4.58 ± 0.068	3.625AlaPhe: 3.625 ± 0.063	6.065AlaGly: 6.065 ± 0.07	1.311AlaHis: 1.311 ± 0.033	5.857AlaIle: 5.857 ± 0.07	5.064AlaLys: 5.064 ± 0.065	7.302AlaLeu: 7.302 ± 0.084	1.892AlaMet: 1.892 ± 0.034	4.085AlaAsn: 4.085 ± 0.06	2.514AlaPro: 2.514 ± 0.046	3.204AlaGln: 3.204 ± 0.043	2.635AlaArg: 2.635 ± 0.047	4.422AlaSer: 4.422 ± 0.058	4.6AlaThr: 4.6 ± 0.061	5.141AlaVal: 5.141 ± 0.065	0.804AlaTrp: 0.804 ± 0.024	3.07AlaTyr: 3.07 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.556CysAla: 0.556 ± 0.021	0.143CysCys: 0.143 ± 0.01	0.378CysAsp: 0.378 ± 0.017	0.367CysGlu: 0.367 ± 0.014	0.438CysPhe: 0.438 ± 0.021	0.628CysGly: 0.628 ± 0.023	0.196CysHis: 0.196 ± 0.013	0.607CysIle: 0.607 ± 0.023	0.5CysLys: 0.5 ± 0.018	0.755CysLeu: 0.755 ± 0.02	0.189CysMet: 0.189 ± 0.012	0.373CysAsn: 0.373 ± 0.016	0.306CysPro: 0.306 ± 0.015	0.215CysGln: 0.215 ± 0.014	0.325CysArg: 0.325 ± 0.016	0.514CysSer: 0.514 ± 0.02	0.43CysThr: 0.43 ± 0.021	0.468CysVal: 0.468 ± 0.02	0.084CysTrp: 0.084 ± 0.007	0.28CysTyr: 0.28 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.449AspAla: 4.449 ± 0.062	0.384AspCys: 0.384 ± 0.018	2.9AspAsp: 2.9 ± 0.057	3.447AspGlu: 3.447 ± 0.054	2.966AspPhe: 2.966 ± 0.049	3.768AspGly: 3.768 ± 0.068	1.004AspHis: 1.004 ± 0.03	4.19AspIle: 4.19 ± 0.061	4.123AspLys: 4.123 ± 0.057	4.758AspLeu: 4.758 ± 0.062	1.327AspMet: 1.327 ± 0.032	3.071AspAsn: 3.071 ± 0.043	2.01AspPro: 2.01 ± 0.037	1.679AspGln: 1.679 ± 0.035	2.079AspArg: 2.079 ± 0.044	2.841AspSer: 2.841 ± 0.048	2.927AspThr: 2.927 ± 0.048	3.684AspVal: 3.684 ± 0.045	0.725AspTrp: 0.725 ± 0.024	2.494AspTyr: 2.494 ± 0.046	0.001AspXaa: 0.001 ± 0.001
Glu	4.14GluAla: 4.14 ± 0.061	0.32GluCys: 0.32 ± 0.017	2.622GluAsp: 2.622 ± 0.047	3.316GluGlu: 3.316 ± 0.06	2.35GluPhe: 2.35 ± 0.046	3.197GluGly: 3.197 ± 0.06	1.156GluHis: 1.156 ± 0.026	4.073GluIle: 4.073 ± 0.059	4.142GluLys: 4.142 ± 0.06	5.571GluLeu: 5.571 ± 0.08	1.407GluMet: 1.407 ± 0.033	2.822GluAsn: 2.822 ± 0.047	1.738GluPro: 1.738 ± 0.042	2.425GluGln: 2.425 ± 0.045	2.373GluArg: 2.373 ± 0.04	2.594GluSer: 2.594 ± 0.042	2.865GluThr: 2.865 ± 0.051	3.646GluVal: 3.646 ± 0.055	0.579GluTrp: 0.579 ± 0.021	2.051GluTyr: 2.051 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.595PheAla: 3.595 ± 0.055	0.445PheCys: 0.445 ± 0.018	2.889PheAsp: 2.889 ± 0.041	2.608PheGlu: 2.608 ± 0.041	2.309PhePhe: 2.309 ± 0.047	3.415PheGly: 3.415 ± 0.06	0.787PheHis: 0.787 ± 0.025	3.577PheIle: 3.577 ± 0.061	3.572PheLys: 3.572 ± 0.054	4.116PheLeu: 4.116 ± 0.06	1.116PheMet: 1.116 ± 0.031	3.199PheAsn: 3.199 ± 0.055	1.659PhePro: 1.659 ± 0.038	1.238PheGln: 1.238 ± 0.031	1.711PheArg: 1.711 ± 0.031	3.268PheSer: 3.268 ± 0.047	3.285PheThr: 3.285 ± 0.054	2.776PheVal: 2.776 ± 0.051	0.583PheTrp: 0.583 ± 0.023	2.068PheTyr: 2.068 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.891GlyAla: 4.891 ± 0.064	0.581GlyCys: 0.581 ± 0.021	3.421GlyAsp: 3.421 ± 0.048	3.322GlyGlu: 3.322 ± 0.053	3.648GlyPhe: 3.648 ± 0.063	4.97GlyGly: 4.97 ± 0.081	1.313GlyHis: 1.313 ± 0.032	5.363GlyIle: 5.363 ± 0.065	5.244GlyLys: 5.244 ± 0.071	6.326GlyLeu: 6.326 ± 0.072	1.664GlyMet: 1.664 ± 0.037	3.731GlyAsn: 3.731 ± 0.055	1.676GlyPro: 1.676 ± 0.039	2.378GlyGln: 2.378 ± 0.041	2.612GlyArg: 2.612 ± 0.05	4.153GlySer: 4.153 ± 0.064	4.145GlyThr: 4.145 ± 0.067	4.558GlyVal: 4.558 ± 0.062	0.962GlyTrp: 0.962 ± 0.029	3.166GlyTyr: 3.166 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.191HisAla: 1.191 ± 0.029	0.177HisCys: 0.177 ± 0.012	0.982HisAsp: 0.982 ± 0.027	0.995HisGlu: 0.995 ± 0.025	1.064HisPhe: 1.064 ± 0.026	1.16HisGly: 1.16 ± 0.032	0.542HisHis: 0.542 ± 0.021	1.477HisIle: 1.477 ± 0.029	1.086HisLys: 1.086 ± 0.032	1.928HisLeu: 1.928 ± 0.041	0.385HisMet: 0.385 ± 0.019	1.004HisAsn: 1.004 ± 0.028	1.049HisPro: 1.049 ± 0.026	0.824HisGln: 0.824 ± 0.025	0.761HisArg: 0.761 ± 0.026	1.04HisSer: 1.04 ± 0.025	1.037HisThr: 1.037 ± 0.029	1.054HisVal: 1.054 ± 0.03	0.224HisTrp: 0.224 ± 0.01	0.888HisTyr: 0.888 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.39IleAla: 6.39 ± 0.072	0.725IleCys: 0.725 ± 0.023	4.4IleAsp: 4.4 ± 0.059	3.94IleGlu: 3.94 ± 0.058	3.071IlePhe: 3.071 ± 0.054	4.959IleGly: 4.959 ± 0.065	1.275IleHis: 1.275 ± 0.028	5.435IleIle: 5.435 ± 0.073	5.298IleLys: 5.298 ± 0.053	6.197IleLeu: 6.197 ± 0.079	1.477IleMet: 1.477 ± 0.041	4.542IleAsn: 4.542 ± 0.067	3.011IlePro: 3.011 ± 0.051	2.27IleGln: 2.27 ± 0.041	2.838IleArg: 2.838 ± 0.041	4.903IleSer: 4.903 ± 0.065	4.946IleThr: 4.946 ± 0.059	4.318IleVal: 4.318 ± 0.065	0.723IleTrp: 0.723 ± 0.021	2.76IleTyr: 2.76 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	5.646LysAla: 5.646 ± 0.069	0.316LysCys: 0.316 ± 0.014	4.026LysAsp: 4.026 ± 0.057	4.099LysGlu: 4.099 ± 0.058	2.793LysPhe: 2.793 ± 0.041	4.448LysGly: 4.448 ± 0.059	1.37LysHis: 1.37 ± 0.03	4.842LysIle: 4.842 ± 0.06	5.346LysLys: 5.346 ± 0.075	6.495LysLeu: 6.495 ± 0.077	1.865LysMet: 1.865 ± 0.038	4.195LysAsn: 4.195 ± 0.056	3.063LysPro: 3.063 ± 0.056	3.073LysGln: 3.073 ± 0.053	2.828LysArg: 2.828 ± 0.045	3.729LysSer: 3.729 ± 0.056	4.287LysThr: 4.287 ± 0.057	4.538LysVal: 4.538 ± 0.059	0.803LysTrp: 0.803 ± 0.023	2.951LysTyr: 2.951 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	7.298LeuAla: 7.298 ± 0.082	0.767LeuCys: 0.767 ± 0.024	4.726LeuAsp: 4.726 ± 0.063	4.387LeuGlu: 4.387 ± 0.059	4.559LeuPhe: 4.559 ± 0.073	5.755LeuGly: 5.755 ± 0.077	1.735LeuHis: 1.735 ± 0.034	6.727LeuIle: 6.727 ± 0.082	7.246LeuLys: 7.246 ± 0.079	9.45LeuLeu: 9.45 ± 0.109	2.279LeuMet: 2.279 ± 0.039	5.806LeuAsn: 5.806 ± 0.081	4.069LeuPro: 4.069 ± 0.053	3.923LeuGln: 3.923 ± 0.064	3.572LeuArg: 3.572 ± 0.052	6.547LeuSer: 6.547 ± 0.067	5.715LeuThr: 5.715 ± 0.064	5.576LeuVal: 5.576 ± 0.064	0.859LeuTrp: 0.859 ± 0.028	3.29LeuTyr: 3.29 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.104MetAla: 2.104 ± 0.042	0.145MetCys: 0.145 ± 0.01	1.239MetAsp: 1.239 ± 0.03	1.291MetGlu: 1.291 ± 0.032	0.864MetPhe: 0.864 ± 0.027	1.578MetGly: 1.578 ± 0.037	0.481MetHis: 0.481 ± 0.017	1.562MetIle: 1.562 ± 0.035	1.857MetLys: 1.857 ± 0.036	2.349MetLeu: 2.349 ± 0.046	0.626MetMet: 0.626 ± 0.026	1.16MetAsn: 1.16 ± 0.031	1.15MetPro: 1.15 ± 0.03	1.065MetGln: 1.065 ± 0.027	0.99MetArg: 0.99 ± 0.03	1.313MetSer: 1.313 ± 0.035	1.049MetThr: 1.049 ± 0.027	1.62MetVal: 1.62 ± 0.035	0.155MetTrp: 0.155 ± 0.01	0.693MetTyr: 0.693 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	4.233AsnAla: 4.233 ± 0.062	0.394AsnCys: 0.394 ± 0.017	2.927AsnAsp: 2.927 ± 0.051	2.87AsnGlu: 2.87 ± 0.047	2.757AsnPhe: 2.757 ± 0.055	4.066AsnGly: 4.066 ± 0.066	1.068AsnHis: 1.068 ± 0.03	4.37AsnIle: 4.37 ± 0.06	3.794AsnLys: 3.794 ± 0.058	5.099AsnLeu: 5.099 ± 0.064	1.271AsnMet: 1.271 ± 0.029	3.674AsnAsn: 3.674 ± 0.061	2.707AsnPro: 2.707 ± 0.046	2.17AsnGln: 2.17 ± 0.047	2.323AsnArg: 2.323 ± 0.042	3.317AsnSer: 3.317 ± 0.049	3.436AsnThr: 3.436 ± 0.068	3.349AsnVal: 3.349 ± 0.055	0.749AsnTrp: 0.749 ± 0.023	2.781AsnTyr: 2.781 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	3.518ProAla: 3.518 ± 0.062	0.218ProCys: 0.218 ± 0.012	2.633ProAsp: 2.633 ± 0.046	2.622ProGlu: 2.622 ± 0.049	1.918ProPhe: 1.918 ± 0.039	2.92ProGly: 2.92 ± 0.048	0.688ProHis: 0.688 ± 0.024	2.393ProIle: 2.393 ± 0.044	2.326ProLys: 2.326 ± 0.049	3.317ProLeu: 3.317 ± 0.052	0.78ProMet: 0.78 ± 0.025	2.025ProAsn: 2.025 ± 0.039	1.1ProPro: 1.1 ± 0.04	1.562ProGln: 1.562 ± 0.032	1.064ProArg: 1.064 ± 0.029	2.049ProSer: 2.049 ± 0.041	2.056ProThr: 2.056 ± 0.035	3.321ProVal: 3.321 ± 0.052	0.434ProTrp: 0.434 ± 0.016	1.61ProTyr: 1.61 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.912GlnAla: 2.912 ± 0.045	0.197GlnCys: 0.197 ± 0.013	1.696GlnAsp: 1.696 ± 0.034	1.936GlnGlu: 1.936 ± 0.043	1.716GlnPhe: 1.716 ± 0.036	2.076GlnGly: 2.076 ± 0.038	0.851GlnHis: 0.851 ± 0.025	2.656GlnIle: 2.656 ± 0.046	2.764GlnLys: 2.764 ± 0.052	4.003GlnLeu: 4.003 ± 0.063	0.933GlnMet: 0.933 ± 0.024	2.147GlnAsn: 2.147 ± 0.044	1.6GlnPro: 1.6 ± 0.038	2.254GlnGln: 2.254 ± 0.064	1.541GlnArg: 1.541 ± 0.037	2.21GlnSer: 2.21 ± 0.042	2.298GlnThr: 2.298 ± 0.037	2.471GlnVal: 2.471 ± 0.046	0.419GlnTrp: 0.419 ± 0.017	1.536GlnTyr: 1.536 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.512ArgAla: 2.512 ± 0.05	0.245ArgCys: 0.245 ± 0.015	1.983ArgAsp: 1.983 ± 0.038	2.126ArgGlu: 2.126 ± 0.042	2.065ArgPhe: 2.065 ± 0.04	2.166ArgGly: 2.166 ± 0.046	0.725ArgHis: 0.725 ± 0.025	2.937ArgIle: 2.937 ± 0.051	2.823ArgLys: 2.823 ± 0.047	3.771ArgLeu: 3.771 ± 0.056	1.038ArgMet: 1.038 ± 0.025	2.251ArgAsn: 2.251 ± 0.041	1.368ArgPro: 1.368 ± 0.037	1.522ArgGln: 1.522 ± 0.038	1.597ArgArg: 1.597 ± 0.034	2.3ArgSer: 2.3 ± 0.039	1.968ArgThr: 1.968 ± 0.038	2.433ArgVal: 2.433 ± 0.042	0.467ArgTrp: 0.467 ± 0.019	1.815ArgTyr: 1.815 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.775SerAla: 4.775 ± 0.054	0.515SerCys: 0.515 ± 0.019	2.904SerAsp: 2.904 ± 0.045	2.759SerGlu: 2.759 ± 0.05	3.288SerPhe: 3.288 ± 0.054	4.6SerGly: 4.6 ± 0.065	1.088SerHis: 1.088 ± 0.03	4.508SerIle: 4.508 ± 0.061	3.834SerLys: 3.834 ± 0.05	5.791SerLeu: 5.791 ± 0.069	1.257SerMet: 1.257 ± 0.033	3.08SerAsn: 3.08 ± 0.057	2.378SerPro: 2.378 ± 0.045	1.967SerGln: 1.967 ± 0.036	2.337SerArg: 2.337 ± 0.042	3.596SerSer: 3.596 ± 0.056	3.486SerThr: 3.486 ± 0.054	4.031SerVal: 4.031 ± 0.06	0.668SerTrp: 0.668 ± 0.025	2.613SerTyr: 2.613 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.969ThrAla: 4.969 ± 0.063	0.405ThrCys: 0.405 ± 0.017	3.668ThrAsp: 3.668 ± 0.055	3.06ThrGlu: 3.06 ± 0.046	2.808ThrPhe: 2.808 ± 0.048	5.027ThrGly: 5.027 ± 0.06	1.064ThrHis: 1.064 ± 0.029	4.497ThrIle: 4.497 ± 0.063	3.29ThrLys: 3.29 ± 0.046	5.57ThrLeu: 5.57 ± 0.063	1.079ThrMet: 1.079 ± 0.03	3.143ThrAsn: 3.143 ± 0.063	2.656ThrPro: 2.656 ± 0.049	2.047ThrGln: 2.047 ± 0.045	2.008ThrArg: 2.008 ± 0.041	3.406ThrSer: 3.406 ± 0.056	3.64ThrThr: 3.64 ± 0.059	4.039ThrVal: 4.039 ± 0.053	0.617ThrTrp: 0.617 ± 0.023	2.518ThrTyr: 2.518 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	5.035ValAla: 5.035 ± 0.063	0.584ValCys: 0.584 ± 0.022	3.463ValAsp: 3.463 ± 0.051	3.193ValGlu: 3.193 ± 0.051	3.133ValPhe: 3.133 ± 0.051	3.781ValGly: 3.781 ± 0.054	1.058ValHis: 1.058 ± 0.023	4.975ValIle: 4.975 ± 0.065	4.782ValLys: 4.782 ± 0.066	6.224ValLeu: 6.224 ± 0.07	1.568ValMet: 1.568 ± 0.033	3.824ValAsn: 3.824 ± 0.057	2.432ValPro: 2.432 ± 0.039	2.057ValGln: 2.057 ± 0.042	2.218ValArg: 2.218 ± 0.039	4.205ValSer: 4.205 ± 0.062	4.217ValThr: 4.217 ± 0.063	4.201ValVal: 4.201 ± 0.072	0.675ValTrp: 0.675 ± 0.02	2.586ValTyr: 2.586 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.792TrpAla: 0.792 ± 0.026	0.123TrpCys: 0.123 ± 0.009	0.693TrpAsp: 0.693 ± 0.024	0.577TrpGlu: 0.577 ± 0.019	0.624TrpPhe: 0.624 ± 0.022	0.804TrpGly: 0.804 ± 0.021	0.268TrpHis: 0.268 ± 0.013	0.679TrpIle: 0.679 ± 0.024	0.763TrpLys: 0.763 ± 0.024	1.181TrpLeu: 1.181 ± 0.03	0.315TrpMet: 0.315 ± 0.015	0.587TrpAsn: 0.587 ± 0.02	0.354TrpPro: 0.354 ± 0.016	0.562TrpGln: 0.562 ± 0.02	0.483TrpArg: 0.483 ± 0.019	0.545TrpSer: 0.545 ± 0.023	0.545TrpThr: 0.545 ± 0.02	0.698TrpVal: 0.698 ± 0.027	0.192TrpTrp: 0.192 ± 0.012	0.43TrpTyr: 0.43 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.88TyrAla: 2.88 ± 0.041	0.347TyrCys: 0.347 ± 0.017	2.286TyrAsp: 2.286 ± 0.05	1.896TyrGlu: 1.896 ± 0.042	2.22TyrPhe: 2.22 ± 0.041	2.739TyrGly: 2.739 ± 0.046	0.889TyrHis: 0.889 ± 0.027	2.75TyrIle: 2.75 ± 0.047	2.858TyrLys: 2.858 ± 0.048	4.084TyrLeu: 4.084 ± 0.059	0.822TyrMet: 0.822 ± 0.021	2.635TyrAsn: 2.635 ± 0.049	1.715TyrPro: 1.715 ± 0.036	1.781TyrGln: 1.781 ± 0.04	1.816TyrArg: 1.816 ± 0.039	2.522TyrSer: 2.522 ± 0.045	2.579TyrThr: 2.579 ± 0.049	2.289TyrVal: 2.289 ± 0.042	0.493TyrTrp: 0.493 ± 0.02	1.894TyrTyr: 1.894 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4311 proteins (1404697 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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