Amino acid dipepetide frequency for Rhizobium tubonense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.091AlaAla: 15.091 ± 0.132
0.938AlaCys: 0.938 ± 0.024
6.517AlaAsp: 6.517 ± 0.07
6.84AlaGlu: 6.84 ± 0.072
4.451AlaPhe: 4.451 ± 0.056
9.409AlaGly: 9.409 ± 0.073
2.051AlaHis: 2.051 ± 0.037
7.118AlaIle: 7.118 ± 0.063
4.583AlaLys: 4.583 ± 0.053
11.976AlaLeu: 11.976 ± 0.101
3.377AlaMet: 3.377 ± 0.04
3.205AlaAsn: 3.205 ± 0.037
4.488AlaPro: 4.488 ± 0.066
3.35AlaGln: 3.35 ± 0.054
7.169AlaArg: 7.169 ± 0.07
6.831AlaSer: 6.831 ± 0.061
5.982AlaThr: 5.982 ± 0.067
8.339AlaVal: 8.339 ± 0.072
1.323AlaTrp: 1.323 ± 0.029
2.509AlaTyr: 2.509 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.848CysAla: 0.848 ± 0.019
0.096CysCys: 0.096 ± 0.007
0.491CysAsp: 0.491 ± 0.018
0.43CysGlu: 0.43 ± 0.019
0.326CysPhe: 0.326 ± 0.014
0.866CysGly: 0.866 ± 0.023
0.249CysHis: 0.249 ± 0.013
0.423CysIle: 0.423 ± 0.015
0.211CysLys: 0.211 ± 0.012
0.852CysLeu: 0.852 ± 0.022
0.172CysMet: 0.172 ± 0.01
0.206CysAsn: 0.206 ± 0.01
0.364CysPro: 0.364 ± 0.017
0.212CysGln: 0.212 ± 0.011
0.561CysArg: 0.561 ± 0.02
0.509CysSer: 0.509 ± 0.017
0.375CysThr: 0.375 ± 0.014
0.583CysVal: 0.583 ± 0.019
0.095CysTrp: 0.095 ± 0.007
0.211CysTyr: 0.211 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.424AspAla: 6.424 ± 0.065
0.485AspCys: 0.485 ± 0.017
3.266AspAsp: 3.266 ± 0.047
3.398AspGlu: 3.398 ± 0.047
2.402AspPhe: 2.402 ± 0.038
5.176AspGly: 5.176 ± 0.054
1.301AspHis: 1.301 ± 0.026
3.598AspIle: 3.598 ± 0.042
2.03AspLys: 2.03 ± 0.035
5.743AspLeu: 5.743 ± 0.057
1.405AspMet: 1.405 ± 0.031
1.62AspAsn: 1.62 ± 0.032
3.231AspPro: 3.231 ± 0.045
1.801AspGln: 1.801 ± 0.033
4.115AspArg: 4.115 ± 0.05
2.308AspSer: 2.308 ± 0.039
2.554AspThr: 2.554 ± 0.037
4.287AspVal: 4.287 ± 0.05
0.921AspTrp: 0.921 ± 0.023
1.511AspTyr: 1.511 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
6.764GluAla: 6.764 ± 0.078
0.349GluCys: 0.349 ± 0.013
2.795GluAsp: 2.795 ± 0.049
3.219GluGlu: 3.219 ± 0.052
1.941GluPhe: 1.941 ± 0.034
4.003GluGly: 4.003 ± 0.052
1.184GluHis: 1.184 ± 0.025
3.814GluIle: 3.814 ± 0.045
2.566GluLys: 2.566 ± 0.04
5.338GluLeu: 5.338 ± 0.05
1.598GluMet: 1.598 ± 0.028
1.804GluAsn: 1.804 ± 0.034
2.477GluPro: 2.477 ± 0.04
2.089GluGln: 2.089 ± 0.036
4.442GluArg: 4.442 ± 0.055
2.324GluSer: 2.324 ± 0.036
3.52GluThr: 3.52 ± 0.047
3.662GluVal: 3.662 ± 0.053
0.677GluTrp: 0.677 ± 0.022
1.061GluTyr: 1.061 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
4.617PheAla: 4.617 ± 0.059
0.407PheCys: 0.407 ± 0.017
2.807PheAsp: 2.807 ± 0.045
2.25PheGlu: 2.25 ± 0.033
1.61PhePhe: 1.61 ± 0.029
3.743PheGly: 3.743 ± 0.045
0.823PheHis: 0.823 ± 0.019
2.009PheIle: 2.009 ± 0.033
1.254PheLys: 1.254 ± 0.027
3.65PheLeu: 3.65 ± 0.047
0.902PheMet: 0.902 ± 0.021
1.194PheAsn: 1.194 ± 0.028
1.684PhePro: 1.684 ± 0.033
1.121PheGln: 1.121 ± 0.024
2.31PheArg: 2.31 ± 0.035
2.615PheSer: 2.615 ± 0.035
2.027PheThr: 2.027 ± 0.036
3.034PheVal: 3.034 ± 0.04
0.57PheTrp: 0.57 ± 0.019
1.044PheTyr: 1.044 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
8.184GlyAla: 8.184 ± 0.073
0.773GlyCys: 0.773 ± 0.023
4.303GlyAsp: 4.303 ± 0.05
4.405GlyGlu: 4.405 ± 0.052
3.676GlyPhe: 3.676 ± 0.05
6.741GlyGly: 6.741 ± 0.075
1.891GlyHis: 1.891 ± 0.034
5.097GlyIle: 5.097 ± 0.052
3.824GlyLys: 3.824 ± 0.054
8.432GlyLeu: 8.432 ± 0.066
2.277GlyMet: 2.277 ± 0.033
2.527GlyAsn: 2.527 ± 0.043
3.098GlyPro: 3.098 ± 0.045
2.699GlyGln: 2.699 ± 0.043
5.462GlyArg: 5.462 ± 0.052
4.981GlySer: 4.981 ± 0.055
4.537GlyThr: 4.537 ± 0.056
5.766GlyVal: 5.766 ± 0.064
1.278GlyTrp: 1.278 ± 0.029
2.392GlyTyr: 2.392 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
2.12HisAla: 2.12 ± 0.035
0.213HisCys: 0.213 ± 0.012
1.27HisAsp: 1.27 ± 0.027
1.059HisGlu: 1.059 ± 0.023
0.968HisPhe: 0.968 ± 0.02
1.87HisGly: 1.87 ± 0.031
0.596HisHis: 0.596 ± 0.021
1.086HisIle: 1.086 ± 0.028
0.539HisLys: 0.539 ± 0.021
2.109HisLeu: 2.109 ± 0.037
0.568HisMet: 0.568 ± 0.018
0.524HisAsn: 0.524 ± 0.018
1.279HisPro: 1.279 ± 0.027
0.635HisGln: 0.635 ± 0.018
1.374HisArg: 1.374 ± 0.024
1.076HisSer: 1.076 ± 0.024
0.802HisThr: 0.802 ± 0.023
1.511HisVal: 1.511 ± 0.028
0.301HisTrp: 0.301 ± 0.012
0.581HisTyr: 0.581 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
7.895IleAla: 7.895 ± 0.065
0.596IleCys: 0.596 ± 0.018
3.934IleAsp: 3.934 ± 0.046
3.745IleGlu: 3.745 ± 0.049
2.134IlePhe: 2.134 ± 0.038
5.483IleGly: 5.483 ± 0.067
1.018IleHis: 1.018 ± 0.021
2.881IleIle: 2.881 ± 0.047
1.821IleLys: 1.821 ± 0.034
5.07IleLeu: 5.07 ± 0.066
1.121IleMet: 1.121 ± 0.024
1.714IleAsn: 1.714 ± 0.034
2.58IlePro: 2.58 ± 0.043
1.377IleGln: 1.377 ± 0.03
3.449IleArg: 3.449 ± 0.046
3.824IleSer: 3.824 ± 0.045
2.897IleThr: 2.897 ± 0.041
4.848IleVal: 4.848 ± 0.056
0.667IleTrp: 0.667 ± 0.019
1.301IleTyr: 1.301 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
4.707LysAla: 4.707 ± 0.054
0.179LysCys: 0.179 ± 0.011
2.08LysAsp: 2.08 ± 0.037
1.859LysGlu: 1.859 ± 0.034
1.097LysPhe: 1.097 ± 0.025
2.886LysGly: 2.886 ± 0.045
0.687LysHis: 0.687 ± 0.022
2.208LysIle: 2.208 ± 0.037
1.581LysLys: 1.581 ± 0.033
3.78LysLeu: 3.78 ± 0.048
1.026LysMet: 1.026 ± 0.026
1.079LysAsn: 1.079 ± 0.03
2.326LysPro: 2.326 ± 0.032
1.25LysGln: 1.25 ± 0.031
2.556LysArg: 2.556 ± 0.039
2.435LysSer: 2.435 ± 0.037
2.389LysThr: 2.389 ± 0.035
2.836LysVal: 2.836 ± 0.04
0.433LysTrp: 0.433 ± 0.016
0.736LysTyr: 0.736 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
12.255LeuAla: 12.255 ± 0.097
0.837LeuCys: 0.837 ± 0.024
5.859LeuAsp: 5.859 ± 0.057
5.108LeuGlu: 5.108 ± 0.054
3.784LeuPhe: 3.784 ± 0.054
7.878LeuGly: 7.878 ± 0.068
1.831LeuHis: 1.831 ± 0.03
5.355LeuIle: 5.355 ± 0.063
4.186LeuLys: 4.186 ± 0.055
9.385LeuLeu: 9.385 ± 0.098
2.486LeuMet: 2.486 ± 0.035
2.84LeuAsn: 2.84 ± 0.042
5.179LeuPro: 5.179 ± 0.059
2.997LeuGln: 2.997 ± 0.041
6.109LeuArg: 6.109 ± 0.069
7.105LeuSer: 7.105 ± 0.067
5.575LeuThr: 5.575 ± 0.052
7.29LeuVal: 7.29 ± 0.068
1.077LeuTrp: 1.077 ± 0.026
2.101LeuTyr: 2.101 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
3.0MetAla: 3.0 ± 0.043
0.156MetCys: 0.156 ± 0.008
1.21MetAsp: 1.21 ± 0.023
1.164MetGlu: 1.164 ± 0.027
0.794MetPhe: 0.794 ± 0.025
1.74MetGly: 1.74 ± 0.03
0.457MetHis: 0.457 ± 0.017
1.579MetIle: 1.579 ± 0.031
1.163MetLys: 1.163 ± 0.021
2.473MetLeu: 2.473 ± 0.046
0.72MetMet: 0.72 ± 0.021
0.904MetAsn: 0.904 ± 0.022
1.495MetPro: 1.495 ± 0.031
0.863MetGln: 0.863 ± 0.02
1.793MetArg: 1.793 ± 0.032
1.862MetSer: 1.862 ± 0.029
2.003MetThr: 2.003 ± 0.029
1.731MetVal: 1.731 ± 0.028
0.213MetTrp: 0.213 ± 0.013
0.329MetTyr: 0.329 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.356AsnAla: 3.356 ± 0.05
0.25AsnCys: 0.25 ± 0.011
1.687AsnAsp: 1.687 ± 0.033
1.45AsnGlu: 1.45 ± 0.032
1.204AsnPhe: 1.204 ± 0.029
2.784AsnGly: 2.784 ± 0.04
0.601AsnHis: 0.601 ± 0.018
1.679AsnIle: 1.679 ± 0.035
0.864AsnLys: 0.864 ± 0.02
2.886AsnLeu: 2.886 ± 0.036
0.724AsnMet: 0.724 ± 0.02
0.895AsnAsn: 0.895 ± 0.024
1.87AsnPro: 1.87 ± 0.032
0.918AsnGln: 0.918 ± 0.025
1.974AsnArg: 1.974 ± 0.035
1.645AsnSer: 1.645 ± 0.03
1.388AsnThr: 1.388 ± 0.027
2.257AsnVal: 2.257 ± 0.038
0.48AsnTrp: 0.48 ± 0.016
0.784AsnTyr: 0.784 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
5.23ProAla: 5.23 ± 0.075
0.276ProCys: 0.276 ± 0.013
3.361ProAsp: 3.361 ± 0.043
3.359ProGlu: 3.359 ± 0.047
2.016ProPhe: 2.016 ± 0.033
3.946ProGly: 3.946 ± 0.043
1.0ProHis: 1.0 ± 0.025
2.537ProIle: 2.537 ± 0.04
1.813ProLys: 1.813 ± 0.034
4.595ProLeu: 4.595 ± 0.049
1.128ProMet: 1.128 ± 0.027
1.482ProAsn: 1.482 ± 0.031
2.241ProPro: 2.241 ± 0.046
1.606ProGln: 1.606 ± 0.034
2.531ProArg: 2.531 ± 0.042
2.979ProSer: 2.979 ± 0.044
2.51ProThr: 2.51 ± 0.037
3.897ProVal: 3.897 ± 0.047
0.611ProTrp: 0.611 ± 0.02
1.181ProTyr: 1.181 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.783GlnAla: 3.783 ± 0.047
0.186GlnCys: 0.186 ± 0.011
1.402GlnAsp: 1.402 ± 0.032
1.494GlnGlu: 1.494 ± 0.028
1.186GlnPhe: 1.186 ± 0.023
2.215GlnGly: 2.215 ± 0.039
0.616GlnHis: 0.616 ± 0.02
1.95GlnIle: 1.95 ± 0.034
1.373GlnLys: 1.373 ± 0.029
2.962GlnLeu: 2.962 ± 0.043
0.933GlnMet: 0.933 ± 0.021
0.981GlnAsn: 0.981 ± 0.023
1.763GlnPro: 1.763 ± 0.037
1.346GlnGln: 1.346 ± 0.033
2.211GlnArg: 2.211 ± 0.038
2.1GlnSer: 2.1 ± 0.037
1.851GlnThr: 1.851 ± 0.031
2.093GlnVal: 2.093 ± 0.036
0.414GlnTrp: 0.414 ± 0.014
0.655GlnTyr: 0.655 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
6.469ArgAla: 6.469 ± 0.066
0.458ArgCys: 0.458 ± 0.015
3.789ArgAsp: 3.789 ± 0.048
3.735ArgGlu: 3.735 ± 0.051
2.82ArgPhe: 2.82 ± 0.046
4.247ArgGly: 4.247 ± 0.05
1.606ArgHis: 1.606 ± 0.026
4.03ArgIle: 4.03 ± 0.049
2.491ArgLys: 2.491 ± 0.04
7.144ArgLeu: 7.144 ± 0.066
1.812ArgMet: 1.812 ± 0.031
2.074ArgAsn: 2.074 ± 0.037
3.053ArgPro: 3.053 ± 0.048
2.517ArgGln: 2.517 ± 0.039
4.962ArgArg: 4.962 ± 0.06
3.909ArgSer: 3.909 ± 0.053
3.156ArgThr: 3.156 ± 0.043
4.175ArgVal: 4.175 ± 0.041
0.895ArgTrp: 0.895 ± 0.022
1.721ArgTyr: 1.721 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.521SerAla: 6.521 ± 0.068
0.454SerCys: 0.454 ± 0.018
3.521SerAsp: 3.521 ± 0.047
3.23SerGlu: 3.23 ± 0.042
2.558SerPhe: 2.558 ± 0.039
5.887SerGly: 5.887 ± 0.062
1.277SerHis: 1.277 ± 0.027
3.459SerIle: 3.459 ± 0.043
2.12SerLys: 2.12 ± 0.041
6.079SerLeu: 6.079 ± 0.058
1.533SerMet: 1.533 ± 0.029
1.788SerAsn: 1.788 ± 0.031
2.909SerPro: 2.909 ± 0.042
1.871SerGln: 1.871 ± 0.034
3.76SerArg: 3.76 ± 0.05
3.702SerSer: 3.702 ± 0.054
3.181SerThr: 3.181 ± 0.041
4.491SerVal: 4.491 ± 0.055
0.81SerTrp: 0.81 ± 0.025
1.455SerTyr: 1.455 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.004ThrAla: 6.004 ± 0.058
0.413ThrCys: 0.413 ± 0.016
2.965ThrAsp: 2.965 ± 0.043
2.777ThrGlu: 2.777 ± 0.039
2.183ThrPhe: 2.183 ± 0.037
4.931ThrGly: 4.931 ± 0.054
1.063ThrHis: 1.063 ± 0.025
3.394ThrIle: 3.394 ± 0.048
1.812ThrLys: 1.812 ± 0.033
5.601ThrLeu: 5.601 ± 0.065
1.279ThrMet: 1.279 ± 0.025
1.531ThrAsn: 1.531 ± 0.029
3.02ThrPro: 3.02 ± 0.045
1.476ThrGln: 1.476 ± 0.034
3.025ThrArg: 3.025 ± 0.043
3.293ThrSer: 3.293 ± 0.044
3.07ThrThr: 3.07 ± 0.049
4.447ThrVal: 4.447 ± 0.051
0.652ThrTrp: 0.652 ± 0.018
1.243ThrTyr: 1.243 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
8.763ValAla: 8.763 ± 0.074
0.636ValCys: 0.636 ± 0.017
4.181ValAsp: 4.181 ± 0.047
4.301ValGlu: 4.301 ± 0.052
2.915ValPhe: 2.915 ± 0.039
5.56ValGly: 5.56 ± 0.064
1.383ValHis: 1.383 ± 0.028
4.354ValIle: 4.354 ± 0.048
2.622ValLys: 2.622 ± 0.04
7.236ValLeu: 7.236 ± 0.066
1.774ValMet: 1.774 ± 0.031
2.148ValAsn: 2.148 ± 0.035
3.472ValPro: 3.472 ± 0.045
2.027ValGln: 2.027 ± 0.035
4.556ValArg: 4.556 ± 0.052
4.803ValSer: 4.803 ± 0.056
4.548ValThr: 4.548 ± 0.054
6.015ValVal: 6.015 ± 0.071
0.875ValTrp: 0.875 ± 0.022
1.565ValTyr: 1.565 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.136TrpAla: 1.136 ± 0.023
0.13TrpCys: 0.13 ± 0.008
0.608TrpAsp: 0.608 ± 0.019
0.558TrpGlu: 0.558 ± 0.02
0.557TrpPhe: 0.557 ± 0.019
0.81TrpGly: 0.81 ± 0.019
0.346TrpHis: 0.346 ± 0.014
0.697TrpIle: 0.697 ± 0.02
0.528TrpLys: 0.528 ± 0.019
1.582TrpLeu: 1.582 ± 0.034
0.343TrpMet: 0.343 ± 0.012
0.501TrpAsn: 0.501 ± 0.018
0.668TrpPro: 0.668 ± 0.021
0.593TrpGln: 0.593 ± 0.017
0.967TrpArg: 0.967 ± 0.024
0.875TrpSer: 0.875 ± 0.028
0.723TrpThr: 0.723 ± 0.021
0.753TrpVal: 0.753 ± 0.021
0.2TrpTrp: 0.2 ± 0.011
0.312TrpTyr: 0.312 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.38TyrAla: 2.38 ± 0.037
0.248TyrCys: 0.248 ± 0.011
1.532TyrAsp: 1.532 ± 0.029
1.243TyrGlu: 1.243 ± 0.028
1.05TyrPhe: 1.05 ± 0.024
2.169TyrGly: 2.169 ± 0.038
0.5TyrHis: 0.5 ± 0.016
1.085TyrIle: 1.085 ± 0.025
0.75TyrLys: 0.75 ± 0.021
2.344TyrLeu: 2.344 ± 0.037
0.473TyrMet: 0.473 ± 0.017
0.679TyrAsn: 0.679 ± 0.021
1.101TyrPro: 1.101 ± 0.025
0.77TyrGln: 0.77 ± 0.02
1.738TyrArg: 1.738 ± 0.031
1.428TyrSer: 1.428 ± 0.034
1.091TyrThr: 1.091 ± 0.025
1.717TyrVal: 1.717 ± 0.031
0.396TyrTrp: 0.396 ± 0.016
0.63TyrTyr: 0.63 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6043 proteins (1816925 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski