Amino acid dipepetide frequency for Yoonia litorea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.544AlaAla: 15.544 ± 0.171	1.044AlaCys: 1.044 ± 0.036	7.262AlaAsp: 7.262 ± 0.097	7.912AlaGlu: 7.912 ± 0.131	4.523AlaPhe: 4.523 ± 0.071	9.918AlaGly: 9.918 ± 0.116	2.212AlaHis: 2.212 ± 0.051	6.488AlaIle: 6.488 ± 0.08	4.354AlaLys: 4.354 ± 0.082	12.646AlaLeu: 12.646 ± 0.132	3.719AlaMet: 3.719 ± 0.066	3.092AlaAsn: 3.092 ± 0.06	5.135AlaPro: 5.135 ± 0.076	4.37AlaGln: 4.37 ± 0.066	7.395AlaArg: 7.395 ± 0.111	5.691AlaSer: 5.691 ± 0.075	6.322AlaThr: 6.322 ± 0.084	8.198AlaVal: 8.198 ± 0.107	1.373AlaTrp: 1.373 ± 0.04	2.66AlaTyr: 2.66 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.034CysAla: 1.034 ± 0.036	0.099CysCys: 0.099 ± 0.01	0.671CysAsp: 0.671 ± 0.03	0.499CysGlu: 0.499 ± 0.022	0.317CysPhe: 0.317 ± 0.016	0.941CysGly: 0.941 ± 0.03	0.262CysHis: 0.262 ± 0.016	0.413CysIle: 0.413 ± 0.022	0.221CysLys: 0.221 ± 0.014	0.772CysLeu: 0.772 ± 0.031	0.158CysMet: 0.158 ± 0.012	0.231CysAsn: 0.231 ± 0.015	0.473CysPro: 0.473 ± 0.024	0.26CysGln: 0.26 ± 0.014	0.471CysArg: 0.471 ± 0.019	0.405CysSer: 0.405 ± 0.02	0.412CysThr: 0.412 ± 0.024	0.638CysVal: 0.638 ± 0.03	0.106CysTrp: 0.106 ± 0.01	0.212CysTyr: 0.212 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.769AspAla: 7.769 ± 0.099	0.521AspCys: 0.521 ± 0.024	4.105AspAsp: 4.105 ± 0.104	3.872AspGlu: 3.872 ± 0.068	2.469AspPhe: 2.469 ± 0.051	5.862AspGly: 5.862 ± 0.109	1.417AspHis: 1.417 ± 0.045	3.391AspIle: 3.391 ± 0.065	1.814AspLys: 1.814 ± 0.045	6.602AspLeu: 6.602 ± 0.089	1.685AspMet: 1.685 ± 0.042	1.464AspAsn: 1.464 ± 0.044	3.581AspPro: 3.581 ± 0.074	2.205AspGln: 2.205 ± 0.044	4.065AspArg: 4.065 ± 0.067	2.17AspSer: 2.17 ± 0.053	3.102AspThr: 3.102 ± 0.08	4.761AspVal: 4.761 ± 0.076	1.172AspTrp: 1.172 ± 0.039	1.608AspTyr: 1.608 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.858GluAla: 7.858 ± 0.123	0.366GluCys: 0.366 ± 0.018	3.561GluAsp: 3.561 ± 0.074	3.64GluGlu: 3.64 ± 0.081	1.787GluPhe: 1.787 ± 0.044	4.792GluGly: 4.792 ± 0.078	1.103GluHis: 1.103 ± 0.033	3.815GluIle: 3.815 ± 0.066	2.323GluLys: 2.323 ± 0.059	4.873GluLeu: 4.873 ± 0.081	1.921GluMet: 1.921 ± 0.05	2.042GluAsn: 2.042 ± 0.054	2.282GluPro: 2.282 ± 0.049	1.905GluGln: 1.905 ± 0.051	3.975GluArg: 3.975 ± 0.072	2.323GluSer: 2.323 ± 0.048	4.084GluThr: 4.084 ± 0.068	4.6GluVal: 4.6 ± 0.074	0.684GluTrp: 0.684 ± 0.027	1.011GluTyr: 1.011 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.787PheAla: 4.787 ± 0.068	0.441PheCys: 0.441 ± 0.022	3.021PheAsp: 3.021 ± 0.055	2.343PheGlu: 2.343 ± 0.05	1.596PhePhe: 1.596 ± 0.047	3.941PheGly: 3.941 ± 0.071	0.733PheHis: 0.733 ± 0.025	1.887PheIle: 1.887 ± 0.047	1.029PheLys: 1.029 ± 0.029	3.487PheLeu: 3.487 ± 0.067	0.898PheMet: 0.898 ± 0.034	1.113PheAsn: 1.113 ± 0.038	1.549PhePro: 1.549 ± 0.038	1.099PheGln: 1.099 ± 0.036	2.063PheArg: 2.063 ± 0.054	2.094PheSer: 2.094 ± 0.042	2.098PheThr: 2.098 ± 0.054	3.005PheVal: 3.005 ± 0.057	0.66PheTrp: 0.66 ± 0.031	1.027PheTyr: 1.027 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.176GlyAla: 9.176 ± 0.105	0.829GlyCys: 0.829 ± 0.03	4.986GlyAsp: 4.986 ± 0.132	4.684GlyGlu: 4.684 ± 0.071	3.812GlyPhe: 3.812 ± 0.068	7.182GlyGly: 7.182 ± 0.121	1.812GlyHis: 1.812 ± 0.048	4.583GlyIle: 4.583 ± 0.071	3.29GlyLys: 3.29 ± 0.069	8.771GlyLeu: 8.771 ± 0.103	2.576GlyMet: 2.576 ± 0.051	2.23GlyAsn: 2.23 ± 0.07	3.495GlyPro: 3.495 ± 0.052	3.323GlyGln: 3.323 ± 0.069	5.236GlyArg: 5.236 ± 0.085	4.175GlySer: 4.175 ± 0.068	4.803GlyThr: 4.803 ± 0.102	6.411GlyVal: 6.411 ± 0.077	1.416GlyTrp: 1.416 ± 0.041	2.267GlyTyr: 2.267 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.218HisAla: 2.218 ± 0.049	0.199HisCys: 0.199 ± 0.013	1.273HisAsp: 1.273 ± 0.037	1.012HisGlu: 1.012 ± 0.034	0.858HisPhe: 0.858 ± 0.031	1.779HisGly: 1.779 ± 0.049	0.569HisHis: 0.569 ± 0.033	1.12HisIle: 1.12 ± 0.035	0.581HisLys: 0.581 ± 0.025	2.049HisLeu: 2.049 ± 0.049	0.549HisMet: 0.549 ± 0.023	0.462HisAsn: 0.462 ± 0.022	1.353HisPro: 1.353 ± 0.038	0.622HisGln: 0.622 ± 0.025	1.256HisArg: 1.256 ± 0.039	0.84HisSer: 0.84 ± 0.029	0.824HisThr: 0.824 ± 0.025	1.462HisVal: 1.462 ± 0.04	0.357HisTrp: 0.357 ± 0.018	0.589HisTyr: 0.589 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.613IleAla: 7.613 ± 0.089	0.601IleCys: 0.601 ± 0.027	3.759IleAsp: 3.759 ± 0.069	3.489IleGlu: 3.489 ± 0.058	1.964IlePhe: 1.964 ± 0.047	5.253IleGly: 5.253 ± 0.072	0.896IleHis: 0.896 ± 0.031	2.781IleIle: 2.781 ± 0.058	1.759IleLys: 1.759 ± 0.043	4.897IleLeu: 4.897 ± 0.082	1.278IleMet: 1.278 ± 0.034	1.668IleAsn: 1.668 ± 0.053	2.463IlePro: 2.463 ± 0.053	1.233IleGln: 1.233 ± 0.035	2.975IleArg: 2.975 ± 0.054	3.269IleSer: 3.269 ± 0.069	3.341IleThr: 3.341 ± 0.095	4.128IleVal: 4.128 ± 0.072	0.77IleTrp: 0.77 ± 0.029	1.24IleTyr: 1.24 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.188LysAla: 4.188 ± 0.079	0.194LysCys: 0.194 ± 0.014	2.148LysAsp: 2.148 ± 0.049	1.79LysGlu: 1.79 ± 0.045	1.016LysPhe: 1.016 ± 0.035	2.852LysGly: 2.852 ± 0.061	0.697LysHis: 0.697 ± 0.03	1.84LysIle: 1.84 ± 0.05	1.358LysLys: 1.358 ± 0.048	3.124LysLeu: 3.124 ± 0.059	0.964LysMet: 0.964 ± 0.032	0.884LysAsn: 0.884 ± 0.028	1.863LysPro: 1.863 ± 0.045	0.985LysGln: 0.985 ± 0.033	2.373LysArg: 2.373 ± 0.058	2.041LysSer: 2.041 ± 0.047	2.1LysThr: 2.1 ± 0.045	2.373LysVal: 2.373 ± 0.054	0.421LysTrp: 0.421 ± 0.021	0.642LysTyr: 0.642 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.911LeuAla: 11.911 ± 0.143	0.894LeuCys: 0.894 ± 0.035	5.844LeuAsp: 5.844 ± 0.08	5.26LeuGlu: 5.26 ± 0.068	3.459LeuPhe: 3.459 ± 0.072	8.011LeuGly: 8.011 ± 0.096	1.729LeuHis: 1.729 ± 0.044	5.439LeuIle: 5.439 ± 0.072	3.247LeuLys: 3.247 ± 0.058	8.415LeuLeu: 8.415 ± 0.119	2.675LeuMet: 2.675 ± 0.061	2.796LeuAsn: 2.796 ± 0.056	5.195LeuPro: 5.195 ± 0.085	3.015LeuGln: 3.015 ± 0.053	6.6LeuArg: 6.6 ± 0.085	6.614LeuSer: 6.614 ± 0.091	6.051LeuThr: 6.051 ± 0.085	6.608LeuVal: 6.608 ± 0.087	1.293LeuTrp: 1.293 ± 0.038	2.008LeuTyr: 2.008 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.386MetAla: 3.386 ± 0.068	0.188MetCys: 0.188 ± 0.013	1.442MetAsp: 1.442 ± 0.042	1.359MetGlu: 1.359 ± 0.044	0.838MetPhe: 0.838 ± 0.031	2.276MetGly: 2.276 ± 0.057	0.51MetHis: 0.51 ± 0.022	1.695MetIle: 1.695 ± 0.04	1.121MetLys: 1.121 ± 0.033	2.585MetLeu: 2.585 ± 0.055	0.849MetMet: 0.849 ± 0.035	0.926MetAsn: 0.926 ± 0.034	1.515MetPro: 1.515 ± 0.038	1.034MetGln: 1.034 ± 0.032	1.955MetArg: 1.955 ± 0.046	1.763MetSer: 1.763 ± 0.043	2.15MetThr: 2.15 ± 0.056	1.909MetVal: 1.909 ± 0.047	0.288MetTrp: 0.288 ± 0.017	0.345MetTyr: 0.345 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.519AsnAla: 3.519 ± 0.063	0.287AsnCys: 0.287 ± 0.019	1.768AsnAsp: 1.768 ± 0.063	1.396AsnGlu: 1.396 ± 0.038	1.063AsnPhe: 1.063 ± 0.036	2.621AsnGly: 2.621 ± 0.073	0.549AsnHis: 0.549 ± 0.023	1.516AsnIle: 1.516 ± 0.046	0.725AsnLys: 0.725 ± 0.027	2.659AsnLeu: 2.659 ± 0.056	0.777AsnMet: 0.777 ± 0.025	0.781AsnAsn: 0.781 ± 0.034	1.911AsnPro: 1.911 ± 0.044	0.801AsnGln: 0.801 ± 0.029	1.755AsnArg: 1.755 ± 0.04	1.195AsnSer: 1.195 ± 0.032	1.438AsnThr: 1.438 ± 0.047	2.061AsnVal: 2.061 ± 0.053	0.453AsnTrp: 0.453 ± 0.019	0.695AsnTyr: 0.695 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.174ProAla: 5.174 ± 0.073	0.335ProCys: 0.335 ± 0.021	3.907ProAsp: 3.907 ± 0.076	3.833ProGlu: 3.833 ± 0.06	2.063ProPhe: 2.063 ± 0.044	3.517ProGly: 3.517 ± 0.063	1.053ProHis: 1.053 ± 0.031	2.388ProIle: 2.388 ± 0.05	1.761ProLys: 1.761 ± 0.046	4.499ProLeu: 4.499 ± 0.068	1.302ProMet: 1.302 ± 0.039	1.348ProAsn: 1.348 ± 0.037	2.104ProPro: 2.104 ± 0.061	1.816ProGln: 1.816 ± 0.047	2.488ProArg: 2.488 ± 0.055	2.547ProSer: 2.547 ± 0.057	2.551ProThr: 2.551 ± 0.055	4.029ProVal: 4.029 ± 0.066	0.64ProTrp: 0.64 ± 0.025	1.163ProTyr: 1.163 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.944GlnAla: 3.944 ± 0.075	0.216GlnCys: 0.216 ± 0.019	1.822GlnAsp: 1.822 ± 0.044	1.763GlnGlu: 1.763 ± 0.042	1.2GlnPhe: 1.2 ± 0.033	2.546GlnGly: 2.546 ± 0.052	0.621GlnHis: 0.621 ± 0.025	2.284GlnIle: 2.284 ± 0.05	1.128GlnLys: 1.128 ± 0.033	3.028GlnLeu: 3.028 ± 0.056	1.149GlnMet: 1.149 ± 0.032	1.007GlnAsn: 1.007 ± 0.033	1.561GlnPro: 1.561 ± 0.039	1.199GlnGln: 1.199 ± 0.041	2.184GlnArg: 2.184 ± 0.055	2.011GlnSer: 2.011 ± 0.05	2.076GlnThr: 2.076 ± 0.044	2.379GlnVal: 2.379 ± 0.05	0.475GlnTrp: 0.475 ± 0.023	0.596GlnTyr: 0.596 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.975ArgAla: 6.975 ± 0.099	0.436ArgCys: 0.436 ± 0.021	4.081ArgAsp: 4.081 ± 0.07	3.602ArgGlu: 3.602 ± 0.071	2.681ArgPhe: 2.681 ± 0.048	4.179ArgGly: 4.179 ± 0.068	1.39ArgHis: 1.39 ± 0.033	3.675ArgIle: 3.675 ± 0.057	2.427ArgLys: 2.427 ± 0.056	6.648ArgLeu: 6.648 ± 0.105	1.846ArgMet: 1.846 ± 0.047	1.83ArgAsn: 1.83 ± 0.042	3.014ArgPro: 3.014 ± 0.054	2.267ArgGln: 2.267 ± 0.055	4.353ArgArg: 4.353 ± 0.078	3.045ArgSer: 3.045 ± 0.058	2.888ArgThr: 2.888 ± 0.051	4.358ArgVal: 4.358 ± 0.065	0.897ArgTrp: 0.897 ± 0.03	1.472ArgTyr: 1.472 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.824SerAla: 5.824 ± 0.081	0.451SerCys: 0.451 ± 0.021	3.609SerAsp: 3.609 ± 0.062	3.141SerGlu: 3.141 ± 0.057	2.399SerPhe: 2.399 ± 0.053	5.323SerGly: 5.323 ± 0.088	1.073SerHis: 1.073 ± 0.031	2.629SerIle: 2.629 ± 0.065	1.624SerLys: 1.624 ± 0.046	4.998SerLeu: 4.998 ± 0.072	1.404SerMet: 1.404 ± 0.038	1.498SerAsn: 1.498 ± 0.043	2.452SerPro: 2.452 ± 0.053	1.742SerGln: 1.742 ± 0.039	3.064SerArg: 3.064 ± 0.058	2.527SerSer: 2.527 ± 0.058	2.474SerThr: 2.474 ± 0.054	3.857SerVal: 3.857 ± 0.075	0.68SerTrp: 0.68 ± 0.023	1.283SerTyr: 1.283 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.257ThrAla: 6.257 ± 0.082	0.516ThrCys: 0.516 ± 0.026	3.542ThrAsp: 3.542 ± 0.069	3.099ThrGlu: 3.099 ± 0.054	2.22ThrPhe: 2.22 ± 0.054	5.236ThrGly: 5.236 ± 0.105	1.16ThrHis: 1.16 ± 0.035	3.122ThrIle: 3.122 ± 0.074	1.719ThrLys: 1.719 ± 0.043	5.928ThrLeu: 5.928 ± 0.081	1.336ThrMet: 1.336 ± 0.03	1.491ThrAsn: 1.491 ± 0.042	3.353ThrPro: 3.353 ± 0.058	1.747ThrGln: 1.747 ± 0.042	3.204ThrArg: 3.204 ± 0.066	2.968ThrSer: 2.968 ± 0.063	3.116ThrThr: 3.116 ± 0.073	4.604ThrVal: 4.604 ± 0.094	0.665ThrTrp: 0.665 ± 0.028	1.409ThrTyr: 1.409 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	8.743ValAla: 8.743 ± 0.103	0.619ValCys: 0.619 ± 0.027	4.296ValAsp: 4.296 ± 0.071	4.273ValGlu: 4.273 ± 0.064	3.052ValPhe: 3.052 ± 0.059	5.692ValGly: 5.692 ± 0.085	1.358ValHis: 1.358 ± 0.037	4.587ValIle: 4.587 ± 0.074	2.286ValLys: 2.286 ± 0.056	7.208ValLeu: 7.208 ± 0.092	2.131ValMet: 2.131 ± 0.05	2.018ValAsn: 2.018 ± 0.052	3.451ValPro: 3.451 ± 0.065	2.201ValGln: 2.201 ± 0.045	4.087ValArg: 4.087 ± 0.072	4.478ValSer: 4.478 ± 0.067	4.883ValThr: 4.883 ± 0.078	5.727ValVal: 5.727 ± 0.08	0.971ValTrp: 0.971 ± 0.035	1.542ValTyr: 1.542 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.369TrpAla: 1.369 ± 0.038	0.118TrpCys: 0.118 ± 0.011	0.868TrpAsp: 0.868 ± 0.03	0.706TrpGlu: 0.706 ± 0.032	0.61TrpPhe: 0.61 ± 0.025	0.981TrpGly: 0.981 ± 0.038	0.302TrpHis: 0.302 ± 0.017	0.729TrpIle: 0.729 ± 0.029	0.433TrpLys: 0.433 ± 0.021	1.571TrpLeu: 1.571 ± 0.041	0.436TrpMet: 0.436 ± 0.018	0.442TrpAsn: 0.442 ± 0.02	0.69TrpPro: 0.69 ± 0.027	0.599TrpGln: 0.599 ± 0.027	1.021TrpArg: 1.021 ± 0.034	0.783TrpSer: 0.783 ± 0.025	0.822TrpThr: 0.822 ± 0.032	0.947TrpVal: 0.947 ± 0.029	0.237TrpTrp: 0.237 ± 0.016	0.266TrpTyr: 0.266 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.569TyrAla: 2.569 ± 0.049	0.24TyrCys: 0.24 ± 0.014	1.668TyrAsp: 1.668 ± 0.044	1.271TyrGlu: 1.271 ± 0.037	0.944TyrPhe: 0.944 ± 0.026	2.153TyrGly: 2.153 ± 0.049	0.525TyrHis: 0.525 ± 0.022	0.998TyrIle: 0.998 ± 0.032	0.649TyrLys: 0.649 ± 0.027	2.306TyrLeu: 2.306 ± 0.048	0.48TyrMet: 0.48 ± 0.021	0.649TyrAsn: 0.649 ± 0.027	1.08TyrPro: 1.08 ± 0.032	0.765TyrGln: 0.765 ± 0.027	1.544TyrArg: 1.544 ± 0.045	1.114TyrSer: 1.114 ± 0.034	1.158TyrThr: 1.158 ± 0.033	1.549TyrVal: 1.549 ± 0.045	0.371TyrTrp: 0.371 ± 0.018	0.591TyrTyr: 0.591 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3293 proteins (1020791 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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