Amino acid dipepetide frequency for Bat coronavirus HKU9-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.252AlaAla: 5.252 ± 2.0
2.521AlaCys: 2.521 ± 0.477
3.571AlaAsp: 3.571 ± 0.622
2.836AlaGlu: 2.836 ± 0.642
3.991AlaPhe: 3.991 ± 0.537
4.096AlaGly: 4.096 ± 0.721
1.365AlaHis: 1.365 ± 0.289
4.936AlaIle: 4.936 ± 0.986
4.096AlaLys: 4.096 ± 1.337
5.882AlaLeu: 5.882 ± 1.046
2.941AlaMet: 2.941 ± 0.941
3.886AlaAsn: 3.886 ± 0.793
2.836AlaPro: 2.836 ± 1.046
3.361AlaGln: 3.361 ± 0.999
2.941AlaArg: 2.941 ± 0.612
4.831AlaSer: 4.831 ± 0.61
3.676AlaThr: 3.676 ± 0.804
6.092AlaVal: 6.092 ± 0.903
0.525AlaTrp: 0.525 ± 0.369
4.201AlaTyr: 4.201 ± 0.912
0.0AlaXaa: 0.0 ± 0.0
Cys
2.101CysAla: 2.101 ± 0.661
0.84CysCys: 0.84 ± 0.291
1.786CysAsp: 1.786 ± 0.68
0.84CysGlu: 0.84 ± 0.452
1.996CysPhe: 1.996 ± 1.24
2.101CysGly: 2.101 ± 0.682
0.63CysHis: 0.63 ± 0.353
1.05CysIle: 1.05 ± 0.489
1.786CysLys: 1.786 ± 0.503
2.311CysLeu: 2.311 ± 1.252
0.63CysMet: 0.63 ± 0.192
1.575CysAsn: 1.575 ± 0.742
0.945CysPro: 0.945 ± 0.361
0.945CysGln: 0.945 ± 0.298
0.945CysArg: 0.945 ± 0.407
2.101CysSer: 2.101 ± 0.854
2.731CysThr: 2.731 ± 0.753
3.676CysVal: 3.676 ± 1.771
0.42CysTrp: 0.42 ± 0.226
2.521CysTyr: 2.521 ± 0.857
0.0CysXaa: 0.0 ± 0.0
Asp
4.201AspAla: 4.201 ± 0.82
0.84AspCys: 0.84 ± 0.28
2.836AspAsp: 2.836 ± 0.96
2.101AspGlu: 2.101 ± 0.764
2.521AspPhe: 2.521 ± 0.651
4.201AspGly: 4.201 ± 1.138
0.63AspHis: 0.63 ± 0.339
3.781AspIle: 3.781 ± 0.852
2.206AspLys: 2.206 ± 0.699
4.726AspLeu: 4.726 ± 0.81
1.68AspMet: 1.68 ± 0.263
1.996AspAsn: 1.996 ± 0.533
2.416AspPro: 2.416 ± 1.035
1.365AspGln: 1.365 ± 0.437
1.68AspArg: 1.68 ± 0.583
2.416AspSer: 2.416 ± 0.293
3.991AspThr: 3.991 ± 0.479
4.096AspVal: 4.096 ± 1.115
0.945AspTrp: 0.945 ± 0.407
3.571AspTyr: 3.571 ± 0.849
0.0AspXaa: 0.0 ± 0.0
Glu
2.836GluAla: 2.836 ± 0.571
1.26GluCys: 1.26 ± 0.397
1.68GluAsp: 1.68 ± 1.206
2.731GluGlu: 2.731 ± 1.949
1.26GluPhe: 1.26 ± 0.352
2.836GluGly: 2.836 ± 1.392
1.05GluHis: 1.05 ± 0.484
0.84GluIle: 0.84 ± 0.28
1.365GluLys: 1.365 ± 0.445
4.096GluLeu: 4.096 ± 0.671
0.525GluMet: 0.525 ± 0.329
1.996GluAsn: 1.996 ± 0.634
1.68GluPro: 1.68 ± 0.535
1.365GluGln: 1.365 ± 0.39
1.996GluArg: 1.996 ± 0.669
2.941GluSer: 2.941 ± 0.652
1.891GluThr: 1.891 ± 1.029
3.781GluVal: 3.781 ± 0.878
0.21GluTrp: 0.21 ± 0.271
1.26GluTyr: 1.26 ± 0.44
0.0GluXaa: 0.0 ± 0.0
Phe
2.521PheAla: 2.521 ± 1.609
1.786PheCys: 1.786 ± 0.41
3.046PheAsp: 3.046 ± 0.492
1.365PheGlu: 1.365 ± 0.32
0.735PhePhe: 0.735 ± 0.242
3.676PheGly: 3.676 ± 1.054
0.735PheHis: 0.735 ± 0.395
1.786PheIle: 1.786 ± 1.015
2.731PheLys: 2.731 ± 0.733
2.836PheLeu: 2.836 ± 0.799
1.575PheMet: 1.575 ± 0.244
3.151PheAsn: 3.151 ± 1.34
1.155PhePro: 1.155 ± 0.91
1.47PheGln: 1.47 ± 1.151
1.26PheArg: 1.26 ± 0.509
4.096PheSer: 4.096 ± 1.045
3.466PheThr: 3.466 ± 1.085
4.936PheVal: 4.936 ± 1.044
0.735PheTrp: 0.735 ± 0.218
2.521PheTyr: 2.521 ± 0.654
0.0PheXaa: 0.0 ± 0.0
Gly
4.516GlyAla: 4.516 ± 0.94
1.575GlyCys: 1.575 ± 0.548
3.676GlyAsp: 3.676 ± 0.994
2.416GlyGlu: 2.416 ± 0.749
4.306GlyPhe: 4.306 ± 0.611
4.201GlyGly: 4.201 ± 0.754
0.945GlyHis: 0.945 ± 0.508
1.786GlyIle: 1.786 ± 0.452
2.731GlyLys: 2.731 ± 0.801
4.936GlyLeu: 4.936 ± 1.155
0.945GlyMet: 0.945 ± 0.4
2.941GlyAsn: 2.941 ± 1.396
2.416GlyPro: 2.416 ± 0.726
1.26GlyGln: 1.26 ± 0.232
2.626GlyArg: 2.626 ± 1.69
4.831GlySer: 4.831 ± 1.21
5.567GlyThr: 5.567 ± 0.896
7.772GlyVal: 7.772 ± 1.096
1.155GlyTrp: 1.155 ± 0.465
3.256GlyTyr: 3.256 ± 0.507
0.0GlyXaa: 0.0 ± 0.0
His
1.575HisAla: 1.575 ± 0.533
0.315HisCys: 0.315 ± 0.373
0.525HisAsp: 0.525 ± 0.282
0.21HisGlu: 0.21 ± 0.113
1.47HisPhe: 1.47 ± 0.287
1.26HisGly: 1.26 ± 0.772
0.315HisHis: 0.315 ± 0.169
1.05HisIle: 1.05 ± 0.426
1.155HisLys: 1.155 ± 0.751
1.575HisLeu: 1.575 ± 0.485
0.21HisMet: 0.21 ± 0.113
1.05HisAsn: 1.05 ± 0.394
0.735HisPro: 0.735 ± 0.313
0.315HisGln: 0.315 ± 0.169
0.21HisArg: 0.21 ± 0.284
0.84HisSer: 0.84 ± 0.303
1.786HisThr: 1.786 ± 0.524
2.416HisVal: 2.416 ± 0.738
0.21HisTrp: 0.21 ± 0.284
1.155HisTyr: 1.155 ± 0.411
0.0HisXaa: 0.0 ± 0.0
Ile
3.046IleAla: 3.046 ± 0.91
0.735IleCys: 0.735 ± 0.515
2.101IleAsp: 2.101 ± 0.614
1.155IleGlu: 1.155 ± 0.374
1.68IlePhe: 1.68 ± 0.335
2.731IleGly: 2.731 ± 1.293
0.42IleHis: 0.42 ± 0.371
1.575IleIle: 1.575 ± 1.036
1.786IleLys: 1.786 ± 0.328
4.411IleLeu: 4.411 ± 1.683
1.05IleMet: 1.05 ± 0.394
2.731IleAsn: 2.731 ± 0.805
1.575IlePro: 1.575 ± 0.316
0.735IleGln: 0.735 ± 0.62
1.996IleArg: 1.996 ± 0.938
3.886IleSer: 3.886 ± 1.204
2.731IleThr: 2.731 ± 0.737
4.516IleVal: 4.516 ± 0.667
0.42IleTrp: 0.42 ± 0.226
1.996IleTyr: 1.996 ± 0.461
0.0IleXaa: 0.0 ± 0.0
Lys
3.676LysAla: 3.676 ± 0.753
1.365LysCys: 1.365 ± 0.439
2.311LysAsp: 2.311 ± 0.738
2.206LysGlu: 2.206 ± 0.626
1.891LysPhe: 1.891 ± 0.683
3.361LysGly: 3.361 ± 0.826
1.365LysHis: 1.365 ± 0.568
1.365LysIle: 1.365 ± 0.254
2.101LysLys: 2.101 ± 1.554
5.252LysLeu: 5.252 ± 1.051
0.84LysMet: 0.84 ± 0.243
1.891LysAsn: 1.891 ± 0.78
4.096LysPro: 4.096 ± 1.217
1.786LysGln: 1.786 ± 0.58
3.466LysArg: 3.466 ± 1.107
2.311LysSer: 2.311 ± 0.72
2.101LysThr: 2.101 ± 0.703
4.621LysVal: 4.621 ± 0.828
0.735LysTrp: 0.735 ± 0.273
2.521LysTyr: 2.521 ± 0.498
0.0LysXaa: 0.0 ± 0.0
Leu
7.562LeuAla: 7.562 ± 0.948
4.306LeuCys: 4.306 ± 0.865
4.516LeuAsp: 4.516 ± 1.303
4.096LeuGlu: 4.096 ± 1.073
3.886LeuPhe: 3.886 ± 1.276
4.516LeuGly: 4.516 ± 0.615
2.731LeuHis: 2.731 ± 0.918
3.466LeuIle: 3.466 ± 0.633
4.726LeuLys: 4.726 ± 1.565
10.713LeuLeu: 10.713 ± 3.076
1.891LeuMet: 1.891 ± 0.612
4.201LeuAsn: 4.201 ± 1.024
4.936LeuPro: 4.936 ± 1.036
4.201LeuGln: 4.201 ± 0.754
4.516LeuArg: 4.516 ± 0.836
6.302LeuSer: 6.302 ± 1.156
4.726LeuThr: 4.726 ± 0.745
8.087LeuVal: 8.087 ± 1.038
1.786LeuTrp: 1.786 ± 1.499
4.831LeuTyr: 4.831 ± 1.038
0.0LeuXaa: 0.0 ± 0.0
Met
1.575MetAla: 1.575 ± 0.624
1.26MetCys: 1.26 ± 0.29
0.525MetAsp: 0.525 ± 0.282
0.735MetGlu: 0.735 ± 0.395
0.735MetPhe: 0.735 ± 0.41
1.05MetGly: 1.05 ± 0.427
0.315MetHis: 0.315 ± 0.169
0.735MetIle: 0.735 ± 0.273
0.21MetLys: 0.21 ± 0.113
3.466MetLeu: 3.466 ± 0.259
0.42MetMet: 0.42 ± 0.226
1.155MetAsn: 1.155 ± 0.412
1.47MetPro: 1.47 ± 0.473
1.26MetGln: 1.26 ± 0.337
1.05MetArg: 1.05 ± 0.381
2.416MetSer: 2.416 ± 0.48
1.365MetThr: 1.365 ± 0.312
2.206MetVal: 2.206 ± 0.841
0.21MetTrp: 0.21 ± 0.284
1.26MetTyr: 1.26 ± 0.356
0.0MetXaa: 0.0 ± 0.0
Asn
3.991AsnAla: 3.991 ± 0.565
1.47AsnCys: 1.47 ± 0.517
1.891AsnAsp: 1.891 ± 1.052
1.786AsnGlu: 1.786 ± 1.218
2.206AsnPhe: 2.206 ± 1.575
4.096AsnGly: 4.096 ± 0.907
0.84AsnHis: 0.84 ± 0.588
2.206AsnIle: 2.206 ± 0.33
2.416AsnLys: 2.416 ± 0.573
5.041AsnLeu: 5.041 ± 1.337
0.84AsnMet: 0.84 ± 0.311
3.466AsnAsn: 3.466 ± 1.152
2.311AsnPro: 2.311 ± 0.913
0.945AsnGln: 0.945 ± 0.499
2.206AsnArg: 2.206 ± 0.935
3.361AsnSer: 3.361 ± 0.939
3.256AsnThr: 3.256 ± 1.359
5.041AsnVal: 5.041 ± 0.614
0.525AsnTrp: 0.525 ± 0.282
2.836AsnTyr: 2.836 ± 0.638
0.0AsnXaa: 0.0 ± 0.0
Pro
3.781ProAla: 3.781 ± 0.817
0.945ProCys: 0.945 ± 0.298
2.206ProAsp: 2.206 ± 0.324
2.101ProGlu: 2.101 ± 1.011
1.68ProPhe: 1.68 ± 0.456
3.676ProGly: 3.676 ± 1.624
0.945ProHis: 0.945 ± 0.383
3.046ProIle: 3.046 ± 0.425
2.836ProLys: 2.836 ± 1.873
4.831ProLeu: 4.831 ± 1.031
0.84ProMet: 0.84 ± 0.408
2.311ProAsn: 2.311 ± 1.333
2.416ProPro: 2.416 ± 1.037
1.365ProGln: 1.365 ± 0.414
1.365ProArg: 1.365 ± 1.01
2.101ProSer: 2.101 ± 0.558
3.256ProThr: 3.256 ± 0.438
3.466ProVal: 3.466 ± 1.016
0.63ProTrp: 0.63 ± 0.206
1.996ProTyr: 1.996 ± 0.457
0.0ProXaa: 0.0 ± 0.0
Gln
2.206GlnAla: 2.206 ± 0.788
0.315GlnCys: 0.315 ± 0.208
1.786GlnAsp: 1.786 ± 0.589
1.26GlnGlu: 1.26 ± 0.487
2.101GlnPhe: 2.101 ± 0.654
1.786GlnGly: 1.786 ± 0.355
0.945GlnHis: 0.945 ± 0.272
0.63GlnIle: 0.63 ± 0.198
1.365GlnLys: 1.365 ± 0.395
4.096GlnLeu: 4.096 ± 0.643
0.735GlnMet: 0.735 ± 0.193
1.891GlnAsn: 1.891 ± 1.234
1.786GlnPro: 1.786 ± 0.309
1.575GlnGln: 1.575 ± 0.558
1.575GlnArg: 1.575 ± 0.752
1.891GlnSer: 1.891 ± 0.582
2.416GlnThr: 2.416 ± 0.689
2.731GlnVal: 2.731 ± 0.619
1.155GlnTrp: 1.155 ± 0.286
0.945GlnTyr: 0.945 ± 0.499
0.0GlnXaa: 0.0 ± 0.0
Arg
3.256ArgAla: 3.256 ± 0.689
2.206ArgCys: 2.206 ± 0.652
1.47ArgAsp: 1.47 ± 0.419
1.786ArgGlu: 1.786 ± 0.282
1.786ArgPhe: 1.786 ± 1.096
2.521ArgGly: 2.521 ± 2.127
1.05ArgHis: 1.05 ± 0.538
1.26ArgIle: 1.26 ± 0.344
2.311ArgLys: 2.311 ± 0.895
3.991ArgLeu: 3.991 ± 0.94
1.05ArgMet: 1.05 ± 0.394
1.996ArgAsn: 1.996 ± 1.893
1.68ArgPro: 1.68 ± 0.717
1.575ArgGln: 1.575 ± 0.55
1.786ArgArg: 1.786 ± 0.84
1.996ArgSer: 1.996 ± 0.674
2.836ArgThr: 2.836 ± 0.492
3.151ArgVal: 3.151 ± 0.869
0.525ArgTrp: 0.525 ± 0.665
2.311ArgTyr: 2.311 ± 0.903
0.0ArgXaa: 0.0 ± 0.0
Ser
4.831SerAla: 4.831 ± 1.193
2.836SerCys: 2.836 ± 1.223
5.147SerAsp: 5.147 ± 0.655
3.256SerGlu: 3.256 ± 1.025
3.046SerPhe: 3.046 ± 0.684
4.201SerGly: 4.201 ± 0.584
1.05SerHis: 1.05 ± 0.427
3.151SerIle: 3.151 ± 0.931
3.571SerLys: 3.571 ± 0.622
6.512SerLeu: 6.512 ± 0.967
1.996SerMet: 1.996 ± 0.452
2.521SerAsn: 2.521 ± 0.708
1.996SerPro: 1.996 ± 0.396
1.26SerGln: 1.26 ± 0.435
3.361SerArg: 3.361 ± 2.362
5.462SerSer: 5.462 ± 1.751
4.096SerThr: 4.096 ± 0.528
7.352SerVal: 7.352 ± 1.558
0.945SerTrp: 0.945 ± 0.242
2.101SerTyr: 2.101 ± 0.616
0.0SerXaa: 0.0 ± 0.0
Thr
5.147ThrAla: 5.147 ± 0.554
2.521ThrCys: 2.521 ± 0.486
3.256ThrAsp: 3.256 ± 0.747
1.155ThrGlu: 1.155 ± 0.448
3.361ThrPhe: 3.361 ± 0.875
4.831ThrGly: 4.831 ± 0.885
0.84ThrHis: 0.84 ± 0.497
2.416ThrIle: 2.416 ± 0.464
2.836ThrLys: 2.836 ± 0.83
6.092ThrLeu: 6.092 ± 1.17
1.68ThrMet: 1.68 ± 0.643
2.941ThrAsn: 2.941 ± 1.112
4.306ThrPro: 4.306 ± 0.727
2.101ThrGln: 2.101 ± 0.893
2.101ThrArg: 2.101 ± 0.853
3.886ThrSer: 3.886 ± 0.601
5.357ThrThr: 5.357 ± 2.216
7.877ThrVal: 7.877 ± 1.434
0.315ThrTrp: 0.315 ± 0.169
2.731ThrTyr: 2.731 ± 0.872
0.0ThrXaa: 0.0 ± 0.0
Val
7.247ValAla: 7.247 ± 1.447
3.046ValCys: 3.046 ± 0.744
4.936ValAsp: 4.936 ± 1.297
3.466ValGlu: 3.466 ± 1.127
3.781ValPhe: 3.781 ± 0.953
5.252ValGly: 5.252 ± 0.761
1.365ValHis: 1.365 ± 0.493
3.361ValIle: 3.361 ± 1.182
5.672ValLys: 5.672 ± 0.769
9.873ValLeu: 9.873 ± 2.592
2.626ValMet: 2.626 ± 0.72
5.567ValAsn: 5.567 ± 1.067
3.886ValPro: 3.886 ± 0.651
4.516ValGln: 4.516 ± 1.107
3.466ValArg: 3.466 ± 1.028
9.033ValSer: 9.033 ± 1.778
6.092ValThr: 6.092 ± 1.103
10.398ValVal: 10.398 ± 1.162
1.26ValTrp: 1.26 ± 0.412
3.991ValTyr: 3.991 ± 1.184
0.0ValXaa: 0.0 ± 0.0
Trp
0.525TrpAla: 0.525 ± 0.162
0.525TrpCys: 0.525 ± 0.336
1.05TrpAsp: 1.05 ± 0.564
0.42TrpGlu: 0.42 ± 0.371
0.525TrpPhe: 0.525 ± 0.378
0.525TrpGly: 0.525 ± 0.58
0.21TrpHis: 0.21 ± 0.159
0.525TrpIle: 0.525 ± 0.162
0.63TrpLys: 0.63 ± 0.392
1.996TrpLeu: 1.996 ± 0.751
0.105TrpMet: 0.105 ± 0.298
0.525TrpAsn: 0.525 ± 0.281
0.63TrpPro: 0.63 ± 0.555
0.315TrpGln: 0.315 ± 0.169
0.42TrpArg: 0.42 ± 0.318
1.05TrpSer: 1.05 ± 0.451
0.84TrpThr: 0.84 ± 0.318
1.155TrpVal: 1.155 ± 0.844
0.105TrpTrp: 0.105 ± 0.056
1.26TrpTyr: 1.26 ± 0.536
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.991TyrAla: 3.991 ± 0.593
1.26TyrCys: 1.26 ± 0.295
3.886TyrAsp: 3.886 ± 0.888
1.786TyrGlu: 1.786 ± 0.449
2.626TyrPhe: 2.626 ± 0.705
2.941TyrGly: 2.941 ± 0.913
0.63TyrHis: 0.63 ± 0.232
2.311TyrIle: 2.311 ± 0.431
2.731TyrLys: 2.731 ± 0.619
3.361TyrLeu: 3.361 ± 1.025
0.735TyrMet: 0.735 ± 0.242
2.941TyrAsn: 2.941 ± 1.273
2.521TyrPro: 2.521 ± 0.718
1.47TyrGln: 1.47 ± 0.31
1.575TyrArg: 1.575 ± 0.355
2.941TyrSer: 2.941 ± 0.745
3.571TyrThr: 3.571 ± 0.562
5.462TyrVal: 5.462 ± 1.285
0.525TyrTrp: 0.525 ± 0.606
2.521TyrTyr: 2.521 ± 0.779
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (9522 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski