Amino acid dipepetide frequency for Carboxydocella sporoproducens DSM 16521

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.107AlaAla: 10.107 ± 0.139
1.048AlaCys: 1.048 ± 0.045
3.939AlaAsp: 3.939 ± 0.065
7.085AlaGlu: 7.085 ± 0.115
3.221AlaPhe: 3.221 ± 0.073
8.225AlaGly: 8.225 ± 0.119
1.454AlaHis: 1.454 ± 0.044
5.951AlaIle: 5.951 ± 0.089
4.08AlaLys: 4.08 ± 0.085
10.288AlaLeu: 10.288 ± 0.126
2.219AlaMet: 2.219 ± 0.063
2.674AlaAsn: 2.674 ± 0.07
2.841AlaPro: 2.841 ± 0.068
3.503AlaGln: 3.503 ± 0.074
6.279AlaArg: 6.279 ± 0.101
3.733AlaSer: 3.733 ± 0.069
3.991AlaThr: 3.991 ± 0.076
7.245AlaVal: 7.245 ± 0.099
1.224AlaTrp: 1.224 ± 0.042
2.539AlaTyr: 2.539 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.792CysAla: 0.792 ± 0.034
0.207CysCys: 0.207 ± 0.017
0.462CysAsp: 0.462 ± 0.026
0.47CysGlu: 0.47 ± 0.027
0.347CysPhe: 0.347 ± 0.021
1.266CysGly: 1.266 ± 0.049
0.738CysHis: 0.738 ± 0.1
0.501CysIle: 0.501 ± 0.023
0.442CysLys: 0.442 ± 0.02
1.031CysLeu: 1.031 ± 0.038
0.23CysMet: 0.23 ± 0.021
0.356CysAsn: 0.356 ± 0.021
0.782CysPro: 0.782 ± 0.041
0.639CysGln: 0.639 ± 0.031
0.736CysArg: 0.736 ± 0.033
0.604CysSer: 0.604 ± 0.029
0.572CysThr: 0.572 ± 0.032
0.551CysVal: 0.551 ± 0.03
0.168CysTrp: 0.168 ± 0.015
0.384CysTyr: 0.384 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
2.912AspAla: 2.912 ± 0.059
0.587AspCys: 0.587 ± 0.032
1.6AspAsp: 1.6 ± 0.054
2.929AspGlu: 2.929 ± 0.067
1.937AspPhe: 1.937 ± 0.052
3.173AspGly: 3.173 ± 0.077
0.725AspHis: 0.725 ± 0.033
3.163AspIle: 3.163 ± 0.07
2.332AspLys: 2.332 ± 0.063
5.447AspLeu: 5.447 ± 0.082
0.974AspMet: 0.974 ± 0.037
1.497AspAsn: 1.497 ± 0.049
2.315AspPro: 2.315 ± 0.066
1.612AspGln: 1.612 ± 0.038
2.427AspArg: 2.427 ± 0.056
1.748AspSer: 1.748 ± 0.044
1.891AspThr: 1.891 ± 0.059
2.801AspVal: 2.801 ± 0.06
0.846AspTrp: 0.846 ± 0.034
1.785AspTyr: 1.785 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
6.403GluAla: 6.403 ± 0.1
0.528GluCys: 0.528 ± 0.032
2.696GluAsp: 2.696 ± 0.063
6.647GluGlu: 6.647 ± 0.11
2.232GluPhe: 2.232 ± 0.054
4.463GluGly: 4.463 ± 0.084
1.259GluHis: 1.259 ± 0.04
5.884GluIle: 5.884 ± 0.102
5.711GluLys: 5.711 ± 0.113
8.315GluLeu: 8.315 ± 0.121
2.051GluMet: 2.051 ± 0.055
2.572GluAsn: 2.572 ± 0.059
2.236GluPro: 2.236 ± 0.051
3.694GluGln: 3.694 ± 0.084
4.402GluArg: 4.402 ± 0.08
2.202GluSer: 2.202 ± 0.049
3.046GluThr: 3.046 ± 0.069
5.343GluVal: 5.343 ± 0.102
0.714GluTrp: 0.714 ± 0.026
1.957GluTyr: 1.957 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.104PheAla: 3.104 ± 0.074
0.543PheCys: 0.543 ± 0.027
1.649PheAsp: 1.649 ± 0.048
1.681PheGlu: 1.681 ± 0.041
1.727PhePhe: 1.727 ± 0.058
2.996PheGly: 2.996 ± 0.071
0.696PheHis: 0.696 ± 0.033
2.362PheIle: 2.362 ± 0.063
1.541PheLys: 1.541 ± 0.044
4.257PheLeu: 4.257 ± 0.081
0.707PheMet: 0.707 ± 0.03
1.455PheAsn: 1.455 ± 0.041
1.52PhePro: 1.52 ± 0.041
1.273PheGln: 1.273 ± 0.042
1.757PheArg: 1.757 ± 0.046
2.166PheSer: 2.166 ± 0.059
1.988PheThr: 1.988 ± 0.05
2.232PheVal: 2.232 ± 0.052
0.653PheTrp: 0.653 ± 0.031
1.371PheTyr: 1.371 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
6.262GlyAla: 6.262 ± 0.101
1.022GlyCys: 1.022 ± 0.045
3.091GlyAsp: 3.091 ± 0.068
5.271GlyGlu: 5.271 ± 0.1
2.831GlyPhe: 2.831 ± 0.059
5.908GlyGly: 5.908 ± 0.122
1.45GlyHis: 1.45 ± 0.045
5.779GlyIle: 5.779 ± 0.087
5.038GlyLys: 5.038 ± 0.081
8.831GlyLeu: 8.831 ± 0.133
2.094GlyMet: 2.094 ± 0.054
2.482GlyAsn: 2.482 ± 0.059
2.74GlyPro: 2.74 ± 0.059
3.91GlyGln: 3.91 ± 0.079
4.325GlyArg: 4.325 ± 0.084
3.644GlySer: 3.644 ± 0.083
4.129GlyThr: 4.129 ± 0.093
5.609GlyVal: 5.609 ± 0.107
1.251GlyTrp: 1.251 ± 0.045
2.801GlyTyr: 2.801 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.215HisAla: 1.215 ± 0.042
0.307HisCys: 0.307 ± 0.019
0.762HisAsp: 0.762 ± 0.04
0.849HisGlu: 0.849 ± 0.032
0.76HisPhe: 0.76 ± 0.033
1.571HisGly: 1.571 ± 0.06
0.472HisHis: 0.472 ± 0.027
1.064HisIle: 1.064 ± 0.036
0.795HisLys: 0.795 ± 0.033
2.121HisLeu: 2.121 ± 0.047
0.355HisMet: 0.355 ± 0.019
0.705HisAsn: 0.705 ± 0.034
1.268HisPro: 1.268 ± 0.042
0.788HisGln: 0.788 ± 0.035
1.035HisArg: 1.035 ± 0.037
0.978HisSer: 0.978 ± 0.038
0.913HisThr: 0.913 ± 0.043
0.942HisVal: 0.942 ± 0.035
0.413HisTrp: 0.413 ± 0.023
0.7HisTyr: 0.7 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.048IleAla: 6.048 ± 0.086
0.71IleCys: 0.71 ± 0.032
3.142IleAsp: 3.142 ± 0.071
4.112IleGlu: 4.112 ± 0.092
2.485IlePhe: 2.485 ± 0.067
4.91IleGly: 4.91 ± 0.097
1.09IleHis: 1.09 ± 0.035
4.944IleIle: 4.944 ± 0.091
4.299IleLys: 4.299 ± 0.089
6.772IleLeu: 6.772 ± 0.101
1.454IleMet: 1.454 ± 0.045
3.012IleAsn: 3.012 ± 0.076
3.096IlePro: 3.096 ± 0.072
2.115IleGln: 2.115 ± 0.049
3.384IleArg: 3.384 ± 0.082
3.686IleSer: 3.686 ± 0.076
3.734IleThr: 3.734 ± 0.076
4.328IleVal: 4.328 ± 0.078
0.712IleTrp: 0.712 ± 0.036
2.153IleTyr: 2.153 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
4.837LysAla: 4.837 ± 0.079
0.513LysCys: 0.513 ± 0.034
2.451LysAsp: 2.451 ± 0.058
4.837LysGlu: 4.837 ± 0.088
1.614LysPhe: 1.614 ± 0.051
3.988LysGly: 3.988 ± 0.075
0.925LysHis: 0.925 ± 0.034
4.157LysIle: 4.157 ± 0.088
3.897LysLys: 3.897 ± 0.089
5.436LysLeu: 5.436 ± 0.094
1.523LysMet: 1.523 ± 0.049
2.175LysAsn: 2.175 ± 0.061
2.465LysPro: 2.465 ± 0.066
2.468LysGln: 2.468 ± 0.059
2.693LysArg: 2.693 ± 0.063
2.115LysSer: 2.115 ± 0.054
2.759LysThr: 2.759 ± 0.058
4.27LysVal: 4.27 ± 0.083
0.579LysTrp: 0.579 ± 0.028
1.858LysTyr: 1.858 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
13.254LeuAla: 13.254 ± 0.146
1.009LeuCys: 1.009 ± 0.04
4.793LeuAsp: 4.793 ± 0.089
7.793LeuGlu: 7.793 ± 0.104
3.721LeuPhe: 3.721 ± 0.085
8.71LeuGly: 8.71 ± 0.126
1.714LeuHis: 1.714 ± 0.049
6.141LeuIle: 6.141 ± 0.11
6.214LeuLys: 6.214 ± 0.093
12.966LeuLeu: 12.966 ± 0.193
2.232LeuMet: 2.232 ± 0.052
3.889LeuAsn: 3.889 ± 0.071
5.588LeuPro: 5.588 ± 0.091
4.651LeuGln: 4.651 ± 0.096
5.591LeuArg: 5.591 ± 0.098
5.278LeuSer: 5.278 ± 0.084
6.166LeuThr: 6.166 ± 0.099
8.717LeuVal: 8.717 ± 0.107
1.282LeuTrp: 1.282 ± 0.045
2.946LeuTyr: 2.946 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.756MetAla: 2.756 ± 0.066
0.186MetCys: 0.186 ± 0.016
1.056MetAsp: 1.056 ± 0.038
1.645MetGlu: 1.645 ± 0.047
0.624MetPhe: 0.624 ± 0.028
1.796MetGly: 1.796 ± 0.057
0.347MetHis: 0.347 ± 0.024
1.306MetIle: 1.306 ± 0.04
1.422MetLys: 1.422 ± 0.045
2.414MetLeu: 2.414 ± 0.06
0.592MetMet: 0.592 ± 0.034
0.795MetAsn: 0.795 ± 0.032
1.032MetPro: 1.032 ± 0.038
0.922MetGln: 0.922 ± 0.036
1.204MetArg: 1.204 ± 0.038
1.08MetSer: 1.08 ± 0.036
1.171MetThr: 1.171 ± 0.041
1.892MetVal: 1.892 ± 0.054
0.188MetTrp: 0.188 ± 0.016
0.474MetTyr: 0.474 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.28AsnAla: 2.28 ± 0.063
0.56AsnCys: 0.56 ± 0.036
1.158AsnAsp: 1.158 ± 0.042
1.835AsnGlu: 1.835 ± 0.052
1.406AsnPhe: 1.406 ± 0.046
2.603AsnGly: 2.603 ± 0.065
0.618AsnHis: 0.618 ± 0.028
2.477AsnIle: 2.477 ± 0.069
2.015AsnLys: 2.015 ± 0.054
4.224AsnLeu: 4.224 ± 0.07
0.79AsnMet: 0.79 ± 0.034
1.431AsnAsn: 1.431 ± 0.052
2.207AsnPro: 2.207 ± 0.055
1.63AsnGln: 1.63 ± 0.044
2.202AsnArg: 2.202 ± 0.051
1.762AsnSer: 1.762 ± 0.052
1.589AsnThr: 1.589 ± 0.056
2.118AsnVal: 2.118 ± 0.052
0.633AsnTrp: 0.633 ± 0.032
1.257AsnTyr: 1.257 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
4.34ProAla: 4.34 ± 0.085
0.384ProCys: 0.384 ± 0.022
2.351ProAsp: 2.351 ± 0.06
4.164ProGlu: 4.164 ± 0.078
1.58ProPhe: 1.58 ± 0.044
4.32ProGly: 4.32 ± 0.091
0.872ProHis: 0.872 ± 0.039
2.185ProIle: 2.185 ± 0.059
1.737ProLys: 1.737 ± 0.05
4.746ProLeu: 4.746 ± 0.091
0.745ProMet: 0.745 ± 0.035
1.203ProAsn: 1.203 ± 0.041
1.801ProPro: 1.801 ± 0.061
1.862ProGln: 1.862 ± 0.054
2.438ProArg: 2.438 ± 0.057
1.625ProSer: 1.625 ± 0.043
1.846ProThr: 1.846 ± 0.053
4.185ProVal: 4.185 ± 0.086
0.747ProTrp: 0.747 ± 0.033
1.397ProTyr: 1.397 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
4.599GlnAla: 4.599 ± 0.073
0.37GlnCys: 0.37 ± 0.024
1.609GlnAsp: 1.609 ± 0.048
3.817GlnGlu: 3.817 ± 0.08
1.18GlnPhe: 1.18 ± 0.039
3.48GlnGly: 3.48 ± 0.074
0.748GlnHis: 0.748 ± 0.031
2.816GlnIle: 2.816 ± 0.059
2.606GlnLys: 2.606 ± 0.061
5.13GlnLeu: 5.13 ± 0.098
1.006GlnMet: 1.006 ± 0.042
1.321GlnAsn: 1.321 ± 0.039
2.078GlnPro: 2.078 ± 0.06
2.657GlnGln: 2.657 ± 0.078
2.433GlnArg: 2.433 ± 0.065
1.439GlnSer: 1.439 ± 0.045
1.873GlnThr: 1.873 ± 0.049
3.671GlnVal: 3.671 ± 0.076
0.501GlnTrp: 0.501 ± 0.026
1.078GlnTyr: 1.078 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
4.324ArgAla: 4.324 ± 0.08
0.614ArgCys: 0.614 ± 0.031
2.462ArgAsp: 2.462 ± 0.055
5.279ArgGlu: 5.279 ± 0.103
1.972ArgPhe: 1.972 ± 0.053
3.723ArgGly: 3.723 ± 0.07
1.048ArgHis: 1.048 ± 0.035
3.788ArgIle: 3.788 ± 0.072
3.078ArgLys: 3.078 ± 0.063
6.641ArgLeu: 6.641 ± 0.11
1.364ArgMet: 1.364 ± 0.045
1.723ArgAsn: 1.723 ± 0.05
2.444ArgPro: 2.444 ± 0.059
3.484ArgGln: 3.484 ± 0.072
3.533ArgArg: 3.533 ± 0.077
2.129ArgSer: 2.129 ± 0.054
2.441ArgThr: 2.441 ± 0.063
4.094ArgVal: 4.094 ± 0.081
0.942ArgTrp: 0.942 ± 0.044
1.843ArgTyr: 1.843 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.442SerAla: 3.442 ± 0.072
0.623SerCys: 0.623 ± 0.042
1.721SerAsp: 1.721 ± 0.049
2.481SerGlu: 2.481 ± 0.069
1.875SerPhe: 1.875 ± 0.053
4.179SerGly: 4.179 ± 0.087
0.86SerHis: 0.86 ± 0.034
2.681SerIle: 2.681 ± 0.066
2.233SerLys: 2.233 ± 0.059
5.24SerLeu: 5.24 ± 0.09
0.968SerMet: 0.968 ± 0.037
1.549SerAsn: 1.549 ± 0.059
2.13SerPro: 2.13 ± 0.056
2.059SerGln: 2.059 ± 0.053
2.852SerArg: 2.852 ± 0.063
2.457SerSer: 2.457 ± 0.071
2.232SerThr: 2.232 ± 0.065
2.629SerVal: 2.629 ± 0.06
0.884SerTrp: 0.884 ± 0.036
1.48SerTyr: 1.48 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
4.74ThrAla: 4.74 ± 0.077
0.651ThrCys: 0.651 ± 0.034
2.158ThrAsp: 2.158 ± 0.054
3.174ThrGlu: 3.174 ± 0.062
1.619ThrPhe: 1.619 ± 0.044
4.967ThrGly: 4.967 ± 0.084
0.771ThrHis: 0.771 ± 0.036
3.442ThrIle: 3.442 ± 0.067
1.861ThrLys: 1.861 ± 0.052
4.923ThrLeu: 4.923 ± 0.082
1.134ThrMet: 1.134 ± 0.039
1.641ThrAsn: 1.641 ± 0.053
2.461ThrPro: 2.461 ± 0.067
1.397ThrGln: 1.397 ± 0.04
2.721ThrArg: 2.721 ± 0.058
2.323ThrSer: 2.323 ± 0.075
2.693ThrThr: 2.693 ± 0.08
4.068ThrVal: 4.068 ± 0.075
0.639ThrTrp: 0.639 ± 0.029
1.438ThrTyr: 1.438 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
6.972ValAla: 6.972 ± 0.109
0.803ValCys: 0.803 ± 0.041
3.566ValAsp: 3.566 ± 0.07
5.687ValGlu: 5.687 ± 0.095
2.63ValPhe: 2.63 ± 0.064
4.815ValGly: 4.815 ± 0.082
1.187ValHis: 1.187 ± 0.042
5.22ValIle: 5.22 ± 0.094
4.363ValLys: 4.363 ± 0.081
7.778ValLeu: 7.778 ± 0.099
1.686ValMet: 1.686 ± 0.046
2.706ValAsn: 2.706 ± 0.058
3.202ValPro: 3.202 ± 0.069
2.614ValGln: 2.614 ± 0.053
3.788ValArg: 3.788 ± 0.081
3.455ValSer: 3.455 ± 0.075
3.814ValThr: 3.814 ± 0.071
6.048ValVal: 6.048 ± 0.104
0.802ValTrp: 0.802 ± 0.031
2.101ValTyr: 2.101 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
1.122TrpAla: 1.122 ± 0.036
0.123TrpCys: 0.123 ± 0.013
0.601TrpAsp: 0.601 ± 0.029
0.964TrpGlu: 0.964 ± 0.037
0.504TrpPhe: 0.504 ± 0.028
0.901TrpGly: 0.901 ± 0.039
0.301TrpHis: 0.301 ± 0.02
0.524TrpIle: 0.524 ± 0.028
0.532TrpLys: 0.532 ± 0.026
2.098TrpLeu: 2.098 ± 0.065
0.248TrpMet: 0.248 ± 0.017
0.421TrpAsn: 0.421 ± 0.023
0.75TrpPro: 0.75 ± 0.033
1.419TrpGln: 1.419 ± 0.049
0.956TrpArg: 0.956 ± 0.036
0.648TrpSer: 0.648 ± 0.03
0.517TrpThr: 0.517 ± 0.029
0.742TrpVal: 0.742 ± 0.032
0.273TrpTrp: 0.273 ± 0.021
0.389TrpTyr: 0.389 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.137TyrAla: 2.137 ± 0.047
0.491TyrCys: 0.491 ± 0.028
1.436TyrAsp: 1.436 ± 0.048
1.633TyrGlu: 1.633 ± 0.047
1.414TyrPhe: 1.414 ± 0.047
2.473TyrGly: 2.473 ± 0.052
0.738TyrHis: 0.738 ± 0.033
1.799TyrIle: 1.799 ± 0.054
1.363TyrLys: 1.363 ± 0.049
3.999TyrLeu: 3.999 ± 0.079
0.528TyrMet: 0.528 ± 0.025
1.189TyrAsn: 1.189 ± 0.041
1.571TyrPro: 1.571 ± 0.046
1.717TyrGln: 1.717 ± 0.049
2.169TyrArg: 2.169 ± 0.055
1.503TyrSer: 1.503 ± 0.046
1.455TyrThr: 1.455 ± 0.043
1.753TyrVal: 1.753 ± 0.049
0.579TyrTrp: 0.579 ± 0.029
1.281TyrTyr: 1.281 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2660 proteins (791629 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski