Amino acid dipepetide frequency for Streptococcus phage Javan187

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.735AlaAla: 5.735 ± 0.994
0.51AlaCys: 0.51 ± 0.265
4.843AlaAsp: 4.843 ± 0.835
4.971AlaGlu: 4.971 ± 0.519
3.186AlaPhe: 3.186 ± 0.586
4.716AlaGly: 4.716 ± 1.174
0.637AlaHis: 0.637 ± 0.282
4.716AlaIle: 4.716 ± 0.859
7.265AlaLys: 7.265 ± 0.951
7.775AlaLeu: 7.775 ± 1.014
2.931AlaMet: 2.931 ± 0.776
3.569AlaAsn: 3.569 ± 0.708
0.637AlaPro: 0.637 ± 0.353
2.549AlaGln: 2.549 ± 0.608
2.167AlaArg: 2.167 ± 0.444
3.441AlaSer: 3.441 ± 0.997
3.059AlaThr: 3.059 ± 0.629
3.696AlaVal: 3.696 ± 0.796
0.637AlaTrp: 0.637 ± 0.272
2.422AlaTyr: 2.422 ± 0.537
0.0AlaXaa: 0.0 ± 0.0
Cys
0.127CysAla: 0.127 ± 0.128
0.127CysCys: 0.127 ± 0.146
0.51CysAsp: 0.51 ± 0.259
1.02CysGlu: 1.02 ± 0.472
0.127CysPhe: 0.127 ± 0.126
0.51CysGly: 0.51 ± 0.291
0.127CysHis: 0.127 ± 0.128
0.0CysIle: 0.0 ± 0.0
0.51CysLys: 0.51 ± 0.238
0.127CysLeu: 0.127 ± 0.124
0.51CysMet: 0.51 ± 0.239
0.382CysAsn: 0.382 ± 0.207
0.127CysPro: 0.127 ± 0.148
0.127CysGln: 0.127 ± 0.146
0.255CysArg: 0.255 ± 0.22
0.382CysSer: 0.382 ± 0.194
0.255CysThr: 0.255 ± 0.147
0.127CysVal: 0.127 ± 0.128
0.127CysTrp: 0.127 ± 0.128
0.255CysTyr: 0.255 ± 0.195
0.0CysXaa: 0.0 ± 0.0
Asp
3.186AspAla: 3.186 ± 0.641
0.255AspCys: 0.255 ± 0.195
4.843AspAsp: 4.843 ± 0.96
5.353AspGlu: 5.353 ± 0.821
4.588AspPhe: 4.588 ± 0.636
4.843AspGly: 4.843 ± 0.924
0.637AspHis: 0.637 ± 0.26
6.118AspIle: 6.118 ± 1.133
5.353AspLys: 5.353 ± 0.872
6.118AspLeu: 6.118 ± 0.85
1.657AspMet: 1.657 ± 0.336
2.422AspAsn: 2.422 ± 0.803
1.402AspPro: 1.402 ± 0.509
1.02AspGln: 1.02 ± 0.347
1.657AspArg: 1.657 ± 0.747
4.716AspSer: 4.716 ± 0.813
2.677AspThr: 2.677 ± 0.568
4.461AspVal: 4.461 ± 0.804
1.147AspTrp: 1.147 ± 0.391
4.079AspTyr: 4.079 ± 0.76
0.0AspXaa: 0.0 ± 0.0
Glu
5.608GluAla: 5.608 ± 0.962
0.51GluCys: 0.51 ± 0.234
3.824GluAsp: 3.824 ± 0.73
6.118GluGlu: 6.118 ± 1.038
2.294GluPhe: 2.294 ± 0.482
2.931GluGly: 2.931 ± 0.626
1.147GluHis: 1.147 ± 0.38
5.098GluIle: 5.098 ± 0.538
7.01GluLys: 7.01 ± 0.812
8.667GluLeu: 8.667 ± 1.1
2.167GluMet: 2.167 ± 0.642
5.226GluAsn: 5.226 ± 0.88
1.402GluPro: 1.402 ± 0.364
3.696GluGln: 3.696 ± 0.75
3.314GluArg: 3.314 ± 0.635
3.314GluSer: 3.314 ± 0.793
4.079GluThr: 4.079 ± 0.724
5.353GluVal: 5.353 ± 0.841
1.147GluTrp: 1.147 ± 0.452
3.441GluTyr: 3.441 ± 0.56
0.0GluXaa: 0.0 ± 0.0
Phe
3.314PheAla: 3.314 ± 0.566
0.255PheCys: 0.255 ± 0.147
4.461PheAsp: 4.461 ± 0.925
3.059PheGlu: 3.059 ± 0.511
1.02PhePhe: 1.02 ± 0.407
2.677PheGly: 2.677 ± 0.507
0.382PheHis: 0.382 ± 0.255
2.677PheIle: 2.677 ± 0.828
4.588PheLys: 4.588 ± 0.802
2.549PheLeu: 2.549 ± 0.611
1.147PheMet: 1.147 ± 0.311
2.931PheAsn: 2.931 ± 0.547
1.02PhePro: 1.02 ± 0.318
1.275PheGln: 1.275 ± 0.584
1.912PheArg: 1.912 ± 0.503
2.294PheSer: 2.294 ± 0.482
1.529PheThr: 1.529 ± 0.396
2.422PheVal: 2.422 ± 0.526
0.382PheTrp: 0.382 ± 0.199
1.275PheTyr: 1.275 ± 0.406
0.0PheXaa: 0.0 ± 0.0
Gly
3.441GlyAla: 3.441 ± 0.927
0.51GlyCys: 0.51 ± 0.259
3.696GlyAsp: 3.696 ± 0.735
4.206GlyGlu: 4.206 ± 0.803
2.677GlyPhe: 2.677 ± 0.442
4.461GlyGly: 4.461 ± 0.9
1.147GlyHis: 1.147 ± 0.315
5.99GlyIle: 5.99 ± 1.224
5.353GlyLys: 5.353 ± 0.793
5.735GlyLeu: 5.735 ± 0.862
1.529GlyMet: 1.529 ± 0.409
3.314GlyAsn: 3.314 ± 0.778
1.147GlyPro: 1.147 ± 0.456
2.677GlyGln: 2.677 ± 0.699
1.912GlyArg: 1.912 ± 0.578
3.824GlySer: 3.824 ± 0.614
3.569GlyThr: 3.569 ± 0.85
2.804GlyVal: 2.804 ± 0.651
0.255GlyTrp: 0.255 ± 0.198
2.549GlyTyr: 2.549 ± 0.473
0.0GlyXaa: 0.0 ± 0.0
His
1.402HisAla: 1.402 ± 0.415
0.255HisCys: 0.255 ± 0.176
0.382HisAsp: 0.382 ± 0.206
1.275HisGlu: 1.275 ± 0.333
1.147HisPhe: 1.147 ± 0.386
0.637HisGly: 0.637 ± 0.227
0.765HisHis: 0.765 ± 0.352
1.784HisIle: 1.784 ± 0.509
1.02HisLys: 1.02 ± 0.361
0.765HisLeu: 0.765 ± 0.318
0.255HisMet: 0.255 ± 0.196
0.765HisAsn: 0.765 ± 0.319
0.637HisPro: 0.637 ± 0.25
0.382HisGln: 0.382 ± 0.259
0.51HisArg: 0.51 ± 0.219
0.765HisSer: 0.765 ± 0.427
1.147HisThr: 1.147 ± 0.334
0.765HisVal: 0.765 ± 0.42
0.255HisTrp: 0.255 ± 0.158
0.765HisTyr: 0.765 ± 0.377
0.0HisXaa: 0.0 ± 0.0
Ile
6.628IleAla: 6.628 ± 1.078
0.382IleCys: 0.382 ± 0.265
5.735IleAsp: 5.735 ± 1.129
5.99IleGlu: 5.99 ± 0.929
2.422IlePhe: 2.422 ± 0.567
4.843IleGly: 4.843 ± 0.824
1.275IleHis: 1.275 ± 0.385
5.226IleIle: 5.226 ± 0.737
6.5IleLys: 6.5 ± 0.958
4.716IleLeu: 4.716 ± 0.501
1.784IleMet: 1.784 ± 0.375
5.226IleAsn: 5.226 ± 0.697
2.039IlePro: 2.039 ± 0.403
2.422IleGln: 2.422 ± 0.624
3.441IleArg: 3.441 ± 0.576
6.118IleSer: 6.118 ± 0.984
4.716IleThr: 4.716 ± 0.621
3.951IleVal: 3.951 ± 0.808
1.147IleTrp: 1.147 ± 0.37
3.059IleTyr: 3.059 ± 0.694
0.0IleXaa: 0.0 ± 0.0
Lys
6.245LysAla: 6.245 ± 0.961
0.255LysCys: 0.255 ± 0.174
5.098LysAsp: 5.098 ± 0.996
7.01LysGlu: 7.01 ± 0.773
2.804LysPhe: 2.804 ± 0.607
4.333LysGly: 4.333 ± 0.88
1.402LysHis: 1.402 ± 0.53
7.01LysIle: 7.01 ± 0.958
8.412LysLys: 8.412 ± 1.63
9.686LysLeu: 9.686 ± 1.21
2.422LysMet: 2.422 ± 0.594
6.755LysAsn: 6.755 ± 0.698
2.549LysPro: 2.549 ± 0.792
3.951LysGln: 3.951 ± 0.61
4.333LysArg: 4.333 ± 0.758
4.206LysSer: 4.206 ± 0.528
5.608LysThr: 5.608 ± 0.879
4.971LysVal: 4.971 ± 0.799
0.637LysTrp: 0.637 ± 0.25
2.422LysTyr: 2.422 ± 0.642
0.0LysXaa: 0.0 ± 0.0
Leu
6.882LeuAla: 6.882 ± 1.17
0.892LeuCys: 0.892 ± 0.386
5.608LeuAsp: 5.608 ± 0.824
5.99LeuGlu: 5.99 ± 1.158
2.931LeuPhe: 2.931 ± 0.608
5.99LeuGly: 5.99 ± 0.834
1.147LeuHis: 1.147 ± 0.375
4.971LeuIle: 4.971 ± 0.941
8.157LeuLys: 8.157 ± 0.882
5.608LeuLeu: 5.608 ± 0.672
1.912LeuMet: 1.912 ± 0.54
4.716LeuAsn: 4.716 ± 0.838
3.441LeuPro: 3.441 ± 0.695
2.422LeuGln: 2.422 ± 0.604
4.206LeuArg: 4.206 ± 0.579
6.755LeuSer: 6.755 ± 1.133
7.01LeuThr: 7.01 ± 0.697
5.353LeuVal: 5.353 ± 0.876
0.382LeuTrp: 0.382 ± 0.165
1.657LeuTyr: 1.657 ± 0.414
0.0LeuXaa: 0.0 ± 0.0
Met
1.657MetAla: 1.657 ± 0.537
0.0MetCys: 0.0 ± 0.0
2.039MetAsp: 2.039 ± 0.473
2.039MetGlu: 2.039 ± 0.566
1.147MetPhe: 1.147 ± 0.394
0.765MetGly: 0.765 ± 0.278
0.0MetHis: 0.0 ± 0.0
2.294MetIle: 2.294 ± 0.457
1.657MetLys: 1.657 ± 0.542
2.167MetLeu: 2.167 ± 0.558
1.02MetMet: 1.02 ± 0.306
1.529MetAsn: 1.529 ± 0.374
1.02MetPro: 1.02 ± 0.317
1.02MetGln: 1.02 ± 0.376
1.275MetArg: 1.275 ± 0.468
2.039MetSer: 2.039 ± 0.444
2.549MetThr: 2.549 ± 0.568
1.02MetVal: 1.02 ± 0.348
0.51MetTrp: 0.51 ± 0.188
0.382MetTyr: 0.382 ± 0.214
0.0MetXaa: 0.0 ± 0.0
Asn
4.461AsnAla: 4.461 ± 0.966
0.127AsnCys: 0.127 ± 0.112
3.186AsnAsp: 3.186 ± 0.73
3.059AsnGlu: 3.059 ± 0.596
2.422AsnPhe: 2.422 ± 0.524
4.333AsnGly: 4.333 ± 0.641
1.02AsnHis: 1.02 ± 0.375
4.206AsnIle: 4.206 ± 0.696
4.206AsnLys: 4.206 ± 0.677
4.971AsnLeu: 4.971 ± 1.027
0.892AsnMet: 0.892 ± 0.318
3.186AsnAsn: 3.186 ± 0.808
2.804AsnPro: 2.804 ± 0.547
2.549AsnGln: 2.549 ± 0.545
2.677AsnArg: 2.677 ± 0.623
3.441AsnSer: 3.441 ± 0.774
2.549AsnThr: 2.549 ± 0.501
3.824AsnVal: 3.824 ± 0.669
0.637AsnTrp: 0.637 ± 0.402
2.931AsnTyr: 2.931 ± 0.715
0.0AsnXaa: 0.0 ± 0.0
Pro
1.275ProAla: 1.275 ± 0.47
0.127ProCys: 0.127 ± 0.128
1.657ProAsp: 1.657 ± 0.513
2.677ProGlu: 2.677 ± 0.633
1.147ProPhe: 1.147 ± 0.46
0.765ProGly: 0.765 ± 0.415
0.765ProHis: 0.765 ± 0.314
2.677ProIle: 2.677 ± 0.499
2.294ProLys: 2.294 ± 0.523
2.549ProLeu: 2.549 ± 0.396
0.51ProMet: 0.51 ± 0.221
1.912ProAsn: 1.912 ± 0.561
0.51ProPro: 0.51 ± 0.227
1.402ProGln: 1.402 ± 0.437
0.51ProArg: 0.51 ± 0.25
1.402ProSer: 1.402 ± 0.508
1.529ProThr: 1.529 ± 0.429
1.657ProVal: 1.657 ± 0.4
0.127ProTrp: 0.127 ± 0.127
0.765ProTyr: 0.765 ± 0.316
0.0ProXaa: 0.0 ± 0.0
Gln
3.186GlnAla: 3.186 ± 0.554
0.127GlnCys: 0.127 ± 0.13
1.784GlnAsp: 1.784 ± 0.411
2.167GlnGlu: 2.167 ± 0.503
1.529GlnPhe: 1.529 ± 0.552
1.657GlnGly: 1.657 ± 0.505
0.892GlnHis: 0.892 ± 0.431
3.696GlnIle: 3.696 ± 0.645
2.804GlnLys: 2.804 ± 0.673
4.716GlnLeu: 4.716 ± 0.774
0.892GlnMet: 0.892 ± 0.295
2.294GlnAsn: 2.294 ± 0.451
0.51GlnPro: 0.51 ± 0.253
1.657GlnGln: 1.657 ± 0.561
1.275GlnArg: 1.275 ± 0.36
1.912GlnSer: 1.912 ± 0.437
2.677GlnThr: 2.677 ± 0.543
1.402GlnVal: 1.402 ± 0.313
0.0GlnTrp: 0.0 ± 0.0
1.147GlnTyr: 1.147 ± 0.415
0.0GlnXaa: 0.0 ± 0.0
Arg
2.677ArgAla: 2.677 ± 0.542
0.255ArgCys: 0.255 ± 0.171
3.059ArgAsp: 3.059 ± 0.81
3.441ArgGlu: 3.441 ± 0.733
1.529ArgPhe: 1.529 ± 0.383
2.294ArgGly: 2.294 ± 0.433
0.637ArgHis: 0.637 ± 0.343
3.059ArgIle: 3.059 ± 0.686
3.441ArgLys: 3.441 ± 0.751
2.294ArgLeu: 2.294 ± 0.701
1.529ArgMet: 1.529 ± 0.406
2.039ArgAsn: 2.039 ± 0.433
1.147ArgPro: 1.147 ± 0.317
1.402ArgGln: 1.402 ± 0.383
1.529ArgArg: 1.529 ± 0.415
1.657ArgSer: 1.657 ± 0.515
2.039ArgThr: 2.039 ± 0.408
1.912ArgVal: 1.912 ± 0.638
0.382ArgTrp: 0.382 ± 0.197
2.294ArgTyr: 2.294 ± 0.556
0.0ArgXaa: 0.0 ± 0.0
Ser
4.206SerAla: 4.206 ± 0.977
0.127SerCys: 0.127 ± 0.112
4.333SerAsp: 4.333 ± 0.782
5.863SerGlu: 5.863 ± 1.086
1.784SerPhe: 1.784 ± 0.478
3.569SerGly: 3.569 ± 0.755
0.51SerHis: 0.51 ± 0.403
4.206SerIle: 4.206 ± 1.101
6.373SerLys: 6.373 ± 0.744
4.843SerLeu: 4.843 ± 0.851
1.275SerMet: 1.275 ± 0.368
2.677SerAsn: 2.677 ± 0.485
1.02SerPro: 1.02 ± 0.37
1.912SerGln: 1.912 ± 0.412
1.784SerArg: 1.784 ± 0.481
3.951SerSer: 3.951 ± 0.987
3.569SerThr: 3.569 ± 0.898
3.569SerVal: 3.569 ± 0.798
0.637SerTrp: 0.637 ± 0.305
2.931SerTyr: 2.931 ± 0.629
0.0SerXaa: 0.0 ± 0.0
Thr
2.549ThrAla: 2.549 ± 0.612
0.382ThrCys: 0.382 ± 0.254
3.186ThrAsp: 3.186 ± 0.781
3.441ThrGlu: 3.441 ± 0.594
3.314ThrPhe: 3.314 ± 0.931
5.098ThrGly: 5.098 ± 1.008
1.402ThrHis: 1.402 ± 0.314
5.735ThrIle: 5.735 ± 0.818
4.716ThrLys: 4.716 ± 0.549
4.333ThrLeu: 4.333 ± 0.62
1.402ThrMet: 1.402 ± 0.389
2.931ThrAsn: 2.931 ± 0.744
1.657ThrPro: 1.657 ± 0.359
2.294ThrGln: 2.294 ± 0.56
1.912ThrArg: 1.912 ± 0.438
3.696ThrSer: 3.696 ± 0.746
5.098ThrThr: 5.098 ± 0.721
3.569ThrVal: 3.569 ± 0.782
0.892ThrTrp: 0.892 ± 0.358
1.784ThrTyr: 1.784 ± 0.441
0.0ThrXaa: 0.0 ± 0.0
Val
4.843ValAla: 4.843 ± 0.83
0.127ValCys: 0.127 ± 0.128
3.696ValAsp: 3.696 ± 0.827
4.716ValGlu: 4.716 ± 0.81
2.677ValPhe: 2.677 ± 0.544
3.186ValGly: 3.186 ± 0.717
0.51ValHis: 0.51 ± 0.266
5.608ValIle: 5.608 ± 1.15
5.99ValLys: 5.99 ± 0.953
3.441ValLeu: 3.441 ± 0.54
1.275ValMet: 1.275 ± 0.382
2.804ValAsn: 2.804 ± 0.457
1.784ValPro: 1.784 ± 0.423
1.275ValGln: 1.275 ± 0.287
2.167ValArg: 2.167 ± 0.437
3.314ValSer: 3.314 ± 0.459
4.079ValThr: 4.079 ± 0.832
3.441ValVal: 3.441 ± 0.748
0.637ValTrp: 0.637 ± 0.314
2.294ValTyr: 2.294 ± 0.479
0.0ValXaa: 0.0 ± 0.0
Trp
0.255TrpAla: 0.255 ± 0.19
0.382TrpCys: 0.382 ± 0.226
0.892TrpAsp: 0.892 ± 0.404
0.892TrpGlu: 0.892 ± 0.391
0.637TrpPhe: 0.637 ± 0.244
0.255TrpGly: 0.255 ± 0.16
0.255TrpHis: 0.255 ± 0.181
0.637TrpIle: 0.637 ± 0.289
0.892TrpLys: 0.892 ± 0.315
0.892TrpLeu: 0.892 ± 0.287
0.382TrpMet: 0.382 ± 0.204
0.892TrpAsn: 0.892 ± 0.329
0.127TrpPro: 0.127 ± 0.1
0.382TrpGln: 0.382 ± 0.175
0.255TrpArg: 0.255 ± 0.16
0.892TrpSer: 0.892 ± 0.247
0.382TrpThr: 0.382 ± 0.235
1.02TrpVal: 1.02 ± 0.414
0.0TrpTrp: 0.0 ± 0.0
0.51TrpTyr: 0.51 ± 0.21
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.784TyrAla: 1.784 ± 0.35
0.127TyrCys: 0.127 ± 0.135
3.696TyrAsp: 3.696 ± 0.935
3.059TyrGlu: 3.059 ± 0.473
1.912TyrPhe: 1.912 ± 0.584
2.931TyrGly: 2.931 ± 0.476
1.02TyrHis: 1.02 ± 0.356
1.912TyrIle: 1.912 ± 0.528
3.569TyrLys: 3.569 ± 1.015
4.079TyrLeu: 4.079 ± 0.692
0.51TyrMet: 0.51 ± 0.285
1.912TyrAsn: 1.912 ± 0.59
1.275TyrPro: 1.275 ± 0.424
1.912TyrGln: 1.912 ± 0.409
1.529TyrArg: 1.529 ± 0.452
1.02TyrSer: 1.02 ± 0.413
1.275TyrThr: 1.275 ± 0.433
2.549TyrVal: 2.549 ± 0.617
0.892TyrTrp: 0.892 ± 0.291
1.529TyrTyr: 1.529 ± 0.499
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 42 proteins (7847 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski