Amino acid dipepetide frequency for Neorhizobium sp. JUb45

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.316AlaAla: 15.316 ± 0.14	0.906AlaCys: 0.906 ± 0.024	6.818AlaAsp: 6.818 ± 0.067	7.242AlaGlu: 7.242 ± 0.092	4.455AlaPhe: 4.455 ± 0.05	10.095AlaGly: 10.095 ± 0.081	2.039AlaHis: 2.039 ± 0.036	7.018AlaIle: 7.018 ± 0.072	4.538AlaLys: 4.538 ± 0.065	12.069AlaLeu: 12.069 ± 0.118	3.558AlaMet: 3.558 ± 0.051	3.12AlaAsn: 3.12 ± 0.059	4.747AlaPro: 4.747 ± 0.071	3.702AlaGln: 3.702 ± 0.061	7.215AlaArg: 7.215 ± 0.074	6.684AlaSer: 6.684 ± 0.073	6.067AlaThr: 6.067 ± 0.107	8.408AlaVal: 8.408 ± 0.09	1.299AlaTrp: 1.299 ± 0.033	2.544AlaTyr: 2.544 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.757CysAla: 0.757 ± 0.023	0.088CysCys: 0.088 ± 0.007	0.492CysAsp: 0.492 ± 0.017	0.411CysGlu: 0.411 ± 0.015	0.301CysPhe: 0.301 ± 0.013	0.829CysGly: 0.829 ± 0.023	0.208CysHis: 0.208 ± 0.011	0.387CysIle: 0.387 ± 0.014	0.174CysLys: 0.174 ± 0.01	0.742CysLeu: 0.742 ± 0.023	0.164CysMet: 0.164 ± 0.008	0.213CysAsn: 0.213 ± 0.011	0.366CysPro: 0.366 ± 0.015	0.215CysGln: 0.215 ± 0.011	0.513CysArg: 0.513 ± 0.018	0.425CysSer: 0.425 ± 0.013	0.325CysThr: 0.325 ± 0.013	0.54CysVal: 0.54 ± 0.018	0.102CysTrp: 0.102 ± 0.008	0.183CysTyr: 0.183 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.689AspAla: 6.689 ± 0.071	0.45AspCys: 0.45 ± 0.016	3.185AspAsp: 3.185 ± 0.057	3.416AspGlu: 3.416 ± 0.054	2.387AspPhe: 2.387 ± 0.037	5.326AspGly: 5.326 ± 0.078	1.283AspHis: 1.283 ± 0.026	3.628AspIle: 3.628 ± 0.047	1.951AspLys: 1.951 ± 0.039	5.915AspLeu: 5.915 ± 0.06	1.519AspMet: 1.519 ± 0.029	1.636AspAsn: 1.636 ± 0.032	3.132AspPro: 3.132 ± 0.052	1.751AspGln: 1.751 ± 0.033	4.052AspArg: 4.052 ± 0.063	2.122AspSer: 2.122 ± 0.044	2.77AspThr: 2.77 ± 0.063	4.189AspVal: 4.189 ± 0.052	0.89AspTrp: 0.89 ± 0.02	1.546AspTyr: 1.546 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.001GluAla: 7.001 ± 0.078	0.317GluCys: 0.317 ± 0.014	2.894GluAsp: 2.894 ± 0.05	3.326GluGlu: 3.326 ± 0.055	1.923GluPhe: 1.923 ± 0.033	4.056GluGly: 4.056 ± 0.044	1.144GluHis: 1.144 ± 0.026	3.765GluIle: 3.765 ± 0.052	2.899GluLys: 2.899 ± 0.049	5.223GluLeu: 5.223 ± 0.072	1.553GluMet: 1.553 ± 0.034	2.046GluAsn: 2.046 ± 0.03	2.608GluPro: 2.608 ± 0.048	2.247GluGln: 2.247 ± 0.041	4.378GluArg: 4.378 ± 0.062	2.277GluSer: 2.277 ± 0.036	3.726GluThr: 3.726 ± 0.057	3.644GluVal: 3.644 ± 0.053	0.715GluTrp: 0.715 ± 0.02	1.026GluTyr: 1.026 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.54PheAla: 4.54 ± 0.054	0.404PheCys: 0.404 ± 0.014	2.789PheAsp: 2.789 ± 0.047	2.234PheGlu: 2.234 ± 0.036	1.583PhePhe: 1.583 ± 0.036	3.786PheGly: 3.786 ± 0.052	0.74PheHis: 0.74 ± 0.022	1.955PheIle: 1.955 ± 0.035	1.161PheLys: 1.161 ± 0.027	3.566PheLeu: 3.566 ± 0.054	0.901PheMet: 0.901 ± 0.025	1.211PheAsn: 1.211 ± 0.027	1.59PhePro: 1.59 ± 0.034	1.09PheGln: 1.09 ± 0.024	2.251PheArg: 2.251 ± 0.039	2.682PheSer: 2.682 ± 0.041	2.079PheThr: 2.079 ± 0.07	2.903PheVal: 2.903 ± 0.048	0.573PheTrp: 0.573 ± 0.022	0.976PheTyr: 0.976 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	8.232GlyAla: 8.232 ± 0.076	0.725GlyCys: 0.725 ± 0.02	4.409GlyAsp: 4.409 ± 0.061	4.748GlyGlu: 4.748 ± 0.063	3.756GlyPhe: 3.756 ± 0.054	6.972GlyGly: 6.972 ± 0.096	1.827GlyHis: 1.827 ± 0.034	4.983GlyIle: 4.983 ± 0.055	3.755GlyLys: 3.755 ± 0.064	8.543GlyLeu: 8.543 ± 0.092	2.426GlyMet: 2.426 ± 0.033	2.583GlyAsn: 2.583 ± 0.07	3.162GlyPro: 3.162 ± 0.044	2.873GlyGln: 2.873 ± 0.047	5.486GlyArg: 5.486 ± 0.057	4.906GlySer: 4.906 ± 0.069	4.751GlyThr: 4.751 ± 0.134	5.768GlyVal: 5.768 ± 0.067	1.25GlyTrp: 1.25 ± 0.031	2.351GlyTyr: 2.351 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.203HisAla: 2.203 ± 0.039	0.191HisCys: 0.191 ± 0.01	1.243HisAsp: 1.243 ± 0.026	1.069HisGlu: 1.069 ± 0.027	0.848HisPhe: 0.848 ± 0.02	1.829HisGly: 1.829 ± 0.03	0.573HisHis: 0.573 ± 0.023	1.028HisIle: 1.028 ± 0.024	0.559HisLys: 0.559 ± 0.019	2.038HisLeu: 2.038 ± 0.038	0.545HisMet: 0.545 ± 0.016	0.46HisAsn: 0.46 ± 0.015	1.183HisPro: 1.183 ± 0.026	0.608HisGln: 0.608 ± 0.018	1.306HisArg: 1.306 ± 0.032	1.0HisSer: 1.0 ± 0.024	0.802HisThr: 0.802 ± 0.024	1.467HisVal: 1.467 ± 0.027	0.311HisTrp: 0.311 ± 0.014	0.552HisTyr: 0.552 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.903IleAla: 7.903 ± 0.087	0.553IleCys: 0.553 ± 0.018	3.956IleAsp: 3.956 ± 0.044	3.739IleGlu: 3.739 ± 0.047	2.05IlePhe: 2.05 ± 0.039	5.439IleGly: 5.439 ± 0.072	0.978IleHis: 0.978 ± 0.024	2.799IleIle: 2.799 ± 0.045	1.743IleLys: 1.743 ± 0.032	4.966IleLeu: 4.966 ± 0.06	1.24IleMet: 1.24 ± 0.027	1.703IleAsn: 1.703 ± 0.039	2.398IlePro: 2.398 ± 0.037	1.275IleGln: 1.275 ± 0.027	3.468IleArg: 3.468 ± 0.053	3.68IleSer: 3.68 ± 0.05	3.236IleThr: 3.236 ± 0.072	4.618IleVal: 4.618 ± 0.057	0.64IleTrp: 0.64 ± 0.021	1.285IleTyr: 1.285 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.796LysAla: 4.796 ± 0.065	0.168LysCys: 0.168 ± 0.009	2.092LysAsp: 2.092 ± 0.048	1.831LysGlu: 1.831 ± 0.036	1.088LysPhe: 1.088 ± 0.029	2.837LysGly: 2.837 ± 0.057	0.649LysHis: 0.649 ± 0.018	2.181LysIle: 2.181 ± 0.045	1.574LysLys: 1.574 ± 0.039	3.775LysLeu: 3.775 ± 0.058	0.911LysMet: 0.911 ± 0.026	1.168LysAsn: 1.168 ± 0.026	2.352LysPro: 2.352 ± 0.048	1.161LysGln: 1.161 ± 0.025	2.461LysArg: 2.461 ± 0.045	2.253LysSer: 2.253 ± 0.042	2.466LysThr: 2.466 ± 0.043	2.689LysVal: 2.689 ± 0.044	0.41LysTrp: 0.41 ± 0.015	0.669LysTyr: 0.669 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	12.297LeuAla: 12.297 ± 0.102	0.803LeuCys: 0.803 ± 0.022	5.786LeuAsp: 5.786 ± 0.07	5.182LeuGlu: 5.182 ± 0.065	3.605LeuPhe: 3.605 ± 0.056	7.885LeuGly: 7.885 ± 0.082	1.788LeuHis: 1.788 ± 0.035	5.334LeuIle: 5.334 ± 0.068	4.035LeuLys: 4.035 ± 0.057	8.935LeuLeu: 8.935 ± 0.102	2.471LeuMet: 2.471 ± 0.043	2.714LeuAsn: 2.714 ± 0.038	5.283LeuPro: 5.283 ± 0.066	2.833LeuGln: 2.833 ± 0.039	5.906LeuArg: 5.906 ± 0.07	7.178LeuSer: 7.178 ± 0.081	5.927LeuThr: 5.927 ± 0.088	7.148LeuVal: 7.148 ± 0.07	1.015LeuTrp: 1.015 ± 0.026	1.994LeuTyr: 1.994 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	3.18MetAla: 3.18 ± 0.043	0.135MetCys: 0.135 ± 0.009	1.257MetAsp: 1.257 ± 0.029	1.227MetGlu: 1.227 ± 0.027	0.792MetPhe: 0.792 ± 0.022	1.758MetGly: 1.758 ± 0.033	0.448MetHis: 0.448 ± 0.016	1.608MetIle: 1.608 ± 0.033	1.16MetLys: 1.16 ± 0.027	2.695MetLeu: 2.695 ± 0.039	0.717MetMet: 0.717 ± 0.021	0.836MetAsn: 0.836 ± 0.019	1.63MetPro: 1.63 ± 0.033	0.919MetGln: 0.919 ± 0.022	1.883MetArg: 1.883 ± 0.03	1.876MetSer: 1.876 ± 0.033	2.079MetThr: 2.079 ± 0.032	1.816MetVal: 1.816 ± 0.039	0.208MetTrp: 0.208 ± 0.01	0.302MetTyr: 0.302 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.481AsnAla: 3.481 ± 0.058	0.223AsnCys: 0.223 ± 0.011	1.722AsnAsp: 1.722 ± 0.057	1.464AsnGlu: 1.464 ± 0.026	1.136AsnPhe: 1.136 ± 0.03	2.861AsnGly: 2.861 ± 0.091	0.578AsnHis: 0.578 ± 0.02	1.634AsnIle: 1.634 ± 0.035	0.825AsnLys: 0.825 ± 0.026	2.819AsnLeu: 2.819 ± 0.041	0.714AsnMet: 0.714 ± 0.02	0.91AsnAsn: 0.91 ± 0.024	1.916AsnPro: 1.916 ± 0.039	0.825AsnGln: 0.825 ± 0.021	1.975AsnArg: 1.975 ± 0.033	1.536AsnSer: 1.536 ± 0.036	1.507AsnThr: 1.507 ± 0.033	2.138AsnVal: 2.138 ± 0.049	0.482AsnTrp: 0.482 ± 0.017	0.723AsnTyr: 0.723 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.666ProAla: 5.666 ± 0.074	0.243ProCys: 0.243 ± 0.011	3.353ProAsp: 3.353 ± 0.037	3.358ProGlu: 3.358 ± 0.047	1.989ProPhe: 1.989 ± 0.036	3.864ProGly: 3.864 ± 0.054	1.027ProHis: 1.027 ± 0.024	2.42ProIle: 2.42 ± 0.037	1.873ProLys: 1.873 ± 0.034	4.427ProLeu: 4.427 ± 0.056	1.222ProMet: 1.222 ± 0.026	1.38ProAsn: 1.38 ± 0.03	2.069ProPro: 2.069 ± 0.041	1.706ProGln: 1.706 ± 0.032	2.453ProArg: 2.453 ± 0.043	2.857ProSer: 2.857 ± 0.042	2.482ProThr: 2.482 ± 0.044	4.221ProVal: 4.221 ± 0.063	0.586ProTrp: 0.586 ± 0.019	1.19ProTyr: 1.19 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.958GlnAla: 3.958 ± 0.051	0.167GlnCys: 0.167 ± 0.01	1.458GlnAsp: 1.458 ± 0.021	1.569GlnGlu: 1.569 ± 0.035	1.152GlnPhe: 1.152 ± 0.027	2.186GlnGly: 2.186 ± 0.039	0.65GlnHis: 0.65 ± 0.021	1.999GlnIle: 1.999 ± 0.06	1.349GlnLys: 1.349 ± 0.028	2.891GlnLeu: 2.891 ± 0.049	0.995GlnMet: 0.995 ± 0.026	1.014GlnAsn: 1.014 ± 0.027	1.808GlnPro: 1.808 ± 0.035	1.387GlnGln: 1.387 ± 0.035	2.234GlnArg: 2.234 ± 0.037	1.981GlnSer: 1.981 ± 0.033	1.894GlnThr: 1.894 ± 0.031	2.264GlnVal: 2.264 ± 0.043	0.383GlnTrp: 0.383 ± 0.014	0.617GlnTyr: 0.617 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	6.314ArgAla: 6.314 ± 0.074	0.399ArgCys: 0.399 ± 0.016	3.78ArgAsp: 3.78 ± 0.056	3.737ArgGlu: 3.737 ± 0.05	2.751ArgPhe: 2.751 ± 0.048	4.281ArgGly: 4.281 ± 0.063	1.611ArgHis: 1.611 ± 0.036	4.012ArgIle: 4.012 ± 0.054	2.437ArgLys: 2.437 ± 0.041	6.92ArgLeu: 6.92 ± 0.077	1.914ArgMet: 1.914 ± 0.035	2.02ArgAsn: 2.02 ± 0.035	3.007ArgPro: 3.007 ± 0.054	2.575ArgGln: 2.575 ± 0.047	4.681ArgArg: 4.681 ± 0.068	3.678ArgSer: 3.678 ± 0.056	3.15ArgThr: 3.15 ± 0.042	4.165ArgVal: 4.165 ± 0.056	0.831ArgTrp: 0.831 ± 0.023	1.712ArgTyr: 1.712 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.621SerAla: 6.621 ± 0.084	0.398SerCys: 0.398 ± 0.015	3.325SerAsp: 3.325 ± 0.063	3.176SerGlu: 3.176 ± 0.042	2.571SerPhe: 2.571 ± 0.04	5.978SerGly: 5.978 ± 0.073	1.195SerHis: 1.195 ± 0.022	3.332SerIle: 3.332 ± 0.045	1.957SerLys: 1.957 ± 0.033	5.827SerLeu: 5.827 ± 0.062	1.516SerMet: 1.516 ± 0.027	1.63SerAsn: 1.63 ± 0.033	2.753SerPro: 2.753 ± 0.043	1.821SerGln: 1.821 ± 0.031	3.66SerArg: 3.66 ± 0.051	3.558SerSer: 3.558 ± 0.051	3.153SerThr: 3.153 ± 0.064	4.458SerVal: 4.458 ± 0.066	0.783SerTrp: 0.783 ± 0.022	1.447SerTyr: 1.447 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.603ThrAla: 6.603 ± 0.112	0.376ThrCys: 0.376 ± 0.015	3.103ThrAsp: 3.103 ± 0.062	2.827ThrGlu: 2.827 ± 0.034	2.249ThrPhe: 2.249 ± 0.049	5.198ThrGly: 5.198 ± 0.115	1.02ThrHis: 1.02 ± 0.026	3.456ThrIle: 3.456 ± 0.083	1.759ThrLys: 1.759 ± 0.032	5.833ThrLeu: 5.833 ± 0.074	1.356ThrMet: 1.356 ± 0.03	1.533ThrAsn: 1.533 ± 0.041	3.162ThrPro: 3.162 ± 0.067	1.587ThrGln: 1.587 ± 0.037	3.073ThrArg: 3.073 ± 0.043	3.238ThrSer: 3.238 ± 0.051	3.108ThrThr: 3.108 ± 0.063	4.77ThrVal: 4.77 ± 0.138	0.655ThrTrp: 0.655 ± 0.018	1.377ThrTyr: 1.377 ± 0.071	0.0ThrXaa: 0.0 ± 0.0
Val	8.78ValAla: 8.78 ± 0.083	0.564ValCys: 0.564 ± 0.018	4.088ValAsp: 4.088 ± 0.048	4.415ValGlu: 4.415 ± 0.056	2.863ValPhe: 2.863 ± 0.047	5.376ValGly: 5.376 ± 0.066	1.299ValHis: 1.299 ± 0.031	4.473ValIle: 4.473 ± 0.052	2.572ValLys: 2.572 ± 0.053	7.075ValLeu: 7.075 ± 0.072	1.954ValMet: 1.954 ± 0.037	2.139ValAsn: 2.139 ± 0.08	3.481ValPro: 3.481 ± 0.041	2.041ValGln: 2.041 ± 0.035	4.276ValArg: 4.276 ± 0.054	5.053ValSer: 5.053 ± 0.072	4.794ValThr: 4.794 ± 0.144	5.707ValVal: 5.707 ± 0.075	0.81ValTrp: 0.81 ± 0.02	1.519ValTyr: 1.519 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.104TrpAla: 1.104 ± 0.027	0.117TrpCys: 0.117 ± 0.009	0.623TrpAsp: 0.623 ± 0.021	0.535TrpGlu: 0.535 ± 0.018	0.545TrpPhe: 0.545 ± 0.015	0.822TrpGly: 0.822 ± 0.026	0.306TrpHis: 0.306 ± 0.014	0.65TrpIle: 0.65 ± 0.02	0.5TrpLys: 0.5 ± 0.017	1.513TrpLeu: 1.513 ± 0.028	0.36TrpMet: 0.36 ± 0.015	0.475TrpAsn: 0.475 ± 0.018	0.614TrpPro: 0.614 ± 0.02	0.599TrpGln: 0.599 ± 0.019	0.966TrpArg: 0.966 ± 0.025	0.813TrpSer: 0.813 ± 0.022	0.737TrpThr: 0.737 ± 0.021	0.741TrpVal: 0.741 ± 0.022	0.203TrpTrp: 0.203 ± 0.01	0.283TrpTyr: 0.283 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.396TyrAla: 2.396 ± 0.038	0.208TyrCys: 0.208 ± 0.01	1.465TyrAsp: 1.465 ± 0.03	1.261TyrGlu: 1.261 ± 0.026	0.968TyrPhe: 0.968 ± 0.022	2.128TyrGly: 2.128 ± 0.04	0.45TyrHis: 0.45 ± 0.015	1.008TyrIle: 1.008 ± 0.021	0.711TyrLys: 0.711 ± 0.024	2.35TyrLeu: 2.35 ± 0.035	0.491TyrMet: 0.491 ± 0.018	0.676TyrAsn: 0.676 ± 0.024	1.13TyrPro: 1.13 ± 0.024	0.74TyrGln: 0.74 ± 0.023	1.738TyrArg: 1.738 ± 0.034	1.362TyrSer: 1.362 ± 0.029	1.23TyrThr: 1.23 ± 0.065	1.625TyrVal: 1.625 ± 0.032	0.361TyrTrp: 0.361 ± 0.015	0.624TyrTyr: 0.624 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5878 proteins (1828676 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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