Amino acid dipepetide frequency for Planctomycetes bacterium Pla133

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.49AlaAla: 17.49 ± 0.149	1.171AlaCys: 1.171 ± 0.028	7.238AlaAsp: 7.238 ± 0.072	7.776AlaGlu: 7.776 ± 0.09	3.767AlaPhe: 3.767 ± 0.039	12.216AlaGly: 12.216 ± 0.1	2.082AlaHis: 2.082 ± 0.039	4.599AlaIle: 4.599 ± 0.053	2.35AlaLys: 2.35 ± 0.048	14.783AlaLeu: 14.783 ± 0.135	2.098AlaMet: 2.098 ± 0.034	2.223AlaAsn: 2.223 ± 0.038	6.966AlaPro: 6.966 ± 0.073	4.04AlaGln: 4.04 ± 0.051	10.167AlaArg: 10.167 ± 0.103	7.284AlaSer: 7.284 ± 0.063	6.401AlaThr: 6.401 ± 0.066	9.12AlaVal: 9.12 ± 0.078	2.051AlaTrp: 2.051 ± 0.035	1.923AlaTyr: 1.923 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.083CysAla: 1.083 ± 0.027	0.11CysCys: 0.11 ± 0.008	0.534CysAsp: 0.534 ± 0.019	0.541CysGlu: 0.541 ± 0.017	0.305CysPhe: 0.305 ± 0.014	0.978CysGly: 0.978 ± 0.026	0.286CysHis: 0.286 ± 0.022	0.268CysIle: 0.268 ± 0.012	0.135CysLys: 0.135 ± 0.008	0.851CysLeu: 0.851 ± 0.021	0.127CysMet: 0.127 ± 0.007	0.18CysAsn: 0.18 ± 0.01	0.476CysPro: 0.476 ± 0.018	0.216CysGln: 0.216 ± 0.01	0.576CysArg: 0.576 ± 0.017	0.567CysSer: 0.567 ± 0.019	0.424CysThr: 0.424 ± 0.014	0.67CysVal: 0.67 ± 0.02	0.111CysTrp: 0.111 ± 0.007	0.186CysTyr: 0.186 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.292AspAla: 7.292 ± 0.073	0.52AspCys: 0.52 ± 0.019	4.102AspAsp: 4.102 ± 0.07	4.438AspGlu: 4.438 ± 0.059	2.125AspPhe: 2.125 ± 0.038	7.88AspGly: 7.88 ± 0.106	1.27AspHis: 1.27 ± 0.028	1.484AspIle: 1.484 ± 0.03	0.829AspLys: 0.829 ± 0.023	8.128AspLeu: 8.128 ± 0.075	0.831AspMet: 0.831 ± 0.02	0.959AspAsn: 0.959 ± 0.026	4.886AspPro: 4.886 ± 0.057	1.916AspGln: 1.916 ± 0.034	4.983AspArg: 4.983 ± 0.063	3.053AspSer: 3.053 ± 0.041	2.18AspThr: 2.18 ± 0.035	4.728AspVal: 4.728 ± 0.057	1.154AspTrp: 1.154 ± 0.026	1.176AspTyr: 1.176 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.697GluAla: 7.697 ± 0.081	0.404GluCys: 0.404 ± 0.014	3.017GluAsp: 3.017 ± 0.043	3.124GluGlu: 3.124 ± 0.051	2.053GluPhe: 2.053 ± 0.032	5.452GluGly: 5.452 ± 0.063	1.463GluHis: 1.463 ± 0.03	2.379GluIle: 2.379 ± 0.036	1.022GluLys: 1.022 ± 0.029	9.451GluLeu: 9.451 ± 0.096	0.891GluMet: 0.891 ± 0.022	1.071GluAsn: 1.071 ± 0.024	3.809GluPro: 3.809 ± 0.047	2.336GluGln: 2.336 ± 0.039	7.193GluArg: 7.193 ± 0.093	3.464GluSer: 3.464 ± 0.045	2.626GluThr: 2.626 ± 0.033	5.398GluVal: 5.398 ± 0.059	0.877GluTrp: 0.877 ± 0.022	1.011GluTyr: 1.011 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.15PheAla: 4.15 ± 0.049	0.31PheCys: 0.31 ± 0.013	3.062PheAsp: 3.062 ± 0.041	2.916PheGlu: 2.916 ± 0.042	1.085PhePhe: 1.085 ± 0.026	3.669PheGly: 3.669 ± 0.046	0.678PheHis: 0.678 ± 0.02	0.798PheIle: 0.798 ± 0.021	0.566PheLys: 0.566 ± 0.017	3.16PheLeu: 3.16 ± 0.043	0.508PheMet: 0.508 ± 0.017	0.756PheAsn: 0.756 ± 0.023	1.507PhePro: 1.507 ± 0.032	0.944PheGln: 0.944 ± 0.021	1.999PheArg: 1.999 ± 0.033	1.805PheSer: 1.805 ± 0.041	1.708PheThr: 1.708 ± 0.028	2.772PheVal: 2.772 ± 0.038	0.451PheTrp: 0.451 ± 0.017	0.596PheTyr: 0.596 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.635GlyAla: 11.635 ± 0.094	0.906GlyCys: 0.906 ± 0.025	6.319GlyAsp: 6.319 ± 0.085	6.076GlyGlu: 6.076 ± 0.06	3.38GlyPhe: 3.38 ± 0.047	9.937GlyGly: 9.937 ± 0.134	1.856GlyHis: 1.856 ± 0.029	3.255GlyIle: 3.255 ± 0.052	1.858GlyLys: 1.858 ± 0.037	10.47GlyLeu: 10.47 ± 0.088	1.603GlyMet: 1.603 ± 0.035	2.063GlyAsn: 2.063 ± 0.039	5.295GlyPro: 5.295 ± 0.066	3.165GlyGln: 3.165 ± 0.045	7.485GlyArg: 7.485 ± 0.074	6.585GlySer: 6.585 ± 0.077	5.31GlyThr: 5.31 ± 0.074	6.857GlyVal: 6.857 ± 0.074	1.631GlyTrp: 1.631 ± 0.03	1.894GlyTyr: 1.894 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.169HisAla: 2.169 ± 0.035	0.216HisCys: 0.216 ± 0.012	1.123HisAsp: 1.123 ± 0.025	1.154HisGlu: 1.154 ± 0.027	0.795HisPhe: 0.795 ± 0.019	2.023HisGly: 2.023 ± 0.039	0.503HisHis: 0.503 ± 0.016	0.427HisIle: 0.427 ± 0.016	0.301HisLys: 0.301 ± 0.012	2.393HisLeu: 2.393 ± 0.03	0.283HisMet: 0.283 ± 0.012	0.334HisAsn: 0.334 ± 0.014	1.357HisPro: 1.357 ± 0.027	0.495HisGln: 0.495 ± 0.019	1.649HisArg: 1.649 ± 0.035	0.985HisSer: 0.985 ± 0.021	0.771HisThr: 0.771 ± 0.022	1.451HisVal: 1.451 ± 0.028	0.363HisTrp: 0.363 ± 0.013	0.427HisTyr: 0.427 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.834IleAla: 4.834 ± 0.052	0.309IleCys: 0.309 ± 0.011	3.332IleAsp: 3.332 ± 0.048	3.327IleGlu: 3.327 ± 0.041	0.969IlePhe: 0.969 ± 0.023	3.601IleGly: 3.601 ± 0.048	0.725IleHis: 0.725 ± 0.021	0.677IleIle: 0.677 ± 0.024	0.609IleLys: 0.609 ± 0.02	3.068IleLeu: 3.068 ± 0.039	0.315IleMet: 0.315 ± 0.012	0.705IleAsn: 0.705 ± 0.02	1.747IlePro: 1.747 ± 0.031	1.031IleGln: 1.031 ± 0.024	2.066IleArg: 2.066 ± 0.034	1.763IleSer: 1.763 ± 0.034	1.57IleThr: 1.57 ± 0.031	2.957IleVal: 2.957 ± 0.041	0.45IleTrp: 0.45 ± 0.017	0.707IleTyr: 0.707 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	1.97LysAla: 1.97 ± 0.038	0.118LysCys: 0.118 ± 0.008	0.879LysAsp: 0.879 ± 0.023	0.824LysGlu: 0.824 ± 0.026	0.494LysPhe: 0.494 ± 0.016	1.438LysGly: 1.438 ± 0.032	0.37LysHis: 0.37 ± 0.013	0.723LysIle: 0.723 ± 0.019	0.556LysLys: 0.556 ± 0.029	2.091LysLeu: 2.091 ± 0.039	0.25LysMet: 0.25 ± 0.011	0.388LysAsn: 0.388 ± 0.015	1.027LysPro: 1.027 ± 0.026	0.541LysGln: 0.541 ± 0.02	1.51LysArg: 1.51 ± 0.034	1.068LysSer: 1.068 ± 0.024	0.96LysThr: 0.96 ± 0.026	1.435LysVal: 1.435 ± 0.033	0.231LysTrp: 0.231 ± 0.01	0.339LysTyr: 0.339 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	16.123LeuAla: 16.123 ± 0.132	0.986LeuCys: 0.986 ± 0.022	7.934LeuAsp: 7.934 ± 0.071	8.536LeuGlu: 8.536 ± 0.086	3.48LeuPhe: 3.48 ± 0.047	10.605LeuGly: 10.605 ± 0.083	2.072LeuHis: 2.072 ± 0.031	3.67LeuIle: 3.67 ± 0.048	1.621LeuLys: 1.621 ± 0.033	11.507LeuLeu: 11.507 ± 0.099	1.491LeuMet: 1.491 ± 0.03	1.742LeuAsn: 1.742 ± 0.032	6.412LeuPro: 6.412 ± 0.052	2.717LeuGln: 2.717 ± 0.041	9.069LeuArg: 9.069 ± 0.082	5.978LeuSer: 5.978 ± 0.067	5.53LeuThr: 5.53 ± 0.065	9.56LeuVal: 9.56 ± 0.086	1.567LeuTrp: 1.567 ± 0.029	1.907LeuTyr: 1.907 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	1.917MetAla: 1.917 ± 0.034	0.099MetCys: 0.099 ± 0.007	0.894MetAsp: 0.894 ± 0.023	0.767MetGlu: 0.767 ± 0.019	0.367MetPhe: 0.367 ± 0.014	1.409MetGly: 1.409 ± 0.028	0.308MetHis: 0.308 ± 0.013	0.595MetIle: 0.595 ± 0.019	0.417MetLys: 0.417 ± 0.015	1.58MetLeu: 1.58 ± 0.03	0.212MetMet: 0.212 ± 0.01	0.421MetAsn: 0.421 ± 0.015	0.92MetPro: 0.92 ± 0.022	0.538MetGln: 0.538 ± 0.015	1.254MetArg: 1.254 ± 0.029	1.058MetSer: 1.058 ± 0.023	1.088MetThr: 1.088 ± 0.022	1.258MetVal: 1.258 ± 0.024	0.144MetTrp: 0.144 ± 0.008	0.185MetTyr: 0.185 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.056AsnAla: 2.056 ± 0.037	0.183AsnCys: 0.183 ± 0.01	1.158AsnAsp: 1.158 ± 0.031	0.96AsnGlu: 0.96 ± 0.022	0.722AsnPhe: 0.722 ± 0.022	1.979AsnGly: 1.979 ± 0.044	0.404AsnHis: 0.404 ± 0.013	0.59AsnIle: 0.59 ± 0.02	0.322AsnLys: 0.322 ± 0.013	2.203AsnLeu: 2.203 ± 0.035	0.285AsnMet: 0.285 ± 0.013	0.437AsnAsn: 0.437 ± 0.021	1.492AsnPro: 1.492 ± 0.031	0.609AsnGln: 0.609 ± 0.018	1.387AsnArg: 1.387 ± 0.03	1.059AsnSer: 1.059 ± 0.023	0.902AsnThr: 0.902 ± 0.03	1.474AsnVal: 1.474 ± 0.029	0.323AsnTrp: 0.323 ± 0.013	0.454AsnTyr: 0.454 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	7.191ProAla: 7.191 ± 0.073	0.404ProCys: 0.404 ± 0.015	3.903ProAsp: 3.903 ± 0.046	3.964ProGlu: 3.964 ± 0.061	2.008ProPhe: 2.008 ± 0.033	6.147ProGly: 6.147 ± 0.074	0.989ProHis: 0.989 ± 0.024	2.208ProIle: 2.208 ± 0.033	1.023ProLys: 1.023 ± 0.021	5.896ProLeu: 5.896 ± 0.059	0.983ProMet: 0.983 ± 0.021	1.214ProAsn: 1.214 ± 0.029	3.262ProPro: 3.262 ± 0.052	1.701ProGln: 1.701 ± 0.032	4.018ProArg: 4.018 ± 0.054	3.665ProSer: 3.665 ± 0.049	3.383ProThr: 3.383 ± 0.053	4.212ProVal: 4.212 ± 0.053	0.992ProTrp: 0.992 ± 0.022	0.985ProTyr: 0.985 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.745GlnAla: 3.745 ± 0.046	0.199GlnCys: 0.199 ± 0.01	1.367GlnAsp: 1.367 ± 0.025	1.387GlnGlu: 1.387 ± 0.03	0.917GlnPhe: 0.917 ± 0.022	2.568GlnGly: 2.568 ± 0.038	0.509GlnHis: 0.509 ± 0.016	1.276GlnIle: 1.276 ± 0.03	0.469GlnLys: 0.469 ± 0.018	3.514GlnLeu: 3.514 ± 0.041	0.557GlnMet: 0.557 ± 0.017	0.547GlnAsn: 0.547 ± 0.016	1.862GlnPro: 1.862 ± 0.031	0.903GlnGln: 0.903 ± 0.023	2.618GlnArg: 2.618 ± 0.039	1.724GlnSer: 1.724 ± 0.033	1.478GlnThr: 1.478 ± 0.028	2.825GlnVal: 2.825 ± 0.037	0.495GlnTrp: 0.495 ± 0.018	0.449GlnTyr: 0.449 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	10.148ArgAla: 10.148 ± 0.106	0.679ArgCys: 0.679 ± 0.017	4.362ArgAsp: 4.362 ± 0.055	5.301ArgGlu: 5.301 ± 0.065	3.074ArgPhe: 3.074 ± 0.04	6.388ArgGly: 6.388 ± 0.072	1.504ArgHis: 1.504 ± 0.035	3.137ArgIle: 3.137 ± 0.042	1.257ArgLys: 1.257 ± 0.027	9.032ArgLeu: 9.032 ± 0.09	1.585ArgMet: 1.585 ± 0.029	1.333ArgAsn: 1.333 ± 0.031	4.325ArgPro: 4.325 ± 0.059	2.056ArgGln: 2.056 ± 0.036	7.369ArgArg: 7.369 ± 0.102	4.661ArgSer: 4.661 ± 0.06	3.64ArgThr: 3.64 ± 0.049	6.369ArgVal: 6.369 ± 0.069	1.362ArgTrp: 1.362 ± 0.028	1.592ArgTyr: 1.592 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.908SerAla: 6.908 ± 0.07	0.526SerCys: 0.526 ± 0.02	3.405SerAsp: 3.405 ± 0.049	3.192SerGlu: 3.192 ± 0.042	2.169SerPhe: 2.169 ± 0.038	6.463SerGly: 6.463 ± 0.078	0.954SerHis: 0.954 ± 0.021	2.581SerIle: 2.581 ± 0.039	1.155SerLys: 1.155 ± 0.028	6.048SerLeu: 6.048 ± 0.054	1.066SerMet: 1.066 ± 0.023	1.337SerAsn: 1.337 ± 0.031	3.519SerPro: 3.519 ± 0.047	1.59SerGln: 1.59 ± 0.029	3.628SerArg: 3.628 ± 0.052	3.916SerSer: 3.916 ± 0.057	3.393SerThr: 3.393 ± 0.044	4.206SerVal: 4.206 ± 0.05	0.904SerTrp: 0.904 ± 0.023	1.047SerTyr: 1.047 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	5.837ThrAla: 5.837 ± 0.062	0.449ThrCys: 0.449 ± 0.016	3.129ThrAsp: 3.129 ± 0.046	2.654ThrGlu: 2.654 ± 0.037	1.857ThrPhe: 1.857 ± 0.036	5.049ThrGly: 5.049 ± 0.064	0.885ThrHis: 0.885 ± 0.021	2.175ThrIle: 2.175 ± 0.038	0.89ThrLys: 0.89 ± 0.026	5.734ThrLeu: 5.734 ± 0.06	0.692ThrMet: 0.692 ± 0.02	1.082ThrAsn: 1.082 ± 0.028	3.269ThrPro: 3.269 ± 0.046	1.313ThrGln: 1.313 ± 0.026	3.093ThrArg: 3.093 ± 0.041	3.032ThrSer: 3.032 ± 0.042	2.853ThrThr: 2.853 ± 0.046	4.214ThrVal: 4.214 ± 0.05	0.966ThrTrp: 0.966 ± 0.025	1.036ThrTyr: 1.036 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.073ValAla: 10.073 ± 0.087	0.68ValCys: 0.68 ± 0.018	6.087ValAsp: 6.087 ± 0.068	5.922ValGlu: 5.922 ± 0.063	2.492ValPhe: 2.492 ± 0.04	7.106ValGly: 7.106 ± 0.07	1.643ValHis: 1.643 ± 0.027	2.575ValIle: 2.575 ± 0.036	1.167ValLys: 1.167 ± 0.028	8.685ValLeu: 8.685 ± 0.076	1.045ValMet: 1.045 ± 0.026	1.438ValAsn: 1.438 ± 0.031	4.301ValPro: 4.301 ± 0.043	2.271ValGln: 2.271 ± 0.037	5.969ValArg: 5.969 ± 0.06	4.011ValSer: 4.011 ± 0.044	4.032ValThr: 4.032 ± 0.054	7.068ValVal: 7.068 ± 0.079	1.052ValTrp: 1.052 ± 0.023	1.438ValTyr: 1.438 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.434TrpAla: 1.434 ± 0.028	0.169TrpCys: 0.169 ± 0.009	0.751TrpAsp: 0.751 ± 0.021	0.754TrpGlu: 0.754 ± 0.021	0.625TrpPhe: 0.625 ± 0.019	1.022TrpGly: 1.022 ± 0.023	0.333TrpHis: 0.333 ± 0.014	0.9TrpIle: 0.9 ± 0.022	0.37TrpLys: 0.37 ± 0.015	1.877TrpLeu: 1.877 ± 0.032	0.345TrpMet: 0.345 ± 0.014	0.423TrpAsn: 0.423 ± 0.016	0.774TrpPro: 0.774 ± 0.018	0.451TrpGln: 0.451 ± 0.015	1.516TrpArg: 1.516 ± 0.024	1.282TrpSer: 1.282 ± 0.026	1.022TrpThr: 1.022 ± 0.02	1.094TrpVal: 1.094 ± 0.03	0.305TrpTrp: 0.305 ± 0.012	0.292TrpTyr: 0.292 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.992TyrAla: 1.992 ± 0.031	0.186TyrCys: 0.186 ± 0.009	1.339TyrAsp: 1.339 ± 0.029	1.125TyrGlu: 1.125 ± 0.025	0.756TyrPhe: 0.756 ± 0.025	1.648TyrGly: 1.648 ± 0.034	0.384TyrHis: 0.384 ± 0.015	0.444TyrIle: 0.444 ± 0.017	0.293TyrLys: 0.293 ± 0.014	2.037TyrLeu: 2.037 ± 0.033	0.265TyrMet: 0.265 ± 0.011	0.349TyrAsn: 0.349 ± 0.013	0.942TyrPro: 0.942 ± 0.024	0.577TyrGln: 0.577 ± 0.019	1.626TyrArg: 1.626 ± 0.028	1.046TyrSer: 1.046 ± 0.024	0.936TyrThr: 0.936 ± 0.025	1.388TyrVal: 1.388 ± 0.027	0.307TyrTrp: 0.307 ± 0.012	0.429TyrTyr: 0.429 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5200 proteins (2059126 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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