Amino acid dipepetide frequency for Weissella koreensis (strain KACC 15510)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.095AlaAla: 6.095 ± 0.204
0.129AlaCys: 0.129 ± 0.018
4.44AlaAsp: 4.44 ± 0.159
4.657AlaGlu: 4.657 ± 0.11
2.987AlaPhe: 2.987 ± 0.097
5.665AlaGly: 5.665 ± 0.164
1.334AlaHis: 1.334 ± 0.072
5.64AlaIle: 5.64 ± 0.139
4.942AlaLys: 4.942 ± 0.137
7.783AlaLeu: 7.783 ± 0.158
2.378AlaMet: 2.378 ± 0.075
3.663AlaAsn: 3.663 ± 0.098
2.138AlaPro: 2.138 ± 0.061
3.72AlaGln: 3.72 ± 0.101
2.935AlaArg: 2.935 ± 0.096
4.187AlaSer: 4.187 ± 0.155
4.244AlaThr: 4.244 ± 0.124
5.266AlaVal: 5.266 ± 0.137
0.787AlaTrp: 0.787 ± 0.053
2.331AlaTyr: 2.331 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
0.131CysAla: 0.131 ± 0.017
0.012CysCys: 0.012 ± 0.005
0.084CysAsp: 0.084 ± 0.014
0.099CysGlu: 0.099 ± 0.016
0.121CysPhe: 0.121 ± 0.017
0.176CysGly: 0.176 ± 0.021
0.037CysHis: 0.037 ± 0.011
0.106CysIle: 0.106 ± 0.018
0.059CysLys: 0.059 ± 0.013
0.228CysLeu: 0.228 ± 0.024
0.04CysMet: 0.04 ± 0.01
0.084CysAsn: 0.084 ± 0.015
0.079CysPro: 0.079 ± 0.015
0.069CysGln: 0.069 ± 0.015
0.062CysArg: 0.062 ± 0.012
0.146CysSer: 0.146 ± 0.023
0.092CysThr: 0.092 ± 0.015
0.141CysVal: 0.141 ± 0.02
0.022CysTrp: 0.022 ± 0.008
0.064CysTyr: 0.064 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.284AspAla: 4.284 ± 0.109
0.101AspCys: 0.101 ± 0.016
3.625AspAsp: 3.625 ± 0.13
4.45AspGlu: 4.45 ± 0.125
2.665AspPhe: 2.665 ± 0.087
3.727AspGly: 3.727 ± 0.116
1.195AspHis: 1.195 ± 0.055
3.88AspIle: 3.88 ± 0.098
3.252AspLys: 3.252 ± 0.12
6.172AspLeu: 6.172 ± 0.16
1.487AspMet: 1.487 ± 0.069
2.96AspAsn: 2.96 ± 0.128
2.061AspPro: 2.061 ± 0.069
3.618AspGln: 3.618 ± 0.107
2.324AspArg: 2.324 ± 0.084
3.333AspSer: 3.333 ± 0.347
2.665AspThr: 2.665 ± 0.089
3.987AspVal: 3.987 ± 0.117
0.775AspTrp: 0.775 ± 0.054
2.331AspTyr: 2.331 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
4.672GluAla: 4.672 ± 0.148
0.077GluCys: 0.077 ± 0.013
3.044GluAsp: 3.044 ± 0.113
3.68GluGlu: 3.68 ± 0.14
2.49GluPhe: 2.49 ± 0.081
2.804GluGly: 2.804 ± 0.098
1.292GluHis: 1.292 ± 0.056
5.053GluIle: 5.053 ± 0.137
4.172GluLys: 4.172 ± 0.13
6.486GluLeu: 6.486 ± 0.162
2.089GluMet: 2.089 ± 0.074
3.564GluAsn: 3.564 ± 0.122
1.826GluPro: 1.826 ± 0.081
3.2GluGln: 3.2 ± 0.093
2.762GluArg: 2.762 ± 0.091
3.041GluSer: 3.041 ± 0.137
3.329GluThr: 3.329 ± 0.083
4.222GluVal: 4.222 ± 0.117
0.562GluTrp: 0.562 ± 0.036
2.086GluTyr: 2.086 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
2.942PheAla: 2.942 ± 0.108
0.116PheCys: 0.116 ± 0.019
2.809PheAsp: 2.809 ± 0.076
2.621PheGlu: 2.621 ± 0.088
1.948PhePhe: 1.948 ± 0.087
3.383PheGly: 3.383 ± 0.105
0.671PheHis: 0.671 ± 0.04
3.507PheIle: 3.507 ± 0.118
2.938PheLys: 2.938 ± 0.085
3.732PheLeu: 3.732 ± 0.128
1.299PheMet: 1.299 ± 0.071
2.618PheAsn: 2.618 ± 0.093
1.326PhePro: 1.326 ± 0.057
1.413PheGln: 1.413 ± 0.071
1.163PheArg: 1.163 ± 0.051
2.89PheSer: 2.89 ± 0.092
2.232PheThr: 2.232 ± 0.079
2.967PheVal: 2.967 ± 0.104
0.517PheTrp: 0.517 ± 0.037
1.468PheTyr: 1.468 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
4.994GlyAla: 4.994 ± 0.107
0.129GlyCys: 0.129 ± 0.019
3.574GlyAsp: 3.574 ± 0.118
3.403GlyGlu: 3.403 ± 0.111
2.989GlyPhe: 2.989 ± 0.092
4.331GlyGly: 4.331 ± 0.129
1.433GlyHis: 1.433 ± 0.053
5.796GlyIle: 5.796 ± 0.136
3.789GlyLys: 3.789 ± 0.107
6.902GlyLeu: 6.902 ± 0.165
2.118GlyMet: 2.118 ± 0.084
2.908GlyAsn: 2.908 ± 0.101
1.527GlyPro: 1.527 ± 0.064
2.774GlyGln: 2.774 ± 0.1
2.764GlyArg: 2.764 ± 0.098
4.167GlySer: 4.167 ± 0.113
4.118GlyThr: 4.118 ± 0.119
4.855GlyVal: 4.855 ± 0.121
0.817GlyTrp: 0.817 ± 0.043
2.559GlyTyr: 2.559 ± 0.083
0.0GlyXaa: 0.0 ± 0.0
His
1.322HisAla: 1.322 ± 0.063
0.045HisCys: 0.045 ± 0.012
1.183HisAsp: 1.183 ± 0.058
1.171HisGlu: 1.171 ± 0.062
0.879HisPhe: 0.879 ± 0.049
1.381HisGly: 1.381 ± 0.061
0.604HisHis: 0.604 ± 0.047
1.116HisIle: 1.116 ± 0.056
0.935HisLys: 0.935 ± 0.047
2.044HisLeu: 2.044 ± 0.073
0.48HisMet: 0.48 ± 0.034
0.968HisAsn: 0.968 ± 0.053
0.943HisPro: 0.943 ± 0.053
1.153HisGln: 1.153 ± 0.056
0.784HisArg: 0.784 ± 0.046
1.02HisSer: 1.02 ± 0.05
0.945HisThr: 0.945 ± 0.044
1.255HisVal: 1.255 ± 0.052
0.186HisTrp: 0.186 ± 0.019
0.765HisTyr: 0.765 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
5.976IleAla: 5.976 ± 0.134
0.213IleCys: 0.213 ± 0.029
5.009IleAsp: 5.009 ± 0.131
4.737IleGlu: 4.737 ± 0.134
3.494IlePhe: 3.494 ± 0.135
5.415IleGly: 5.415 ± 0.174
1.371IleHis: 1.371 ± 0.054
6.182IleIle: 6.182 ± 0.168
5.187IleLys: 5.187 ± 0.115
7.714IleLeu: 7.714 ± 0.17
2.022IleMet: 2.022 ± 0.078
4.365IleAsn: 4.365 ± 0.128
2.938IlePro: 2.938 ± 0.105
2.965IleGln: 2.965 ± 0.08
2.658IleArg: 2.658 ± 0.095
5.009IleSer: 5.009 ± 0.131
4.467IleThr: 4.467 ± 0.125
5.348IleVal: 5.348 ± 0.124
0.829IleTrp: 0.829 ± 0.052
2.514IleTyr: 2.514 ± 0.089
0.0IleXaa: 0.0 ± 0.0
Lys
4.432LysAla: 4.432 ± 0.118
0.032LysCys: 0.032 ± 0.009
3.39LysAsp: 3.39 ± 0.113
3.643LysGlu: 3.643 ± 0.094
2.282LysPhe: 2.282 ± 0.083
3.088LysGly: 3.088 ± 0.104
1.173LysHis: 1.173 ± 0.059
5.439LysIle: 5.439 ± 0.123
4.94LysLys: 4.94 ± 0.136
5.939LysLeu: 5.939 ± 0.142
2.408LysMet: 2.408 ± 0.075
4.098LysAsn: 4.098 ± 0.118
2.069LysPro: 2.069 ± 0.088
3.343LysGln: 3.343 ± 0.126
2.688LysArg: 2.688 ± 0.091
3.492LysSer: 3.492 ± 0.145
4.068LysThr: 4.068 ± 0.126
4.299LysVal: 4.299 ± 0.131
0.619LysTrp: 0.619 ± 0.043
2.398LysTyr: 2.398 ± 0.082
0.0LysXaa: 0.0 ± 0.0
Leu
8.236LeuAla: 8.236 ± 0.166
0.2LeuCys: 0.2 ± 0.024
6.001LeuAsp: 6.001 ± 0.135
5.645LeuGlu: 5.645 ± 0.157
3.947LeuPhe: 3.947 ± 0.134
6.664LeuGly: 6.664 ± 0.169
1.665LeuHis: 1.665 ± 0.067
8.347LeuIle: 8.347 ± 0.227
6.402LeuLys: 6.402 ± 0.158
9.127LeuLeu: 9.127 ± 0.227
3.019LeuMet: 3.019 ± 0.101
5.583LeuAsn: 5.583 ± 0.139
3.987LeuPro: 3.987 ± 0.112
3.977LeuGln: 3.977 ± 0.106
3.492LeuArg: 3.492 ± 0.11
6.491LeuSer: 6.491 ± 0.174
6.286LeuThr: 6.286 ± 0.127
6.947LeuVal: 6.947 ± 0.141
0.891LeuTrp: 0.891 ± 0.045
2.539LeuTyr: 2.539 ± 0.095
0.0LeuXaa: 0.0 ± 0.0
Met
2.561MetAla: 2.561 ± 0.093
0.032MetCys: 0.032 ± 0.01
1.653MetAsp: 1.653 ± 0.067
1.571MetGlu: 1.571 ± 0.056
1.104MetPhe: 1.104 ± 0.064
2.012MetGly: 2.012 ± 0.087
0.507MetHis: 0.507 ± 0.039
2.225MetIle: 2.225 ± 0.081
1.784MetLys: 1.784 ± 0.058
2.757MetLeu: 2.757 ± 0.092
0.958MetMet: 0.958 ± 0.057
1.688MetAsn: 1.688 ± 0.067
1.18MetPro: 1.18 ± 0.045
1.455MetGln: 1.455 ± 0.056
1.104MetArg: 1.104 ± 0.049
1.675MetSer: 1.675 ± 0.069
1.958MetThr: 1.958 ± 0.064
2.106MetVal: 2.106 ± 0.068
0.247MetTrp: 0.247 ± 0.028
0.777MetTyr: 0.777 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
3.405AsnAla: 3.405 ± 0.117
0.089AsnCys: 0.089 ± 0.013
3.262AsnAsp: 3.262 ± 0.111
3.368AsnGlu: 3.368 ± 0.101
2.443AsnPhe: 2.443 ± 0.078
3.66AsnGly: 3.66 ± 0.109
1.23AsnHis: 1.23 ± 0.064
3.838AsnIle: 3.838 ± 0.118
3.371AsnLys: 3.371 ± 0.108
5.43AsnLeu: 5.43 ± 0.139
1.49AsnMet: 1.49 ± 0.064
3.252AsnAsn: 3.252 ± 0.129
2.264AsnPro: 2.264 ± 0.069
3.064AsnGln: 3.064 ± 0.114
2.042AsnArg: 2.042 ± 0.076
3.116AsnSer: 3.116 ± 0.16
2.438AsnThr: 2.438 ± 0.085
3.472AsnVal: 3.472 ± 0.101
0.713AsnTrp: 0.713 ± 0.042
2.106AsnTyr: 2.106 ± 0.079
0.0AsnXaa: 0.0 ± 0.0
Pro
2.514ProAla: 2.514 ± 0.089
0.052ProCys: 0.052 ± 0.011
2.084ProAsp: 2.084 ± 0.07
2.779ProGlu: 2.779 ± 0.097
1.529ProPhe: 1.529 ± 0.061
2.057ProGly: 2.057 ± 0.073
0.591ProHis: 0.591 ± 0.035
2.544ProIle: 2.544 ± 0.086
2.396ProLys: 2.396 ± 0.086
3.237ProLeu: 3.237 ± 0.104
0.992ProMet: 0.992 ± 0.053
1.915ProAsn: 1.915 ± 0.079
0.384ProPro: 0.384 ± 0.032
1.344ProGln: 1.344 ± 0.055
1.151ProArg: 1.151 ± 0.061
1.883ProSer: 1.883 ± 0.063
2.123ProThr: 2.123 ± 0.078
2.722ProVal: 2.722 ± 0.108
0.334ProTrp: 0.334 ± 0.027
1.168ProTyr: 1.168 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
3.885GlnAla: 3.885 ± 0.109
0.072GlnCys: 0.072 ± 0.016
2.198GlnAsp: 2.198 ± 0.078
2.398GlnGlu: 2.398 ± 0.086
1.891GlnPhe: 1.891 ± 0.071
2.579GlnGly: 2.579 ± 0.075
0.906GlnHis: 0.906 ± 0.05
3.955GlnIle: 3.955 ± 0.112
3.455GlnLys: 3.455 ± 0.109
4.855GlnLeu: 4.855 ± 0.141
1.421GlnMet: 1.421 ± 0.062
2.641GlnAsn: 2.641 ± 0.092
1.584GlnPro: 1.584 ± 0.061
2.601GlnGln: 2.601 ± 0.113
2.009GlnArg: 2.009 ± 0.082
2.495GlnSer: 2.495 ± 0.082
2.73GlnThr: 2.73 ± 0.09
3.309GlnVal: 3.309 ± 0.091
0.539GlnTrp: 0.539 ± 0.04
1.678GlnTyr: 1.678 ± 0.072
0.0GlnXaa: 0.0 ± 0.0
Arg
2.655ArgAla: 2.655 ± 0.092
0.074ArgCys: 0.074 ± 0.015
2.168ArgAsp: 2.168 ± 0.074
2.465ArgGlu: 2.465 ± 0.085
1.735ArgPhe: 1.735 ± 0.068
2.467ArgGly: 2.467 ± 0.092
0.792ArgHis: 0.792 ± 0.052
2.794ArgIle: 2.794 ± 0.09
2.277ArgLys: 2.277 ± 0.082
3.935ArgLeu: 3.935 ± 0.112
1.128ArgMet: 1.128 ± 0.053
1.93ArgAsn: 1.93 ± 0.077
1.411ArgPro: 1.411 ± 0.067
1.987ArgGln: 1.987 ± 0.073
2.111ArgArg: 2.111 ± 0.085
2.141ArgSer: 2.141 ± 0.067
2.024ArgThr: 2.024 ± 0.083
2.544ArgVal: 2.544 ± 0.101
0.384ArgTrp: 0.384 ± 0.031
1.564ArgTyr: 1.564 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
4.217SerAla: 4.217 ± 0.116
0.104SerCys: 0.104 ± 0.018
4.125SerAsp: 4.125 ± 0.398
3.806SerGlu: 3.806 ± 0.156
2.621SerPhe: 2.621 ± 0.075
4.497SerGly: 4.497 ± 0.115
1.116SerHis: 1.116 ± 0.05
4.526SerIle: 4.526 ± 0.127
3.762SerLys: 3.762 ± 0.177
5.472SerLeu: 5.472 ± 0.129
1.532SerMet: 1.532 ± 0.063
3.321SerAsn: 3.321 ± 0.166
1.584SerPro: 1.584 ± 0.065
2.492SerGln: 2.492 ± 0.08
2.151SerArg: 2.151 ± 0.073
3.621SerSer: 3.621 ± 0.172
3.551SerThr: 3.551 ± 0.2
4.056SerVal: 4.056 ± 0.11
0.73SerTrp: 0.73 ± 0.043
1.985SerTyr: 1.985 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
4.368ThrAla: 4.368 ± 0.121
0.067ThrCys: 0.067 ± 0.013
3.247ThrAsp: 3.247 ± 0.081
3.16ThrGlu: 3.16 ± 0.092
2.452ThrPhe: 2.452 ± 0.086
4.227ThrGly: 4.227 ± 0.133
1.012ThrHis: 1.012 ± 0.046
4.68ThrIle: 4.68 ± 0.124
3.668ThrLys: 3.668 ± 0.155
5.61ThrLeu: 5.61 ± 0.149
1.512ThrMet: 1.512 ± 0.068
2.994ThrAsn: 2.994 ± 0.094
2.465ThrPro: 2.465 ± 0.07
2.264ThrGln: 2.264 ± 0.071
1.906ThrArg: 1.906 ± 0.07
3.581ThrSer: 3.581 ± 0.196
3.4ThrThr: 3.4 ± 0.11
4.242ThrVal: 4.242 ± 0.104
0.611ThrTrp: 0.611 ± 0.042
1.814ThrTyr: 1.814 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
5.534ValAla: 5.534 ± 0.141
0.161ValCys: 0.161 ± 0.019
4.328ValAsp: 4.328 ± 0.112
4.506ValGlu: 4.506 ± 0.166
2.705ValPhe: 2.705 ± 0.091
4.855ValGly: 4.855 ± 0.113
1.171ValHis: 1.171 ± 0.057
5.613ValIle: 5.613 ± 0.121
4.405ValLys: 4.405 ± 0.116
6.862ValLeu: 6.862 ± 0.153
1.893ValMet: 1.893 ± 0.064
3.425ValAsn: 3.425 ± 0.107
2.509ValPro: 2.509 ± 0.087
2.796ValGln: 2.796 ± 0.09
2.45ValArg: 2.45 ± 0.072
4.291ValSer: 4.291 ± 0.128
4.301ValThr: 4.301 ± 0.097
5.444ValVal: 5.444 ± 0.137
0.624ValTrp: 0.624 ± 0.042
2.052ValTyr: 2.052 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.75TrpAla: 0.75 ± 0.048
0.035TrpCys: 0.035 ± 0.009
0.564TrpAsp: 0.564 ± 0.044
0.465TrpGlu: 0.465 ± 0.036
0.547TrpPhe: 0.547 ± 0.037
0.668TrpGly: 0.668 ± 0.041
0.299TrpHis: 0.299 ± 0.028
0.893TrpIle: 0.893 ± 0.055
0.505TrpLys: 0.505 ± 0.041
1.262TrpLeu: 1.262 ± 0.062
0.334TrpMet: 0.334 ± 0.032
0.557TrpAsn: 0.557 ± 0.036
0.327TrpPro: 0.327 ± 0.031
0.609TrpGln: 0.609 ± 0.04
0.46TrpArg: 0.46 ± 0.033
0.74TrpSer: 0.74 ± 0.043
0.525TrpThr: 0.525 ± 0.035
0.681TrpVal: 0.681 ± 0.049
0.178TrpTrp: 0.178 ± 0.02
0.356TrpTyr: 0.356 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.346TyrAla: 2.346 ± 0.083
0.114TyrCys: 0.114 ± 0.019
2.108TyrAsp: 2.108 ± 0.077
1.826TyrGlu: 1.826 ± 0.075
1.732TyrPhe: 1.732 ± 0.078
2.292TyrGly: 2.292 ± 0.067
0.777TyrHis: 0.777 ± 0.044
2.277TyrIle: 2.277 ± 0.076
1.604TyrLys: 1.604 ± 0.067
3.9TyrLeu: 3.9 ± 0.117
0.752TyrMet: 0.752 ± 0.046
1.517TyrAsn: 1.517 ± 0.066
1.198TyrPro: 1.198 ± 0.06
2.353TyrGln: 2.353 ± 0.088
1.571TyrArg: 1.571 ± 0.058
1.948TyrSer: 1.948 ± 0.071
1.784TyrThr: 1.784 ± 0.073
2.064TyrVal: 2.064 ± 0.072
0.391TyrTrp: 0.391 ± 0.027
1.322TyrTyr: 1.322 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1346 proteins (404084 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski