Amino acid dipepetide frequency for Sphingomonas indica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.29AlaAla: 22.29 ± 0.291	1.019AlaCys: 1.019 ± 0.037	8.692AlaAsp: 8.692 ± 0.115	8.867AlaGlu: 8.867 ± 0.139	4.657AlaPhe: 4.657 ± 0.084	12.338AlaGly: 12.338 ± 0.134	2.334AlaHis: 2.334 ± 0.059	7.25AlaIle: 7.25 ± 0.108	4.38AlaLys: 4.38 ± 0.078	15.065AlaLeu: 15.065 ± 0.195	4.095AlaMet: 4.095 ± 0.083	2.99AlaAsn: 2.99 ± 0.07	7.024AlaPro: 7.024 ± 0.107	4.131AlaGln: 4.131 ± 0.08	10.604AlaArg: 10.604 ± 0.146	6.27AlaSer: 6.27 ± 0.091	6.459AlaThr: 6.459 ± 0.079	9.144AlaVal: 9.144 ± 0.119	1.722AlaTrp: 1.722 ± 0.05	2.701AlaTyr: 2.701 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.964CysAla: 0.964 ± 0.037	0.058CysCys: 0.058 ± 0.01	0.491CysAsp: 0.491 ± 0.026	0.369CysGlu: 0.369 ± 0.021	0.279CysPhe: 0.279 ± 0.02	0.82CysGly: 0.82 ± 0.033	0.21CysHis: 0.21 ± 0.024	0.341CysIle: 0.341 ± 0.02	0.152CysLys: 0.152 ± 0.012	0.596CysLeu: 0.596 ± 0.023	0.123CysMet: 0.123 ± 0.013	0.194CysAsn: 0.194 ± 0.016	0.42CysPro: 0.42 ± 0.021	0.169CysGln: 0.169 ± 0.014	0.525CysArg: 0.525 ± 0.023	0.379CysSer: 0.379 ± 0.025	0.376CysThr: 0.376 ± 0.019	0.472CysVal: 0.472 ± 0.022	0.09CysTrp: 0.09 ± 0.01	0.165CysTyr: 0.165 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	9.094AspAla: 9.094 ± 0.114	0.481AspCys: 0.481 ± 0.027	3.411AspAsp: 3.411 ± 0.087	3.502AspGlu: 3.502 ± 0.07	2.159AspPhe: 2.159 ± 0.051	5.854AspGly: 5.854 ± 0.092	1.228AspHis: 1.228 ± 0.041	2.933AspIle: 2.933 ± 0.06	1.633AspLys: 1.633 ± 0.054	5.6AspLeu: 5.6 ± 0.095	1.368AspMet: 1.368 ± 0.04	1.283AspAsn: 1.283 ± 0.037	3.916AspPro: 3.916 ± 0.064	1.72AspGln: 1.72 ± 0.048	5.412AspArg: 5.412 ± 0.088	2.25AspSer: 2.25 ± 0.059	2.537AspThr: 2.537 ± 0.054	4.25AspVal: 4.25 ± 0.069	1.055AspTrp: 1.055 ± 0.037	1.637AspTyr: 1.637 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	8.67GluAla: 8.67 ± 0.127	0.318GluCys: 0.318 ± 0.02	2.825GluAsp: 2.825 ± 0.063	3.222GluGlu: 3.222 ± 0.079	1.411GluPhe: 1.411 ± 0.044	5.062GluGly: 5.062 ± 0.071	0.983GluHis: 0.983 ± 0.034	2.924GluIle: 2.924 ± 0.059	1.939GluLys: 1.939 ± 0.056	4.745GluLeu: 4.745 ± 0.08	1.575GluMet: 1.575 ± 0.05	1.299GluAsn: 1.299 ± 0.043	2.658GluPro: 2.658 ± 0.057	1.903GluGln: 1.903 ± 0.049	5.357GluArg: 5.357 ± 0.08	2.346GluSer: 2.346 ± 0.053	3.27GluThr: 3.27 ± 0.069	3.72GluVal: 3.72 ± 0.077	0.784GluTrp: 0.784 ± 0.03	0.942GluTyr: 0.942 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.933PheAla: 4.933 ± 0.075	0.283PheCys: 0.283 ± 0.018	2.695PheAsp: 2.695 ± 0.058	1.977PheGlu: 1.977 ± 0.055	1.228PhePhe: 1.228 ± 0.043	3.594PheGly: 3.594 ± 0.066	0.702PheHis: 0.702 ± 0.03	1.299PheIle: 1.299 ± 0.044	0.762PheLys: 0.762 ± 0.029	3.048PheLeu: 3.048 ± 0.063	0.69PheMet: 0.69 ± 0.028	0.896PheAsn: 0.896 ± 0.035	1.453PhePro: 1.453 ± 0.038	0.905PheGln: 0.905 ± 0.031	2.384PheArg: 2.384 ± 0.053	1.872PheSer: 1.872 ± 0.057	1.927PheThr: 1.927 ± 0.045	2.627PheVal: 2.627 ± 0.055	0.497PheTrp: 0.497 ± 0.026	0.896PheTyr: 0.896 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	11.061GlyAla: 11.061 ± 0.131	0.822GlyCys: 0.822 ± 0.036	5.481GlyAsp: 5.481 ± 0.087	5.074GlyGlu: 5.074 ± 0.087	3.631GlyPhe: 3.631 ± 0.067	8.96GlyGly: 8.96 ± 0.228	1.817GlyHis: 1.817 ± 0.052	4.446GlyIle: 4.446 ± 0.08	3.174GlyLys: 3.174 ± 0.09	8.602GlyLeu: 8.602 ± 0.092	2.225GlyMet: 2.225 ± 0.061	2.269GlyAsn: 2.269 ± 0.07	3.779GlyPro: 3.779 ± 0.064	2.83GlyGln: 2.83 ± 0.058	7.009GlyArg: 7.009 ± 0.094	4.816GlySer: 4.816 ± 0.111	4.726GlyThr: 4.726 ± 0.117	6.252GlyVal: 6.252 ± 0.091	1.694GlyTrp: 1.694 ± 0.046	2.283GlyTyr: 2.283 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.292HisAla: 2.292 ± 0.057	0.181HisCys: 0.181 ± 0.016	1.128HisAsp: 1.128 ± 0.038	0.936HisGlu: 0.936 ± 0.032	0.798HisPhe: 0.798 ± 0.031	1.852HisGly: 1.852 ± 0.052	0.532HisHis: 0.532 ± 0.029	0.899HisIle: 0.899 ± 0.034	0.452HisLys: 0.452 ± 0.024	1.839HisLeu: 1.839 ± 0.048	0.437HisMet: 0.437 ± 0.022	0.419HisAsn: 0.419 ± 0.024	1.263HisPro: 1.263 ± 0.037	0.5HisGln: 0.5 ± 0.022	1.468HisArg: 1.468 ± 0.044	0.86HisSer: 0.86 ± 0.03	0.634HisThr: 0.634 ± 0.026	1.353HisVal: 1.353 ± 0.045	0.322HisTrp: 0.322 ± 0.021	0.496HisTyr: 0.496 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	8.531IleAla: 8.531 ± 0.105	0.399IleCys: 0.399 ± 0.021	3.93IleAsp: 3.93 ± 0.079	3.445IleGlu: 3.445 ± 0.064	1.498IlePhe: 1.498 ± 0.044	5.205IleGly: 5.205 ± 0.087	0.842IleHis: 0.842 ± 0.035	1.749IleIle: 1.749 ± 0.049	1.065IleLys: 1.065 ± 0.038	4.121IleLeu: 4.121 ± 0.078	0.79IleMet: 0.79 ± 0.035	1.188IleAsn: 1.188 ± 0.044	2.187IlePro: 2.187 ± 0.053	1.048IleGln: 1.048 ± 0.035	3.269IleArg: 3.269 ± 0.065	2.258IleSer: 2.258 ± 0.054	2.366IleThr: 2.366 ± 0.054	4.283IleVal: 4.283 ± 0.072	0.549IleTrp: 0.549 ± 0.029	0.898IleTyr: 0.898 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.235LysAla: 4.235 ± 0.093	0.137LysCys: 0.137 ± 0.012	1.553LysAsp: 1.553 ± 0.062	1.276LysGlu: 1.276 ± 0.041	0.711LysPhe: 0.711 ± 0.031	2.51LysGly: 2.51 ± 0.062	0.487LysHis: 0.487 ± 0.027	1.44LysIle: 1.44 ± 0.042	1.099LysLys: 1.099 ± 0.043	3.151LysLeu: 3.151 ± 0.071	0.713LysMet: 0.713 ± 0.032	0.645LysAsn: 0.645 ± 0.029	1.983LysPro: 1.983 ± 0.063	0.889LysGln: 0.889 ± 0.036	2.354LysArg: 2.354 ± 0.062	1.562LysSer: 1.562 ± 0.046	1.657LysThr: 1.657 ± 0.052	2.093LysVal: 2.093 ± 0.061	0.339LysTrp: 0.339 ± 0.02	0.538LysTyr: 0.538 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	14.773LeuAla: 14.773 ± 0.177	0.674LeuCys: 0.674 ± 0.033	6.149LeuAsp: 6.149 ± 0.093	4.878LeuGlu: 4.878 ± 0.07	3.561LeuPhe: 3.561 ± 0.076	8.338LeuGly: 8.338 ± 0.106	1.807LeuHis: 1.807 ± 0.047	4.867LeuIle: 4.867 ± 0.082	3.226LeuLys: 3.226 ± 0.076	9.577LeuLeu: 9.577 ± 0.15	2.09LeuMet: 2.09 ± 0.057	2.188LeuAsn: 2.188 ± 0.054	5.36LeuPro: 5.36 ± 0.085	2.406LeuGln: 2.406 ± 0.052	6.764LeuArg: 6.764 ± 0.098	5.45LeuSer: 5.45 ± 0.082	5.279LeuThr: 5.279 ± 0.074	7.045LeuVal: 7.045 ± 0.098	1.213LeuTrp: 1.213 ± 0.041	1.917LeuTyr: 1.917 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.187MetAla: 3.187 ± 0.07	0.143MetCys: 0.143 ± 0.014	1.092MetAsp: 1.092 ± 0.039	1.046MetGlu: 1.046 ± 0.039	0.641MetPhe: 0.641 ± 0.029	1.883MetGly: 1.883 ± 0.046	0.399MetHis: 0.399 ± 0.021	1.335MetIle: 1.335 ± 0.039	0.938MetLys: 0.938 ± 0.035	2.522MetLeu: 2.522 ± 0.06	0.574MetMet: 0.574 ± 0.031	0.666MetAsn: 0.666 ± 0.025	1.424MetPro: 1.424 ± 0.04	0.695MetGln: 0.695 ± 0.028	1.944MetArg: 1.944 ± 0.043	1.35MetSer: 1.35 ± 0.036	1.664MetThr: 1.664 ± 0.043	1.446MetVal: 1.446 ± 0.046	0.23MetTrp: 0.23 ± 0.017	0.283MetTyr: 0.283 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.184AsnAla: 3.184 ± 0.064	0.217AsnCys: 0.217 ± 0.017	1.258AsnAsp: 1.258 ± 0.043	1.029AsnGlu: 1.029 ± 0.035	0.909AsnPhe: 0.909 ± 0.037	2.194AsnGly: 2.194 ± 0.071	0.383AsnHis: 0.383 ± 0.022	1.239AsnIle: 1.239 ± 0.05	0.56AsnLys: 0.56 ± 0.029	2.314AsnLeu: 2.314 ± 0.056	0.494AsnMet: 0.494 ± 0.025	0.605AsnAsn: 0.605 ± 0.031	1.733AsnPro: 1.733 ± 0.05	0.699AsnGln: 0.699 ± 0.032	1.909AsnArg: 1.909 ± 0.048	1.106AsnSer: 1.106 ± 0.043	0.98AsnThr: 0.98 ± 0.038	1.804AsnVal: 1.804 ± 0.044	0.364AsnTrp: 0.364 ± 0.021	0.637AsnTyr: 0.637 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	7.631ProAla: 7.631 ± 0.116	0.284ProCys: 0.284 ± 0.016	3.91ProAsp: 3.91 ± 0.064	3.689ProGlu: 3.689 ± 0.071	1.882ProPhe: 1.882 ± 0.051	5.043ProGly: 5.043 ± 0.097	1.083ProHis: 1.083 ± 0.038	2.459ProIle: 2.459 ± 0.05	1.553ProLys: 1.553 ± 0.047	4.93ProLeu: 4.93 ± 0.081	1.145ProMet: 1.145 ± 0.037	1.233ProAsn: 1.233 ± 0.036	3.373ProPro: 3.373 ± 0.112	1.639ProGln: 1.639 ± 0.052	3.38ProArg: 3.38 ± 0.06	2.634ProSer: 2.634 ± 0.051	2.449ProThr: 2.449 ± 0.059	4.387ProVal: 4.387 ± 0.083	0.659ProTrp: 0.659 ± 0.031	1.11ProTyr: 1.11 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.917GlnAla: 3.917 ± 0.077	0.22GlnCys: 0.22 ± 0.017	1.317GlnAsp: 1.317 ± 0.041	1.211GlnGlu: 1.211 ± 0.038	0.968GlnPhe: 0.968 ± 0.034	2.399GlnGly: 2.399 ± 0.056	0.525GlnHis: 0.525 ± 0.023	1.6GlnIle: 1.6 ± 0.049	0.815GlnLys: 0.815 ± 0.035	2.784GlnLeu: 2.784 ± 0.059	0.735GlnMet: 0.735 ± 0.029	0.661GlnAsn: 0.661 ± 0.028	1.913GlnPro: 1.913 ± 0.059	1.134GlnGln: 1.134 ± 0.046	2.529GlnArg: 2.529 ± 0.056	1.571GlnSer: 1.571 ± 0.044	1.519GlnThr: 1.519 ± 0.049	2.068GlnVal: 2.068 ± 0.055	0.358GlnTrp: 0.358 ± 0.023	0.529GlnTyr: 0.529 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	10.046ArgAla: 10.046 ± 0.124	0.508ArgCys: 0.508 ± 0.026	4.782ArgAsp: 4.782 ± 0.078	4.22ArgGlu: 4.22 ± 0.078	3.219ArgPhe: 3.219 ± 0.066	5.73ArgGly: 5.73 ± 0.087	1.619ArgHis: 1.619 ± 0.045	4.44ArgIle: 4.44 ± 0.078	2.06ArgLys: 2.06 ± 0.05	8.467ArgLeu: 8.467 ± 0.116	2.032ArgMet: 2.032 ± 0.05	1.792ArgAsn: 1.792 ± 0.051	4.009ArgPro: 4.009 ± 0.073	2.377ArgGln: 2.377 ± 0.054	6.427ArgArg: 6.427 ± 0.107	3.573ArgSer: 3.573 ± 0.069	3.647ArgThr: 3.647 ± 0.066	4.923ArgVal: 4.923 ± 0.083	1.291ArgTrp: 1.291 ± 0.049	1.935ArgTyr: 1.935 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	6.413SerAla: 6.413 ± 0.092	0.324SerCys: 0.324 ± 0.02	3.001SerAsp: 3.001 ± 0.056	2.578SerGlu: 2.578 ± 0.06	2.039SerPhe: 2.039 ± 0.054	5.286SerGly: 5.286 ± 0.113	0.888SerHis: 0.888 ± 0.035	2.498SerIle: 2.498 ± 0.061	1.294SerLys: 1.294 ± 0.042	4.691SerLeu: 4.691 ± 0.072	0.979SerMet: 0.979 ± 0.034	1.249SerAsn: 1.249 ± 0.042	2.735SerPro: 2.735 ± 0.06	1.287SerGln: 1.287 ± 0.035	3.465SerArg: 3.465 ± 0.074	2.324SerSer: 2.324 ± 0.059	2.213SerThr: 2.213 ± 0.054	3.471SerVal: 3.471 ± 0.062	0.654SerTrp: 0.654 ± 0.029	1.281SerTyr: 1.281 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.501ThrAla: 6.501 ± 0.098	0.321ThrCys: 0.321 ± 0.02	2.796ThrAsp: 2.796 ± 0.057	2.26ThrGlu: 2.26 ± 0.063	1.726ThrPhe: 1.726 ± 0.048	5.259ThrGly: 5.259 ± 0.107	0.811ThrHis: 0.811 ± 0.032	2.817ThrIle: 2.817 ± 0.069	1.199ThrLys: 1.199 ± 0.043	5.595ThrLeu: 5.595 ± 0.08	1.089ThrMet: 1.089 ± 0.037	1.181ThrAsn: 1.181 ± 0.042	3.438ThrPro: 3.438 ± 0.074	1.279ThrGln: 1.279 ± 0.038	3.466ThrArg: 3.466 ± 0.069	2.298ThrSer: 2.298 ± 0.058	2.434ThrThr: 2.434 ± 0.052	4.044ThrVal: 4.044 ± 0.068	0.558ThrTrp: 0.558 ± 0.025	1.12ThrTyr: 1.12 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	10.126ValAla: 10.126 ± 0.121	0.526ValCys: 0.526 ± 0.024	4.532ValAsp: 4.532 ± 0.075	4.599ValGlu: 4.599 ± 0.075	2.004ValPhe: 2.004 ± 0.048	5.563ValGly: 5.563 ± 0.096	1.269ValHis: 1.269 ± 0.04	3.609ValIle: 3.609 ± 0.063	2.13ValLys: 2.13 ± 0.054	6.142ValLeu: 6.142 ± 0.091	1.605ValMet: 1.605 ± 0.047	1.898ValAsn: 1.898 ± 0.059	4.019ValPro: 4.019 ± 0.065	1.992ValGln: 1.992 ± 0.051	5.428ValArg: 5.428 ± 0.09	3.811ValSer: 3.811 ± 0.07	4.344ValThr: 4.344 ± 0.082	5.179ValVal: 5.179 ± 0.097	0.823ValTrp: 0.823 ± 0.032	1.382ValTyr: 1.382 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.445TrpAla: 1.445 ± 0.046	0.097TrpCys: 0.097 ± 0.011	0.702TrpAsp: 0.702 ± 0.028	0.601TrpGlu: 0.601 ± 0.033	0.508TrpPhe: 0.508 ± 0.025	0.902TrpGly: 0.902 ± 0.034	0.295TrpHis: 0.295 ± 0.016	0.645TrpIle: 0.645 ± 0.031	0.419TrpLys: 0.419 ± 0.022	1.771TrpLeu: 1.771 ± 0.065	0.324TrpMet: 0.324 ± 0.019	0.392TrpAsn: 0.392 ± 0.023	0.755TrpPro: 0.755 ± 0.032	0.535TrpGln: 0.535 ± 0.024	1.396TrpArg: 1.396 ± 0.04	0.847TrpSer: 0.847 ± 0.031	0.823TrpThr: 0.823 ± 0.031	0.822TrpVal: 0.822 ± 0.036	0.24TrpTrp: 0.24 ± 0.018	0.249TrpTyr: 0.249 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.74TyrAla: 2.74 ± 0.058	0.18TyrCys: 0.18 ± 0.014	1.579TyrAsp: 1.579 ± 0.037	1.175TyrGlu: 1.175 ± 0.04	0.837TyrPhe: 0.837 ± 0.032	2.16TyrGly: 2.16 ± 0.053	0.449TyrHis: 0.449 ± 0.023	0.83TyrIle: 0.83 ± 0.035	0.522TyrLys: 0.522 ± 0.024	2.002TyrLeu: 2.002 ± 0.053	0.378TyrMet: 0.378 ± 0.02	0.572TyrAsn: 0.572 ± 0.028	1.029TyrPro: 1.029 ± 0.033	0.639TyrGln: 0.639 ± 0.031	2.005TyrArg: 2.005 ± 0.057	1.092TyrSer: 1.092 ± 0.041	0.887TyrThr: 0.887 ± 0.032	1.6TyrVal: 1.6 ± 0.044	0.324TyrTrp: 0.324 ± 0.021	0.625TyrTyr: 0.625 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2739 proteins (862315 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---