Amino acid dipepetide frequency for Brevundimonas sp. Root1279

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.242AlaAla: 21.242 ± 0.237	1.133AlaCys: 1.133 ± 0.038	8.233AlaAsp: 8.233 ± 0.113	8.591AlaGlu: 8.591 ± 0.11	4.796AlaPhe: 4.796 ± 0.083	12.523AlaGly: 12.523 ± 0.17	2.153AlaHis: 2.153 ± 0.051	5.357AlaIle: 5.357 ± 0.078	3.524AlaLys: 3.524 ± 0.075	13.98AlaLeu: 13.98 ± 0.155	3.356AlaMet: 3.356 ± 0.061	2.967AlaAsn: 2.967 ± 0.074	7.408AlaPro: 7.408 ± 0.129	4.334AlaGln: 4.334 ± 0.069	9.93AlaArg: 9.93 ± 0.134	6.519AlaSer: 6.519 ± 0.074	6.184AlaThr: 6.184 ± 0.085	10.312AlaVal: 10.312 ± 0.118	2.055AlaTrp: 2.055 ± 0.052	2.673AlaTyr: 2.673 ± 0.057	0.002AlaXaa: 0.002 ± 0.001
Cys	0.956CysAla: 0.956 ± 0.033	0.07CysCys: 0.07 ± 0.008	0.451CysAsp: 0.451 ± 0.023	0.382CysGlu: 0.382 ± 0.021	0.215CysPhe: 0.215 ± 0.015	0.75CysGly: 0.75 ± 0.03	0.152CysHis: 0.152 ± 0.012	0.276CysIle: 0.276 ± 0.018	0.139CysLys: 0.139 ± 0.011	0.625CysLeu: 0.625 ± 0.025	0.121CysMet: 0.121 ± 0.01	0.157CysAsn: 0.157 ± 0.015	0.377CysPro: 0.377 ± 0.024	0.18CysGln: 0.18 ± 0.014	0.496CysArg: 0.496 ± 0.028	0.371CysSer: 0.371 ± 0.022	0.354CysThr: 0.354 ± 0.024	0.559CysVal: 0.559 ± 0.024	0.095CysTrp: 0.095 ± 0.009	0.142CysTyr: 0.142 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.111AspAla: 8.111 ± 0.098	0.405AspCys: 0.405 ± 0.023	3.777AspAsp: 3.777 ± 0.115	3.426AspGlu: 3.426 ± 0.071	2.18AspPhe: 2.18 ± 0.05	6.492AspGly: 6.492 ± 0.159	1.266AspHis: 1.266 ± 0.032	2.572AspIle: 2.572 ± 0.066	1.507AspLys: 1.507 ± 0.043	6.223AspLeu: 6.223 ± 0.086	1.275AspMet: 1.275 ± 0.04	1.29AspAsn: 1.29 ± 0.043	3.9AspPro: 3.9 ± 0.069	1.978AspGln: 1.978 ± 0.049	4.996AspArg: 4.996 ± 0.079	2.23AspSer: 2.23 ± 0.061	2.832AspThr: 2.832 ± 0.123	4.443AspVal: 4.443 ± 0.092	1.185AspTrp: 1.185 ± 0.032	1.543AspTyr: 1.543 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	9.234GluAla: 9.234 ± 0.138	0.259GluCys: 0.259 ± 0.016	2.969GluAsp: 2.969 ± 0.06	2.779GluGlu: 2.779 ± 0.062	1.588GluPhe: 1.588 ± 0.038	5.252GluGly: 5.252 ± 0.075	1.156GluHis: 1.156 ± 0.038	2.872GluIle: 2.872 ± 0.052	1.678GluLys: 1.678 ± 0.049	4.988GluLeu: 4.988 ± 0.076	1.345GluMet: 1.345 ± 0.043	1.271GluAsn: 1.271 ± 0.041	3.095GluPro: 3.095 ± 0.053	2.067GluGln: 2.067 ± 0.044	5.103GluArg: 5.103 ± 0.094	2.305GluSer: 2.305 ± 0.05	3.773GluThr: 3.773 ± 0.063	4.128GluVal: 4.128 ± 0.071	0.747GluTrp: 0.747 ± 0.027	0.882GluTyr: 0.882 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.579PheAla: 4.579 ± 0.078	0.286PheCys: 0.286 ± 0.017	2.721PheAsp: 2.721 ± 0.058	2.261PheGlu: 2.261 ± 0.049	1.16PhePhe: 1.16 ± 0.038	3.719PheGly: 3.719 ± 0.064	0.693PheHis: 0.693 ± 0.027	1.419PheIle: 1.419 ± 0.039	0.846PheLys: 0.846 ± 0.032	2.943PheLeu: 2.943 ± 0.062	0.763PheMet: 0.763 ± 0.027	1.11PheAsn: 1.11 ± 0.036	1.375PhePro: 1.375 ± 0.038	1.014PheGln: 1.014 ± 0.033	2.127PheArg: 2.127 ± 0.046	1.927PheSer: 1.927 ± 0.046	2.037PheThr: 2.037 ± 0.052	2.631PheVal: 2.631 ± 0.052	0.528PheTrp: 0.528 ± 0.028	0.81PheTyr: 0.81 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.583GlyAla: 11.583 ± 0.189	0.751GlyCys: 0.751 ± 0.031	5.808GlyAsp: 5.808 ± 0.188	5.521GlyGlu: 5.521 ± 0.078	3.664GlyPhe: 3.664 ± 0.063	10.081GlyGly: 10.081 ± 0.524	1.664GlyHis: 1.664 ± 0.043	3.104GlyIle: 3.104 ± 0.076	2.732GlyLys: 2.732 ± 0.06	9.639GlyLeu: 9.639 ± 0.116	2.196GlyMet: 2.196 ± 0.042	2.041GlyAsn: 2.041 ± 0.131	4.319GlyPro: 4.319 ± 0.083	3.3GlyGln: 3.3 ± 0.058	7.049GlyArg: 7.049 ± 0.102	4.923GlySer: 4.923 ± 0.117	3.943GlyThr: 3.943 ± 0.107	7.981GlyVal: 7.981 ± 0.1	1.792GlyTrp: 1.792 ± 0.047	2.247GlyTyr: 2.247 ± 0.06	0.001GlyXaa: 0.001 ± 0.001
His	2.199HisAla: 2.199 ± 0.047	0.16HisCys: 0.16 ± 0.012	1.086HisAsp: 1.086 ± 0.034	1.042HisGlu: 1.042 ± 0.032	0.642HisPhe: 0.642 ± 0.026	1.883HisGly: 1.883 ± 0.052	0.454HisHis: 0.454 ± 0.023	0.68HisIle: 0.68 ± 0.028	0.372HisLys: 0.372 ± 0.017	1.719HisLeu: 1.719 ± 0.047	0.403HisMet: 0.403 ± 0.02	0.382HisAsn: 0.382 ± 0.017	1.25HisPro: 1.25 ± 0.035	0.512HisGln: 0.512 ± 0.022	1.269HisArg: 1.269 ± 0.04	0.756HisSer: 0.756 ± 0.03	0.709HisThr: 0.709 ± 0.03	1.347HisVal: 1.347 ± 0.04	0.32HisTrp: 0.32 ± 0.019	0.452HisTyr: 0.452 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.932IleAla: 5.932 ± 0.078	0.343IleCys: 0.343 ± 0.018	3.471IleAsp: 3.471 ± 0.07	3.283IleGlu: 3.283 ± 0.051	1.289IlePhe: 1.289 ± 0.039	4.469IleGly: 4.469 ± 0.088	0.803IleHis: 0.803 ± 0.029	1.651IleIle: 1.651 ± 0.051	1.069IleLys: 1.069 ± 0.035	3.806IleLeu: 3.806 ± 0.07	0.746IleMet: 0.746 ± 0.028	1.185IleAsn: 1.185 ± 0.04	1.895IlePro: 1.895 ± 0.045	1.23IleGln: 1.23 ± 0.035	2.773IleArg: 2.773 ± 0.049	2.172IleSer: 2.172 ± 0.053	2.352IleThr: 2.352 ± 0.063	3.628IleVal: 3.628 ± 0.07	0.539IleTrp: 0.539 ± 0.021	0.802IleTyr: 0.802 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.305LysAla: 4.305 ± 0.085	0.104LysCys: 0.104 ± 0.011	1.453LysAsp: 1.453 ± 0.047	1.109LysGlu: 1.109 ± 0.04	0.727LysPhe: 0.727 ± 0.032	2.424LysGly: 2.424 ± 0.052	0.467LysHis: 0.467 ± 0.026	1.177LysIle: 1.177 ± 0.042	0.986LysLys: 0.986 ± 0.035	2.551LysLeu: 2.551 ± 0.066	0.517LysMet: 0.517 ± 0.024	0.592LysAsn: 0.592 ± 0.027	1.8LysPro: 1.8 ± 0.051	0.736LysGln: 0.736 ± 0.024	2.03LysArg: 2.03 ± 0.052	1.386LysSer: 1.386 ± 0.033	1.69LysThr: 1.69 ± 0.045	2.086LysVal: 2.086 ± 0.053	0.321LysTrp: 0.321 ± 0.017	0.478LysTyr: 0.478 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.961LeuAla: 13.961 ± 0.171	0.659LeuCys: 0.659 ± 0.025	6.13LeuAsp: 6.13 ± 0.085	5.366LeuGlu: 5.366 ± 0.078	3.463LeuPhe: 3.463 ± 0.064	8.297LeuGly: 8.297 ± 0.104	1.623LeuHis: 1.623 ± 0.041	4.856LeuIle: 4.856 ± 0.098	3.431LeuLys: 3.431 ± 0.072	8.47LeuLeu: 8.47 ± 0.134	2.236LeuMet: 2.236 ± 0.057	2.784LeuAsn: 2.784 ± 0.066	4.99LeuPro: 4.99 ± 0.075	2.647LeuGln: 2.647 ± 0.051	6.362LeuArg: 6.362 ± 0.091	5.854LeuSer: 5.854 ± 0.076	6.129LeuThr: 6.129 ± 0.09	6.94LeuVal: 6.94 ± 0.083	1.25LeuTrp: 1.25 ± 0.04	1.95LeuTyr: 1.95 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.14MetAla: 3.14 ± 0.056	0.11MetCys: 0.11 ± 0.012	1.15MetAsp: 1.15 ± 0.033	0.965MetGlu: 0.965 ± 0.029	0.649MetPhe: 0.649 ± 0.031	1.856MetGly: 1.856 ± 0.039	0.356MetHis: 0.356 ± 0.02	1.172MetIle: 1.172 ± 0.035	0.86MetLys: 0.86 ± 0.029	2.015MetLeu: 2.015 ± 0.053	0.507MetMet: 0.507 ± 0.024	0.65MetAsn: 0.65 ± 0.026	1.246MetPro: 1.246 ± 0.042	0.665MetGln: 0.665 ± 0.024	1.625MetArg: 1.625 ± 0.038	1.517MetSer: 1.517 ± 0.041	1.989MetThr: 1.989 ± 0.046	1.458MetVal: 1.458 ± 0.039	0.204MetTrp: 0.204 ± 0.015	0.248MetTyr: 0.248 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.236AsnAla: 3.236 ± 0.06	0.181AsnCys: 0.181 ± 0.014	1.647AsnAsp: 1.647 ± 0.107	1.091AsnGlu: 1.091 ± 0.036	0.815AsnPhe: 0.815 ± 0.034	2.477AsnGly: 2.477 ± 0.094	0.441AsnHis: 0.441 ± 0.025	1.098AsnIle: 1.098 ± 0.04	0.454AsnLys: 0.454 ± 0.022	2.471AsnLeu: 2.471 ± 0.061	0.477AsnMet: 0.477 ± 0.022	0.648AsnAsn: 0.648 ± 0.034	1.752AsnPro: 1.752 ± 0.044	0.752AsnGln: 0.752 ± 0.032	1.672AsnArg: 1.672 ± 0.043	1.077AsnSer: 1.077 ± 0.039	1.217AsnThr: 1.217 ± 0.037	1.908AsnVal: 1.908 ± 0.061	0.372AsnTrp: 0.372 ± 0.019	0.569AsnTyr: 0.569 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.806ProAla: 7.806 ± 0.124	0.273ProCys: 0.273 ± 0.016	3.777ProAsp: 3.777 ± 0.068	3.911ProGlu: 3.911 ± 0.07	1.967ProPhe: 1.967 ± 0.046	5.055ProGly: 5.055 ± 0.08	0.972ProHis: 0.972 ± 0.03	2.183ProIle: 2.183 ± 0.047	1.436ProLys: 1.436 ± 0.045	4.588ProLeu: 4.588 ± 0.076	1.137ProMet: 1.137 ± 0.031	1.365ProAsn: 1.365 ± 0.043	3.191ProPro: 3.191 ± 0.1	1.627ProGln: 1.627 ± 0.037	3.166ProArg: 3.166 ± 0.057	2.769ProSer: 2.769 ± 0.053	2.956ProThr: 2.956 ± 0.064	4.45ProVal: 4.45 ± 0.072	0.831ProTrp: 0.831 ± 0.032	1.076ProTyr: 1.076 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.763GlnAla: 4.763 ± 0.073	0.161GlnCys: 0.161 ± 0.014	1.497GlnAsp: 1.497 ± 0.043	1.322GlnGlu: 1.322 ± 0.04	0.99GlnPhe: 0.99 ± 0.033	2.689GlnGly: 2.689 ± 0.057	0.5GlnHis: 0.5 ± 0.023	1.495GlnIle: 1.495 ± 0.042	0.805GlnLys: 0.805 ± 0.034	2.731GlnLeu: 2.731 ± 0.052	0.806GlnMet: 0.806 ± 0.028	0.711GlnAsn: 0.711 ± 0.029	1.873GlnPro: 1.873 ± 0.043	1.001GlnGln: 1.001 ± 0.035	2.278GlnArg: 2.278 ± 0.053	1.694GlnSer: 1.694 ± 0.064	1.969GlnThr: 1.969 ± 0.046	2.407GlnVal: 2.407 ± 0.046	0.396GlnTrp: 0.396 ± 0.018	0.591GlnTyr: 0.591 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.867ArgAla: 8.867 ± 0.12	0.429ArgCys: 0.429 ± 0.02	4.301ArgAsp: 4.301 ± 0.069	4.145ArgGlu: 4.145 ± 0.077	2.941ArgPhe: 2.941 ± 0.055	5.321ArgGly: 5.321 ± 0.096	1.311ArgHis: 1.311 ± 0.04	3.691ArgIle: 3.691 ± 0.057	1.836ArgLys: 1.836 ± 0.048	8.361ArgLeu: 8.361 ± 0.125	1.879ArgMet: 1.879 ± 0.045	1.6ArgAsn: 1.6 ± 0.039	4.236ArgPro: 4.236 ± 0.082	2.304ArgGln: 2.304 ± 0.056	6.025ArgArg: 6.025 ± 0.114	3.402ArgSer: 3.402 ± 0.069	3.786ArgThr: 3.786 ± 0.064	5.068ArgVal: 5.068 ± 0.089	1.174ArgTrp: 1.174 ± 0.033	1.721ArgTyr: 1.721 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.279SerAla: 6.279 ± 0.091	0.282SerCys: 0.282 ± 0.019	3.113SerAsp: 3.113 ± 0.062	2.582SerGlu: 2.582 ± 0.06	1.811SerPhe: 1.811 ± 0.042	5.426SerGly: 5.426 ± 0.135	0.879SerHis: 0.879 ± 0.032	2.316SerIle: 2.316 ± 0.059	1.265SerLys: 1.265 ± 0.035	5.084SerLeu: 5.084 ± 0.074	1.112SerMet: 1.112 ± 0.031	1.337SerAsn: 1.337 ± 0.043	3.003SerPro: 3.003 ± 0.065	1.538SerGln: 1.538 ± 0.041	3.433SerArg: 3.433 ± 0.062	2.504SerSer: 2.504 ± 0.055	2.67SerThr: 2.67 ± 0.049	3.819SerVal: 3.819 ± 0.069	0.754SerTrp: 0.754 ± 0.027	1.135SerTyr: 1.135 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	7.155ThrAla: 7.155 ± 0.094	0.346ThrCys: 0.346 ± 0.02	3.152ThrAsp: 3.152 ± 0.06	2.609ThrGlu: 2.609 ± 0.053	1.931ThrPhe: 1.931 ± 0.05	5.761ThrGly: 5.761 ± 0.118	0.913ThrHis: 0.913 ± 0.033	2.318ThrIle: 2.318 ± 0.064	1.147ThrLys: 1.147 ± 0.036	5.873ThrLeu: 5.873 ± 0.088	0.934ThrMet: 0.934 ± 0.03	1.289ThrAsn: 1.289 ± 0.036	3.892ThrPro: 3.892 ± 0.066	1.436ThrGln: 1.436 ± 0.038	3.381ThrArg: 3.381 ± 0.065	2.489ThrSer: 2.489 ± 0.055	2.91ThrThr: 2.91 ± 0.067	4.726ThrVal: 4.726 ± 0.079	0.75ThrTrp: 0.75 ± 0.03	1.253ThrTyr: 1.253 ± 0.048	0.001ThrXaa: 0.001 ± 0.001
Val	9.728ValAla: 9.728 ± 0.114	0.62ValCys: 0.62 ± 0.027	4.686ValAsp: 4.686 ± 0.084	5.193ValGlu: 5.193 ± 0.067	2.772ValPhe: 2.772 ± 0.057	6.434ValGly: 6.434 ± 0.1	1.263ValHis: 1.263 ± 0.039	3.775ValIle: 3.775 ± 0.069	1.95ValLys: 1.95 ± 0.049	7.653ValLeu: 7.653 ± 0.091	1.764ValMet: 1.764 ± 0.053	2.012ValAsn: 2.012 ± 0.057	3.207ValPro: 3.207 ± 0.065	2.242ValGln: 2.242 ± 0.048	5.588ValArg: 5.588 ± 0.084	4.345ValSer: 4.345 ± 0.077	4.754ValThr: 4.754 ± 0.083	6.586ValVal: 6.586 ± 0.091	1.17ValTrp: 1.17 ± 0.036	1.456ValTyr: 1.456 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.632TrpAla: 1.632 ± 0.048	0.099TrpCys: 0.099 ± 0.009	0.742TrpAsp: 0.742 ± 0.031	0.634TrpGlu: 0.634 ± 0.027	0.573TrpPhe: 0.573 ± 0.026	1.125TrpGly: 1.125 ± 0.033	0.218TrpHis: 0.218 ± 0.014	0.744TrpIle: 0.744 ± 0.03	0.479TrpLys: 0.479 ± 0.021	1.775TrpLeu: 1.775 ± 0.047	0.416TrpMet: 0.416 ± 0.021	0.413TrpAsn: 0.413 ± 0.021	0.793TrpPro: 0.793 ± 0.026	0.452TrpGln: 0.452 ± 0.022	1.459TrpArg: 1.459 ± 0.046	0.964TrpSer: 0.964 ± 0.036	1.054TrpThr: 1.054 ± 0.032	0.974TrpVal: 0.974 ± 0.032	0.283TrpTrp: 0.283 ± 0.016	0.26TrpTyr: 0.26 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.562TyrAla: 2.562 ± 0.05	0.196TyrCys: 0.196 ± 0.015	1.468TyrAsp: 1.468 ± 0.041	1.279TyrGlu: 1.279 ± 0.041	0.777TyrPhe: 0.777 ± 0.031	2.304TyrGly: 2.304 ± 0.052	0.354TyrHis: 0.354 ± 0.02	0.679TyrIle: 0.679 ± 0.026	0.423TyrLys: 0.423 ± 0.02	1.901TyrLeu: 1.901 ± 0.048	0.392TyrMet: 0.392 ± 0.018	0.552TyrAsn: 0.552 ± 0.025	0.933TyrPro: 0.933 ± 0.035	0.662TyrGln: 0.662 ± 0.029	1.637TyrArg: 1.637 ± 0.048	1.137TyrSer: 1.137 ± 0.035	0.957TyrThr: 0.957 ± 0.037	1.749TyrVal: 1.749 ± 0.036	0.323TyrTrp: 0.323 ± 0.019	0.496TyrTyr: 0.496 ± 0.022	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.002XaaSer: 0.002 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3236 proteins (1015852 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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